Association of BRCA1 with Rad51 in Mitotic and Meiotic Cells

A Strong Candidate for the Breast and Ovarian Cancer Susceptibility Gene BRCA1

Miki, Y., Swensen, J. J., Shattuck-Eidens, D. M., Futreal, P. A., Harshman, K., Tavtigian, S. V., Liu, Q., Cochran, C., Bennett, L. M., Ding, W., et al. (1994) · Science · doi:10.1126/science.7545954 · Cited by 6,069 · see citing works

Germ Line p53 Mutations in a Familial Syndrome of Breast Cancer, Sarcomas, and Other Neoplasms

Malkin, D., Li, F. P., Strong, L. C., Fraumeni, J. F., Nelson, C. E., Kim, D. H., Kassel, J., Gryka, M. A., Bischoff, F. Z., Tainsky, M. A., et al. (1990) · Science · doi:10.1126/science.1978757 · Cited by 3,765 · see citing works

Linkage of Early-Onset Familial Breast Cancer to Chromosome 17q21

Hall, J., Lee, M. K., Newman, B. M., Morrow, J. E., Anderson, L. A., Huey, B., & King, M. (1990) · Science · doi:10.1126/science.2270482 · Cited by 2,544 · see citing works

Transfer of purified herpes virus thymidine kinase gene to cultured mouse cells

Wigler, M. H., Silverstein, S. J., Lee, L., Pellicer, À., Cheng, Y., & Axel, R. (1977) · Cell · doi:10.1016/0092-8674(77)90333-6 · Cited by 1,352 · see citing works

Rad51 protein involved in repair and recombination in S. cerevisiae is a RecA-like protein

Shinohara, A., Ogawa, H., & Ogawa, T. (1992) · Cell · doi:10.1016/0092-8674(92)90447-k · Cited by 1,248 · see citing works

Genetic linkage analysis in familial breast and ovarian cancer: results from 214 families. The Breast Cancer Linkage Consortium.

Easton, D. F., Bishop, D. T., Ford, D., & Crockford, G. P. (1993) · Europe PMC (PubMed Central) · Cited by 1,243 · see citing works

Molecular cloning and functional analysis of the adenovirus E1A-associated 300-kD protein (p300) reveals a protein with properties of a transcriptional adaptor.Preprint

Eckner, R., Ewen, M. E., Newsome, D., Gerdes, M., DeCaprio, J. A., Lawrence, J. B., & Livingston, D. M. (1994) · Genes & Development · doi:10.1101/gad.8.8.869 · Cited by 1,045 · see citing works

Genetic analysis of breast cancer in the cancer and steroid hormone study.

Claus, E. B., RISCH, N. J., & Thompson, W. D. (1991) · PubMed · Cited by 911 · see citing works

Catalysis of ATP-Dependent Homologous DNA Pairing and Strand Exchange by Yeast RAD51 Protein

Sung, P. (1994) · Science · doi:10.1126/science.8066464 · Cited by 869 · see citing works

Involvement of mouse Mlh1 in DNA mismatch repair and meiotic crossing over

Baker, S. M., Plug, A. W., Prolla, T. A., Bronner, C. E., Harris, A. C., Yao, X., Christie, D. M., Monell, C. R., Arnheim, N., Bradley, A., et al. (1996) · Nature Genetics · doi:10.1038/ng0796-336 · Cited by 821 · see citing works

Expression cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like properties

Kaelin, W. G., Krek, W., Sellers, W. R., DeCaprio, J. A., Ajchenbaum, F., Fuchs, C. S., Chittenden, T. D., Li, Y., Farnham, P., Blanar, M. A., et al. (1992) · Cell · doi:10.1016/0092-8674(92)90108-o · Cited by 819 · see citing works

Targeted disruption of the Rad51 gene leads to lethality in embryonic mice.

Tsuzuki, T., Fujii, Y., Sakumi, K., Tominaga, Y., Nakao, K., Sekiguchi, M., Matsushiro, A., Yoshimura, Y., & MoritaT (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.13.6236 · Cited by 792 · see citing works

Breast and Other Cancers in Families with Ataxia-Telangiectasia

Swift, M., Reitnauer, P. J., Morrell, D., & Chase, C. L. (1987) · New England Journal of Medicine · doi:10.1056/nejm198705213162101 · Cited by 717 · see citing works

FIDELITY MECHANISMS IN DNA REPLICATION

Echols, H., & Goodman, M. F. (1991) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.60.070191.002401 · Cited by 712 · cited 1× · see citing works

Human Rad51 Protein Promotes ATP-Dependent Homologous Pairing and Strand Transfer Reactions In Vitro

Baumann, P., Benson, F. E., & West, S. C. (1996) · Cell · doi:10.1016/s0092-8674(00)81394-x · Cited by 689 · see citing works

A Mutation in Mouse rad51 Results in an Early Embryonic Lethal That Is Suppressed by a Mutation in p53

Lim, D., & Hasty, P. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.12.7133 · Cited by 687 · see citing works

The tumor suppressor gene Brca1 is required for embryonic cellular proliferation in the mouse.

Hakem, R., de la Pompa, J. L., Sirard, C., Mo, R., Woo, M., Hakem, A., Wakeham, A., Potter, J., Reitmair, A., Billia, F., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81302-1 · Cited by 680 · see citing works

Does this have a familiar RING?

Saurin, A. J., Borden, K. L. B., Boddy, M. N., & Freemont, P. S. (1996) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(96)80017-x · Cited by 635 · see citing works

Confirmation of BRCA1 by analysis of germline mutations linked to breast and ovarian cancer in ten families

Friedman, L. S., Ostermeyer, E. A., Szabo, C. I., Dowd, P., Lynch, E. D., Rowell, S. E., & King, M. (1994) · Nature Genetics · doi:10.1038/ng1294-399 · Cited by 622 · see citing works

Biochemistry and genetics of eukaryotic mismatch repair.Preprint

Kolodner, R. D. (1996) · Genes & Development · doi:10.1101/gad.10.12.1433 · Cited by 589 · see citing works

Nuclear foci of mammalian Rad51 recombination protein in somatic cells after DNA damage and its localization in synaptonemal complexes.

Haaf, T., Golub, E. I., Reddy, G., Radding, C. M., & Ward, D. C. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.6.2298 · Cited by 552 · see citing works

Meiotic Pachytene Arrest in MLH1-Deficient Mice

Edelmann, W., Cohen, P. E., Kane, M., Lau, K., Morrow, B. E., Bennett, S. E., Umar, A., Kunkel, T. A., Cattoretti, G., Chaganti, R. S. K., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81312-4 · Cited by 546 · see citing works

Male mice defective in the DNA mismatch repair gene PMS2 exhibit abnormal chromosome synapsis in meiosis

Baker, S. M., Bronner, C. E., Zhang, L., Plug, A. W., Robatzek, M., Warren, G., Elliott, E. A., Yu, J., Ashley, T., Arnheim, N., et al. (1995) · Cell · doi:10.1016/0092-8674(95)90318-6 · Cited by 534 · see citing works

Familial breast-ovarian cancer locus on chromosome 17q12-q23

Lenoir, G. M. (1991) · The Lancet · doi:10.1016/0140-6736(91)90076-2 · Cited by 519 · see citing works

Inheritance of human breast cancer: evidence for autosomal dominant transmission in high-risk families.

Newman, B. M., Austin, M. A., Lee, M., & King, M. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.9.3044 · Cited by 516 · see citing works

THE TUMOR SUPPRESSOR GENES

Levine, A. J. (1993) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.62.070193.003203 · Cited by 506 · see citing works

DNA strand exchange mediated by a RAD51-ssDNA nucleoprotein filament with polarity opposite to that of RecA

Sung, P., & Robberson, D. L. (1995) · Cell · doi:10.1016/0092-8674(95)90434-4 · Cited by 501 · see citing works

RecA homologs Dmc1 and Rad51 interact to form multiple nuclear complexes prior to meiotic chromosome synapsis

Bishop, D. K. (1994) · Cell · doi:10.1016/0092-8674(94)90038-8 · Cited by 498 · see citing works

Brca1 deficiency results in early embryonic lethality characterized by neuroepithelial abnormalities

Gowen, L. C., Johnson, B. L., Latour, A. M., Sulik, K. K., & Koller, B. H. (1996) · Nature Genetics · doi:10.1038/ng0296-191 · Cited by 480 · see citing works

Evidence for a transcriptional activation function of BRCA1 C-terminal region

Monteiro, Á. N. A., August, A., & Hanafusa, H. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.24.13595 · Cited by 447 · see citing works

Transcriptional activation by BRCA1

Chapman, M. S., & Verma, I. M. (1996) · Nature · doi:10.1038/382678a0 · Cited by 437 · see citing works

A collaborative survey of 80 mutations in the BRCA1 breast and ovarian cancer susceptibility gene. Implications for presymptomatic testing and screening.

Shattuck-Eidens, D., Mcclure, M., Simard, J., Labrie, F., Narod, S., Couch, F., Hoskins, K., Weber, B., Castilla, L., & Erdos, M. (1995) · Journal of the American Medical Association (JAMA) · doi:10.1001/jama.1995.03520310033026 · Cited by 436 · see citing works

Meiosis: how could it work?

Kleckner, N. E. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.16.8167 · Cited by 427 · see citing works

The RING Finger

Freemont, P. S. (1993) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1993.tb32280.x · Cited by 424 · see citing works

Somatic mutations in the BRCA1 gene in sporadic ovarian tumours

Merajver, S., Pham, T. M., Caduff, R., Chen, M., Poy, E. L., Cooney, K., Weber, B., Collins, F., Johnston, C., & Frank, T. S. (1995) · Nature Genetics · doi:10.1038/ng0495-439 · Cited by 417 · see citing works

DNA repair mutants defining G2 checkpoint pathways in Schizosaccharomyces pombe.

Al-Khodairy, F. M., & Carr, A. M. (1992) · The EMBO Journal · doi:10.1002/j.1460-2075.1992.tb05179.x · Cited by 414 · see citing works

Allele losses in the region 17q12–21 in familial breast and ovarian cancer involve the wild–type chromosome

Smith, S. A., Easton, D. F., Evans, D. G., & Ponder, B. A. J. (1992) · Nature Genetics · doi:10.1038/ng1092-128 · Cited by 410 · see citing works

Mutations in the BRCA1 gene in families with early-onset breast and ovarian cancer

Castilla, L. H., Couch, F. J., Erdos, M. R., Hoskins, K. F., Calzone, K., Garber, J. E., Boyd, J. A., Lubin, M. B., DeShano, M. L., Brody, L. C., et al. (1994) · Nature Genetics · doi:10.1038/ng1294-387 · Cited by 384 · see citing works

Simultaneous visualization of seven different DNA probes by in situ hybridization using combinatorial fluorescence and digital imaging microscopy.

Ried, T., Baldini, A., Rand, T. C., et al. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.4.1388 · Cited by 384 · see citing works

…Functional motifs…

Koonin, E. V., Altschul, S. F., & Bork, P. (1996) · Nature Genetics · doi:10.1038/ng0796-266 · Cited by 373 · see citing works

The developmental pattern of Brca1 expression implies a role in differentiation of the breast and other tissues

Marquis, S., Rajan, J., Wynshaw-Boris, A., Xu, J., Yin, G., Abel, K., Weber, B., & Chodosh, L. (1995) · Nature Genetics · doi:10.1038/ng0995-17 · Cited by 368 · see citing works

The Schizosaccharomyces pombe rad3 checkpoint gene.

Bentley, N. J., Holtzman, D. A., Flaggs, G., Keegan, K. S., DeMaggio, A. J., Ford, J. C., Hoekstra, M. F., & Carr, A. M. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb01054.x · Cited by 366 · see citing works

Growth retardation and tumour inhibition by BRCA1

Holt, J. T., Thompson, M. E., Szabo, C., et al. (1996) · Nature Genetics · doi:10.1038/ng0396-298 · Cited by 362 · see citing works

The Gene Encoding a Major Component of the Lateral Elements of Synaptonemal Complexes of the Rat Is Related to X-Linked Lymphocyte-Regulated Genes

Lammers, J. H. M., Offenberg, H. H., van Aalderen, M., Vink, A. C. G., Dietrich, A. J. J., & Heyting, C. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.2.1137 · Cited by 361 · see citing works

A human RNA polymerase II complex associated with SRB and DNA-repair proteins

Maldonado, E., Shiekhattar, R., Sheldon, M., Cho, H. K., Drapkin, R., Rickert, P., Lees, E. M., Anderson, C. W., Linn, S., & Reinberg, D. (1996) · Nature · doi:10.1038/381086a0 · Cited by 351 · see citing works

p53 is linked directly to homologous recombination processes via RAD51/RecA protein interaction.

Stürzbecher, H.-W., Donzelmann, B., Henning, W., Knippschild, U., & Buchhop, S. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00550.x · Cited by 338 · see citing works

A collaborative survey of 80 mutations in the BRCA1 breast and ovarian cancer susceptibility gene. Implications for presymptomatic testing and screening

Shattuck-Eidens, D. M. (1995) · JAMA · doi:10.1001/jama.273.7.535 · Cited by 327 · see citing works

Common origins of BRCA1 mutations in Canadian breast and ovarian cancer families

Simard, J., Tonin, P. N., Durocher, F., Morgan, K., Rommens, J. M., Gingras, S., Samson, C., LEBLANC, J., Bélanger, C., Dion, F., et al. (1994) · Nature Genetics · doi:10.1038/ng1294-392 · Cited by 324 · see citing works

Inactivation of the mouse Brca1 gene leads to failure in the morphogenesis of the egg cylinder in early postimplantation development.Preprint

Liu, C., Flesken‐Nikitin, A., Li, S., Zeng, Y., & Lee, W. (1996) · Genes & Development · doi:10.1101/gad.10.14.1835 · Cited by 323 · see citing works

Aberrant Subcellular Localization of BRCA1 in Breast Cancer

Chen, Y., Chen, C., Riley, D. J., Allred, D. C., Chen, P., Hoff, D. D. V., Osborne, C. K., & Lee, W. (1995) · Science · doi:10.1126/science.270.5237.789 · Cited by 309 · see citing works

Functional interaction between E2F-4 and p130: evidence for distinct mechanisms underlying growth suppression by different retinoblastoma protein family members.Preprint

Vairo, G., Livingston, D. M., & Ginsberg, D. (1995) · Genes & Development · doi:10.1101/gad.9.7.869 · Cited by 293 · see citing works

The Atr and Atm protein kinases associate with different sites along meiotically pairing chromosomes.Preprint

Keegan, K. S., Holtzman, D. A., Plug, A. W., Christenson, E., Brainerd, E. E., Flaggs, G., Bentley, N. J., Taylor, E. M., Meyn, M. S., Moss, S. B., et al. (1996) · Genes & Development · doi:10.1101/gad.10.19.2423 · Cited by 283 · see citing works

cDNA cloning and gene mapping of a candidate human cell cycle checkpoint protein.

Cimprich, K. A., Shin, T. B., Keith, C. T., & Schreiber, S. L. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.7.2850 · Cited by 273 · see citing works

BRCA1 is a 220-kDa nuclear phosphoprotein that is expressed and phosphorylated in a cell cycle-dependent manner.

Chen, Y., Farmer, A. A., Chen, C., Jones, D. C., Chen, P., & Lee, W. (1996) · PubMed · Cited by 267 · see citing works

Binding to DNA and the Retinoblastoma Gene Product Promoted by Complex Formation of Different E2F Family Members

Krek, W., Livingston, D. M., & Shirodkar, S. (1993) · Science · doi:10.1126/science.8248803 · Cited by 267 · see citing works

Biochemistry of Genetic Recombination: Energetics and Mechanism of DNA Strand Exchange

Kowalezykowski, S. C. (1991) · Annual Review of Biophysics and Biophysical Chemistry · doi:10.1146/annurev.bb.20.060191.002543 · Cited by 258 · see citing works

Checkpoint controls in Schizosaccharomyces pombe: rad1.

Rowley, R. B., Subramani, S. E., & Young, P. G. (1992) · The EMBO Journal · doi:10.1002/j.1460-2075.1992.tb05178.x · Cited by 218 · see citing works

Location of BRCA1 in Human Breast and Ovarian Cancer Cells

Scully, R., Ganesan, S., Brown, M. A., Caprio, J. A. D., Cannistra, S. A., Feunteun, J., Schnitt, S. J., & Livingston, D. M. (1996) · Science · doi:10.1126/science.272.5258.123 · Cited by 217 · see citing works

Expression of Brca1 is associated with terminal differentiation of ectodermally and mesodermally derived tissues in mice.Preprint

Lane, T. F., Deng, C., Elson, A., Lyu, M. S., Kozak, C. A., & Leder, P. (1995) · Genes & Development · doi:10.1101/gad.9.21.2712 · Cited by 198 · see citing works

Helical interactions in homologous pairing and strand exchange driven by RecA protein.

Radding, C. M. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)67599-x · Cited by 195 · see citing works

Differential subcellular localization, expression and biological toxicity of BRCA1 and the splice variant BRCA1-Δ11b

Wilson, C., Payton, M. N., Elliott, G., Buaas, F. W., Cajulis, E. E., Grosshans, D. R., Ramos, L., Reese, D., Slamon, D. J., & Calzone, F. J. (1997) · Oncogene · doi:10.1038/sj.onc.1200924 · Cited by 193 · see citing works

Hormone-dependent regulation of BRCA1 in human breast cancer cells.

Gudas, J. M., Nguyen, H., Li, T., et al. (1995) · PubMed · Cited by 179 · see citing works

Dynamic changes in Rad51 distribution on chromatin during meiosis in male and female vertebrates

Ashley, T., Plug, A. W., Xu, J., et al. (1995) · Chromosoma · doi:10.1007/bf00352222 · Cited by 176 · see citing works

The identification of febrile, neutropenic children with neoplastic disease at low risk for bacteremia and complications of sepsis

Lucas, K. G., Brown, A. E., Armstrong, D., Chapman, D. S., & Heller, G. (1996) · Cancer · doi:10.1002/(sici)1097-0142(19960215)77:4 · Cited by 174 · see citing works

S phase specific formation of the human Rad51 protein nuclear foci in lymphocytes.

Tashiro, S., Kotomura, N., Shinohara, A., Tanaka, K., Ueda, K., & Kamada, N. (1996) · PubMed · Cited by 165 · see citing works

Localization of RecA-like recombination proteins on chromosomes of the lily at various meiotic stages.Preprint

Terasawa, M., Shinohara, A., Hotta, Y., et al. (1995) · Genes & Development · doi:10.1101/gad.9.8.925 · Cited by 153 · see citing works

Chromomere analysis of the chromosome complement of rye

Lima-de-Faria, A. (1953) · Chromosoma · doi:10.1007/bf01271482 · Cited by 151 · see citing works

BRCA1 expression is induced before DNA synthesis in both normal and tumor-derived breast cells.

Vaughn, J. P., Davis, P. L., Jarboe, M. D., Hüper, G., Evans, A. C., Wiseman, R. W., Berchuck, A., Iglehart, J. D., Futreal, P. A., & Marks, J. R. (1996) · PubMed · Cited by 145 · see citing works

Cell cycle regulation of BRCA1 messenger RNA in human breast epithelial cells.

Gudas, J. M., Li, T., Nguyen, H., Jensen, D., Rauscher, F. J., & Cowan, K. H. (1996) · PubMed · Cited by 145 · see citing works

Induction of apoptosis by the tumor suppressor protein BRCA1.

Shao, N., Chai, Y. L., Shyam, E., Reddy, P., & Rao, V. N. (1996) · PubMed · Cited by 137 · see citing works

Loss of heterozygosity in familial tumors from three BRCA1-linked kindreds.

Neuhausen, S. L., & Marshall, C. J. (1994) · PubMed · Cited by 134 · see citing works

Synaptonemal complex antigen location and conservation.

Møens, P. B., Heyting, C., Dietrich, A. J. J., van Raamsdonk, W., & Chen, Q. (1987) · The Journal of Cell Biology · doi:10.1083/jcb.105.1.93 · Cited by 118 · see citing works

The rad3+ gene of Schizosaccharomyces pombe is involved in multiple checkpoint functions and in DNA repair.

Jimenez, G. S., Yucel, J. K., Rowley, R. B., & Subramani, S. E. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.11.4952 · Cited by 113 · see citing works

Presynaptic association of Rad51 protein with selected sites in meiotic chromatin.

Plug, A. W., Xu, J., Reddy, G., et al. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.12.5920 · Cited by 111 · see citing works

Antisense RNA to the putative tumor suppressor gene BRCA1 transforms mouse fibroblasts.

Rao, V. N., Shao, N., Ahmad, M., et al. (1996) · PubMed · Cited by 73 · see citing works

Checkpoints Take the Next Step

Carr, A. M. (1996) · Science · doi:10.1126/science.271.5247.314 · Cited by 54 · see citing works

BRCA1 mRNA is expressed highly during meiosis and spermiogenesis but not during mitosis of male germ cells.

Zabludoff, S., Wright, W. W., Harshman, K., & Wold, B. J. (1996) · PubMed · Cited by 37 · see citing works

BRCA1, a gene involved in inherited predisposition to breast and ovarian cancer.

Feunteun, J., & Lenoir, G. (1996) · Biochimica et Biophysica Acta · doi:10.1016/0304-419x(95)00016-9 · Cited by 28 · see citing works

EDITORIAL

Macgregor, H. C. (1997) · Chromosome Research · doi:10.1023/a:1018406120484 · Cited by 4 · see citing works

Triple-negative breast cancer: challenges and opportunities of a heterogeneous disease

Bianchini, G., Balko, J. M., Mayer, I. A., Sanders, M. E., & Gianni, L. (2016) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2016.66 · Cited by 3,079 · see citing works

The multifaceted roles of PARP1 in DNA repair and chromatin remodelling

Ray Chaudhuri, A., & Nussenzweig, A. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.53 · Cited by 1,786 · see citing works

Cancer Susceptibility and the Functions of BRCA1 and BRCA2

Venkitaraman, A. R. (2002) · Cell · doi:10.1016/s0092-8674(02)00615-3 · Cited by 1,713 · see citing works

53BP1 Inhibits Homologous Recombination in Brca1-Deficient Cells by Blocking Resection of DNA Breaks

Bunting, S. F., Callén, E., Wong, N., Chen, H.-T., Polato, F., Gunn, A., Bothmer, A., Feldhahn, N., Fernandez-Capetillo, O., Cao, L., et al. (2010) · Cell · doi:10.1016/j.cell.2010.03.012 · Cited by 1,671 · see citing works

Brca1 Controls Homology-Directed DNA Repair

Moynahan, M. E., Chiu, J. W., Koller, B. H., & Jasin, M. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80202-6 · Cited by 1,245 · see citing works

The hMre11/hRad50 Protein Complex and Nijmegen Breakage Syndrome: Linkage of Double-Strand Break Repair to the Cellular DNA Damage Response

Carney, J. P., Maser, R. S., Olivares, H., Davis, E. M., Le Beau, M., Yates, J. R., Hays, L., Morgan, W. F., & Petrini, J. H. J. (1998) · Cell · doi:10.1016/s0092-8674(00)81175-7 · Cited by 1,226 · see citing works

BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures.

Wang, Y., Cortez, D., Yazdi, P., Neff, N., Elledge, S. J., & Qin, J. (2000) · Genes & Development · doi:10.1101/gad.14.8.927 · Cited by 1,221 · see citing works

Interaction of the Fanconi Anemia Proteins and BRCA1 in a Common Pathway

Garcia-Higuera, I., Taniguchi, T., Ganesan, S., Meyn, M. S., Timmers, C., Hejna, J., Grompe, M., & D'Andrea, A. D. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00173-3 · Cited by 1,198 · see citing works

Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress

Ward, I. M., & Chen, J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.c100569200 · Cited by 1,150 · see citing works

Requirement of ATM-Dependent Phosphorylation of Brca1 in the DNA Damage Response to Double-Strand Breaks

Cortez, D., Wang, Y., Qin, J., & Elledge, S. J. (1999) · Science · doi:10.1126/science.286.5442.1162 · Cited by 1,020 · see citing works

BRCA1 and BRCA2: 1994 and beyond

Narod, S. A., & Foulkes, W. D. (2004) · Nature Reviews Cancer · doi:10.1038/nrc1431 · Cited by 967 · see citing works

Homologous Recombination and Human Health: The Roles of BRCA1, BRCA2, and Associated Proteins

Prakash, R., Zhang, Y., Feng, W., & Jasin, M. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a016600 · Cited by 869 · see citing works

Dynamic changes of BRCA1 subnuclear location and phosphorylation state are initiated by DNA damage

Scully, R., Chen, J., Ochs, R. L., Keegan, K., Hoekstra, M., Feunteun, J., & Livingston, D. M. (1997) · Cell · doi:10.1016/s0092-8674(00)80503-6 · Cited by 900 · see citing works

Showing your ID: intrinsic disorder as an ID for recognition, regulation and cell signaling

Uversky, V. N., Oldfield, C. J., & Dunker, A. K. (2005) · Journal of Molecular Recognition · doi:10.1002/jmr.747 · Cited by 847 · see citing works

Substrate Specificities and Identification of Putative Substrates of ATM Kinase Family Members

Kim, S.-T., Lim, D.-S., Canman, C. E., & Kastan, M. B. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.53.37538 · Cited by 810 · see citing works

The many substrates and functions of ATM.

Kastan, M. B., & Lim, D.-S. (2000) · Nature Reviews Molecular Cell Biology · doi:10.1038/35043058 · Cited by 779 · see citing works

Role of BRCA1 and BRCA2 as regulators of DNA repair, transcription, and cell cycle in response to DNA damage

Yoshida, K., & Miki, Y. (2004) · Cancer Science · doi:10.1111/j.1349-7006.2004.tb02195.x · Cited by 753 · see citing works

Endogenous DNA double-strand breaks: production, fidelity of repair, and induction of cancer

Vilenchik, M. M., & Knudson, A. G. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2135498100 · Cited by 717 · see citing works

Insights into DNA recombination from the structure of a RAD51–BRCA2 complex

Pellegrini, L., Yu, D. S., Lo, T., Anand, S., Lee, M., Blundell, T. L., & Venkitaraman, A. R. (2002) · Nature · doi:10.1038/nature01230 · Cited by 704 · see citing works

Multifactorial Analysis of Differences Between Sporadic Breast Cancers and Cancers Involving BRCA1 and BRCA2 Mutations

Lakhani, S. R., Jacquemier, J., Sloane, J. P., Gusterson, B. A., Anderson, T. J., van de Vijver, M. J., Farid, L. M., Venter, D., Antoniou, A., Storfer-Isser, A., et al. (1998) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/90.15.1138 · Cited by 707 · see citing works

BACH1, a Novel Helicase-like Protein, Interacts Directly with BRCA1 and Contributes to Its DNA Repair Function

Cantor, S. B., Bell, D. W., Ganesan, S., Kass, E. M., Drapkin, R., Grossman, S., Wahrer, D. C. R., Sgroi, D. C., Lane, W. S., Haber, D. A., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00304-x · Cited by 674 · see citing works

In search of the tumour-suppressor functions of BRCA1 and BRCA2

Scully, R., & Livingston, D. M. (2000) · Nature · doi:10.1038/35044000 · Cited by 643 · see citing works

BRCA1 and BRCA2 and the genetics of breast and ovarian cancer

Welcsh, P. L. (2001) · Human Molecular Genetics · doi:10.1093/hmg/10.7.705 · Cited by 648 · see citing works

Association of BRCA1 with the hRad50-hMre11-p95 Complex and the DNA Damage Response

Zhong, Q., Chen, C.-F., Li, S., Chen, Y., Wang, C.-C., Xiao, J., Chen, P.-L., Sharp, Z. D., & Lee, W.-H. (1999) · Science · doi:10.1126/science.285.5428.747 · Cited by 626 · see citing works

Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress

Tibbetts, R. S., Cortez, D., Brumbaugh, K. M., Scully, R., Livingston, D., Elledge, S. J., & Abraham, R. T. (2000) · Genes & Development · doi:10.1101/gad.851000 · Cited by 512 · see citing works

hMre11 and hRad50 Nuclear Foci Are Induced During the Normal Cellular Response to DNA Double-Strand Breaks †

Maser, R. S., Monsen, K. J., Nelms, B. E., & Petrini, J. H. J. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.10.6087 · Cited by 499 · see citing works

DNA damage-induced cell cycle checkpoints and DNA strand break repair in development and tumorigenesis

Dasika, G. K., Lin, S.-C. J., Zhao, S., Sung, P., Tomkinson, A., & Lee, E. Y.-H. P. (1999) · Oncogene · doi:10.1038/sj.onc.1203283 · Cited by 427 · see citing works

BRCA1–BARD1 promotes RAD51-mediated homologous DNA pairing

Zhao, W., Steinfeld, J. B., Liang, F., Chen, X., Maranon, D. G., Jian Ma, C., Kwon, Y., Rao, T., Wang, W., Sheng, C., et al. (2017) · Nature · doi:10.1038/nature24060 · Cited by 393 · see citing works

Recognition, signaling, and repair of DNA double-strand breaks produced by ionizing radiation in mammalian cells: the molecular choreography

Thompson, L. H. (2012) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2012.06.002 · Cited by 357 · see citing works

Genetic Analysis of BRCA1 Function in a Defined Tumor Cell Line

Scully, R., Ganesan, S., Vlasakova, K., Chen, J., Socolovsky, M., & Livingston, D. M. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80238-5 · Cited by 359 · see citing works

Chk2 Phosphorylation of BRCA1 Regulates DNA Double-Strand Break Repair

Zhang, J., Willers, H., Feng, Z., Ghosh, J. C., Kim, S., Weaver, D. T., Chung, J. H., Powell, S. N., & Xia, F. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.2.708-718.2004 · Cited by 323 · see citing works

Multifactorial contributions to an acute DNA damage response by BRCA1/BARD1-containing complexes

Greenberg, R. A., Sobhian, B., Pathania, S., Cantor, S. B., Nakatani, Y., & Livingston, D. M. (2006) · Genes & Development · doi:10.1101/gad.1381306 · Cited by 308 · see citing works

Senescence, aging, and malignant transformation mediated by p53 in mice lacking the Brca1 full-length isoform

Cao, L., Li, W., Kim, S., Brodie, S. G., & Deng, C.-X. (2003) · Genes & Development · doi:10.1101/gad.1050003 · Cited by 293 · see citing works

DNA Damage and Associated DNA Repair Defects in Disease and Premature Aging

Tiwari, V., & Wilson, D. M. (2019) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2019.06.005 · Cited by 244 · see citing works

The role of BRCA1 in DNA damage response

Wu, J., Lu, L.-Y., & Yu, X. (2010) · Protein & Cell · doi:10.1007/s13238-010-0010-5 · Cited by 235 · see citing works

Structure of the BRCT Repeats of BRCA1 Bound to a BACH1 Phosphopeptide

Shiozaki, E. N., Gu, L., Yan, N., & Shi, Y. (2004) · Molecular Cell · doi:10.1016/s1097-2765(04)00238-2 · Cited by 174 · see citing works

RAD51 is involved in repair of damage associated with DNA replication in mammalian cells

Lundin, C., Schultz, N., Arnaudeau, C., Mohindra, A., Hansen, L. T., & Helleday, T. (2003) · Journal of Molecular Biology · doi:10.1016/s0022-2836(03)00313-9 · Cited by 113 · see citing works

The role of BRCA1 in DNA double-strand repair: Past and present

Caestecker, K. W., & Van de Walle, G. R. (2013) · Experimental Cell Research · doi:10.1016/j.yexcr.2012.11.013 · Cited by 108 · see citing works

New insights into the mechanism of homologous recombination in yeast

Aylon, Y., & Kupiec, M. (2004) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2003.10.001 · Cited by 100 · see citing works

BACH1 is a DNA repair protein supporting BRCA1 damage response

Peng, M., Litman, R., Jin, Z., Fong, G., & Cantor, S. B. (2006) · Oncogene · doi:10.1038/sj.onc.1209257 · Cited by 88 · see citing works

Distinct functions of BRCA1 and BRCA2 in double-strand break repair

Liu, Y., & West, S. C. (2001) · Breast Cancer Research · doi:10.1186/bcr417 · Cited by 87 · see citing works

BRCA1 tumor suppressor network: focusing on its tail

Wang, B. (2012) · Cell & Bioscience · doi:10.1186/2045-3701-2-6 · Cited by 78 · see citing works

Familial breast cancer: an investigation into the outcome of treatment for early stage disease

Eccles, D., Simmonds, P., Goddard, J., Coultas, M., Hodgson, S., Lalloo, F., Evans, G., & Haites, N. (2001) · Familial Cancer · doi:10.1023/a:1013867917101 · Cited by 53 · see citing works

BRCA1 contributes to transcription-coupled repair of DNA damage through polyubiquitination and degradation of Cockayne syndrome B protein.

Wei, L., Lan, L., Yasui, A., Tanaka, K., Saijo, M., Matsuzawa, A., Kashiwagi, R., Maseki, E., Hu, Y., Parvin, J. D., et al. (2011) · Cancer Science · doi:10.1111/j.1349-7006.2011.02037.x · Cited by 48 · see citing works

NFBD1/MDC1, 53BP1 and BRCA1 have both redundant and unique roles in the ATM pathway

Wilson, K. A., & Stern, D. F. (2008) · Cell Cycle · doi:10.4161/cc.7.22.7102 · Cited by 43 · see citing works

Abstract CN05-04: Opportunities for targeting homologous recombination in human cancers.

Powell, S. N. (2011) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.targ-11-cn05-04

High Levels of Wild-Type BRCA2 Suppress Homologous Recombination

Magwood, A. C., Mundia, M. M., & Baker, M. D. (2012) · Journal of Molecular Biology · doi:10.1016/j.jmb.2012.05.007 · Cited by 18 · see citing works

Recovery of deficient homologous recombination in Brca2-depleted mouse cells by wild-type Rad51 expression

Lee, S. A., Lopez‐Roques, C., Magwood, A. C., Masson, J., & Baker, M. D. (2008) · DNA repair · doi:10.1016/j.dnarep.2008.10.002 · Cited by 43 · see citing works

RPS15 Coordinates with CtIP to Facilitate Homologous Recombination and Confer Therapeutic Resistance in Breast Cancer

Lin, B., Huang, G., Yuan, Z., Peng, X., Yu, C., Zheng, J., Li, Z., Li, J., Liang, J., & Xu, B. (2024) · Radiation Research · doi:10.1667/rade-24-00134.1 · Cited by 2 · see citing works

Isolation and Characterization of Monomeric Human RAD51: A Novel Tool for Investigating Homologous Recombination in Cancer

Rinaldi, F., Schipani, F., Balboni, B., Catalano, F., Marotta, R., Myers, S. H., Previtali, V., Veronesi, M., Scietti, L., Cecatiello, V., et al. (2023) · Angewandte Chemie · doi:10.1002/ange.202312517 · Cited by 1 · see citing works