Cited by 648BRCA gene mutations in cancerDNA Repair MechanismsPARP inhibition in cancer therapy

The DOI matches its Crossref record; 92 of the 93 references it cites were found in a registry or an index.

BRCA1 and BRCA2 and the genetics of breast and ovarian cancer

Welcsh, P. L.·2001·Human Molecular Genetics

Open this paper in CoChat — free account

Abstract

Germline mutations in the tumor suppressor genes BRCA1 and BRCA2 predispose individuals to breast and ovarian cancers. Progress in determining the function of BRCA1 and BRCA2 suggests that they are involved in two fundamental cellular processes: DNA damage repair and transcriptional regulation. We evaluate current knowledge of BRCA1 and BRCA2 functions to explain why mutations in BRCA1 and BRCA2 lead specifically to breast and ovarian cancer. The BRCA1 and BRCA2 genes contain unusually high densities of repetitive elements. These features of the BRCAs genomic regions contribute to chromosomal instability of these genes. We propose that somatic alterations of BRCA1 and BRCA2 are common and driven by rearrangements between repetitive elements. Inherited and somatic mutations occur in BRCA1 and BRCA2; virtually all somatic mutations are the result of large genomic rearrangements. What are the consequences of such large somatic mutations of BRCA1 and BRCA2 in women with or without inherited mutations? The breast and ovary are estrogen-responsive tissues. Beginning in puberty, the breast epithelium proliferates rapidly in response to fluctuating levels of estrogen. We present a genetic model outlining how BRCA-deficient cells may gain uncontrolled proliferation leading to tumor formation. Central to this model of BRCA-mediated tumorigenesis are estrogen-mediated proliferation of breast and ovarian epithelium and the distinctive genomic context of the BRCA genes.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1093/hmg/10.7.705

Cites

92 of 92 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

A Strong Candidate for the Breast and Ovarian Cancer Susceptibility Gene BRCA1
Miki, Y., Swensen, J. J., Shattuck-Eidens, D. M., Futreal, P. A., Harshman, K., Tavtigian, S. V., Liu, Q., Cochran, C., Bennett, L. M., Ding, W., et al. (1994) · Science · doi:10.1126/science.7545954 · Cited by 6,069
Identification of the breast cancer susceptibility gene BRCA2
Wooster, R., Bignell, G. R., Lancaster, J., Swift, S., Seal, S., Mangion, J., Collins, N., Gregory, S. G., Gumbs, C. E., Micklem, G., et al. (1995) · Nature · doi:10.1038/378789a0 · Cited by 3,645
Linkage of Early-Onset Familial Breast Cancer to Chromosome 17q21
Hall, J., Lee, M. K., Newman, B. M., Morrow, J. E., Anderson, L. A., Huey, B., & King, M. (1990) · Science · doi:10.1126/science.2270482 · Cited by 2,544
A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage
Paull, T. T., Rogakou, E. P., Yamazaki, V., Kirchgessner, C. U., Gellert, M., & Bonner, W. M. (2000) · Current Biology · doi:10.1016/s0960-9822(00)00610-2 · Cited by 2,098
Localization of a Breast Cancer Susceptibility Gene, BRCA2 , to Chromosome 13q12-13
Wooster, R., Neuhausen, S. L., Mangion, J., Quirk, Y., Ford, D., Collins, N., Nguyen, K. N., Seal, S., Tran, T. D., Averill, D., et al. (1994) · Science · doi:10.1126/science.8091231 · Cited by 1,918
Risks of cancer in BRCA1-mutation carriers
FORD, D. (1994) · The Lancet · doi:10.1016/s0140-6736(94)91578-4 · Cited by 1,850
Association of BRCA1 with Rad51 in Mitotic and Meiotic Cells
Scully, R., Chen, J., Plug, A., Xiao, Y., Weaver, D., Feunteun, J., Ashley, T., & Livingston, D. M. (1997) · Cell · doi:10.1016/s0092-8674(00)81847-4 · Cited by 1,459
Cancer risks in BRCA2 mutation carriers.
Olsson, H. (1999) · Journal of the National Cancer Institute · doi:10.1093/jnci/91.15.1310 · Cited by 1,404
BRCA1 mutations in primary breast and ovarian carcinomas.
Futreal, P., Liu, Q., Shattuck-Eidens, D., Cochran, C., Harshman, K., Tavtigian, S., Bennett, L., Haugen-Strano, A., Swensen, J., & Miki, Y. (1994) · Science · doi:10.1126/science.7939630 · Cited by 1,378
BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures.
Wang, Y., Cortez, D., Yazdi, P., Neff, N., Elledge, S. J., & Qin, J. (2000) · Genes & Development · doi:10.1101/gad.14.8.927 · Cited by 1,221
Dynamic changes of BRCA1 subnuclear location and phosphorylation state are initiated by DNA damage
Scully, R., Chen, J., Ochs, R. L., Keegan, K., Hoekstra, M., Feunteun, J., & Livingston, D. M. (1997) · Cell · doi:10.1016/s0092-8674(00)80503-6 · Cited by 900
Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation
Xu, X., Wagner, K., Larson, D. M., Ohler, Z. W., Li, C., Ried, T., Hennighausen, L. G., Wynshaw-Boris, A. J., & Deng, C. (1999) · Nature Genetics · doi:10.1038/8743 · Cited by 766
Identification of a RING protein that can interact in vivo with the BRCA1 gene product
Wu, L. C., Wang, Z. W., Tsan, J. T., Spillman, M. A., Phung, A., Xu, X. L., Yang, M.-C. W., Hwang, L.-Y., Bowcock, A. M., & Baer, R. J. (1996) · Nature Genetics · doi:10.1038/ng1296-430 · Cited by 743
BAP1: a novel ubiquitin hydrolase which binds to the BRCA1 RING finger and enhances BRCA1-mediated cell growth suppression
Jensen, D. E., Proctor, M. L., Marquis, S. T., Gardner, H. P., Ha, S. I., Chodosh, L. A., Ishov, A. M., Tommerup, N., Vissing, H., Sekido, Y., et al. (1998) · Oncogene · doi:10.1038/sj.onc.1201861 · Cited by 725
In search of the tumour-suppressor functions of BRCA1 and BRCA2
Scully, R., & Livingston, D. M. (2000) · Nature · doi:10.1038/35044000 · Cited by 643
Pattern formation by local self-activation and lateral inhibition
Meinhardt, H., & Gierer, A. (2000) · BioEssays · doi:10.1002/1521-1878(200008)22:8 · Cited by 629
Association of BRCA1 with the hRad50-hMre11-p95 Complex and the DNA Damage Response
Zhong, Q., Chen, C.-F., Li, S., Chen, Y., Wang, C.-C., Xiao, J., Chen, P.-L., Sharp, Z. D., & Lee, W.-H. (1999) · Science · doi:10.1126/science.285.5428.747 · Cited by 626
Human genome organization: Alu, LINES, and the molecular structure of metaphase chromosome bands
Korenberg, J. R., & Rykowski, M. C. (1988) · Cell · doi:10.1016/0092-8674(88)90159-6 · Cited by 560
Induction of GADD45 and JNK/SAPK-Dependent Apoptosis following Inducible Expression of BRCA1
Harkin, D. P., Bean, J. M., Miklos, D. B., Song, Y., Truong, V. B., Englert, C., Christians, F. C., Ellisen, L. W., Maheswaran, S., Oliner, J. D., et al. (1999) · Cell · doi:10.1016/s0092-8674(00)80769-2 · Cited by 558
An entire functional mammary gland may comprise the progeny from a single cell
Kordon, E. C., & Smith, G. H. (1998) · Development · doi:10.1242/dev.125.10.1921 · Cited by 553
BRCA1 Is Associated with a Human SWI/SNF-Related Complex
Bochar, D. A., Wang, L., Beniya, H., Kinev, A. V., Xue, Y., Lane, W. S., Wang, W., Kashanchi, F., & Shiekhattar, R. (2000) · Cell · doi:10.1016/s0092-8674(00)00030-1 · Cited by 546
hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response
Lee, J., Collins, K. M., Brown, A. L., Lee, C. H., & Chung, J. H. (2000) · Nature · doi:10.1038/35004614 · Cited by 529
BRCA1 inhibition of estrogen receptor signaling in transfected cells.
Fan, S., Wang, J.-A., Yuan, R., Ma, Y., Meng, Q., Erdos, M., Pestell, R., Yuan, F., Auborn, K., Goldberg, I., et al. (1999) · Science · doi:10.1126/science.284.5418.1354 · Cited by 521
Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress
Tibbetts, R. S., Cortez, D., Brumbaugh, K. M., Scully, R., Livingston, D., Elledge, S. J., & Abraham, R. T. (2000) · Genes & Development · doi:10.1101/gad.851000 · Cited by 512
BRCA1 physically associates with p53 and stimulates its transcriptional activity
Zhang, H., Somasundaram, K., Peng, Y., Tian, H., Zhang, H., Bi, D., Weber, B. L., & El‐Deiry, W. S. (1998) · Oncogene · doi:10.1038/sj.onc.1201932 · Cited by 492
BRCA1 is a component of the RNA polymerase II holoenzyme
Scully, R., Anderson, S. F., Chao, D. M., Wei, W., Ye, L., Young, R. A., Livingston, D. M., & Parvin, J. D. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.11.5605 · Cited by 454
Localization of human BRCA1 and its loss in high-grade, non-inherited breast carcinomas
Wilson, C., Ramos, L., Villaseñor, M. R., Anders, K. H., Press, M. F., Clarke, K., Karlan, B. Y., Chen, J.-J., Scully, R., Livingston, D. M., et al. (1999) · Nature Genetics · doi:10.1038/6029 · Cited by 414
Allele losses in the region 17q12–21 in familial breast and ovarian cancer involve the wild–type chromosome
Smith, S. A., Easton, D. F., Evans, D. G., & Ponder, B. A. J. (1992) · Nature Genetics · doi:10.1038/ng1092-128 · Cited by 410
BRCA1 protein is linked to the RNA polymerase II holoenzyme complex via RNA helicase A
Anderson, S. F., Schlegel, B. P., Nakajima, T., Wolpin, E. S., & Parvin, J. D. (1998) · Nature Genetics · doi:10.1038/930 · Cited by 393
The C-terminal (BRCT) Domains of BRCA1 Interact in Vivo with CtIP, a Protein Implicated in the CtBP Pathway of Transcriptional Repression
Yu, X., Wu, L. C., Bowcock, A. M., Aronheim, A., & Baer, R. J. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.39.25388 · Cited by 389
BRCA1 regulates p53-dependent gene expression
Ouchi, T., Monteiro, Á. N. A., August, A., Aaronson, S. A., & Hanafusa, H. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.5.2302 · Cited by 375
Epidermal growth factor-induced nuclear factor κB activation: A major pathway of cell-cycle progression in estrogen-receptor negative breast cancer cells
Biswas, D. K., Cruz, A. P., Gansberger, E., & Pardee, A. B. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.15.8542 · Cited by 353
Functional link of BRCA1 and ataxia telangiectasia gene product in DNA damage response
Li, S., Ting, N. S. Y., Zheng, L., Chen, P., Ziv, Y., Shiloh, Y., Lee, E. Y.-H. P., & Lee, W. (2000) · Nature · doi:10.1038/35018134 · Cited by 336
Insights into the functions of BRCA1 and BRCA2
Welcsh, P. L., Owens, K. N., & King, M. (2000) · Trends in Genetics · doi:10.1016/s0168-9525(99)01930-7 · Cited by 335
Self-citation
BRCA1 interacts with components of the histone deacetylase complex
Yarden, R. I., & Brody, L. C. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.9.4983 · Cited by 328
BRCA1 promoter region hypermethylation in ovarian carcinoma: a population-based study.
Baldwin, R. L., Nemeth, E., Tran, H., Shvartsman, H. S., Cass, I. A., Narod, S. A., & Karlan, B. Y. (2000) · PubMed · Cited by 324
BRCA1 is associated with the centrosome during mitosis
Hsu, L., & White, R. L. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.22.12983 · Cited by 312
Role of direct interaction in BRCA1 inhibition of estrogen receptor activity
Fan, S., Ma, Y.-X., Wang, C.-G., Yuan, R., Meng, Q., Wang, J.-A., Erdos, M., Goldberg, I., Webb, P., Kushner, P., et al. (2001) · Oncogene · doi:10.1038/sj.onc.1204073 · Cited by 293
Complete genomic sequence and analysis of 117 kb of human DNA containing the gene BRCA1.Preprint
Smith, T., Lee, M. K., Szabo, C., Jerome, N., Mceuen, M., Taylor, M. P., Hood, L., & King, M. (1996) · Genome Research · doi:10.1101/gr.6.11.1029 · Cited by 291
Consistent loss of the wild type allele in breast cancers from a family linked to the BRCA2 gene on chromosome 13q12-13.
Collins, N., McManus, R., Wooster, R., Mangion, J., Seal, S., Lakhani, S. R., Ormiston, W. J., Daly, P. A., Ford, D., & Easton, D. F. (1995) · PubMed · Cited by 243
BRCA1 binds c-Myc and inhibits its transcriptional and transforming activity in cells
Wang, Q., Zhang, H., Kajino, K., & Greene, M. I. (1998) · Oncogene · doi:10.1038/sj.onc.1202403 · Cited by 243
Sequence-Specific Transcriptional Corepressor Function for BRCA1 through a Novel Zinc Finger Protein, ZBRK1
Zheng, L., Pan, H., Li, S., Flesken‐Nikitin, A., Chen, P., Boyer, T., & Lee, W. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)00075-7 · Cited by 232
Identification of Id4 as a regulator of BRCA1 expression by using a ribozyme-library-based inverse genomics approach
Beger, C., Pierce, L. N., Krüger, M., Marcusson, E. G., Robbins, J. M., Welcsh, P. L., Welch, P. J., Welte, K., King, M., Barber, J. R., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.1.130 · Cited by 224
Self-citation
CBP/p300 interact with and function as transcriptional coactivators of BRCA1
Pao, G. M., Janknecht, R., Ruffner, H., Hunter, T. R., & Verma, I. M. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.3.1020 · Cited by 222
Unexpected relationships between four large deletions in the human β-globin gene cluster
Vanin, E. F., Henthom, P. S., Kioussis, D., Grosveld, F. G., & Smithies, O. (1983) · Cell · doi:10.1016/0092-8674(83)90103-4 · Cited by 210
The Nuclear Localization Sequences of the BRCA1 Protein Interact with the Importin-α Subunit of the Nuclear Transport Signal Receptor
Chen, C., Li, S., Chen, Y., Chen, P., Sharp, Z. D., & Lee, W. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.51.32863 · Cited by 203
Collaboration of signal transducer and activator of transcription 1 (STAT1) and BRCA1 in differential regulation of IFN-γ target genes
Ouchi, T., Lee, S. W., Ouchi, M., Aaronson, S. A., & Horvath, C. M. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.080469697 · Cited by 202
Binding of CtIP to the BRCT Repeats of BRCA1 Involved in the Transcription Regulation of p21 Is Disrupted Upon DNA Damage
Li, S., Chen, P., Subramanian, T., Chinnadurai, G., Tomlinson, G. E., Osborne, C. K., Sharp, Z. D., & Lee, W. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.16.11334 · Cited by 192
Lessons learned from BRCA1 and BRCA2
Zheng, L., Li, S., Boyer, T., & Lee, W. (2000) · Oncogene · doi:10.1038/sj.onc.1203968 · Cited by 187
Interaction between the Product of the Breast Cancer Susceptibility Gene BRCA2 and DSS1, a Protein Functionally Conserved from Yeast to Mammals
Marston, N. J., Richards, W. J., Hughes, D. A., Bertwistle, D., Marshall, C. J., & Ashworth, A. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.7.4633 · Cited by 186
The second BRCT domain of BRCA1 proteins interacts with p53 and stimulates transcription from the p21WAF1/CIP1 promoter
Chai, Y., Cui, J., Shao, N., Reddy, E. S. P., & Rao, V. N. (1999) · Oncogene · doi:10.1038/sj.onc.1202323 · Cited by 179
Increase of androgen-induced cell death and androgen receptor transactivation by BRCA1 in prostate cancer cells.
Yeh, S., Hu, Y.-C., Rahman, M., Lin, H.-K., Hsu, C.-L., Ting, H., Kang, H.-Y., & Chang, C. (2000) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.190353897 · Cited by 169
BRCA2 in American families with four or more cases of breast or ovarian cancer: recurrent and novel mutations, variable expression, penetrance, and the possibility of families whose cancer is not attributable to BRCA1 or BRCA2.
Schubert, E. L., Lee, M. K., Mefford, H. C., ARGONZA, R. H., Morrow, J. E., Hull, J., Dann, J. L., & King, M. (1997) · PubMed · Cited by 166
Role of the tumor suppressor gene Brca1 in genetic stability and mammary gland tumor formation
Deng, C., & Scott, F. (2000) · Oncogene · doi:10.1038/sj.onc.1203269 · Cited by 163
Characterization of a carboxy-terminal BRCA1 interacting protein
Wong, A. K. C., Ormonde, P. A., Pero, R. S., Chen, Y., Lian, L., Salada, G. C., Berry, S., Lawrence, Q. A., Dayananth, P., Ha, P. C., et al. (1998) · Oncogene · doi:10.1038/sj.onc.1202150 · Cited by 162
BRCA1-associated growth arrest is RB-dependent
Aprelikova, O. N., Fang, B. S., Meissner, E. G., Cotter, S. E., Campbell, M., Kuthiala, A., Bessho, M., Jensen, R. A., & Liu, E. T. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.21.11866 · Cited by 158
Screening for Genomic Rearrangements in Families with Breast and Ovarian Cancer Identifies BRCA1 Mutations Previously Missed by Conformation-Sensitive Gel Electrophoresis or Sequencing
Unger, M. A., Nathanson, K. L., Calzone, K., Antin-Ozerkis, D. E., Shih, H. A., Martin, A., Lenoir, G., Mazoyer, S., & Weber, B. L. (2000) · The American Journal of Human Genetics · doi:10.1086/303076 · Cited by 157
Nuclear structure and the three‐dimensional organization of DNA
Getzenberg, R. H., Pienta, K. J., Ward, W. S., & Coffey, D. S. (1991) · Journal of Cellular Biochemistry · doi:10.1002/jcb.240470402 · Cited by 152
A Human BRCA2 Complex Containing a Structural DNA Binding Component Influences Cell Cycle Progression
Marmorstein, L. Y., Kinev, A. V., Chan, G. K. T., Bochar, D. A., Beniya, H., Epstein, J. A., Yen, T. J., & Shiekhattar, R. (2001) · Cell · doi:10.1016/s0092-8674(01)00209-4 · Cited by 147
BRCA1 proteins are transported to the nucleus in the absence of serum and splice variants BRCA1a, BRCA1b are tyrosine phosphoproteins that associate with E2F, cyclins and cyclin dependent kinases
Wang, H., Shao, N., Ding, Q. M., Cui, J., Reddy, E. S. P., & Rao, V. N. (1997) · Oncogene · doi:10.1038/sj.onc.1201252 · Cited by 130
Regulation of BRCA1 Expression by the Rb-E2F Pathway
Wang, A., Schneider‐Broussard, R., Kumar, A. P., MacLeod, M. C., & Johnson, D. G. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.6.4532 · Cited by 122
Identification of a Novel Cytoplasmic Protein That Specifically Binds to Nuclear Localization Signal Motifs
Li, S., Ku, C.-Y., Farmer, A. A., Cong, Y.-S., Chen, C., & Lee, W. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.11.6183 · Cited by 121
BRCA1 Is Phosphorylated at Serine 1497 In Vivo at a Cyclin-Dependent Kinase 2 Phosphorylation Site
Ruffner, H., Jiang, W. B., Craig, A. G., Hunter, T. R., & Verma, I. M. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.7.4843 · Cited by 115
BRCA2 associates with acetyltransferase activity when bound to P/CAF
Fuks, F., Milner, J., & Kouzarides, T. (1998) · Oncogene · doi:10.1038/sj.onc.1202475 · Cited by 107
Absence of methylation of CpG dinucleotides within the promoter of the breast cancer susceptibility gene BRCA2 in normal tissues and in breast and ovarian cancers
Collins, N., Wooster, R., & Stratton, M. (1997) · British Journal of Cancer · doi:10.1038/bjc.1997.526 · Cited by 103
Tumor Suppressor p53 Is Required To Modulate BRCA1 Expression
Arizti, P., Li, F., Park, I., Yin, Y., Solomon, E., Ouchi, T., Aaronson, S. A., & Lee, S. W. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.20.7450-7459.2000 · Cited by 102
Loss of heterozygosity in sporadic breast tumours at the BRCA2 locus on chromosome 13q12-q13
Cleton-Jansen, A. M., Collins, N., Lakhani, S. R., Weissenbach, J., Devilee, P., Cornelisse, C., & Stratton, M. (1995) · British Journal of Cancer · doi:10.1038/bjc.1995.493 · Cited by 98
MYB oncogene amplification in hereditary BRCA1 breast cancer.
Kauraniemi, P., Hedenfalk, I. A., Persson, K., Duggan, D. J., Tanner, M., Johannsson, O. T., Olsson, H. L., Trent, J. M., Isola, J. J., & Borg, Å. (2000) · PubMed · Cited by 94
A large deletion disrupts the exon 3 transcription activation domain of the BRCA2 gene in a breast/ovarian cancer family.
Nordling, M., Karlsson, P., Wahlström, J., Engwall, Y., Wallgren, A., & Martinsson, T. (1998) · PubMed · Cited by 93
BRCA1: exploring the links to transcription
Monteiro, Á. N. A. (2000) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(00)01632-7 · Cited by 87
BRCA1 and cell signaling
Wang, Q., Zhang, H., Fishel, R. A., & Greene, M. I. (2000) · Oncogene · doi:10.1038/sj.onc.1203974 · Cited by 87
Overexpression of BRCA2 gene in sporadic breast tumours
Bièche, I., Noguès, C., & Lidereau, R. (1999) · Oncogene · doi:10.1038/sj.onc.1202903 · Cited by 77
VCP, a Weak ATPase Involved in Multiple Cellular Events, Interacts Physically with BRCA1 in the Nucleus of Living Cells
Zhang, H., Wang, Q., Kajino, K., & Greene, M. I. (2000) · DNA and Cell Biology · doi:10.1089/10445490050021168 · Cited by 74
Sequences Attaching Loops of Nuclear and Mitochondrial DNA to Underlying Structures in Human Cells: The Role of Transcription Units
Jackson, D. A., Bartlett, J., & Cook, P. R. (1996) · Nucleic Acids Research · doi:10.1093/nar/24.7.1212 · Cited by 74
DNA loops: structural and functional properties of scaffold‐attached regions
Roberge, M., & Gasser, S. M. (1992) · Molecular Microbiology · doi:10.1111/j.1365-2958.1992.tb01485.x · Cited by 70
The Brn-3b POU family transcription factor represses expression of the BRCA-1 anti-oncogene in breast cancer cells
Budhram-Mahadeo, V. S., Ndisang, D., Ward, T., Weber, B. L., & Latchman, D. S. (1999) · Oncogene · doi:10.1038/sj.onc.1203072 · Cited by 69
DNA polymerase stalling, sister chromatid recombination and the BRCA genes
Scully, R., Puget, N., & Vlasáková, K. (2000) · Oncogene · doi:10.1038/sj.onc.1203971 · Cited by 68
The elusive nuclear matrix
Jack, R. S., & Eggert, H. (1992) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1992.tb17314.x · Cited by 67
BRCA1 Physically and Functionally Interacts with ATF1
Houvras, Y. J., Benezra, M., Zhang, H., Manfredi, J. J., Weber, B. L., & Licht, J. D. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m002539200 · Cited by 66
BRCA1 interaction with RNA polymerase II reveals a role for hRPB2 and hRPB10α in activated transcription
Schlegel, B. P., Green, V. J., Ladias, J. A. A., & Parvin, J. D. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.7.3148 · Cited by 63
The BRCT Regions of Tumor Suppressor BRCA1 and of XRCC1 Show DNA End Binding Activity with a Multimerizing Feature
Yamane, K., Katayama, E., & TSURUO, T. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.3983 · Cited by 62
GA-binding protein α/β is a critical regulator of the BRCA1 promoter
Atlas, E., Stramwasser, M., Whiskin, K., & Mueller, C. R. (2000) · Oncogene · doi:10.1038/sj.onc.1203516 · Cited by 55
Induction of the BRCA2 Promoter by Nuclear Factor-κB
Wu, K., Jiang, S. W., Thangaraju, M., Wu, G., & Couch, F. J. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m004390200 · Cited by 54
The Functions of Breast Cancer Susceptibility Gene 1 (BRCA1) Product and Its Associated Proteins
Irminger‐Finger, I., Siegel, B., & Leung, W.-C. (1999) · Biological Chemistry · doi:10.1515/bc.1999.019 · Cited by 53
Low expression of bcl-2 in Brca1-associated breast cancers
Fréneaux, P., Stoppa‐Lyonnet, D., Mouret, E., Kambouchner, M., Nicolas, A., Sigal‐Zafrani, B., Vincent‐Salomon, A., Fourquet, A., Magdelénat, H., & Sastre‐Garau, X. (2000) · British Journal of Cancer · doi:10.1054/bjoc.2000.1438 · Cited by 51
Igfbp-3 mediates TGFβ1 proliferative response in colon cancer cells
Kansra, S., Ewton, D. Z., Wang, J., & Friedman, E. (2000) · International Journal of Cancer · doi:10.1002/1097-0215(20000801)87:3 · Cited by 48
Potential role of BRCA2 in a mitotic checkpoint after phosphorylation by hBUBR1.
Futamura, M., Arakawa, H., Matsuda, K., Katagiri, T., Saji, S., Miki, Y., & Nakamura, Y. (2000) · PubMed · Cited by 48
The frequency and distribution of sister chromatid exchanges in human chromosomes
Morgan, W. F., & Crossen, P. E. (1977) · Human Genetics · doi:10.1007/bf00402152 · Cited by 37
The BRCA2 activation domain associates with and is phosphorylated by a cellular protein kinase
Milner, J., Fuks, F., Hughes‐Davies, L., & Kouzarides, T. (2000) · Oncogene · doi:10.1038/sj.onc.1203793 · Cited by 25
BRCA1-associated growth arrest is RB-dependent
Bessho, M., Kuthiala, A., Meissner, E. G., et al. (2020) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/kgh8-cv59 · Cited by 19
TGF-β1 Inhibits BRCA1 Expression through a Pathway That Requires pRb
Satterwhite, D. J., Matsunami, N., & White, R. L. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.3510 · Cited by 15
The elusive nuclear matrix
Jack, R. S., & Eggert, H. (1993) · Springer eBooks · doi:10.1007/978-3-642-78046-2_18 · Cited by 3

Flagged first, then by citations

1 of the 93 references couldn’t be matched to a known paper.

Sorted by citations

Maintenance Olaparib for Germline BRCA -Mutated Metastatic Pancreatic Cancer
Golan, T., Hammel, P., Reni, M., Van Cutsem, E., Macarulla, T., Hall, M. J., Park, J.-O., Hochhauser, D., Arnold, D., Oh, D.-Y., et al. (2019) · New England Journal of Medicine · doi:10.1056/nejmoa1903387 · Cited by 2,302
Genetic Mapping in Human Disease
Altshuler, D., Daly, M. J., & Lander, E. S. (2008) · Science · doi:10.1126/science.1156409 · Cited by 1,452
Olaparib in patients with recurrent high-grade serous or poorly differentiated ovarian carcinoma or triple-negative breast cancer: a phase 2, multicentre, open-label, non-randomised study
Gelmon, K. A., Tischkowitz, M. D., MacKay, H. J., Swenerton, K. D., Robidoux, A., Tonkin, K. S., Hirte, H. W., Huntsman, D. D., Clemons, M. J., Gilks, C. B., et al. (2011) · The Lancet Oncology · doi:10.1016/s1470-2045(11)70214-5 · Cited by 1,130
Molecular views of recombination proteins and their control
West, S. C. (2003) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1127 · Cited by 977
Control of BRCA2 Cellular and Clinical Functions by a Nuclear Partner, PALB2
Xia, B., Sheng, Q., Nakanishi, K., Ohashi, A., Wu, J., Christ, N., Liu, X., Jasin, M., Couch, F. J., & Livingston, D. M. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.05.022 · Cited by 861

See all 648

Authors: Welcsh, P. L.
Affiliations: University of Washington (US)
Corresponding author: Welcsh, P. L.
Venue: Human Molecular Genetics
Publisher: Oxford University Press (OUP)
Published: 2001-04-01
Volume: 10
Issue: 7
Pages: 705-713
ISSN: 0964-6906 (ISSN-L)
1460-2083
DOI: 10.1093/hmg/10.7.705
OpenAlex: W2124371549
Cited by: 648
References: 93
Citations by year: 2026: 11 · 2025: 16 · 2024: 25 · 2023: 19 · 2022: 19 · 2021: 26 · 2020: 27 · 2019: 33 · 2018: 30 · 2017: 36 · 2016: 34 · 2015: 31 · 2014: 29 · 2013: 25 · 2012: 17
FWCI: 4.10
Type: journal article
Language: en
Open access: closed
Locations: Human Molecular Genetics (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5r01ca027632-22)
National Cancer Institute (CA27632)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › BRCA gene mutations in cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Health Sciences › Medicine › Oncology › PARP inhibition in cancer therapy
Keywords: BRCA1, BRCA2, hereditary breast cancer, hereditary ovarian cancer, germline mutations, somatic mutations, DNA repair, transcriptional regulation, repetitive elements, chromosomal instability, genome rearrangement, carcinogenesis, tumor suppressor
MeSH terms: Breast Neoplasms, Cell Division, Chromosomes, Estrogens, Female, Humans, Models, Biological, Mutation, Neoplasm Proteins, Ovarian Neoplasms, Repetitive Sequences, Nucleic Acid, Transcription Factors, Gene Deletion, Genes, BRCA1, Genetic Predisposition to Disease, BRCA2 Protein

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

BRCA1 and BRCA2 and the genetics of breast and ovarian cancer

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks