The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.
Empirical evidence for discrete neurocognitive subgroups in bipolar disorder: clinical implications
Open accessAbstract
Background: Recent data suggest trait-like neurocognitive impairments in bipolar disorder (BPD), with deficits about 1 s.d.below average, less severe than deficits noted in schizophrenia. The frequency of significant impairment in BPD is approximately 60%, with 40% of patients characterized as cognitively spared. This contrasts with a more homogeneous presentation in schizophrenia. It is not understood why some BPD patients develop deficits while others do not. Method: A total of 136 patients with BPD completed the MATRICS Consensus Cognitive Battery and data were entered into hierarchical cluster analyses to: (1) determine the optimal number of clusters (subgroups) that fit the sample; and (2) assign subjects to a specific cluster based on individual profiles. We then compared subgroups on several clinical factors and real-world community functioning. Results: Three distinct neurocognitive subgroups were found: (1) an intact group with performance comparable with healthy controls on all domains but with superior social cognition; (2) a selective impairment group with moderate deficits on processing speed, attention, verbal learning and social cognition and normal functioning in other domains; and (3) a global impairment group with severe deficits across all cognitive domains comparable with deficits in schizophrenia. Conclusions: These results suggest the presence of multiple cognitive subgroups in BPD with unique profiles and begin to address the relationships between these subgroups, several clinical factors and functional outcome. Next steps will include using these data to help guide future efforts to target these disabling symptoms with treatment.
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Cites
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Cited by
Malhi, G. S., Bell, E., Bassett, D., Boyce, P., Bryant, R., Hazell, P., Hopwood, M., Lyndon, B., Mulder, R., Porter, R., et al. (2021) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/0004867420979353 · Cited by 614
Cognitive Impairment in Bipolar Disorder: Treatment and Prevention Strategies
Solé, B., Jiménez, E., Torrent, C., Reinares, M., Bonnin, C. D. M., Torres, I., Varo, C., Grande, I., Valls, E., Salagre, E., et al. (2017) · International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyx032 · Cited by 299
Meta-analysis of Theory of Mind (ToM) impairment in bipolar disorder
Bora, E., Bartholomeusz, C., & Pantelis, C. (2016) · Psychological Medicine · doi:10.1017/s0033291715001993 · Cited by 216
Lee, R. S. C., Hermens, D. F., Naismith, S. L., Lagopoulos, J., Jones, A., Scott, J., Chitty, K. M., White, D., Robillard, R., Scott, E. M., et al. (2015) · Translational Psychiatry · doi:10.1038/tp.2015.50 · Cited by 134
Neurodevelopmental pathways in bipolar disorder
Kloiber, S., Rosenblat, J. D., Husain, M. I., Ortiz, A., Berk, M., Quevedo, J., Vieta, E., Maes, M., Birmaher, B., Soares, J. C., et al. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.02.005 · Cited by 122
Metadata
- Authors
- Burdick, K. E., Russo, M., Frangou, S., Mahon, K., Braga, R. J., Shanahan, M., & Malhotra, A. K.
- Venue
- Psychological Medicine
- Publisher
- Cambridge University Press (CUP)
- Published
- 2014-03-11
- Volume
- 44
- Issue
- 14
- Pages
- 3083-3096
- ISSN
- 0033-2917 (ISSN-L)
- 1469-8978
- OpenAlex
- W2123808137
- Cited by
- 355
- References
- 47
- FWCI
- 17.29
- Type
- journal article
- Language
- en
- Open access
- green
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