The DOI matches its Crossref record; 46 of the 48 references it cites were found in a registry or an index.
Cholinergic nicotinic receptor genes implicated in a nicotine dependence association study targeting 348 candidate genes with 3713 SNPs
Open accessAbstract
Nicotine dependence is one of the world's leading causes of preventable death. To discover genetic variants that influence risk for nicotine dependence, we targeted over 300 candidate genes and analyzed 3713 single nucleotide polymorphisms (SNPs) in 1050 cases and 879 controls. The Fagerström test for nicotine dependence (FTND) was used to assess dependence, in which cases were required to have an FTND of 4 or more. The control criterion was strict: control subjects must have smoked at least 100 cigarettes in their lifetimes and had an FTND of 0 during the heaviest period of smoking. After correcting for multiple testing by controlling the false discovery rate, several cholinergic nicotinic receptor genes dominated the top signals. The strongest association was from an SNP representing CHRNB3, the beta3 nicotinic receptor subunit gene (P = 9.4 x 10(-5)). Biologically, the most compelling evidence for a risk variant came from a non-synonymous SNP in the alpha5 nicotinic receptor subunit gene CHRNA5 (P = 6.4 x 10(-4)). This SNP exhibited evidence of a recessive mode of inheritance, resulting in individuals having a 2-fold increase in risk of developing nicotine dependence once exposed to cigarette smoking. Other genes among the top signals were KCNJ6 and GABRA4. This study represents one of the most powerful and extensive studies of nicotine dependence to date and has found novel risk loci that require confirmation by replication studies.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“It has been shown that allelic variation in the α5/α3/β4 nAChR subunit gene cluster located in chromosome region 15q25 significantly increases risk of tobacco addiction (Saccone et al. 2007;Berrettini et al. 2008;Lips et al. 2010).”
From Mechanisms of Nicotine Addiction (2021) · cites this paper as Saccone et al. 2007
In the citing paper
“The most compelling evidence for risk variants contributing to smoking behavior was in the CHRNA5/A3/B4 gene cluster, which encodes the α5, α3, and β4 subunits.”
From Nicotine is a selective pharmacological chaperone of acetylcholine receptor number and stoichiometry. Implications for drug discovery (2009) · cites this paper as [91]
In the citing paper
“The most thoroughly investigated and replicated finding to date is the association with rs16969968, in CHRNA5 (91).”
From Nicotine is a selective pharmacological chaperone of acetylcholine receptor number and stoichiometry. Implications for drug discovery (2009) · cites this paper as [91]
In the citing paper
“A second signal in the CHRNA5/A3/B4 cluster is tagged by SNP rs578776; it is strongly associated with nicotine dependence and has a low correlation with rs16969968 (r2 = 0.18), indicating that it represents a statistically independent signal (90,91).”
From Nicotine is a selective pharmacological chaperone of acetylcholine receptor number and stoichiometry. Implications for drug discovery (2009) · cites this paper as [91]
In the citing paper
“With regard to the latter factors, initiation of smoking behavior and transition to dependence (i.e. persistent smoking) has been found to show strong heritability (60). The reported heritability coefficients range from 30% to greater than 80% (a mean of approximately 60% for initiation and 70% for progression to dependence).”
From Tobacco addiction (2008) · cites this paper as [60]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing
Benjamini, Y., & Hochberg, Y. (1995) · Journal of the Royal Statistical Society Series B: Statistical Methodology · doi:10.1111/j.2517-6161.1995.tb02031.x · Cited by 109,482
Inference of Population Structure Using Multilocus Genotype Data
Pritchard, J. K., Stephens, M., & Donnelly, P. (2000) · Genetics · doi:10.1093/genetics/155.2.945 · Cited by 33,871
Haploview: analysis and visualization of LD and haplotype maps
Barrett, J. C., Fry, B., Maller, J., & Daly, M. J. (2004) · Bioinformatics · doi:10.1093/bioinformatics/bth457 · Cited by 14,551
The Fagerstrom Test for Nicotine Dependence: a revision of the Fagerstrom Tolerance Questionnaire
HEATHERTON, T. F., KOZLOWSKI, L. T., FRECKER, R. C., & FAGERSTROM, K. (1991) · British Journal of Addiction · doi:10.1111/j.1360-0443.1991.tb01879.x · Cited by 10,738
Statistical significance for genomewide studies
Storey, J. D., & Tibshirani, R. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1530509100 · Cited by 9,692
A Direct Approach to False Discovery Rates
Storey, J. D. (2002) · Journal of the Royal Statistical Society Series B: Statistical Methodology · doi:10.1111/1467-9868.00346 · Cited by 5,603
More powerful procedures for multiple significance testing
Hochberg, Y., & Benjamini, Y. (1990) · Statistics in Medicine · doi:10.1002/sim.4780090710 · Cited by 2,715
Carlson, C. S., Eberle, M. A., Rieder, M. J., Qian, Y., Kruglyak, L., & Nickerson, D. A. (2004) · The American Journal of Human Genetics · doi:10.1086/381000 · Cited by 1,587
Tanoue, L. T. (2007) · Yearbook of Medicine · doi:10.1016/s0084-3873(08)70176-7 · Cited by 1,413
Mackay, J. M., & Eriksen, M. P. (2002) · Medical Entomology and Zoology · Cited by 1,322
Flagged first, then by citations
2 of the 48 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- Tapper, 2006, Neuronal nicotinic acetylcholine receptors and nicotine dependence
Cited by
Sorted by citations
Items 101–200 of 851
Improgo, M. R., Scofield, M. D., Tapper, A. R., & Gardner, P. D. (2010) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2010.05.003 · Cited by 108
Saccone, N. L., Schwantes-An, T.-H. L., Wang, J.-C., Grucza, R. A., Breslau, N., Hatsukami, D. K., Johnson, E. O., Rice, J. P., Goate, A., & Bierut, L. J. (2010) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2010.00608.x · Cited by 106
Self-citationAssociations between Polygenic Risk for Psychiatric Disorders and Substance Involvement
Carey, C. E., Arpana Agrawal, A., Bucholz, K. K., Hartz, S. M., Lynskey, M. T., Nelson, E. C., Bierut, L. J., & Bogdan, R. (2016) · Frontiers in Genetics · doi:10.3389/fgene.2016.00149 · Cited by 107
Self-citationThe CHRNA5–A3–B4 gene cluster in nicotine addiction
Berrettini, W. H., & Doyle, G. A. R. (2011) · Molecular Psychiatry · doi:10.1038/mp.2011.122 · Cited by 99
Nicotine dependence and genetic variation in the nicotinic receptors
Bierut, L. J. (2009) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2009.06.003 · Cited by 103
Self-citationZeiger, J. S., Haberstick, B. C., Schlaepfer, I. R., Collins, A. C., Corley, R. P., Crowley, T. J., Hewitt, J. K., Hopfer, C. J., Lessem, J. M., McQueen, M. B., et al. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddm344 · Cited by 99
Hoft, N. R., Corley, R. P., McQueen, M. B., Schlaepfer, I. R., Huizinga, D. H., & Ehringer, M. A. (2008) · Neuropsychopharmacology · doi:10.1038/npp.2008.122 · Cited by 97
Shiraishi, K., Kohno, T., Kunitoh, H., WATANABE, S.-I. J., Goto, K., Nishiwaki, Y., Shimada, Y., Hirose, H., Saito, I., Kuchiba, A., et al. (2008) · Carcinogenesis · doi:10.1093/carcin/bgn257 · Cited by 96
Genome-wide significance levels and weighted hypothesis testingPreprint
Roeder, K., & Wasserman, L. (2009) · Cited by 96
Genetics of nicotine dependence and pharmacotherapy
Lessov‐Schlaggar, C. N., Pergadia, M. L., Khroyan, T. V., & Swan, G. E. (2007) · Biochemical Pharmacology · doi:10.1016/j.bcp.2007.08.018 · Cited by 97
Self-citationWithdrawal: Expanding a Key Addiction Construct
Piper, M. E. (2015) · Nicotine & Tobacco Research · doi:10.1093/ntr/ntv048 · Cited by 99
The Genetic Components of Alcohol and Nicotine Co-Addiction: From Genes to Behavior
Schlaepfer, I. R., Hoft, N. R., & Ehringer, M. A. (2008) · Current Drug Abuse Reviews · doi:10.2174/1874473710801020124 · Cited by 96
Sarginson, J. E., Killen, J. D., Lazzeroni, L. C., Fortmann, S. P., Ryan, H. S., Schatzberg, A. F., & Murphy, G. M. (2011) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.31155 · Cited by 93
Dopamine beta‐hydroxylase and its genetic variants in human health and disease
Gonzalez‐Lopez, E., & Vrana, K. E. (2019) · Journal of Neurochemistry · doi:10.1111/jnc.14893 · Cited by 91
Nicotinic acetylcholine receptor variation and response to smoking cessation therapies
Bergen, A. W., Javitz, H. S., Krasnow, R. E., Nishita, D., Michel, M., Conti, D. V., Liu, J., Lee, W., Edlund, C. K., Hall, S. M., et al. (2012) · Pharmacogenetics and Genomics · doi:10.1097/fpc.0b013e32835cdabd · Cited by 92
Self-citationHancock, D. B., Reginsson, G. W., Gaddis, N. C., Chen, X., Saccone, N. L., Lutz, S. M., Qaiser, B., Sherva, R., Steinberg, S., Zink, F., et al. (2015) · Translational Psychiatry · doi:10.1038/tp.2015.149 · Cited by 85
Self-citationThe development of personality across the lifespan
Donnellan, M. B., & Robins, R. W. (2012) · Cambridge University Press eBooks · doi:10.1017/cbo9780511596544.015 · Cited by 89
Common single nucleotide variants underlying drug addiction: more than a decade of research
Bühler, K., Giné, E., Echeverry‐Alzate, V., Calleja‐Conde, J., de Fonseca, F. R., & López‐Moreno, J. A. (2015) · Addiction Biology · doi:10.1111/adb.12204 · Cited by 96
Gene set analysis: A step‐by‐step guide
Mooney, M. A., & Wilmot, B. (2015) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32328 · Cited by 96
The CHRNA5–A3–B4 Gene Cluster and Smoking: From Discovery to Therapeutics
Lassi, G., Taylor, A. E., Timpson, N. J., Kenny, P. J., Mather, R. J., Eisen, T., & Munafò, M. R. (2016) · Trends in Neurosciences · doi:10.1016/j.tins.2016.10.005 · Cited by 85
Current Genetics and Epigenetics of Smoking/Tobacco-Related Cardiovascular Disease
Breitling, L. P. (2013) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.112.300157 · Cited by 87
Berndt, A., Leme, A. S., & Shapiro, S. D. (2012) · EMBO Molecular Medicine · doi:10.1002/emmm.201100627 · Cited by 89
Temperament and brain networks of attention
Posner, M. I., & Rothbart, M. K. (2018) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2017.0254 · Cited by 95
Chanock, S. J., & Hunter, D. J. (2008) · Nature · doi:10.1038/452537a · Cited by 84
A CHRNA5 smoking risk variant decreases the aversive effects of nicotine in humans
Jensen, K. P., DeVito, E. E., Herman, A. I., Valentine, G. W., Gelernter, J., & Sofuoglu, M. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.131 · Cited by 85
Munafo, M. R., & Johnstone, E. C. (2008) · Addiction · doi:10.1111/j.1360-0443.2007.02071.x · Cited by 85
CHRNA3 rs1051730 Genotype and Short-Term Smoking Cessation
Munafo, M. R., Johnstone, E. C., Walther, D. M., Uhl, G. R., Murphy, M. F. G., & Aveyard, P. N. (2011) · Nicotine & Tobacco Research · doi:10.1093/ntr/ntr106 · Cited by 82
Wang, J., & Li, M. D. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2009.178 · Cited by 84
Self-citationGenetic Relationship between Schizophrenia and Nicotine Dependence
Chen, J., Bacanu, S., Yu, H., Zhao, Z., Jia, P., Kendler, K. S., Kranzler, H. R., Gelernter, J. E., Farrer, L. A., Minică, C. C., et al. (2016) · Scientific Reports · doi:10.1038/srep25671 · Cited by 85
Environmental, genetic and epigenetic contributions to cocaine addiction
Pierce, R. C., Fant, B., Swinford-Jackson, S. E., Heller, E. A., Berrettini, W. H., & Wimmer, M. E. (2018) · Neuropsychopharmacology · doi:10.1038/s41386-018-0008-x · Cited by 85
Nicotinic acetylcholine receptor-mediated mechanisms in lung cancer
Improgo, M. R., Tapper, A. R., & Gardner, P. D. (2011) · Biochemical Pharmacology · doi:10.1016/j.bcp.2011.05.020 · Cited by 84
Genome-wide Association Analysis for Multiple Continuous Secondary Phenotypes
Schifano, E. D., Li, L., Christiani, D. C., & Lin, X. (2013) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2013.04.004 · Cited by 79
Reisenzein, R., & Weber, H. (2012) · Cambridge University Press eBooks · doi:10.1017/cbo9780511596544.007 · Cited by 84
Nicotinic acetylcholine receptors: an overview on drug discovery
D’hoedt, D., & Bertrand, D. (2009) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728220902841045 · Cited by 79
Genetic and Phenotypic Stability of Measures of Neuroticism Over 22 Years
Wray, N. R., Birley, A. J., Sullivan, P. F., Visscher, P. M., & Martin, N. G. (2007) · Twin Research and Human Genetics · doi:10.1375/twin.10.5.695 · Cited by 80
Self-citationTranscription Deregulation at the 15q25 Locus in Association with Lung Adenocarcinoma Risk
Falvella, F. S., Galvan, A., Frullanti, E., Spinola, M., Calabrò, E., Carbone, A., Incarbone, M., Santambrogio, L., Pastorino, U., & Dragani, T. A. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-08-2107 · Cited by 82
Chromosome 15q25.1 genetic markers associated with level of response to alcohol in humans
Joslyn, G., Brush, G., Robertson, M. A., Smith, T. L., Kalmijn, J. A., Schuckit, M. A., & White, R. L. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0810970105 · Cited by 80
Ducci, F., Kaakinen, M., Pouta, A. M., Hartikainen, A., Veijola, J. M., Isohanni, M. K., Charoen, P., Coin, L., Hoggart, C., Ekelund, J., et al. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.09.055 · Cited by 76
Fowler, C. D., Tuesta, L. M., & Kenny, P. J. (2013) · Psychopharmacology · doi:10.1007/s00213-013-3235-1 · Cited by 79
Dass, S. A. H., McCracken, K., Pokhvisneva, I., Chen, L. M., Garg, E., Nguyen, T. T. T., Wang, Z., Barth, B., Yaqubi, M., McEwen, L. M., et al. (2019) · EBioMedicine · doi:10.1016/j.ebiom.2019.03.051 · Cited by 80
Genetic Influences on Addiction
(2013) · The MIT Press eBooks · doi:10.7551/mitpress/9391.001.0001 · Cited by 78
Sahoo, S. S., Bodenreider, O., Rutter, J. L., Skinner, K. J., & Sheth, A. (2008) · Journal of Biomedical Informatics · doi:10.1016/j.jbi.2008.02.006 · Cited by 76
Self-citationIncreased Genetic Vulnerability to Smoking at CHRNA5 in Early-Onset Smokers
Hartz, S. M., Short, S. E., Saccone, N. L., Culverhouse, R., Chen, L., Schwantes-An, T.-H., Coon, H., Han, Y., Stephens, S. H., Sun, J., et al. (2012) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2012.124 · Cited by 75
Self-citationUnderstanding the habenula: A major node in circuits regulating emotion and motivation
Ables, J. L., Park, K., & Ibáñez-Tallon, I. (2023) · Pharmacological Research · doi:10.1016/j.phrs.2023.106734 · Cited by 79
Chen, L., Saccone, N. L., Culverhouse, R., Bracci, P. M., Chen, C.-H., Dueker, N., Han, Y., Huang, H., Jin, G., Kohno, T., et al. (2012) · Genetic Epidemiology · doi:10.1002/gepi.21627 · Cited by 77
Self-citationSaccone, S. F., Saccone, N. L., Swan, G. E., Madden, P. A. F., Goate, A., Rice, J. P., & Bierut, L. J. (2008) · Bioinformatics · doi:10.1093/bioinformatics/btn315 · Cited by 73
Self-citationRice, J. P., Hartz, S. M., Arpana Agrawal, A., Almasy, L. A., Bennett, S., Breslau, N., Bucholz, K. K., Doheny, K. F., Edenberg, H. J., Goate, A., et al. (2012) · Addiction · doi:10.1111/j.1360-0443.2012.03922.x · Cited by 78
Self-citationGreenbaum, L., & Lerer, B. (2009) · Molecular Psychiatry · doi:10.1038/mp.2009.59 · Cited by 73
Amos, C. I., Gorlov, I. P., Dong, Q., Wu, X., Zhang, H., Lu, E. Y., Scheet, P. A., Greisinger, A. J., Mills, G. B., & Spitz, M. R. (2010) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djq232 · Cited by 74
Neuronal nicotinic acetylcholine receptors: From the genetic analysis to neurological diseases
Steinlein, O. K., & Bertrand, D. (2008) · Biochemical Pharmacology · doi:10.1016/j.bcp.2008.07.012 · Cited by 74
A common biological basis of obesity and nicotine addiction
Thorgeirsson, T. E., Gudbjartsson, D. F., Sulem, P., Besenbacher, S., Styrkarsdottir, U., Thorleifsson, G., Walters, G. B., TAG Consortium, Oxford-GSK Consortium, ENGAGE consortium, et al. (2013) · Translational Psychiatry · doi:10.1038/tp.2013.81 · Cited by 71
Portugal, G. S., & Gould, T. J. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.05.006 · Cited by 73
Hall, F. S., Drgonová, J., Jain, S., & Uhl, G. R. (2013) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2013.07.006 · Cited by 76
Association of attentional network function with exon 5 variations of the CHRNA4 gene
Winterer, G., Musso, F., Konrad, A., Vučurević, G., Stoeter, P., Sander, T., & Gallinat, J. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddm168 · Cited by 71
Bailey, C. D. C., Alves, N. C., Nashmi, R., De Biasi, M., & Lambe, E. K. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.09.011 · Cited by 69
Interplay of genetic risk factors and parent monitoring in risk for nicotine dependence
Chen, L., Johnson, E. O., Breslau, N., Hatsukami, D., Saccone, N. L., Grucza, R. A., Wang, J. C. C., Hinrichs, A. L., Fox, L. W., Goate, A., et al. (2009) · Addiction · doi:10.1111/j.1360-0443.2009.02697.x · Cited by 72
Self-citationCHRNA3genotype, nicotine dependence, lung function and disease in the general population
Kaur‐Knudsen, D., Nordestgaard, B. G., & Bojesen, S. E. (2012) · European Respiratory Journal · doi:10.1183/09031936.00176811 · Cited by 68
The Role of the Medial Habenula Cholinergic System in Addiction and Emotion-Associated Behaviors
Lee, H. W., Yang, S. H., Kim, J. Y., & Kim, H. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00100 · Cited by 73
Islam, M. S., Ahmed, M. U., Sayeed, M. S. B., Maruf, A. A., Mostofa, A., Hussain, S. M. A., Kabir, Y., Daly, A. K., & Hasnat, A. (2012) · Clinica Chimica Acta · doi:10.1016/j.cca.2012.11.011 · Cited by 69
Genome-Wide Association Studies of Alcohol Dependence and Substance Use Disorders
Treutlein, J., & Rietschel, M. (2011) · Current Psychiatry Reports · doi:10.1007/s11920-011-0176-4 · Cited by 68
Russo, P., Nastrucci, C., Alzetta, G., & Szalai, C. (2011) · Perspectives in biology and medicine · doi:10.1353/pbm.2011.0047 · Cited by 67
Saccone, S. F., Bolze, R., Thomas, P. D., Quan, J., Mehta, G., Deelman, E., Tischfield, J. A., & Rice, J. P. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq513 · Cited by 68
Self-citationThe potential of DNA methylation as a biomarker for obesity and smoking
Heikkinen, A., Bollepalli, S., & Ollikainen, M. (2022) · Journal of Internal Medicine · doi:10.1111/joim.13496 · Cited by 70
Winterer, G., Mittelstraß, K., Giegling, I., Lamina, C., Fehr, C., Brenner, H., Breitling, L. P., Nitz, B., Raum, E., Müller, H., et al. (2010) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.31126 · Cited by 69
Erlich, P. M., Hoffman, S. N., Rukstalis, M. R., Han, J., Chu, X., Kao, W. H. L., Gerhard, G. S., Stewart, W. F., & Boscarino, J. A. (2010) · Human Genetics · doi:10.1007/s00439-010-0876-6 · Cited by 71
Are genetic variants of COMT associated with addiction?
Tammimäki, A., & Männistö, P. T. (2010) · Pharmacogenetics and Genomics · doi:10.1097/fpc.0b013e328340bdf2 · Cited by 67
Li, W., Jiang, K., Yuan, W., Cui, W., & Li, M. D. (2014) · Molecular Neurobiology · doi:10.1007/s12035-014-8997-x · Cited by 68
Neuronal G protein-gated K+ channels
Luo, H., Marron Fernandez de Velasco, E., & Wickman, K. (2022) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00102.2022 · Cited by 62
From smoking to lung cancer: the CHRNA5/A3/B4 connection
Improgo, M. R., Scofield, M. D., Tapper, A. R., & Gardner, P. D. (2010) · Oncogene · doi:10.1038/onc.2010.256 · Cited by 67
Quaak, M., van Schayck, O. C. P., Knaapen, A. M., & van Schooten, F. (2009) · European Respiratory Journal · doi:10.1183/09031936.00056908 · Cited by 66
Substance Use Disorders: Realizing the Promise of Pharmacogenomics and Personalized Medicine
Hutchison, K. E. (2010) · Annual Review of Clinical Psychology · doi:10.1146/annurev.clinpsy.121208.131441 · Cited by 64
Drgon, T., Montoya, I. D., Johnson, C., Liu, Q., Walther, D. M., Hamer, D. H., & Uhl, G. R. (2009) · Molecular Medicine · doi:10.2119/molmed.2008.00096 · Cited by 66
Li, L., Kabesch, M., Bouzigon, E., Démenais, F., Farrall, M., Moffatt, M. F., Lin, X., & Liang, L. (2013) · Frontiers in Genetics · doi:10.3389/fgene.2013.00103 · Cited by 60
Why Have Tobacco Control Policies Stalled? Using Genetic Moderation to Examine Policy Impacts
Fletcher, J. M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0050576 · Cited by 69
Associations of Variants in CHRNA5/A3/B4 Gene Cluster with Smoking Behaviors in a Korean Population
Li, M. D., Yoon, D., Lee, J., Han, B., Niu, T., Payne, T. J., Ma, J. Z., & Park, T. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012183 · Cited by 66
A CHRNA5 allele related to nicotine addiction and schizophrenia
Hong, L. E., Yang, X., Wonodi, I., Hodgkinson, C. A., Goldman, D. A., Stine, O. C., Stein, E. A., & Thaker, G. K. (2011) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2011.00689.x · Cited by 64
From Men to Mice: CHRNA5/CHRNA3, Smoking Behavior and Disease
Ware, J. J., van den Bree, M., & Munafò, M. R. (2012) · Nicotine & Tobacco Research · doi:10.1093/ntr/nts106 · Cited by 62
Johnson, E. O., Chen, L., Breslau, N., Hatsukami, D. K., Robbins, T., Saccone, N. L., Grucza, R. A., & Bierut, L. J. (2010) · Addiction · doi:10.1111/j.1360-0443.2010.03074.x · Cited by 65
Self-citationAddiction‐related neuroadaptations following chronic nicotine exposure
Wills, L., & Kenny, P. J. (2021) · Journal of Neurochemistry · doi:10.1111/jnc.15356 · Cited by 61
Papke, R. L., Trocmé, C., Guendisch, D., Rubaiy, S. A. A. A., & Bloom, S. A. (2011) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.110.177485 · Cited by 61
Wessel, J., McDonald, S. M., Hinds, D. A., Stokowski, R. P., Javitz, H. S., Kennemer, M. I., Krasnow, R. E., Dirks, W., Hardin, J., Pitts, S. J., et al. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2010.120 · Cited by 62
Self-citationBroms, U., Wedenoja, J., Largeau, M. R., Korhonen, T., Pitkäniemi, J. M., Keskitalo‐Vuokko, K., Häppölä, A., Heikkilä, K., Heikkila, K. V., Ripatti, S., et al. (2012) · Nicotine & Tobacco Research · doi:10.1093/ntr/ntr283 · Cited by 59
Self-citationLi, M. D., Xu, Q., Lou, X., Payne, T. J., Niu, T., & Ma, J. Z. (2009) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.31043 · Cited by 60
‘Smoking Genes’: A Genetic Association Study
Verde, Z., Santiago, C., González-Moro, J. M. R., Ramos, P. D. L., Martín, S. L., Bandrés, F., Lucía, A., & Gómez‐Gallego, F. (2011) · PLoS ONE · doi:10.1371/journal.pone.0026668 · Cited by 59
Heath, C. J., King, S. L., Gotti, C., Marks, M. J., & Picciotto, M. R. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2010.130 · Cited by 59
Self-regulation and control in personality functioning
Carver, C. S., & Scheier, M. F. (2012) · Cambridge University Press eBooks · doi:10.1017/cbo9780511596544.027 · Cited by 59
Liu, Y., Liu, P., Wen, W., James, M. A., Wang, Y., Wilson, J., Amos, C. I., Pinney, S. M., Yang, P., de Andrade, M., et al. (2009) · Cancer Research · doi:10.1158/0008-5472.can-09-1833 · Cited by 60
Nicotinic Receptor Contributions to Smoking: Insights from Human Studies and Animal Models
Brunzell, D. H., Stafford, A. M., & Dixon, C. I. (2015) · Current Addiction Reports · doi:10.1007/s40429-015-0042-2 · Cited by 58
Kang, S. J., Rangaswamy, M., Manz, N., Wang, J., Wetherill, L. F., Hinrichs, T., Almasy, L. A., Brooks, A., Chorlian, D. B., Dick, D. M., et al. (2012) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2012.00803.x · Cited by 59
Self-citationRare missense variants in CHRNB4 are associated with reduced risk of nicotine dependence
Haller, G., Druley, T. E., Vallania, F., Mitra, R. D., Li, P., Akk, G., Steinbach, J. H., Breslau, N., Johnson, E. O., Hatsukami, D. K., et al. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr498 · Cited by 59
Self-citationDas, S., & Prochaska, J. J. (2017) · Expert Review of Respiratory Medicine · doi:10.1080/17476348.2017.1361823 · Cited by 60
Jin, X., Guan, Y., Sheng, H., & Liu, Y. (2017) · Oncotarget · doi:10.18632/oncotarget.20441 · Cited by 58
Meta-Analysis of 15 Genome-Wide Linkage Scans of Smoking Behavior
Han, S., Gelernter, J. E., Luο, X., & Yang, B. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.08.028 · Cited by 58
Tammimäki, A., Herder, P., Li, P., Esch, C., Laughlin, J. R., Akk, G., & Stitzel, J. A. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.07.022 · Cited by 61
Function of Human α3β4α5 Nicotinic Acetylcholine Receptors Is Reduced by the α5(D398N) Variant
George, A. A., Lucero, L. M., Damaj, M. I., Lukas, R. J., Chen, X., & Whiteaker, P. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.379339 · Cited by 60
Kaur‐Knudsen, D., Bojesen, S. E., Tybjærg‐Hansen, A., & Nordestgaard, B. G. (2011) · Journal of Clinical Oncology · doi:10.1200/jco.2010.32.9870 · Cited by 59
Historical and current perspective on tobacco use and nicotine addiction
Dani, J. A., & Balfour, D. J. K. (2011) · Trends in Neurosciences · doi:10.1016/j.tins.2011.05.001 · Cited by 68
Addiction science and its genetics
Ball, D. (2007) · Addiction · doi:10.1111/j.1360-0443.2007.02061.x · Cited by 57
Nicotinic α5 receptor subunit mRNA expression is associated with distant 5′ upstream polymorphisms
Smith, R. M., Alachkar, H., Papp, A. C., Wang, D., Mash, D. C., Wang, J., Bierut, L. J., & Sadée, W. (2010) · European Journal of Human Genetics · doi:10.1038/ejhg.2010.120 · Cited by 59
Self-citationNicotine Dependence: Biology, Behavior, and Treatment
Ray, R., Schnoll, R. A., & Lerman, C. E. (2009) · Annual Review of Medicine · doi:10.1146/annurev.med.60.041707.160511 · Cited by 59
Metadata
- Authors
- Saccone, S. F., Hinrichs, A. L., Saccone, N. L., Chase, G. A., Konvicka, K., Madden, P. A. F., Breslau, N., Johnson, E. O., Hatsukami, D., Pomerleau, O., Swan, G. E., Goate, A. M., Rutter, J., Bertelsen, S., Fox, L., Fugman, D., Martin, N. G., Montgomery, G. W., Wang, J. C., Ballinger, D. G., Rice, J. P., & Bierut, L. J.
- Affiliations
- Washington University in St. Louis (US)
- Pennsylvania State University (US)
- Perlegen (United States) (US)
- Michigan State University (US)
- RTI International (US)
- University of Minnesota (US)
- University of Michigan (US)
- SRI International (US)
- National Institute on Drug Abuse (US)
- Rutgers, The State University of New Jersey (US)
- QIMR Berghofer Medical Research Institute (AU)
- Corresponding author
- Saccone, Scott F.
- ORCID
- Venue
- Human Molecular Genetics
- Publisher
- Oxford University Press (OUP)
- Published
- 2006-11-29
- Volume
- 16
- Issue
- 1
- Pages
- 36-49
- ISSN
- 0964-6906 (ISSN-L)
- 1460-2083
- PMC
- PMC2270437
- OpenAlex
- W2118320202
- Cited by
- 850
- References
- 48
- Citations by year
- 2026: 6 · 2025: 8 · 2024: 12 · 2023: 20 · 2022: 16 · 2021: 24 · 2020: 65 · 2019: 37 · 2018: 35 · 2017: 35 · 2016: 54 · 2015: 51 · 2014: 48 · 2013: 58 · 2012: 86
- FWCI
- 31.23
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Human Molecular Genetics (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- HighWire Press Open Archive (submittedVersion)
- Funders
- National Institute on Drug Abuse (R56DA012854, DA12854, DA015129, N01DA07079, K01DA015129, R01DA012854)
- National Cancer Institute (CA89392, P01CA089392)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Smoking Behavior and Cessation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Keywords
- nicotine dependence, CHRNA5, single nucleotide polymorphisms, genetic association, genetic susceptibility loci, recessive inheritance, KCNJ6, GABRA4, smoking, Fagerström Test for Nicotine Dependence
- MeSH terms
- Adult, Aged, Aged, 80 and over, Chromosomes, Human, Pair 8, Female, Genetic Markers, Genotype, Humans, Male, Middle Aged, Receptors, Nicotinic, Tobacco Use Disorder, Genetic Variation, Cluster Analysis, Case-Control Studies, Polymorphism, Single Nucleotide
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
