Fucose, placental evolution and the glycocode
Open accessAbstract
A family of 13 fucosyltransferase genes has evolved to catalyze the addition of fucose in various linkage positions to nascent glycoproteins. Null mutations in mice are unearthing unsuspected functions for glycoprotein fucosylation that affect embryo implantation and growth of the conceptus. Furthermore, as we show here, histological studies demonstrate that a variety of fucosylated structures are found within the glycan-rich interface between trophectoderm and uterine epithelium. We suggest that conservation or change in fucosyltransferase gene expression over evolutionary time has played a role in determining the stability of the maternal-fetal interface and therefore in shaping reproductive compatibility and, in turn, speciation.
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Varki, A. (2017) · Glycobiology · doi:10.1093/glycob/cww086 · Cited by 2,635 · see citing works
“After fertilization, there is evidence that glycans and glycan-binding proteins are involved in the processes of implantation (944) and placental functions (945, 946) in mammals.”
BackgroundSweet complementarity: the functional pairing of glycans with lectins
Gabius, H.-J., Manning, J. C., Kopitz, J., André, S., & Kaltner, H. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2163-8 · Cited by 74 · see citing works
Murphy, P., André, S., & Gabius, H.-J. (2013) · Molecules · doi:10.3390/molecules18044026 · Cited by 54 · see citing works
- Authors
- Aplin, J. D., & Jones, C. J.
- Affiliations
- Manchester Academic Health Science Centre (GB)
- Venue
- Glycobiology
- Publisher
- Oxford University Press (OUP)
- Published
- 2011-10-24
- Volume
- 22
- Issue
- 4
- Pages
- 470-478
- ISSN
- 0959-6658 (ISSN-L)
- 1460-2423
- OpenAlex
- W1968536281
- Cited by
- 61
- References
- 69
- Citations by year
- 2024: 1 · 2023: 7 · 2022: 4 · 2021: 7 · 2020: 4 · 2019: 7 · 2018: 3 · 2017: 8 · 2016: 5 · 2015: 4 · 2014: 7 · 2013: 2 · 2012: 1
- FWCI
- 0.29
- Type
- journal article
- Language
- en
- Open access
- Licence
- other-oa
- Locations
- Glycobiology (publishedVersion)
- PubMed (publishedVersion)
- Research Explorer (The University of Manchester) (publishedVersion, other-oa)
- Research Explorer (The University of Manchester) (submittedVersion, other-oa)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Glycosylation and Glycoproteins Research
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
- Keywords
- fucose, placental evolution, embryo implantation, conceptus growth, maternal-fetal interface, trophectoderm, uterine epithelium, reproductive compatibility, speciation
- MeSH terms
- Animals, Embryo, Mammalian, Female, Fucose, Fucosyltransferases, Glycosylation, Embryo Implantation, Placenta, Pregnancy, Evolution, Molecular
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