Cited by 61Glycosylation and Glycoproteins ResearchReproductive System and PregnancyReproductive Biology and Fertility

Fucose, placental evolution and the glycocode

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Aplin, J. D., Jones, C. J.·2012·Glycobiology

Abstract

A family of 13 fucosyltransferase genes has evolved to catalyze the addition of fucose in various linkage positions to nascent glycoproteins. Null mutations in mice are unearthing unsuspected functions for glycoprotein fucosylation that affect embryo implantation and growth of the conceptus. Furthermore, as we show here, histological studies demonstrate that a variety of fucosylated structures are found within the glycan-rich interface between trophectoderm and uterine epithelium. We suggest that conservation or change in fucosyltransferase gene expression over evolutionary time has played a role in determining the stability of the maternal-fetal interface and therefore in shaping reproductive compatibility and, in turn, speciation.

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Registry

Crossref · 10.1093/glycob/cwr156

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69 of 69 references verified0 citation errors · 0 not checkable

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Authors
Aplin, J. D., & Jones, C. J.
Affiliations
Manchester Academic Health Science Centre (GB)
Venue
Glycobiology
Published
2011-10-24
Volume
22
Issue
4
Pages
470-478
ISSN
  • 0959-6658 (ISSN-L)
  • 1460-2423
OpenAlex
W1968536281
Cited by
61
References
69
Citations by year
2024: 1 · 2023: 7 · 2022: 4 · 2021: 7 · 2020: 4 · 2019: 7 · 2018: 3 · 2017: 8 · 2016: 5 · 2015: 4 · 2014: 7 · 2013: 2 · 2012: 1
FWCI
0.29
Type
journal article
Language
en
Licence
other-oa
Locations
  • Glycobiology (publishedVersion)
  • PubMed (publishedVersion)
  • Research Explorer (The University of Manchester) (publishedVersion, other-oa)
  • Research Explorer (The University of Manchester) (submittedVersion, other-oa)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Glycosylation and Glycoproteins Research
  • Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
Keywords
fucose, placental evolution, embryo implantation, conceptus growth, maternal-fetal interface, trophectoderm, uterine epithelium, reproductive compatibility, speciation
MeSH terms
Animals, Embryo, Mammalian, Female, Fucose, Fucosyltransferases, Glycosylation, Embryo Implantation, Placenta, Pregnancy, Evolution, Molecular

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