Effect of losartan and fish oil on plasma IL-6 and mobility in older persons.The ENRGISe pilot randomized clinical trial
Open accessAbstract
BACKGROUND: Low-grade chronic inflammation, characterized by elevations in plasma Interleukin-6 (IL-6), is an independent risk factor of impaired mobility in older persons. Angiotensin receptor blockers and omega-3 polyunsaturated fatty acids (ω-3) may reduce IL-6 and may potentially improve physical function. To assess the main effects of the angiotensin receptor blocker losartan and ω-3 as fish oil on IL-6 and 400 m walking speed, we conducted the ENRGISE Pilot multicenter randomized clinical trial. METHODS: The ENRGISE Pilot enrolled participants between April 2016 and June 2017, who participated for 12 months. Participants were aged ≥70 years with mobility impairment, had IL-6 between 2.5 and 30 pg/mL, and were able to walk 400 m at baseline. Participants were randomized in three strata 2 × 2 factorial to: (i) losartan 50-100 mg/d or placebo (n = 43), (ii) fish oil 1,400-2,800 mg/d or placebo (n = 180), and (iii) with both (n = 66). RESULTS: Two hundred eighty-nine participants were randomized (mean age 78.3 years, 47.4% women, 17.0% black). There was no effect of losartan (difference of means = -0.065 ± 0.116 [SE], 95% confidence interval [CI]: -0.293-0.163, p = .58) or fish oil (-0.020 ± 0.077, 95% CI: -0.171-0.132, p = .80) on the log of IL-6. Similarly, there was no effect of losartan (-0.025 ± 0.026, 95% CI: -0.076-0.026, p = .34) or fish oil (0.010 ± 0.017, 95% CI: -0.025-0.044, p = .58) on walking speed (m/s). CONCLUSIONS: These results do not support the use of these interventions to prevent mobility loss in older adults at risk of disability with low-grade chronic inflammation. REGISTRATION: Clinicaltrials.gov NCT02676466.
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Apart from McGlory and Pahor, who reported no effects, other studies have identified changes after omega-3 PUFA supplementation.
“Few studies have been carried out regarding the effects of omega-3 PUFAs on muscle cells and, apart from McGlory [34] and Pahor [35] who reported no effects, the other studies have identified changes after omega 3-PUFAs supplementation.”
From Novel Insights on Intake of Fish and Prevention of Sarcopenia: All Reasons for an Adequate Consumption (2020) · cites this paper as [35]
In the two studies that showed no effect of omega-3 PUFAs, the duration of the McGlory et al. study was short compared to other studies, while the Pahor study assessed long-term omega-3 supplementation in a large number of very compromised patients.
“In the two studies that showed no effect of omega-3 PUFAs, the duration of the study by Mcglory et al. [43] was short compared to other studies, while the study by Pahor [35] assessed long-term omega-3 supplementation on a large number of very compromised patients.”
From Novel Insights on Intake of Fish and Prevention of Sarcopenia: All Reasons for an Adequate Consumption (2020) · cites this paper as [35]
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“8 g/d), placebo, or combined losartan plus fish oil on changes in inflammatory burden and gait speed in older adults (N = 290, age ≥ 70 years) with baseline mobility limitations and chronic low-grade inflammation (16).”
BackgroundAydoğan, T. M. I., Toepfer, S., Spira, D., Kreutz, R. H., & Demuth, I. (2025) · medRxiv · doi:10.1101/2025.08.01.25332603
Getting to the heart of sarcopenia and cardiovascular disease
Nezafati, P., Saxena, P., Raman, J., Hebbard, L., & McFarlane, C. (2025) · Aging · doi:10.18632/aging.206296
The “Reducing Inflammation for Greater Health Trial ( RIGHT )” Study—Concept, Rationale, and Design
Sattui, S. E., Bertolet, M. H., Forman, D. E., Danielson, M. E., Yao, S., López, O. L., Glynn, N. W., Nadkarni, N. K., Sekikawa, A. M., Bruno, T. C., et al. (2026) · Journal of the American Geriatrics Society · doi:10.1111/jgs.70272
“We based our power estimates on ENRGISE [20], where the 400-m walking speed at baseline was 0.8 ± 0.2 m/s, and at 12 months the difference and standard error (SE) for the within person change of the 400-m walking speed between losartan versus placebo was − 0.025 ± 0.026 m/s and was 0.010 ± 0.014…”
InfluentialВащилина, Т. С., & Астапенко, А. В. (2025) · Неврология и нейрохирургия Восточная Европа · doi:10.34883/pi.2025.15.4.050
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Ilchenko, L. Y., Ахмедов, В. А., Vinnitskaya, E. V., Иванович, Д. Е., Myazin, R. G., Nikitin, I. G., Tikhomirova, A. S., Khoroshilov, I., Myazin, R. G., Александровна, Э. О., et al. (2026) · Экспериментальная и клиническая гастроэнтерология · doi:10.31146/1682-8658-ecg-236-4-3-36
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- Authors
- Pahor, M., Anton, S. D., Beavers, D. P., Cauley, J. A., Fielding, R. A., Kritchevsky, S. B., Leeuwenburgh, C., Lewis, K. H., Liu, C. K., Lovato, L. C., Lu, J., Manini, T. M., McDermott, M. M., Miller, M. E., Newman, A. B., Radziszewska, B., Stowe, C. L., Tracy, R. P., Walkup, M. P., Wu, S. S., & Ambrosius, W. T.
- Affiliations
- University of Florida (US)
- Wake Forest University Health Sciences (US)
- University of Pittsburgh (US)
- Tufts University (US)
- Boston University (US)
- Northwestern University (US)
- National Institutes of Health (US)
- University of Vermont (US)
- Corresponding author
- Pahor, Marco
- ORCID
- Venue
- The Journals of Gerontology Series A
- Publisher
- Oxford University Press (OUP)
- Published
- 2018-12-12
- Volume
- 74
- Issue
- 10
- Pages
- 1612-1619
- ISSN
- 1079-5006 (ISSN-L)
- 1758-535X
- PMC
- PMC6748815
- OpenAlex
- W2905122684
- Cited by
- 50
- References
- 34
- Citations by year
- 2026: 6 · 2025: 7 · 2024: 3 · 2023: 8 · 2022: 5 · 2021: 6 · 2020: 9 · 2019: 5 · 2018: 1
- FWCI
- 3.61
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- The Journals of Gerontology Series A (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (U01AG050499)
- National Institute on Aging Cooperative Agreement (U01AG050499)
- University of Florida (P30AG028740)
- Wake Forest University (P30AG021332)
- Tufts University (P30AG031679)
- University of Pittsburgh (P30AG024827)
- Boston Rehabilitation Outcomes Center (R24HD065688-01A1)
- U.S. Department of Agriculture (58-1950-0-014)
- Abbott Laboratories
- Topics
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Health Sciences › Medicine › Geriatrics and Gerontology › Frailty in Older Adults
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Keywords
- losartan, fish oil, omega-3 fatty acids, interleukin-6, low-grade inflammation, mobility impairment, walking speed, older adults, angiotensin receptor blockers, physical function
- MeSH terms
- Walking Speed, Aged, Aged, 80 and over, Double-Blind Method, Female, Humans, Male, Pilot Projects, Fatty Acids, Omega-3, Interleukin-6, Losartan, Angiotensin II Type 1 Receptor Blockers, Mobility Limitation
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