Cited by 468Proteoglycans and glycosaminoglycans researchGlycosylation and Glycoproteins ResearchCellular Mechanics and Interactions

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Brain extracellular matrix

Ruoslahti, Erkki·1996·Glycobiology

DOI 10.1093/glycob/6.5.489

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Abstract

The extracellular matrix of the adult brain tissue has a unique composition. The striking feature of this matrix is the prominence of lecticans, proteoglycans that contain a lectin domain and a hyaluronic acid-binding domain. Hyaluronic acid and tenascin family adhesive/anti-adhesive proteins are also abundant. Matrix proteins common in other tissues are nearly absent in adult brain. The brain extracellular matrix appears to have trophic effects on neuronal cells and affect neurite outgrowth. The unique composition of this matrix may be responsible for the resistance of brain tissue toward invasion by tumors of non-neuronal origin.

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Authors: Ruoslahti, E.
Affiliations: Sanford Burnham Prebys Medical Discovery Institute (US)
Corresponding author: Ruoslahti, Erkki
ORCID: Ruoslahti, Erkki
Venue: Glycobiology
Publisher: Oxford University Press (OUP)
Published: 1996
Volume: 6
Issue: 5
Pages: 489-492
ISSN: 0959-6658 (ISSN-L)
1460-2423
DOI: 10.1093/glycob/6.5.489
OpenAlex: W1988575276
Cited by: 467
References: 40
Citations by year: 2026: 10 · 2025: 7 · 2024: 15 · 2023: 14 · 2022: 22 · 2021: 28 · 2020: 35 · 2019: 23 · 2018: 17 · 2017: 19 · 2016: 18 · 2015: 17 · 2014: 25 · 2013: 16 · 2012: 19
FWCI: 6.05
Type: journal article
Language: en
Open access: closed
Locations: Glycobiology (publishedVersion)
PubMed (publishedVersion)
Funders: Karolinska Institutet
National Institutes of Health (5p01ca028896-15)
National Cancer Institute (CA30199, CA 28896, P30CA030199)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Glycosylation and Glycoproteins Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
Keywords: brain extracellular matrix, lecticans, proteoglycans, hyaluronic acid, tenascin, matrix protein, neurite outgrowth
MeSH terms: Adult, Brain Chemistry, Extracellular Matrix, Humans, Hyaluronic Acid, Protein Binding, Proteoglycans, Tenascin, Lectins

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