Cholinergic nicotinic receptor genes implicated in a nicotine dependence association study targeting 348 candidate genes with 3713 SNPs

Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing

Benjamini, Y., & Hochberg, Y. (1995) · Journal of the Royal Statistical Society Series B: Statistical Methodology · doi:10.1111/j.2517-6161.1995.tb02031.x · Cited by 109,482

Inference of Population Structure Using Multilocus Genotype Data

Pritchard, J. K., Stephens, M., & Donnelly, P. (2000) · Genetics · doi:10.1093/genetics/155.2.945 · Cited by 33,871

Haploview: analysis and visualization of LD and haplotype maps

Barrett, J. C., Fry, B., Maller, J., & Daly, M. J. (2004) · Bioinformatics · doi:10.1093/bioinformatics/bth457 · Cited by 14,551

The Fagerstrom Test for Nicotine Dependence: a revision of the Fagerstrom Tolerance Questionnaire

HEATHERTON, T. F., KOZLOWSKI, L. T., FRECKER, R. C., & FAGERSTROM, K. (1991) · British Journal of Addiction · doi:10.1111/j.1360-0443.1991.tb01879.x · Cited by 10,738

Statistical significance for genomewide studies

Storey, J. D., & Tibshirani, R. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1530509100 · Cited by 9,692

A Direct Approach to False Discovery Rates

Storey, J. D. (2002) · Journal of the Royal Statistical Society Series B: Statistical Methodology · doi:10.1111/1467-9868.00346 · Cited by 5,603

More powerful procedures for multiple significance testing

Hochberg, Y., & Benjamini, Y. (1990) · Statistics in Medicine · doi:10.1002/sim.4780090710 · Cited by 2,715

Selecting a Maximally Informative Set of Single-Nucleotide Polymorphisms for Association Analyses Using Linkage Disequilibrium

Carlson, C. S., Eberle, M. A., Rieder, M. J., Qian, Y., Kruglyak, L., & Nickerson, D. A. (2004) · The American Journal of Human Genetics · doi:10.1086/381000 · Cited by 1,587

Annual Smoking-Attributable Mortality, Years of Potential Life Lost, and Productivity Losses—United States, 1997–2001

Tanoue, L. T. (2007) · Yearbook of Medicine · doi:10.1016/s0084-3873(08)70176-7 · Cited by 1,413

The Tobacco Atlas

Mackay, J. M., & Eriksen, M. P. (2002) · Medical Entomology and Zoology · Cited by 1,322

Variants in two adjacent genes, EGLN2 and CYP2A6, influence smoking behavior related to disease risk via different mechanisms

Bloom, A. J., Baker, T. B., Chen, L.-S., Breslau, N., Hatsukami, D. K., Bierut, L. J., & Goate, A. (2013) · Human Molecular Genetics · doi:10.1093/hmg/ddt432 · Cited by 36

Genetic Variation in the Dopamine Pathway and Smoking Cessation

David, S. P., & Munafo, M. R. (2008) · Pharmacogenomics · doi:10.2217/14622416.9.9.1307 · Cited by 36

Variation in the α 5 nicotinic acetylcholine receptor subunit gene predicts cigarette smoking intensity as a function of nicotine content

MacQueen, D. A., Heckman, B. W., Blank, M. D., Rensburg, K. J. V., Park, J. Y., Drobes, D. J., & Evans, D. E. (2013) · The Pharmacogenomics Journal · doi:10.1038/tpj.2012.50 · Cited by 36

Genome‐wide search for replicable risk gene regions in alcohol and nicotine co‐dependence

Zuo, L., Zhang, F., Zhang, H., Zhang, X., Wang, F., Li, C. R., Lu, L., Jiang, H., Lü, L., Krystal, J. H., et al. (2012) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32047 · Cited by 35

Unraveling the neurobiology of nicotine dependence using genetically engineered mice

Stoker, A. K., & Markou, A. (2013) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2013.02.013 · Cited by 38

Use of a predictive model derived from in vivo endophenotype measurements to demonstrate associations with a complex locus, CYP2A6

Bloom, A. J., Harari, O., Martínez, M., Madden, P. A. F., Martin, N. G., Montgomery, G. W., Rice, J. P., Murphy, S. E., Bierut, L. J., & Goate, A. (2012) · Human Molecular Genetics · doi:10.1093/hmg/dds114 · Cited by 35

Mesolimbic Dopamine and Habenulo-Interpeduncular Pathways in Nicotine Withdrawal

Dani, J. A., & De Biasi, M. (2013) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a012138 · Cited by 34

Increased nicotine response in iPSC-derived human neurons carrying the CHRNA5 N398 allele

Oni, E. N., Halikere, A., Li, G., Toro-Ramos, A. J., Swerdel, M. R., Verpeut, J. L., Moore, J. C., Bello, N. T., Bierut, L. J., Goate, A., et al. (2016) · Scientific Reports · doi:10.1038/srep34341 · Cited by 32

Locus of control is associated with tobacco and alcohol consumption in young adults of the Avon Longitudinal Study of Parents and Children

Lassi, G., Taylor, A. E., Mahedy, L., Heron, J., Eisen, T. G., & Munafo, M. R. (2019) · Royal Society Open Science · doi:10.1098/rsos.181133 · Cited by 34

Targeting lung cancer screening to individuals at greatest risk: the role of genetic factors

Lebrett, M. B., Crosbie, E. J., Smith, M. J., Woodward, E. R., Evans, D. G., & Crosbie, P. A. J. (2021) · Journal of Medical Genetics · doi:10.1136/jmedgenet-2020-107399 · Cited by 34

A rare missense mutation in CHRNA4 associates with smoking behavior and its consequences

Thorgeirsson, T. E., Steinberg, S., Reginsson, G. W., Bjornsdottir, G., Rafnar, T., Jonsdottir, I., Helgadottir, A., Gretarsdottir, S., Helgadottir, H., Jonsson, S., et al. (2016) · Molecular Psychiatry · doi:10.1038/mp.2016.13 · Cited by 33

CHRNB2 promoter region: association with subjective effects to nicotine and gene expression differences

Hoft, N. R., Stitzel, J. A., Hutchison, K. E., & Ehringer, M. A. (2010) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2010.00650.x · Cited by 38

Vitamin C to Decrease the Effects of Smoking in Pregnancy on Infant Lung Function (VCSIP): Rationale, design, and methods of a randomized, controlled trial of vitamin C supplementation in pregnancy for the primary prevention of effects of in utero tobacco smoke exposure on infant lung function and respiratory health

McEvoy, C. T., Milner, K. F., Scherman, A. J., Schilling, D., Tiller, C. J., Vuylsteke, B., Shorey‐Kendrick, L. E., Spindel, E. R., Schuff, R. A., Mitchell, J., et al. (2017) · Contemporary Clinical Trials · doi:10.1016/j.cct.2017.05.008 · Cited by 34

A multiancestry study identifies novel genetic associations withCHRNA5methylation in human brain and risk of nicotine dependence

Hancock, D. B., Wang, J., Gaddis, N., Levy, J. L., Saccone, N. L., Stitzel, J. A., Goate, A., Bierut, L. J., & Johnson, E. O. (2015) · Human Molecular Genetics · doi:10.1093/hmg/ddv303 · Cited by 34

In search of causal variants: refining disease association signals using cross-population contrasts

Saccone, N. L., Saccone, S. F., Goate, A., Grucza, R. A., Hinrichs, A. L., Rice, J. P., & Bierut, L. J. (2008) · BMC Genetics · doi:10.1186/1471-2156-9-58 · Cited by 36

Stealing a March in the 21st Century: Accelerating Progress in the 100-Year War Against Tobacco Addiction in the United States

Fiore, M. C., & Baker, T. B. (2009) · American Journal of Public Health · doi:10.2105/ajph.2008.154559 · Cited by 33

ASCL1 Regulates the Expression of the CHRNA5/A3/B4 Lung Cancer Susceptibility Locus

Improgo, M. R., Schlichting, N. A., Cortes, R. Y., Zhao-Shea, R., Tapper, A. R., & Gardner, P. D. (2010) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-09-0185 · Cited by 34

Educational Psychology

Ben‐Eliyahu, A., & Zeidner, M. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108264822.041 · Cited by 33

Commentary: Gene-environment interactions and smoking-related cancers

Thorgeirsson, T. E., & Stefánsson, K. (2010) · International Journal of Epidemiology · doi:10.1093/ije/dyp385 · Cited by 32

Meta-Analyses of Genome-Wide Association Data Hold New Promise for Addiction Genetics

Agrawal, A., Edenberg, H. J., & Gelernter, J. (2016) · Journal of Studies on Alcohol and Drugs · doi:10.15288/jsad.2016.77.676 · Cited by 32

Using Mendelian randomisation to infer causality in depression and anxiety research

Gage, S. H., Smith, G. D., Zammit, S., Hickman, M., & Munafò, M. R. (2013) · Depression and Anxiety · doi:10.1002/da.22150 · Cited by 32

Multiple distinct CHRNB3-CHRNA6 variants are genetic risk factors for nicotine dependence in African Americans and European Americans

Culverhouse, R., Johnson, E. O., Breslau, N., Hatsukami, D. K., Sadler, B. E., Brooks, A. I., HESSELBROCK, V. M., Schuckit, M. A., Tischfield, J. A., Goate, A., et al. (2014) · Addiction · doi:10.1111/add.12478 · Cited by 32

Genetics of biologically based psychological differences

Sallis, H., Smith, G. D., & Munafo, M. R. (2018) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2017.0162 · Cited by 32

Multiple genetic tests for susceptibility to smoking do not outperform simple family history

GARTNER, C. E., Barendregt, J. J., & Hall, W. (2008) · Addiction · doi:10.1111/j.1360-0443.2008.02392.x · Cited by 32

NCAM1-TTC12-ANKK1-DRD2 variants and smoking motives as intermediate phenotypes for nicotine dependence

Bidwell, L. C., McGeary, J. E., Gray, J. C., Palmer, R. H. C., Knopik, V. S., & MacKillop, J. M. (2014) · Psychopharmacology · doi:10.1007/s00213-014-3748-2 · Cited by 29

GWAS ‐based pathway analysis differentiates between fluid and crystallized intelligence

Christoforou, A., Espeseth, T., Davies, G., Fernandes, C. P. D., Giddaluru, S., Mattheisen, M., Tenesa, A., Harris, S. E., Liewald, D. C. M., Payton, A., et al. (2014) · Genes Brain & Behavior · doi:10.1111/gbb.12152 · Cited by 31

Genetic variation within theChrna7gene modulates nicotine reward‐like phenotypes in mice

Harenza, J., Muldoon, P. P., Biasi, M. D., Damaj, M. I., & Miles, M. F. (2013) · Genes Brain & Behavior · doi:10.1111/gbb.12113 · Cited by 35

Modeling complex genetic and environmental influences on comorbid bipolar disorder with tobacco use disorder

McEachin, R. C., Saccone, N. L., Saccone, S. F., Kleyman-Smith, Y. D., Kar, T., Kare, R. K., Ade, A. S., Sartor, M. A., Cavalcoli, J. D., & McInnis, M. G. (2010) · BMC Medical Genetics · doi:10.1186/1471-2350-11-14 · Cited by 31

Association ofCHRNA4polymorphisms with smoking behavior in two populations

Han, S., Yang, B., Kranzler, H. R., Oslin, D. W., Anton, R. F., & Gelernter, J. E. (2011) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.31177 · Cited by 31

TheCHRNA5/CHRNA3/CHRNB4Nicotinic Receptor Regulome: Genomic Architecture, Regulatory Variants, and Clinical Associations

Barrie, E. S., Hartmann, K., Lee, S., Frater, J. T., Seweryn, M. T., Wang, D., & Sadée, W. (2016) · Human Mutation · doi:10.1002/humu.23135 · Cited by 32

Genetic susceptibility variants for lung cancer: replication study and assessment as expression quantitative trait loci

Pintarelli, G., Cotroneo, C. E., Noci, S., Dugo, M., Galvan, A., Carpini, S. D., Citterio, L., Manunta, P., Incarbone, M., Tosi, D., et al. (2017) · Scientific Reports · doi:10.1038/srep42185 · Cited by 32

The Nuclear Transcription Factor PKNOX2 Is a Candidate Gene for Substance Dependence in European-Origin Women

Chen, X. '., Cho, K., Singer, B. H., & Zhang, H. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016002 · Cited by 32

A Systematic Review of the A118G (Asn40Asp) Variant ofOPRM1in Relation to Smoking Initiation, Nicotine Dependence and Smoking Cessation

Verhagen, M., Kleinjan, M., & Engels, R. C. M. E. (2012) · Pharmacogenomics · doi:10.2217/pgs.12.76 · Cited by 32

Compartmentalized Devices as Tools for Investigation of Human Brain Network Dynamics

Fantuzzo, J. A., Hart, R. P., Zahn, J. D., & Pang, Z. P. (2018) · Developmental Dynamics · doi:10.1002/dvdy.24665 · Cited by 31

Addiction Genetics and Pleiotropic Effects of Common Haplotypes that Make Polygenic Contributions to Vulnerability to Substance Dependence

Uhl, G. R., Drgon, T., Johnson, C., & Liu, Q. (2009) · Journal of Neurogenetics · doi:10.1080/01677060802572929 · Cited by 32

Prenatal exposure to maternal cigarette smoking interacts with a polymorphism in the α6 nicotinic acetylcholine receptor gene to influence drug use and striatum volume in adolescence

Lotfipour, S., Leonard, G., Perron, M., Pike, B., Richer, L., Séguin, J. R., Toro, R., Veillette, S., Pausova, Z., & Paus, T. (2010) · Molecular Psychiatry · doi:10.1038/mp.2009.63 · Cited by 31

The pro to toxin LYPD6B modulates heteromeric a3β4‐containing nicotinic acetylcholine receptors, but not α7 homomers

Ochoa, V., George, A. A., Nishi, R., & Whiteaker, P. (2015) · The FASEB Journal · doi:10.1096/fj.15-274548 · Cited by 30

Older Smokers' Motivation and Attempts to Quit Smoking

Breitling, L. P., Rothenbacher, D., Stegmaier, C., Raum, E., & Brenner, H. (2009) · Deutsches Ärzteblatt international · doi:10.3238/arztebl.2009.0451 · Cited by 30

Gene-environment interaction in problematic substance use: interaction betweenDRD4and insecure attachments

Olsson, C. A., Moyzis, R. K., Williamson, E., Ellis, J. A., Parkinson-Bates, M., Patton, G. C., Dwyer, T., Romaniuk, H., & Moore, E. E. (2011) · Addiction Biology · doi:10.1111/j.1369-1600.2011.00413.x · Cited by 33

Nicotine Withdrawal Symptoms in Adolescent and Adult Twins

Pergadia, M. L., Arpana Agrawal, A., Heath, A. C., Martin, N. G., Bucholz, K. K., & Madden, P. A. F. (2010) · Twin Research and Human Genetics · doi:10.1375/twin.13.4.359 · Cited by 30

Variation in the Nicotinic Acetylcholine Receptor Gene Cluster CHRNA5–CHRNA3–CHRNB4 and Its Interaction with Recent Tobacco Use Influence Cognitive Flexibility

Zhang, H., Kranzler, H. R., Poling, J. C., & Gelernter, J. E. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2010.95 · Cited by 29

Neuroimaging, genetics and the treatment of nicotine addiction

Ray, R., Loughead, J., Wang, Z., Detre, J. A., Yang, E., Gur, R. C., & Lerman, C. E. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.05.021 · Cited by 29

Inclusion of African Americans in Genetic Studies: What Is the Barrier?

Hartz, S. M., Johnson, E. O., Saccone, N. L., Hatsukami, D. K., Breslau, N., & Bierut, L. J. (2011) · American Journal of Epidemiology · doi:10.1093/aje/kwr084 · Cited by 29

Genome-Wide Association Study of Heavy Smoking and Daily/Nondaily Smoking in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL)

Saccone, N. L., Emery, L. S., Sofer, T., Gogarten, S. M., Becker, D. M., Böttinger, E. P., Chen, L.-S., Culverhouse, R., Duan, W., Hancock, D. B., et al. (2017) · Nicotine & Tobacco Research · doi:10.1093/ntr/ntx107 · Cited by 29

Personality Neuroscience

DeYoung, C. G., & Blain, S. D. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108264822.026 · Cited by 34

Four SNPs in the CHRNA3/5 Alpha-Neuronal Nicotinic Acetylcholine Receptor Subunit Locus Are Associated with COPD Risk Based on Meta-Analyses

Cui, K., Ge, X., & Ma, H. (2014) · PLoS ONE · doi:10.1371/journal.pone.0102324 · Cited by 29

Developmental effects of maternal smoking during pregnancy on the human frontal cortex transcriptome

Semick, S. A., Collado‐Torres, L., Markunas, C. A., Shin, J. H., Deep‐Soboslay, A., Tao, R., Huestis, M. A., Bierut, L. J., Maher, B. S., Johnson, E. O., et al. (2018) · Molecular Psychiatry · doi:10.1038/s41380-018-0223-1 · Cited by 28

Nicotine dependence may link the 15q25 locus to lung cancer risk

Galvan, A., & Dragani, T. A. (2009) · Carcinogenesis · doi:10.1093/carcin/bgp282 · Cited by 28

Genome-Wide Significant Association Between a Sequence Variant at 15q15.2 and Lung Cancer Risk

Rafnar, Þ., Sulem, P., Besenbacher, S., Gudbjartsson, D. F., Zanon, C., Guðmundsson, J., Stacey, S., Kostic, J. P., Thorgeirsson, T. E., Þorleifsson, G., et al. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-2852 · Cited by 28

CYP2B6 rs2279343 polymorphism is associated with smoking cessation success in bupropion therapy

Tomaz, P. R. X., Santos, J. R., Issa, J. S., Abe, T. O., Gaya, P. V., Krieger, J. E., Pereira, A. C., & Santos, P. C. J. L. (2015) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-015-1896-x · Cited by 28

Genetics of Smoking Behavior and Its Consequences: The Role of Nicotinic Acetylcholine Receptors

Thorgeirsson, T. E., & Stefánsson, K. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.09.010 · Cited by 27

Curious cases: Altered dose–response relationships in addiction genetics

Uhl, G. R., Drgonová, J., & Hall, F. S. (2013) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2013.10.013 · Cited by 28

Research on Integrative Healthcare: Context and Priorities

Deng, G., Weber, W. J., Sood, A., & Kemper, K. J. (2010) · EXPLORE · doi:10.1016/j.explore.2010.03.007 · Cited by 27

Profound alteration in reward processing due to a human polymorphism in CHRNA5: a role in alcohol dependence and feeding behavior

Besson, M., Forget, B., Correia, C., Blanco, R., & Maskos, U. (2019) · Neuropsychopharmacology · doi:10.1038/s41386-019-0462-0 · Cited by 30

Externalizing Behaviors are Associated with SNPs in the CHRNA5/CHRNA3/CHRNB4 Gene Cluster

Stephens, S. H., Hoft, N. R., Schlaepfer, I. R., Young, S. E., Corley, R., McQueen, M. B., Hopfer, C. J., Crowley, T. J., Stallings, M. C., Hewitt, J. K., et al. (2011) · Behavior Genetics · doi:10.1007/s10519-011-9514-x · Cited by 28

Association of nicotine dependence susceptibility gene, CHRNA5, with Parkinson's disease age at onset: Gene and smoking status interaction

Greenbaum, L., Rigbi, A., Lipshtat, N., Cilia, R., Tesei, S., Asselta, R., Djaldetti, R., Goldwurm, S., & Lerer, B. (2012) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2012.07.007 · Cited by 27

The Galanin Receptor 1 Gene Associates with Tobacco Craving in Smokers Seeking Cessation Treatment

Lori, A., Tang, Y., O’Malley, S. S., Picciotto, M. R., Wu, R., Conneely, K. N., & Cubells, J. F. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.25 · Cited by 27

Genetic Risk For Nicotine Dependence in the Cholinergic System and Activation of the Brain Reward System in Healthy Adolescents

Nees, F., Witt, S. H., Lourdusamy, A., Vollstädt‐Klein, S., Steiner, S., Poustka, L., Banaschewski, T., Barker, G. J., Büchel, C., Conrod, P., et al. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.131 · Cited by 27

Insights Into Nicotinic Receptor Signaling in Nicotine Addiction: Implications for Prevention and Treatment

Liu, W., & Li, M. D. (2017) · Current Neuropharmacology · doi:10.2174/1570159x15666170801103009 · Cited by 28

Combined genetic influence of the nicotinic receptor gene cluster CHRNA5/A3/B4 on nicotine dependence

Lee, S., Ahn, W., Seweryn, M. T., & Sadée, W. (2018) · BMC Genomics · doi:10.1186/s12864-018-5219-3 · Cited by 27

Single Nucleotide Polymorphisms in CHRNA5 rs16969968, CHRNA3 rs578776, and LOC123688 rs8034191 Are Associated With Heaviness of Smoking in Women in Northeastern Ontario, Canada

Conlon, M. S., & Bewick, M. A. (2011) · Nicotine & Tobacco Research · doi:10.1093/ntr/ntr140 · Cited by 27

Common polymorphisms in FMO1 are associated with nicotine dependence

Hinrichs, A. L., Murphy, S. E., Wang, J. C. C., Saccone, S. F., Saccone, N. L., Steinbach, J. H., Goate, A., Stevens, V. L., & Bierut, L. J. (2011) · Pharmacogenetics and Genomics · doi:10.1097/fpc.0b013e328346886f · Cited by 27

Enrichment of putative PAX8 target genes at serous epithelial ovarian cancer susceptibility loci

Kar, S., Adler, E. K., Tyrer, J. P., Hazelett, D. J., Anton‐Culver, H., Bandera, E. V., Beckmann, M. W., Berchuck, A., Bogdanova, N. V., Brinton, L. A., et al. (2017) · British Journal of Cancer · doi:10.1038/bjc.2016.426 · Cited by 25

Role of Genetic Susceptibility in Nicotine Addiction and Chronic Obstructive Pulmonary Disease

Pérez-Rubio, G., Córdoba-Lanús, E., Cupertino, P., Cartujano‐Barrera, F., Campos, M., & Falfán‐Valencia, R. (2019) · Revista de investigaci�n Cl�nica · doi:10.24875/ric.18002617 · Cited by 26

Genetic susceptibility to nicotine addiction: Advances and shortcomings in our understanding of the CHRNA5/A3/B4 gene cluster contribution

Icick, R., Forget, B., Cloëz-Tayarani, I., Pons, S., Maskos, U., & Besson, M. (2020) · Neuropharmacology · doi:10.1016/j.neuropharm.2020.108234 · Cited by 31

The Impact of Electronic Nicotine Delivery System (ENDS) Flavors on Nicotinic Acetylcholine Receptors and Nicotine Addiction-Related Behaviors

Cooper, S. Y., & Henderson, B. J. (2020) · Molecules · doi:10.3390/molecules25184223 · Cited by 29

Crucial roles of the CHRNB3–CHRNA6 gene cluster on chromosome 8 in nicotine dependence: update and subjects for future research

Wen, L., Yang, Z., Cui, W., & Li, M. D. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.103 · Cited by 27

Functional Characterization of the α5(Asn398) Variant Associated with Risk for Nicotine Dependence in the α3β4α5 Nicotinic Receptor

Li, P., McCollum, M. M., Bracamontes, J. R., Steinbach, J. H., & Akk, G. (2011) · Molecular Pharmacology · doi:10.1124/mol.111.073841 · Cited by 25

A Genetic Deconstruction of Neurocognitive Traits in Schizophrenia and Bipolar Disorder

Fernandes, C. P. D., Christoforou, A., Giddaluru, S., Ersland, K. M., Djurovic, S., Mattheisen, M., Lundervold, A. J., Reinvang, I., Nöthen, M. M., Rietschel, M., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0081052 · Cited by 25

CHRNA5 polymorphisms and risk of lung cancer in Chinese Han smokers.

Huang, C., Xun, X., A-jing, W., Gao, Y., Ma, J., Chen, Y.-T., Jin, T., Hou, P., & Gu, S. (2015) · Europe PMC (PubMed Central) · Cited by 25

Detecting genetic interactions for quantitative traits with U-statistics

Li, M., Ye, C., Fu, W., Elston, R. C., & Lu, Q. L. (2011) · Genetic Epidemiology · doi:10.1002/gepi.20594 · Cited by 25

The influence of five monoamine genes on trajectories of depressive symptoms across adolescence and young adulthood

Adkins, D. E., Daw, J., McClay, J. L., & van den Oord, E. J. C. G. (2012) · Development and Psychopathology · doi:10.1017/s0954579411000824 · Cited by 26

Identification of N-terminal Extracellular Domain Determinants in Nicotinic Acetylcholine Receptor (nAChR) α6 Subunits That Influence Effects of Wild-type or Mutant β3 Subunits on Function of α6β2*- or α6β4*-nAChR

Dash, B., Bhakta, M., Chang, Y., & Lukas, R. J. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.263673 · Cited by 24

Genetic variants in the MRPS30 region and postmenopausal breast cancer risk

Huang, Y., Ballinger, D. G., Dai, J. Y., Peters, U., Hinds, D. A., Cox, D., Beilharz, E. J., Chlebowski, R. T., Rossouw, J. E., McTiernan, A., et al. (2011) · Genome Medicine · doi:10.1186/gm258 · Cited by 24

SNP Identification by Transcriptome Sequencing and Candidate Gene-Based Association Analysis for Heat Tolerance in the Bay Scallop Argopecten irradians

Du, X., Li, L., Zhang, S., Meng, F., & Zhang, G. (2014) · PLoS ONE · doi:10.1371/journal.pone.0104960 · Cited by 24

Methylome-wide comparison of human genomic DNA extracted from whole blood and from EBV-transformed lymphocyte cell lines

Åberg, K. A., Khachane, A. N., Rudolf, G., Nerella, S., Fugman, D. A., Tischfield, J. A., & van den Oord, E. J. C. G. (2012) · European Journal of Human Genetics · doi:10.1038/ejhg.2012.33 · Cited by 24

Gender-stratified gene and gene–treatment interactions in smoking cessation

Lee, W., Bergen, A. W., Swan, G. E., Li, D., Liu, J., Thomas, P. D., Tyndale, R. F., Benowitz, N. L., Lerman, C., & Conti, D. V. (2011) · The Pharmacogenomics Journal · doi:10.1038/tpj.2011.30 · Cited by 25

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Maskos, U. (2020) · Journal of Neurochemistry · doi:10.1111/jnc.14989 · Cited by 26

Sponsor's foreword

Shurtleff, D., Liu, R., & Sasek, C. A. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.08.009 · Cited by 24

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Reisenzein, R., Hildebrandt, A., & Weber, H. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108264822.009 · Cited by 26

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Flora, A. V., Zambrano, C. A., Gallego, X., Miyamoto, J. H., Johnson, K. A., Cowan, K. A., Stitzel, J. A., & Ehringer, M. A. (2013) · Brain Research · doi:10.1016/j.brainres.2013.07.017 · Cited by 27

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