Cited by 512Muscle Physiology and DisordersImmune cells in cancerNeurogenetic and Muscular Disorders Research

The DOI matches its Crossref record; 60 of the 60 references it cites were found in a registry or an index.

Shifts in macrophage phenotypes and macrophage competition for arginine metabolism affect the severity of muscle pathology in muscular dystrophy

Open access

Villalta, S. A., Nguyen, H. X., Deng, B., Gotoh, T., Tidball, J. G.·2008·Human Molecular Genetics

Open this paper in CoChat — free account Open PDF

Abstract

Duchenne muscular dystrophy (DMD) is the most common, lethal, muscle-wasting disease of childhood. Previous investigations have shown that muscle macrophages may play an important role in promoting the pathology in the mdx mouse model of DMD. In the present study, we investigate the mechanism through which macrophages promote mdx dystrophy and assess whether the phenotype of the macrophages changes between the stage of peak muscle necrosis (4 weeks of age) and muscle regeneration (12 weeks). We find that 4-week-old mdx muscles contain a population of pro-inflammatory, classically activated M1 macrophages that lyse muscle in vitro by NO-mediated mechanisms. Genetic ablation of the iNOS gene in mdx mice also significantly reduces muscle membrane lysis in 4-week-old mdx mice in vivo. However, 4-week mdx muscles also contain a population of alternatively activated, M2a macrophages that express arginase. In vitro assays show that M2a macrophages reduce lysis of muscle cells by M1 macrophages through the competition of arginase in M2a cells with iNOS in M1 cells for their common, enzymatic substrate, arginine. During the transition from the acute peak of mdx pathology to the regenerative stage, expression of IL-4 and IL-10 increases, either of which can deactivate the M1 phenotype and promote activation of a CD163+, M2c phenotype that can increase tissue repair. Our findings further show that IL-10 stimulation of macrophages activates their ability to promote satellite cell proliferation. Deactivation of the M1 phenotype is also associated with a reduced expression of iNOS, IL-6, MCP-1 and IP-10. Thus, these results show that distinct subpopulations of macrophages can promote muscle injury or repair in muscular dystrophy, and that therapeutic interventions that affect the balance between M1 and M2 macrophage populations may influence the course of muscular dystrophy.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1093/hmg/ddn376

Cites

60 of 60 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

The chemokine system in diverse forms of macrophage activation and polarization
MANTOVANI, A., SICA, A., SOZZANI, S., ALLAVENA, P., VECCHI, A., & LOCATI, M. (2004) · Trends in Immunology · doi:10.1016/j.it.2004.09.015 · Cited by 6,534
Alternative activation of macrophages
Gordon, S. (2003) · Nature Reviews Immunology · doi:10.1038/nri978 · Cited by 6,189
Dystrophin: the protein product of the Duchenne muscular dystrophy locus
Hoffman, E. P., Brown, R. H., & Kunkel, L. M. (1987) · Cell · doi:10.1016/0092-8674(87)90579-4 · Cited by 4,693
Arginine metabolism: nitric oxide and beyond
WU, G., & MORRIS, S. M. (1998) · Biochemical Journal · doi:10.1042/bj3360001 · Cited by 2,811
Inflammatory monocytes recruited after skeletal muscle injury switch into antiinflammatory macrophages to support myogenesis
Arnold, L., Henry, A., Poron, F., Baba-Amer, Y., van Rooijen, N., Plonquet, A., Gherardi, R. K., & Chazaud, B. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070075 · Cited by 2,002
The many faces of macrophage activation
Mosser, D. M. (2003) · Journal of Leukocyte Biology · doi:10.1189/jlb.0602325 · Cited by 1,902
Dystrophin protects the sarcolemma from stresses developed during muscle contraction
Petrof, B. J., Shrager, J. B., Stedman, H. H., Kelly, A. M., & Sweeney, H. L. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.8.3710 · Cited by 1,526
Nitric Oxide Synthases: Properties and Catalytic Mechanism
Griffith, O. W., & Stuehr, D. J. (1995) · Annual Review of Physiology · doi:10.1146/annurev.ph.57.030195.003423 · Cited by 1,311
Purification and characterization of the cytokine-induced macrophage nitric oxide synthase: an FAD- and FMN-containing flavoprotein.
Stuehr, D. J., Cho, H. J., Kwon, N. S., Weise, M. F., & Nathan, C. F. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.17.7773 · Cited by 816
Regulation of scavenger receptor CD163 expression in human monocytes and macrophages by pro- and antiinflammatory stimuli
Buechler, C., Ritter, M., Orsó, E., Langmann, T., Klucken, J., & Schmitz, G. (2000) · Journal of Leukocyte Biology · doi:10.1002/jlb.67.1.97 · Cited by 704

Flagged first, then by citations

Show all 60 references

Sorted by citations

Items 201–300 of 509

Macrophage Colony-Stimulating Factor–Induced Macrophage Differentiation Promotes Regrowth in Atrophied Skeletal Muscles and C2C12 Myotubes
Dumont, N. A., & Frenette, J. (2012) · American Journal Of Pathology · doi:10.1016/j.ajpath.2012.10.010 · Cited by 38
Agent-based model illustrates the role of the microenvironment in regeneration in healthy and mdx skeletal muscle
Virgilio, K. M., Martin, K. S., Peirce, S. M., & Blemker, S. S. (2018) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00379.2018 · Cited by 38
Dystrophin Deficiency Leads to Genomic Instability in Human Pluripotent Stem Cells via NO Synthase-Induced Oxidative Stress
Jelínková, Š., Fojtík, P., Kohutová, A., Vilotić, A., Marková, L., Pešl, M., Juráková, T., Krutá, M., Vrbský, J., Gaillyová, R., et al. (2019) · Cells · doi:10.3390/cells8010053 · Cited by 37
“The Social Network” and Muscular Dystrophies: The Lesson Learnt about the Niche Environment as a Target for Therapeutic Strategies
Cappellari, O., Mantuano, P., & Luca, A. D. (2020) · Cells · doi:10.3390/cells9071659 · Cited by 36
Neuronal Nitric Oxide Synthase-Rescue of Dystrophin/Utrophin Double Knockout Mice does not Require nNOS Localization to the Cell Membrane
Wehling-Henricks, M., & Tidball, J. (2011) · PLoS ONE · doi:10.1371/journal.pone.0025071 · Cited by 37
Self-citation
Reciprocal Interaction between TRAF6 and Notch Signaling Regulates Adult Myofiber Regeneration upon Injury
Hindi, S. M., Paul, P. K., Dahiya, S., Mishra, V., Bhatnagar, S., Kuang, S., Choi, Y., & Kumar, A. (2012) · Molecular and Cellular Biology · doi:10.1128/mcb.00717-12 · Cited by 41
Targeting RAGE as a potential therapeutic approach to Duchenne muscular dystrophy
Sagheddu, R., Chiappalupi, S., Salvadori, L., Riuzzi, F., Donato, R., & Sorci, G. (2018) · Human Molecular Genetics · doi:10.1093/hmg/ddy288 · Cited by 34
Use of Nanoformulation to Target Macrophages for Disease Treatment
Liu, X., Xie, X., Jiang, J., Lin, M. J., Zheng, E., Qiu, W., Yeung, I., Zhu, M., Li, Q., Xia, T., et al. (2021) · Advanced Functional Materials · doi:10.1002/adfm.202104487 · Cited by 36
IL-6 signaling blockade increases inflammation but does not affect muscle function in the mdx mouse
Kostek, M., Nagaraju, K., Pistilli, E., Sali, A., Lai, S.-H., Gordon, B. S., & Chen, Y.-W. (2012) · BMC Musculoskeletal Disorders · doi:10.1186/1471-2474-13-106 · Cited by 36
CD13 Regulates Anchorage and Differentiation of the Skeletal Muscle Satellite Stem Cell Population in Ischemic Injury
Rahman, M., Ghosh, M., Subramani, J., Fong, G., Carlson, M. E., & Shapiro, L. H. (2013) · Stem Cells · doi:10.1002/stem.1610 · Cited by 34
CCR2 deficiency does not provide sustained improvement of muscular dystrophy in mdx 5cv mice
Zhao, W., Wang, X., Ransohoff, R. M., & Zhou, L. (2016) · The FASEB Journal · doi:10.1096/fj.201600619r · Cited by 33
Acute extracellular matrix, inflammatory and MAPK response to lengthening contractions in elderly human skeletal muscle
Sorensen, J. R., Skousen, C., Holland, A., Williams, K., & Hyldahl, R. D. (2018) · Experimental Gerontology · doi:10.1016/j.exger.2018.02.013 · Cited by 34
Magnolol Attenuates Cisplatin-Induced Muscle Wasting by M2c Macrophage Activation
Lee, C., Jeong, H., Lee, H., Hong, M., Park, S.-Y., & Bae, H. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00077 · Cited by 37
Anti-interleukin-6 receptor antibody (MR16-1) promotes muscle regeneration via modulation of gene expressions in infiltrated macrophages
Fujita, R., Kawano, F., Ohira, T., Nakai, N., Shibaguchi, T., Nishimoto, N., & Ohira, Y. (2014) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2014.01.014 · Cited by 34
Nutraceuticals and Their Potential to Treat Duchenne Muscular Dystrophy: Separating the Credible from the Conjecture
Woodman, K., Coles, C., Lamandé, S., & White, J. (2016) · Nutrients · doi:10.3390/nu8110713 · Cited by 81
Therapeutic potential of adipose-derived stem cells and macrophages for ischemic skeletal muscle repair.
Rybalko, V. Y., Hsieh, P.-L., Ricles, L., Chung, E., Farrar, R., & Suggs, L. (2017) · Regenerative medicine · doi:10.2217/rme-2016-0094 · Cited by 32
Cellular interactions and microenvironment dynamics in skeletal muscle regeneration and disease
Rodríguez, C., Timóteo-Ferreira, F., Minchiotti, G., Brunelli, S., & Guardiola, O. (2024) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2024.1385399 · Cited by 36
Redox remodeling: a candidate regulator of HMGB1 function in injured skeletal muscle
Vezzoli, M., Castellani, P., Campana, L., Corna, G., Bosurgi, L., Manfredi, A. A., Bianchi, M. E., Rubartelli, A., & Rovere, P. Q. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05748.x · Cited by 33
Advancements in stem cells treatment of skeletal muscle wasting
Meregalli, M., Farini, A., Sitzia, C., & Torrente, Y. (2014) · Frontiers in Physiology · doi:10.3389/fphys.2014.00048 · Cited by 33
Divergent impact of Toll‐like receptor 2 deficiency on repair mechanisms in healthy muscle versus Duchenne muscular dystrophy
Mojumdar, K., Giordano, C., Lemaire, C. F., Liang, F., Divangahi, M., Qureshi, S. T., & Petrof, B. J. (2016) · The Journal of Pathology · doi:10.1002/path.4689 · Cited by 33
Targeting a therapeutic LIF transgene to muscle via the immune system ameliorates muscular dystrophy
Welc, S. S., Flores, I., Wehling‐Henricks, M., Ramos, J. N., Wang, Y., Bertoni, C., & Tidball, J. G. (2019) · Nature Communications · doi:10.1038/s41467-019-10614-1 · Cited by 32
Self-citation
Modulation of Klotho expression in injured muscle perturbs Wnt signalling and influences the rate of muscle growth
Welc, S. S., Wehling‐Henricks, M., Kuro‐o, M., Thomas, K. A., & Tidball, J. G. (2019) · Experimental Physiology · doi:10.1113/ep088142 · Cited by 31
Self-citation
Upregulated IL-1β in dysferlin-deficient muscle attenuates regeneration by blunting the response to pro-inflammatory macrophages
Cohen, T. V., Many, G. M., Fleming, B. D., Gnocchi, V. F., Ghimbovschi, S., Mosser, D., Hoffman, E., & Partridge, T. (2015) · Skeletal Muscle · doi:10.1186/s13395-015-0048-4 · Cited by 30
MKP-1 coordinates ordered macrophage-phenotype transitions essential for stem cell-dependent tissue repair
Perdiguero, E., Kharraz, Y., Serrano, A. L., & Muñoz-Cánoves, P. (2012) · Cell Cycle · doi:10.4161/cc.11.5.19374 · Cited by 30
Intraperitoneal injection of microencapsulated Sertoli cells restores muscle morphology and performance in dystrophic mice
Chiappalupi, S., Luca, G., Mancuso, F., Madaro, L., Fallarino, F., Nicoletti, C., Calvitti, M., Arato, I., Falabella, G., Salvadori, L., et al. (2015) · Biomaterials · doi:10.1016/j.biomaterials.2015.10.029 · Cited by 30
Inflammatory predisposition predicts disease phenotypes in muscular dystrophy
Nitahara‐Kasahara, Y., Takeda, S., & Okada, T. (2016) · Inflammation and Regeneration · doi:10.1186/s41232-016-0019-0 · Cited by 31
Macrophages’ Role in Tissue Disease and Regeneration
Gaffney, L. S., Warren, P. B., Wrona, E. A., Fisher, M. B., & Freytes, D. O. (2017) · Results and problems in cell differentiation · doi:10.1007/978-3-319-54090-0_10 · Cited by 30
Preliminary Evidences of Safety and Efficacy of Flavonoids- and Omega 3-Based Compound for Muscular Dystrophies Treatment: A Randomized Double-Blind Placebo Controlled Pilot Clinical Trial
Sitzia, C., Meregalli, M., Belicchi, M., Farini, A., Arosio, M., Bestetti, D., Villa, C., Valenti, L. V. C., Brambilla, P., & Torrente, Y. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.00755 · Cited by 30
Glioblastoma microenvironment: The stromal interactions
Uyar, R. (2022) · Pathology - Research and Practice · doi:10.1016/j.prp.2022.153813 · Cited by 32
Differential roles of MMP-9 in early and late stages of dystrophic muscles in a mouse model of Duchenne muscular dystrophy.
Shiba, N., Miyazaki, D., Yoshizawa, T., Fukushima, K., Shiba, Y., Inaba, Y., Imamura, M., Takeda, S., Koike, K., & Nakamura, A. (2015) · Biochimica et Biophysica Acta · doi:10.1016/j.bbadis.2015.07.008 · Cited by 24
Fibrosis and inflammation are greater in muscles of beta-sarcoglycan-null mouse than mdx mouse
Gibertini, S., Zanotti, S., Savadori, P., Curcio, M., Saredi, S., Salerno, F., Andreetta, F., Bernasconi, P., Mantegazza, R., & Mora, M. (2014) · Cell and Tissue Research · doi:10.1007/s00441-014-1854-4 · Cited by 29
Absence of T and B lymphocytes modulates dystrophic features in dysferlin deficient animal model
Farini, A., Sitzia, C., Navarro, C. L., D’Antona, G., Belicchi, M., Parolini, D., Fraro, G. D., Razini, P., Bottinelli, R., Meregalli, M., et al. (2012) · Experimental Cell Research · doi:10.1016/j.yexcr.2012.03.010 · Cited by 31
miR-146a deficiency does not aggravate muscular dystrophy in mdx mice
Bronisz-Budzyńska, I., Chwalenia, K., Mucha, O., Podkalicka, P., Karolina-Bukowska-Strakova, Józkowicz, A., Łoboda, A., Kozakowska, M., & Dulak, J. (2019) · Skeletal Muscle · doi:10.1186/s13395-019-0207-0 · Cited by 29
Total Absence of Dystrophin Expression Exacerbates Ectopic Myofiber Calcification and Fibrosis and Alters Macrophage Infiltration Patterns
Young, C., Gosselin, M. R. F., Rumney, R. M. H., Oksiejuk, A., Chira, N., Bożycki, Ł., Matryba, P., Łukasiewicz, K., Kao, A. P., Dunlop, J., et al. (2019) · American Journal Of Pathology · doi:10.1016/j.ajpath.2019.09.021 · Cited by 29
Fibrosis following Acute Skeletal Muscle Injury: Mitigation and Reversal Potential in the Clinic
Gardner, T., Kenter, K., & Li, Y. (2020) · Journal of Sports Medicine · doi:10.1155/2020/7059057 · Cited by 33
Boosting the peripheral immune response in the skeletal muscles improved motor function in ALS transgenic mice
Trolese, M. C., Scarpa, C., Melfi, V., Fabbrizio, P., Sironi, F. M., Rossi, M., Bendotti, C., & Nardo, G. (2022) · Molecular Therapy · doi:10.1016/j.ymthe.2022.04.018 · Cited by 27
Identification and Function of Fibrocytes in Skeletal Muscle Injury Repair and Muscular Dystrophy
Wang, X., Zhao, W., Ransohoff, R. M., & Zhou, L. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1601308 · Cited by 29
Xanthine oxidase is hyper-active in Duchenne muscular dystrophy
Lindsay, A., McCourt, P. M., Karachunski, P. I., Lowe, D. A., & Ervasti, J. M. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.10.404 · Cited by 30
Changes in calsequestrin, TNF ‐α, TGF ‐β and MyoD levels during the progression of skeletal muscle dystrophy in mdx mice: a comparative analysis of the quadriceps, diaphragm and intrinsic laryngeal muscles
Maranhão, J. B., Moreira, D. D. O., Maurício, A. F., de Carvalho, S. C., Ferretti, R., Pereira, J. A., Neto, H. S., & Marques, M. J. (2015) · International Journal of Experimental Pathology · doi:10.1111/iep.12142 · Cited by 28
Myeloid cell‐specific mutation of Spi1 selectively reduces M2 ‐biased macrophage numbers in skeletal muscle, reduces age‐related muscle fibrosis and prevents sarcopenia
Wang, Y., Welc, S. S., Wehling‐Henricks, M., Kong, Y., Thomas, C., Montecino‐Rodriguez, E., Dorshkind, K. A., & Tidball, J. G. (2022) · Aging Cell · doi:10.1111/acel.13690 · Cited by 26
Self-citation
Advancements and challenges in amyotrophic lateral sclerosis
Bradford, D. R., & Rodgers, K. E. (2024) · Frontiers in Neuroscience · doi:10.3389/fnins.2024.1401706 · Cited by 31
Macrophages in the Context of Muscle Regeneration and Duchenne Muscular Dystrophy
Hernández‐Torres, F., Matías-Valiente, L., Alzas-Gomez, V., & Aránega, A. E. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms251910393 · Cited by 29
Cannabinoid type 2 receptor manipulates skeletal muscle regeneration partly by regulating macrophage M1/M2 polarization in IR injury in mice
Jiang, P., Wang, L., Zhang, M., Zhang, M., Wang, C., Zhao, R., & Guan, D.-W. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.117989 · Cited by 27
Early Inflammation in Muscular Dystrophy Differs between Limb and Respiratory Muscles and Increases with Dystrophic Severity
Howard, Z. M., Lowe, J., Blatnik, A. J., Roberts, D., Burghes, A. H. M., Bansal, S. S., & Rafael‐Fortney, J. A. (2021) · American Journal Of Pathology · doi:10.1016/j.ajpath.2021.01.008 · Cited by 29
What Is the Optimal Timing of Transplantation of Neural Stem Cells in Spinal Cord Injury? A Systematic Review and Network Meta-Analysis Based on Animal Studies
Shang, Z., Li, D., Chen, J., Wang, R., Wang, M., Zhang, B., Wang, X., & Wanyan, P. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.855309 · Cited by 26
iNOS Ablation Does Not Improve Specific Force of the Extensor Digitorum Longus Muscle in Dystrophin-Deficient mdx4cv Mice
Li, D., Shin, J., & Duan, D. (2011) · PLoS ONE · doi:10.1371/journal.pone.0021618 · Cited by 27
Spatiotemporal transcriptomic mapping of regenerative inflammation in skeletal muscle reveals a dynamic multilayered tissue architecture
Patsalos, A., Halász, L., Oleksak, D., Wei, X., Nagy, G. N., Tzerpos, P., Conrad, T., Hammers, D. W., Sweeney, H. L., & Nagy, L. (2024) · Journal of Clinical Investigation · doi:10.1172/jci173858 · Cited by 26
Immune Function and Muscle Adaptations to Resistance exercise in Older Adults: Study Protocol for a Randomized Controlled Trial of a Nutritional Supplement
Dennis, R. A., Ponnappan, U., Kodell, R. L., Garner, K. K., Parkes, C. M., Bopp, M. M., Padala, K. P., Peterson, C. A., Padala, P. R., & Sullivan, D. H. (2015) · Trials · doi:10.1186/s13063-015-0631-3 · Cited by 25
Cell-based secondary prevention of childbirth-induced pelvic floor trauma
Callewaert, G., Cunha, M. D. D., Sindhwani, N., Sampaolesi, M., Albersen, M., & Deprest, J. (2017) · Nature reviews. Urology · doi:10.1038/nrurol.2017.42 · Cited by 24
The dual CCR2/CCR5 chemokine receptor antagonist Cenicriviroc reduces macrophage infiltration and disease severity in Duchenne muscular dystrophy (Dmdmdx-4Cv) mice
Liang, F., Giordano, C., Shang, D., Li, Q., & Petrof, B. J. (2018) · PLoS ONE · doi:10.1371/journal.pone.0194421 · Cited by 26
Celecoxib treatment improves muscle function in mdx mice and increases utrophin A expression
Péladeau, C. L., Adam, N., & Jasmin, B. J. (2018) · The FASEB Journal · doi:10.1096/fj.201800081r · Cited by 26
MyD88 is required for satellite cell-mediated myofiber regeneration in dystrophin-deficient mdx mice
Gallot, Y. S., Straughn, A. R., Bohnert, K. R., Xiong, G., Hindi, S. M., & Kumar, A. (2018) · Human Molecular Genetics · doi:10.1093/hmg/ddy258 · Cited by 25
Cellular and molecular modulation of rotator cuff muscle pathophysiology
Fu, C., Huang, A. H., Galatz, L. M., & Han, W. M. (2021) · Journal of Orthopaedic Research® · doi:10.1002/jor.25179 · Cited by 24
New Progress in Basic Research of Macrophages in the Pathogenesis and Treatment of Low Back Pain
Yan, M., Song, Z., Kou, H., Shang, G., Shang, C., Chen, X., Ji, Y., Bao, D., Cheng, T., Li, J., et al. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.866857 · Cited by 25
CCAAT-Enhancer-Binding Protein-Beta (CEBPB) Expression In-Vivo is Associated with Muscle Strength
Harries, L. W., Pilling, L., Hernandez, L., Bradley-Smith, R. M., Henley, W., Singleton, A., Guralnik, J., Bandinelli, S., Ferrucci, L., & Melzer, D. (2012) · Aging Cell · doi:10.1111/j.1474-9726.2011.00782.x · Cited by 31
Mast Cell-Directed Recruitment of MHC Class II Positive Cells and Eosinophils Towards Mesenteric Lymphatic Vessels in Adulthood and Elderly
Chatterjee, V., & Gashev, A. A. (2014) · Lymphatic Research and Biology · doi:10.1089/lrb.2013.0031 · Cited by 25
Biomimetic Systems Involving Macrophages and Their Potential for Targeted Drug Delivery
Savchenko, I. V., Zlotnikov, I. D., & Kudryashova, E. V. (2023) · Biomimetics · doi:10.3390/biomimetics8070543 · Cited by 25
What do mouse models of muscular dystrophy tell us about the DAPC and its components?
Whitmore, C. L., & Morgan, J. E. (2014) · International Journal of Experimental Pathology · doi:10.1111/iep.12095 · Cited by 24
Molecular hydrogen alleviates motor deficits and muscle degeneration inmdxmice
Hasegawa, S., Ito, M., Fukami, M., Hashimoto, M., Hirayama, M., & Ohno, K. (2016) · Redox Report · doi:10.1080/13510002.2015.1135580 · Cited by 25
The Effect of Laminin-111 Hydrogels on Muscle Regeneration in a Murine Model of Injury
Marcinczyk, M., Dunn, A., Haas, G., Madsen, J., Scheidt, R., Patel, K. H., Talović, M., & Garg, K. (2019) · Tissue Engineering. Part A · doi:10.1089/ten.tea.2018.0200 · Cited by 24
Down-regulation of common NFκB-iNOS pathway by chronic Thalidomide treatment improves Hepatopulmonary Syndrome and Muscle Wasting in rats with Biliary Cirrhosis
Li, T., Lee, P., Lee, K., Hsieh, Y., Tsai, C., Yang, Y., Huang, S., Tsai, T., Hsieh, S.-L. E., Hou, M., et al. (2016) · Scientific Reports · doi:10.1038/srep39405 · Cited by 24
Low-Intensity Training and the C5a Complement Antagonist NOX-D21 Rescue the mdx Phenotype through Modulation of Inflammation
Hyzewicz, J., Tanihata, J., Kuraoka, M., Nitahara‐Kasahara, Y., Beylier, T., Rüegg, U. T., Vater, A., & Takeda, S. (2017) · American Journal Of Pathology · doi:10.1016/j.ajpath.2016.12.019 · Cited by 24
Dysferlinopathy Promotes an Intramuscle Expansion of Macrophages with a Cyto-Destructive Phenotype
Baek, J.-H., Many, G. M., Evesson, F. J., & Kelley, V. R. (2017) · American Journal Of Pathology · doi:10.1016/j.ajpath.2017.02.011 · Cited by 23
The linkage between inflammation and fibrosis in muscular dystrophies: The axis autotaxin–lysophosphatidic acid as a new therapeutic target?
Gallardo, F. S., Córdova-Casanova, A., & Brandan, E. (2021) · Journal of Cell Communication and Signaling · doi:10.1007/s12079-021-00610-w · Cited by 27
Skeletal muscle stem cells modulate niche function in Duchenne muscular dystrophy mouse through YY1-CCL5 axis
Li, Y., Li, C.-H., Sun, Q., Liu, X.-Y., Chen, F., Cheung, Y., Zhao, Y., Xie, T., Chazaud, B., Sun, H., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-56474-w · Cited by 23
Skeletal muscle fibrosis: the effect of stromal-derived factor-1α-loaded collagen scaffolds.
Grefte, S., Kuijpers-Jagtman, A., Torensma, R., & den Hoff, J. W. V. (2010) · Regenerative medicine · doi:10.2217/rme.10.69 · Cited by 36
P2X7 Receptor Antagonist Reduces Fibrosis and Inflammation in a Mouse Model of Alpha-Sarcoglycan Muscular Dystrophy
Raffaghello, L., Principi, E., Baratto, S., Panicucci, C., Pintus, S., Antonini, F., Zotto, G. D., Benzi, A., Bruzzone, S., Scudieri, P., et al. (2022) · Pharmaceuticals · doi:10.3390/ph15010089 · Cited by 24
Skeletal Muscle Cells Express ICAM-1 after Muscle Overload and ICAM-1 Contributes to the Ensuing Hypertrophic Response
Dearth, C. L., Goh, Q., Marino, J. S., Cicinelli, P. A., Torres‐Palsa, M. J., Pierre, P., Worth, R. G., & Pizza, F. X. (2013) · PLoS ONE · doi:10.1371/journal.pone.0058486 · Cited by 23
Nestin Expression in End-Stage Disease in Dystrophin-Deficient Heart: Implications for Regeneration From Endogenous Cardiac Stem Cells
Berry, S. E., Andruszkiewicz, P., Chun, J. L., & Hong, J. P. (2013) · Stem Cells Translational Medicine · doi:10.5966/sctm.2012-0174 · Cited by 23
NMAAP1 Expressed in BCG-Activated Macrophage Promotes M1 Macrophage Polarization
Liu, Q., Tian, Y., Zhao, X., Jing, H., Xie, Q., Li, P., Li, D., Yan, D., & Zhu, X. (2015) · Molecules and Cells · doi:10.14348/molcells.2015.0125 · Cited by 23
Potential Synergistic Effects of Stem Cells and Extracellular Matrix Scaffolds
Gaffney, L. S., Wrona, E. A., & Freytes, D. O. (2017) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.7b00083 · Cited by 23
Proteomic Profiling Unravels a Key Role of Specific Macrophage Subtypes in Sporadic Inclusion Body Myositis
Roos, A., Preusse, C., Hathazi, D., Goebel, H., & Stenzel, W. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01040 · Cited by 23
Jieduquyuziyin Prescription-Treated Rat Serum Suppresses Activation of Peritoneal Macrophages in MRL/Lpr Lupus Mice by Inhibiting IRAK1 Signaling Pathway
Ji, L., Hou, X. S., Deng, X., Fan, X., Aiwen, Z., Zhang, X., & Li, R. (2019) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2019/2357217 · Cited by 23
Differential Effects of Myeloid Cell PPARδ and IL-10 in Regulating Macrophage Recruitment, Phenotype, and Regeneration following Acute Muscle Injury
Welc, S. S., Wehling‐Henricks, M., Antoun, J., Ha, T. T., Tous, I., & Tidball, J. G. (2020) · The Journal of Immunology · doi:10.4049/jimmunol.2000247 · Cited by 23
Self-citation
FAPs orchestrate homeostasis of muscle physiology and pathophysiology
Yin, K., Zhang, C., Deng, Z., Wei, X., Xiang, T., Yang, C. H., Chen, C., Chen, Y., & Luo, F. (2024) · The FASEB Journal · doi:10.1096/fj.202400381r · Cited by 22
Response of macrophages in rat skeletal muscle after eccentric exercise
Zuo, Q., Wang, S., Yu, X., & Chao, W. (2018) · Chinese journal of traumatology = Zhonghua chuang shang za zhi · doi:10.1016/j.cjtee.2017.12.001 · Cited by 19
The role of fibrosis in the pathophysiology of muscular dystrophy
Mogharehabed, F., & Czubryt, M. P. (2023) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00196.2023 · Cited by 22
Effects of Hyperbaric Oxygen at 1.25 Atmospheres Absolute with Normal Air on Macrophage Number and Infiltration during Rat Skeletal Muscle Regeneration
Fujita, N., Ono, M., Tomioka, T., & Deie, M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0115685 · Cited by 23
Inflammation et régénération musculaire
Dufresne, S. S., Frenette, J., & Dumont, N. A. (2016) · médecine/sciences · doi:10.1051/medsci/20163206022 · Cited by 25
Myeloid Cell Responses to Contraction-induced Injury Differ in Muscles of Young and Old Mice
Sloboda, D. D., Brown, L. A., & Brooks, S. V. (2018) · The Journals of Gerontology Series A · doi:10.1093/gerona/gly086 · Cited by 22
Precision Medicine and Exercise Therapy in Duchenne Muscular Dystrophy
Kostek, M. C. (2019) · Sports · doi:10.3390/sports7030064 · Cited by 22
The SINE Compound KPT-350 Blocks Dystrophic Pathologies in DMD Zebrafish and Mice
Hightower, R. M., Reid, A. L., Gibbs, D. E., Wang, Y., Widrick, J. J., Kunkel, L. M., Kastenschmidt, J. M., Villalta, S. A., van Groen, T., Chang, H., et al. (2019) · Molecular Therapy · doi:10.1016/j.ymthe.2019.08.016 · Cited by 22
Self-citation
Expression profiling in exercised mdx suggests a role for extracellular proteins in the dystrophic muscle immune response
Coles, C. A., Gordon, L., Hunt, L. C., Webster, T., Piers, A. T., Kintakas, C., Woodman, K. G., Touslon, S. L., Smythe, G. M., White, J. D., et al. (2019) · Human Molecular Genetics · doi:10.1093/hmg/ddz266 · Cited by 20
Dystrophin Threshold Level Necessary for Normalization of Neuronal Nitric Oxide Synthase, Inducible Nitric Oxide Synthase, and Ryanodine Receptor-Calcium Release Channel Type 1 Nitrosylation in Golden Retriever Muscular Dystrophy Dystrophinopathy
Gentil, C., Guiner, C. L., Falcone, S., Hogrel, J., Peccate, C., Lorain, S., Benkhelifa‐Ziyyat, S., Guigand, L., Montus, M., Servais, L., et al. (2016) · Human Gene Therapy · doi:10.1089/hum.2016.041 · Cited by 21
Loss of dystrophin expression in skeletal muscle is associated with senescence of macrophages and endothelial cells
Young, L. V., Morrison, W., Campbell, C., Moore, E. C., Arsenault, M. G., Dial, A. G., Ng, S. Y., Bellissimo, C. A., Perry, C. G. R., Ljubicic, V., et al. (2021) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00397.2020 · Cited by 22
Mechanisms of Myofibre Death in Muscular Dystrophies: The Emergence of the Regulated Forms of Necrosis in Myology
Bencze, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms24010362 · Cited by 20
Magnoliae Cortex Alleviates Muscle Wasting by Modulating M2 Macrophages in a Cisplatin-Induced Sarcopenia Mouse Model
Hong, M., Han, I., Choi, I., Cha, N., Kim, W., Kim, S. K., & Bae, H. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22063188 · Cited by 21
From skeletal muscle damage and regeneration to the hypertrophy induced by exercise: what is the role of different macrophage subsets?
Minari, A. L. A., & dos Santos, R. V. T. (2021) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00038.2021 · Cited by 21
Macrophage plasticity in Duchenne muscular dystrophy: a nexus of pathological remodelling with therapeutic implications
Petrof, B. J. (2021) · The Journal of Physiology · doi:10.1113/jp281673 · Cited by 23
Electroacupuncture at ST‐36 Protects Interstitial Cells of Cajal via Sustaining Heme Oxygenase‐1 Positive M2 Macrophages in the Stomach of Diabetic Mice
Tian, L., Song, S., Zhu, B., & Liu, S. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/3987134 · Cited by 19
A comparative evaluation of the immunotoxicity and immunomodulatory effects on macrophages exposed to aromatic trihalogenated DBPs
Xie, Y., Jiang, L., Qiu, J., & Wang, Y. (2019) · Immunopharmacology and Immunotoxicology · doi:10.1080/08923973.2019.1608444 · Cited by 19
Transcriptomic Analysis Reveals Involvement of the Macrophage Migration Inhibitory Factor Gene Network in Duchenne Muscular Dystrophy
Lombardo, S. D., Mazzon, E., Mangano, K., Basile, M. S., Cavalli, E., Mammana, S., Fagone, P., Nicoletti, F., & Petralia, M. C. (2019) · Genes · doi:10.3390/genes10110939 · Cited by 23
CXCL10 increases in human skeletal muscle following damage but is not necessary for muscle regeneration
Deyhle, M. R., Hafen, P. S., Parmley, J., Preece, C. N., Robison, M., Sorensen, J. R., Jackson, B., Eggett, D. L., Hancock, C. R., & Hyldahl, R. D. (2018) · Physiological Reports · doi:10.14814/phy2.13689 · Cited by 19
Neopterin/7,8‐dihydroneopterin is elevated in Duchenne muscular dystrophy patients and protects mdx skeletal muscle function
Lindsay, A., Schmiechen, A., Chamberlain, C. M., Ervasti, J. M., & Lowe, D. A. (2018) · Experimental Physiology · doi:10.1113/ep087031 · Cited by 19
Inactivation of Venom PLA2 Alleviates Myonecrosis and Facilitates Muscle Regeneration in Envenomed Mice: A Time Course Observation
Xiao, H., Li, H.-R., Zhang, D., Li, Y.-Y., Sun, S., & Huang, C.-H. (2018) · Molecules · doi:10.3390/molecules23081911 · Cited by 20
Downhill Exercise-Induced Changes in Gene Expression Related with Macrophage Polarization and Myogenic Cells in the Triceps Long Head of Rats
Minari, A. L. A., Oyama, L., & Santos, R. V. D. D. (2015) · Inflammation · doi:10.1007/s10753-014-0024-x · Cited by 19
Immune in myocardial ischemia/reperfusion injury: potential mechanisms and therapeutic strategies
Xuan, X., Fan, J., Zhang, J., Ren, M., & Feng, L. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1558484 · Cited by 22
Effective therapy of polymyositis in mice via selective inhibition of the immunoproteasome
Oliva, M. D. R., Kirk, C. J., Groettrup, M., & Basler, M. (2022) · European Journal of Immunology · doi:10.1002/eji.202249851 · Cited by 18
Insights into the Pathogenic Secondary Symptoms Caused by the Primary Loss of Dystrophin
Forcina, L., Pelosi, L., Miano, C., & Musarò, A. (2017) · Journal of Functional Morphology and Kinesiology · doi:10.3390/jfmk2040044 · Cited by 18
First Insights Into the M2 Inflammatory Response After Adipose-Tissue-Derived Stem Cell Injections in Radiation-Injured Muscles
Riccobono, D., Nikovics, K., Francois, S., Favier, A., Jullien, N., Schrock, G., Scherthan, H., & Drouet, M. (2018) · Health Physics · doi:10.1097/hp.0000000000000822 · Cited by 14

Authors: Villalta, S. A., Nguyen, H. X., Deng, B., Gotoh, T., & Tidball, J. G.
Affiliations: University of California, Los Angeles (US)
Kumamoto University (JP)
Corresponding author: Tidball, J. G.
ORCID: Villalta, S. A.
Deng, B.
Gotoh, T.
Tidball, J. G.
Venue: Human Molecular Genetics
Publisher: Oxford University Press (OUP)
Published: 2008-11-07
Volume: 18
Issue: 3
Pages: 482-496
ISSN: 0964-6906 (ISSN-L)
1460-2083
DOI: 10.1093/hmg/ddn376
PMC: PMC2638796
OpenAlex: W2144067550
Cited by: 512
References: 60
Citations by year: 2026: 11 · 2025: 25 · 2024: 18 · 2023: 28 · 2022: 41 · 2021: 32 · 2020: 32 · 2019: 33 · 2018: 39 · 2017: 37 · 2016: 25 · 2015: 39 · 2014: 40 · 2013: 32 · 2012: 27
FWCI: 7.14
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Human Molecular Genetics (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
HighWire Press Open Archive (submittedVersion)
Funders: Muscular Dystrophy Association
National Institutes of Health (5r01ar040343-12, AR40343)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR047855, R01 AR47721, R01 AR 40343, R01AR047721, F31AR054724)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
Health Sciences › Medicine › Genetics (clinical) › Neurogenetic and Muscular Disorders Research
Keywords: Duchenne muscular dystrophy, mdx mice, macrophage polarization, M1 macrophages, M2 macrophages, arginine metabolism, arginase, inducible nitric oxide synthase, nitric oxide, muscle necrosis, muscle regeneration, IL-10, IL-4, CD163, satellite cell proliferation, tissue repair
MeSH terms: Animals, Arginine, Cells, Cultured, Humans, Macrophage Activation, Macrophages, Mice, Inbred C57BL, Mice, Transgenic, Muscular Dystrophy, Animal, Nitric Oxide, Phenotype, Severity of Illness Index, Cytokines, Muscle, Skeletal, Muscular Dystrophy, Duchenne, Cell Proliferation, Mice, Nitric Oxide Synthase Type II

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Shifts in macrophage phenotypes and macrophage competition for arginine metabolism affect the severity of muscle pathology in muscular dystrophy

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks