Trophoblast L-Selectin-Mediated Adhesion at the Maternal-Fetal Interface
Abstract
Trophoblast adhesion to the uterine wall is the requisite first step of implantation and, subsequently, placentation. At the maternal-fetal interface, we investigated the expression of selectin adhesion systems that enable leukocyte capture from the bloodstream. On the maternal side, human uterine epithelial cells up-regulated selectin oligosaccharide-based ligands during the window of receptivity. On the fetal side, human trophoblasts expressed L-selectin. This ligand-receptor system was functional, because beads coated with the selectin ligand 6-sulfo sLe x bound to trophoblasts, and trophoblasts bound to ligand-expressing uterine luminal epithelium in tissue sections. These results suggest that trophoblast L-selectin mediates interactions with the uterus and that this adhesion mechanism may be critical to establishing human pregnancy.
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- Authors
- Genbacev, O. D., Prakobphol, A., Foulk, R. A., Krtolica, A. R., Ilic, D., Singer, M. S., Yang, Z.-Q., Kiessling, L. L., Rosen, S. D., & Fisher, S. J.
- Affiliations
- University of Wisconsin–Madison (US)
- Corresponding author
- Fisher, Susan J.
- Venue
- Science
- Published
- 2003-01-17
- Volume
- 299
- Issue
- 5605
- Pages
- 405-408
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2039585575
- Cited by
- 476
- References
- 18
- Citations by year
- 2026: 4 · 2025: 12 · 2024: 4 · 2023: 12 · 2022: 21 · 2021: 11 · 2020: 18 · 2019: 20 · 2018: 18 · 2017: 24 · 2016: 11 · 2015: 18 · 2014: 26 · 2013: 26 · 2012: 28
- FWCI
- 9.76
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung, and Blood Institute (HL64597, R01HL064597)
- National Institute of General Medical Sciences (R37GM23547, R37GM023547)
- National Institute of Dental and Craniofacial Research (DE-07244)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (U01 HD 42283, U01HD042283)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Keywords
- trophoblast, L-selectin, maternal-fetal interface, implantation, placentation, endometrial receptivity, uterine epithelial cells, selectin ligands, pregnancy establishment
- MeSH terms
- Sialyl Lewis X Antigen, Animals, Antibodies, Blastocyst, Cell Adhesion, Cells, Cultured, Endometrium, Epithelial Cells, Female, Follicular Phase, Humans, Ligands, Luteal Phase, Microspheres, Oligosaccharides, Organ Culture Techniques, Embryo Implantation, Pregnancy, Trophoblasts, Immunoblotting, Up-Regulation, L-Selectin, Jurkat Cells, Mice
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