The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Most genome-wide significant susceptibility loci for schizophrenia and bipolar disorder reported to date cross-traditional diagnostic boundaries
Open accessAbstract
Recent findings from genetic epidemiology and from genome-wide association studies point strongly to a partial overlap in the genes that contribute susceptibility to schizophrenia and bipolar disorder (BD). Previous data have also directly implicated one of the best supported schizophrenia-associated loci, zinc finger binding protein 804A (ZNF804A), as showing trans-disorder effects, and the same is true for one of the best supported bipolar loci, calcium channel, voltage-dependent, L type, alpha 1C subunit (CACNA1C) which has also been associated with schizophrenia. We have undertaken a cross-phenotype study based upon the remaining variants that show genome-wide evidence for association in large schizophrenia and BD meta-analyses. These comprise in schizophrenia, SNPs in or in the vicinity of transcription factor 4 (TCF4), neurogranin (NRGN) and an extended region covering the MHC locus on chromosome 6. For BD, the strongly supported variants are in the vicinity of ankyrin 3, node of Ranvier (ANK3) and polybromo-1 (PBRM1). Using data sets entirely independent of their original discoveries, we observed strong evidence that the PBRM1 locus is also associated with schizophrenia (P = 0.00015) and nominally significant evidence (P < 0.05) that the NRGN and the extended MHC region are associated with BD. Moreover, considering this highly restricted set of loci as a group, the evidence for trans-disorder effects is compelling (P = 4.7 × 10(-5)). Including earlier reported data for trans-disorder effects for ZNF804A and CACNA1C, six out of eight of the most robustly associated loci for either disorder show trans-disorder effects.
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Cites
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
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Self-citationCommon polygenic variation contributes to risk of schizophrenia and bipolar disorder
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Common variants conferring risk of schizophrenia
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“Association to the MHC region was detected at genome-wide levels of significance through a combined analysis of three schizophrenia GWASs (7,10,11).”
BackgroundMethodInfluentialThe Heritability of Bipolar Affective Disorder and the Genetic Relationship to Unipolar Depression
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Self-citationIdentification of loci associated with schizophrenia by genome-wide association and follow-up
Molecular Genetics of Schizophrenia Collaboration, O'Donovan, M. C., Craddock, N., Norton, N., Williams, H., Peirce, T., Moskvina, V., Nikolov, I., Hamshere, M., Carroll, L., et al. (2008) · Nature Genetics · doi:10.1038/ng.201 · Cited by 1,070
Self-citationEstimation of significance thresholds for genomewide association scans
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“The observation that some alleles impact on both schizophrenia and BD does not imply the existence of a unitary condition (3).”
BackgroundSelf-citation
Cited by
Talkowski, M. E., Rosenfeld, J. A., Blumenthal, I., Pillalamarri, V., Chiang, C., Heilbut, A., Ernst, C., Hanscom, C., Rossin, E., Lindgren, A. M., et al. (2012) · Cell · doi:10.1016/j.cell.2012.03.028 · Cited by 577
Narcolepsy onset is seasonal and increased following the 2009 H1N1 pandemic in china
Han, F., Lin, L., Warby, S. C., Faraco, J., Li, J., Dong, S. X., An, P., Zhao, L., Wang, L. H., Li, Q. Y., et al. (2011) · Annals of Neurology · doi:10.1002/ana.22587 · Cited by 512
The genetics of attention deficit/hyperactivity disorder in adults, a review
on behalf of the International Multicentre persistent ADHD CollaboraTion (IMpACT), Franke, B., Faraone, S. V., Asherson, P., Buitelaar, J., Bau, C. H. D., Ramos-Quiroga, J. A., Mick, E., Grevet, E. H., Johansson, S., et al. (2012) · Molecular Psychiatry · doi:10.1038/mp.2011.138 · Cited by 432
Ayalew, M., Le-Niculescu, H., Levey, D. F., Jain, N., Changala, B., Patel, S. D., Winiger, E., Breier, A., Shekhar, A., Amdur, R., et al. (2012) · Molecular Psychiatry · doi:10.1038/mp.2012.37 · Cited by 397
Self-citationEmpirical evidence for discrete neurocognitive subgroups in bipolar disorder: clinical implications
Burdick, K. E., Russo, M., Frangou, S., Mahon, K., Braga, R. J., Shanahan, M., & Malhotra, A. K. (2014) · Psychological Medicine · doi:10.1017/s0033291714000439 · Cited by 355
Metadata
- Authors
- Williams, H. J., Craddock, N., Russo, G., Hamshere, M. L., Moskvina, V., Dwyer, S., Smith, R. L., Green, E., Grozeva, D., Holmans, P., Owen, M. J., & O'Donovan, M. C.
- Venue
- Human Molecular Genetics
- Publisher
- Oxford University Press (OUP)
- Published
- 2010-10-29
- Volume
- 20
- Issue
- 2
- Pages
- 387-391
- ISSN
- 0964-6906 (ISSN-L)
- 1460-2083
- OpenAlex
- W2115600578
- Cited by
- 191
- References
- 9
- FWCI
- 18.94
- Type
- journal article
- Language
- en
- Open access
- green
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- Williams, H. J., Craddock, N., Russo, G., Hamshere, M. L., Moskvina, V., Dwyer, S., Smith, R. L., Green, E., Grozeva, D., Holmans, P., Owen, M. J., & O'Donovan, M. C. (2011). Most genome-wide significant susceptibility loci for schizophrenia and bipolar disorder reported to date cross-traditional diagnostic boundaries. Human Molecular Genetics. https://doi.org/10.1093/hmg/ddq471
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