Identification of loci associated with schizophrenia by genome-wide association and follow-up
Abstract
We carried out a genome-wide association study of schizophrenia (479 cases, 2,937 controls) and tested loci with P < 10(-5) in up to 16,726 additional subjects. Of 12 loci followed up, 3 had strong independent support (P < 5 x 10(-4)), and the overall pattern of replication was unlikely to occur by chance (P = 9 x 10(-8)). Meta-analysis provided strongest evidence for association around ZNF804A (P = 1.61 x 10(-7)) and this strengthened when the affected phenotype included bipolar disorder (P = 9.96 x 10(-9)).
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Common susceptibility genes for both BD and psychosis have been identified, including ZNF804A on chromosome 2q32.
“Common susceptibility genes for both disorders have also been identified. The first of such commonalities identified included zinc finger–binding protein 804A gene (ZNF804A) on chromosome 2q32 (185).”
From Childhood Trauma, the HPA Axis and Psychiatric Illnesses: A Targeted Literature Synthesis (2022) · cites this paper as [185]
For SCZ and BIP, sign tests comparing the consistency of association tests from discovery GWAS and replication samples for sets of top signals are usually highly significant even if most loci do not meet genome-wide significance.
“For SCZ and BIP, sign tests comparing the consistency of association tests from discovery GWAS and replication samples for sets of top signals are usually highly significant even if most loci do not meet genome-wide significance. 58,59,174”
From Genetic architectures of psychiatric disorders: the emerging picture and its implications (2012) · cites this paper as [174]
Cites
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
The Wellcome Trust Case Control Consortium, Management Committee, Burton, P. R., Clayton, D. G., Cardon, L. R., Craddock, N., Deloukas, P., Duncanson, A., Kwiatkowski, D. P., McCarthy, M. I., et al. (2007) · Nature · doi:10.1038/nature05911 · Cited by 9,442 · see citing works
Self-citationFrayling, T. M., Timpson, N. J., Weedon, M. N., Zeggini, E., Freathy, R. M., Lindgren, C. M., Perry, J. R. B., Elliott, K. S., Lango, H., Rayner, N. W., et al. (2007) · Science · doi:10.1126/science.1141634 · Cited by 4,531 · see citing works
Genomic Control for Association Studies
Devlin, B., & Roeder, K. (1999) · Biometrics · doi:10.1111/j.0006-341x.1999.00997.x · Cited by 3,162 · see citing works
The Wellcome Trust Case Control Consortium, U.K.
Mossman, K. (2008) · Scientific American · doi:10.1038/scientificamerican0108-42a · Cited by 2,714 · see citing works
A new multipoint method for genome-wide association studies by imputation of genotypes
Marchini, J., Howie, B., Myers, S., McVean, G., & Donnelly, P. (2007) · Nature Genetics · doi:10.1038/ng2088 · Cited by 2,609 · see citing works
Self-citationReplication of Genome-Wide Association Signals in UK Samples Reveals Risk Loci for Type 2 Diabetes
Zeggini, E., Weedon, M. N., Lindgren, C. M., Frayling, T. M., Elliott, K. S., Lango, H., Timpson, N. J., Perry, J. R. B., Rayner, N. W., Freathy, R. M., et al. (2007) · Science · doi:10.1126/science.1142364 · Cited by 2,194 · see citing works
Self-citationRioux, J. D., Xavier, R. J., Taylor, K. D., Silverberg, M. S., Goyette, P., Huett, A., Green, T., Kuballa, P., Barmada, M. M., Datta, L. W., et al. (2007) · Nature Genetics · doi:10.1038/ng2032 · Cited by 1,769 · see citing works
Linkage strategies for genetically complex traits. I. Multilocus models.
RISCH, N. J. (1990) · PubMed · Cited by 1,315 · see citing works
Ross, C. A., Margolis, R. L., Reading, S. A. J., Pletnikov, M. V., & Coyle, J. T. (2006) · Neuron · doi:10.1016/j.neuron.2006.09.015 · Cited by 697 · see citing works
The genetics of schizophrenia and bipolar disorder: dissecting psychosis
Craddock, N., O’Donovan, M. C., & Owen, M. J. (2005) · Journal of Medical Genetics · doi:10.1136/jmg.2005.030718 · Cited by 574 · see citing works
Self-citationCardno, A. G., & Gottesman, I. I. (2000) · American Journal of Medical Genetics · doi:10.1002/(sici)1096-8628(200021)97:1
Flagged first, then by citations
Cited by
Sorted by citations
Biological insights from 108 schizophrenia-associated genetic loci
Schizophrenia Working Group of the Psychiatric Genomics Consortium (2014) · Nature · doi:10.1038/nature13595 · Cited by 7,577 · see citing works
Common polygenic variation contributes to risk of schizophrenia and bipolar disorder
The International Schizophrenia Consortium (2009) · Nature · doi:10.1038/nature08185 · Cited by 4,821 · see citing works
(2013) · The Lancet · doi:10.1016/s0140-6736(12)62129-1 · Cited by 3,010 · see citing works
The Dopamine Hypothesis of Schizophrenia: Version III--The Final Common Pathway
Howes, O. D., & Kapur, S. (2009) · Schizophrenia Bulletin · doi:10.1093/schbul/sbp006 · Cited by 2,693 · see citing works
Animal models of neuropsychiatric disorders
Nestler, E. J., & Hyman, S. E. (2010) · Nature Neuroscience · doi:10.1038/nn.2647 · Cited by 2,023 · see citing works
Prenatal Infection and Schizophrenia: A Review of Epidemiologic and Translational Studies
Brown, A. S., & Derkits, E. J. (2010) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2009.09030361 · Cited by 1,269 · see citing works
Genetic architectures of psychiatric disorders: the emerging picture and its implications
Sullivan, P. F., Daly, M. J., & O'Donovan, M. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3240 · Cited by 1,177 · see citing works
Self-citationThe Diagnosis of Mental Disorders: The Problem of Reification
Hyman, S. E. (2010) · Annual Review of Clinical Psychology · doi:10.1146/annurev.clinpsy.3.022806.091532 · Cited by 1,052 · see citing works
Li, Y., Willer, C., Sanna, S., & Abecasis, G. (2009) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev.genom.9.081307.164242 · Cited by 990 · see citing works
Common genetic variants on 5p14.1 associate with autism spectrum disorders
Wang, K., Zhang, H., Ma, D., Bucan, M., Glessner, J. T., Abrahams, B. S., Salyakina, D., Imielinski, M., Bradfield, J. P., Sleiman, P. M. A., et al. (2009) · Nature · doi:10.1038/nature07999 · Cited by 989 · see citing works
Talkowski, M. E., Rosenfeld, J. A., Blumenthal, I., Pillalamarri, V., Chiang, C., Heilbut, A., Ernst, C., Hanscom, C., Rossin, E., Lindgren, A. M., et al. (2012) · Cell · doi:10.1016/j.cell.2012.03.028 · Cited by 577 · see citing works
The Kraepelinian dichotomy – going, going … but still not gone
Craddock, N., & Owen, M. J. (2010) · British Journal of Psychiatry · doi:10.1192/bjp.bp.109.073429 · Cited by 587 · see citing works
Self-citationWellcome Trust Case Control Consortium, Green, E. K., Grozeva, D., Jones, I., Jones, L., Kirov, G., Caesar, S., Gordon-Smith, K., Fraser, C., Forty, L., et al. (2010) · Molecular Psychiatry · doi:10.1038/mp.2009.49 · Cited by 526 · see citing works
Self-citationGenetic architecture: the shape of the genetic contribution to human traits and disease
Timpson, N. J., Greenwood, C. M. T., Soranzo, N., Lawson, D. J., & Richards, J. B. (2018) · Nature Reviews Genetics · doi:10.1038/nrg.2017.101 · Cited by 434 · see citing works
Meta-Analysis of Genome-Wide Association Studies of Attention-Deficit/Hyperactivity Disorder
Neale, B. M., Medland, S. E., Ripke, S., Asherson, P., Franke, B., Lesch, K.-P., Faraone, S. V., Nguyen, T. T., Schäfer, H., Holmans, P., et al. (2010) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2010.06.008 · Cited by 450 · see citing works
Self-citationGenomewide Association Studies: History, Rationale, and Prospects for Psychiatric Disorders
Psychiatric GWAS Consortium Coordinating Committee (2009) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2008.08091354 · Cited by 450 · see citing works
The genetics of bipolar disorder
Barnett, J. H., & Smoller, J. W. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.03.080 · Cited by 407 · see citing works
Neural Mechanisms of a Genome-Wide Supported Psychosis Variant
Esslinger, C., Walter, H., Kirsch, P., Erk, S., Schnell, K., Arnold, C., Haddad, L., Mier, D., Opitz von Boberfeld, C., Raab, K., et al. (2009) · Science · doi:10.1126/science.1167768 · Cited by 400 · see citing works
Self-citationMoskvina, V, Craddock, N., Holmans, P., Nikolov, I., Pahwa, J. S., Green, E., Wellcome Trust Case Control Consortium, Owen, M. J., & O'Donovan, M. C. (2009) · Molecular Psychiatry · doi:10.1038/mp.2008.133 · Cited by 363 · see citing works
Self-citationGenome-wide association study in obsessive-compulsive disorder: results from the OCGAS
Mattheisen, M., Samuels, J. F., Wang, Y., Greenberg, B. D., Fyer, A. J., McCracken, J. T., Geller, D. A., Murphy, D. L., Knowles, J. A., Grados, M. A., et al. (2015) · Molecular Psychiatry · doi:10.1038/mp.2014.43 · Cited by 321 · see citing works
Genetic overlap between autism, schizophrenia and bipolar disorder
Carroll, L. S., & Owen, M. J. (2009) · Genome Medicine · doi:10.1186/gm102 · Cited by 326 · see citing works
Self-citationYue, W.-H., Wang, H.-F., Sun, L.-D., Tang, F.-L., Liu, Z.-H., Zhang, H.-X., Li, W.-Q., Zhang, Y.-L., Zhang, Y., Ma, C.-C., et al. (2011) · Nature Genetics · doi:10.1038/ng.979 · Cited by 289 · see citing works
Sebat, J., Levy, D. L., & McCarthy, S. E. (2009) · Trends in Genetics · doi:10.1016/j.tig.2009.10.004 · Cited by 260 · see citing works
Talkowski, M. E., Mullegama, S. V., Rosenfeld, J. A., van Bon, B. W. M., Shen, Y., Repnikova, E. A., Gastier-Foster, J., Thrush, D. L., Kathiresan, S., Ruderfer, D. M., et al. (2011) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2011.09.011 · Cited by 249 · see citing works
Doherty, J. L., & Owen, M. J. (2014) · Genome Medicine · doi:10.1186/gm546 · Cited by 228 · see citing works
Self-citationO'Dushlaine, C., Kenny, E., Heron, E., Donohoe, G., Gill, M., Morris, D., The International Schizophrenia Consortium, & Corvin, A. (2011) · Molecular Psychiatry · doi:10.1038/mp.2010.7 · Cited by 228 · see citing works
Self-citationSleep and Circadian Rhythm Disruption in Social Jetlag and Mental Illness
Foster, R. G., Peirson, S. N., Wulff, K., Winnebeck, E., Vetter, C., & Roenneberg, T. (2013) · Progress in Molecular Biology and Translational Science · doi:10.1016/b978-0-12-396971-2.00011-7 · Cited by 224 · see citing works
Schork, A. J., Won, H., Appadurai, V., Nudel, R., Gandal, M., Delaneau, O., Revsbech Christiansen, M., Hougaard, D. M., Bækved-Hansen, M., Bybjerg-Grauholm, J., et al. (2019) · Nature Neuroscience · doi:10.1038/s41593-018-0320-0 · Cited by 223 · see citing works
Craddock, N., O'Donovan, M. C., & Owen, M. J. (2009) · Schizophrenia Bulletin · doi:10.1093/schbul/sbp020 · Cited by 216 · see citing works
Self-citationA genome-wide association study on common SNPs and rare CNVs in anorexia nervosa
Wang, K., Zhang, H., Bloss, C. S., Duvvuri, V, Kaye, W., Schork, N. J., Berrettini, W., Hakonarson, H., & the Price Foundation Collaborative Group (2011) · Molecular Psychiatry · doi:10.1038/mp.2010.107 · Cited by 212 · see citing works
Cross-disorder genomewide analysis of schizophrenia, bipolar disorder, and depression
Huang, J., Perlis, R. H., Lee, P. H., Rush, A. J., Fava, M., Sachs, G. S., Lieberman, J., Hamilton, S. P., Sullivan, P., Sklar, P., et al. (2010) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2010.09091335 · Cited by 213 · see citing works
Diverse types of genetic variation converge on functional gene networks involved in schizophrenia
Gilman, S. R., Chang, J., Xu, B., Bawa, T. S., Gogos, J. A., Karayiorgou, M., & Vitkup, D. (2012) · Nature Neuroscience · doi:10.1038/nn.3261 · Cited by 200 · see citing works
From maps to multi-dimensional network mechanisms of mental disorders
Braun, U., Schaefer, A., Betzel, R. F., Tost, H., Meyer-Lindenberg, A., & Bassett, D. S. (2018) · Neuron · doi:10.1016/j.neuron.2017.11.007 · Cited by 177 · see citing works
Grozeva, D. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2010.25 · Cited by 192 · see citing works
Genetics of schizophrenia: new findings and challenges
Gejman, P. V., Sanders, A. R., & Kendler, K. S. (2011) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev-genom-082410-101459 · Cited by 183 · see citing works
Self-citationPenetrance for copy number variants associated with schizophrenia
Vassos, E., Collier, D. A., Holden, S., Patch, C., Rujescu, D., St Clair, D., & Lewis, C. M. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddq259 · Cited by 182 · see citing works
Self-citationChildhood Trauma, the HPA Axis and Psychiatric Illnesses: A Targeted Literature Synthesis
Murphy, F., Nasa, A., Cullinane, D., Raajakesary, K., Gazzaz, A., Sooknarine, V., Haines, M., Roman, E., Kelly, L., O'Neill, A., et al. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.748372 · Cited by 181 · see citing works
“The first of such commonalities identified included zinc finger–binding protein 804A gene (ZNF804A) on chromosome 2q32 (185).”
BackgroundMood, anxiety and psychotic phenomena measure a common psychopathological factor
Stochl, J., Khandaker, G. M., Lewis, G., Perez, J., Goodyer, I. M., Zammit, S., Sullivan, S., Croudace, T. J., & Jones, P. B. (2015) · Psychological Medicine · doi:10.1017/s003329171400261x · Cited by 153 · see citing works
Self-citationVisscher, P. M., Goddard, M. E., Derks, E. M., & Wray, N. R. (2012) · Molecular Psychiatry · doi:10.1038/mp.2011.65 · Cited by 138 · see citing works
McClay, J. L., Adkins, D. E., Åberg, K., Bukszár, J., Khachane, A. N., Keefe, R. S. E., Perkins, D. O., McEvoy, J. P., Stroup, T. S., Vann, R. E., et al. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2010.193 · Cited by 124 · see citing works
Diémé, B., Mavel, S., Blasco, H., Tripi, G., Bonnet-Brilhault, F., Malvy, J., Bocca, C., Andres, C. R., Nadal-Desbarats, L., & Emond, P. (2015) · Journal of Proteome Research · doi:10.1021/acs.jproteome.5b00699 · Cited by 122 · see citing works
Involvement of SMARCA2/BRM in the SWI/SNF chromatin-remodeling complex in schizophrenia
Koga, M., Ishiguro, H., Yazaki, S., Horiuchi, Y., Arai, M., Niizato, K., Iritani, S., Itokawa, M., Inada, T., Iwata, N., et al. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp166 · Cited by 112 · see citing works
Self-citationPotential roles of zinc in the pathophysiology and treatment of major depressive disorder
Swardfager, W., Herrmann, N., McIntyre, R. S., Mazereeuw, G., Goldberger, K., Cha, D. S., Schwartz, Y., & Lanctôt, K. L. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.03.018 · Cited by 116 · see citing works
Genetic contributions to behavioural diversity at the gene-environment interface
Bendesky, A., & Bargmann, C. I. (2011) · Nature Reviews Genetics · doi:10.1038/nrg3065 · Cited by 103 · see citing works
Immune system gene dysregulation in autism and schizophrenia
Michel, M., Schmidt, M. J., & Mirnics, K. (2012) · Developmental Neurobiology · doi:10.1002/dneu.22044 · Cited by 107 · see citing works
Common variant at 16p11.2 conferring risk of psychosis
Steinberg, S., de Jong, S., Mattheisen, M., Costas, J., Demontis, D., Jamain, S., Pietiläinen, O. P. H., Lin, K., Papiol, S., Huttenlocher, J., et al. (2014) · Molecular Psychiatry · doi:10.1038/mp.2012.157 · Cited by 104 · see citing works
Self-citationSchizophrenia Genetics: Where Next?
Kim, Y., Zerwas, S., Trace, S. E., & Sullivan, P. F. (2011) · Schizophrenia Bulletin · doi:10.1093/schbul/sbr031 · Cited by 101 · see citing works
The Role of DNA Copy Number Variation in Schizophrenia
Tam, G. W. C., Redon, R., Carter, N. P., & Grant, S. G. N. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.07.027 · Cited by 98 · see citing works
Common genetic variation and performance on standardized cognitive tests
Cirulli, E. T., Kasperavičiūtė, D., Attix, D. K., Need, A. C., Ge, D., Gibson, G., & Goldstein, D. B. (2010) · European Journal of Human Genetics · doi:10.1038/ejhg.2010.2 · Cited by 98 · see citing works
Kushima, I., Nakamura, Y., Aleksic, B., Ikeda, M., Ito, Y., Shiino, T., Okochi, T., Fukuo, Y., Ujike, H., Suzuki, M., et al. (2012) · Schizophrenia Bulletin · doi:10.1093/schbul/sbq118 · Cited by 92 · see citing works
Self-citationMühleisen, T. W., Mattheisen, M., Strohmaier, J., Degenhardt, F., Priebe, L., Schultz, C. C., Breuer, R., Meier, S., Hoffmann, P., Rivandeneira, F., et al. (2012) · Schizophrenia Research · doi:10.1016/j.schres.2012.03.007 · Cited by 80 · see citing works
Self-citationGenome-wide Analysis of the Role of Copy Number Variation in Schizophrenia Risk in Chinese
Li, Z., Chen, J., Xu, Y., Yi, Q., Ji, W., Wang, P., Shen, J., Song, Z., Wang, M., Yang, P., et al. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.11.012 · Cited by 72 · see citing works
Self-citationBuizer-Voskamp, J. E., Muntjewerff, J.-W., Strengman, E., Sabatti, C., Stefansson, H., Vorstman, J. A. S., & Ophoff, R. A. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.02.015 · Cited by 68 · see citing works
Genomic Analysis of Mental Illness: A Changing Landscape
McClellan, J., & King, M.-C. (2010) · JAMA · doi:10.1001/jama.2010.869 · Cited by 63 · see citing works
Tereshko, L., Gao, Y., Cary, B. A., Turrigiano, G. G., & Sengupta, P. (2021) · eLife · doi:10.7554/elife.65427 · Cited by 60 · see citing works
Pedroso, I., Lourdusamy, A., Rietschel, M., Nöthen, M. M., Cichon, S., McGuffin, P., Al-Chalabi, A., Barnes, M. R., & Breen, G. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.12.031 · Cited by 59 · see citing works
Self-citationMutation screening of SCN2A in schizophrenia and identification of a novel loss-of-function mutation
Carroll, L. S., Woolf, R., Ibrahim, Y., Williams, H. J., Dwyer, S., Walters, J., Kirov, G., O’Donovan, M. C., & Owen, M. J. (2016) · Psychiatric Genetics · doi:10.1097/ypg.0000000000000110 · Cited by 54 · see citing works
Self-citationMoskvina, V., O'Dushlaine, C., Purcell, S., Craddock, N., Holmans, P., & O'Donovan, M. C. (2011) · Genetic Epidemiology · doi:10.1002/gepi.20636 · Cited by 49 · see citing works
Self-citationZhang, R., Lu, S., Meng, L., Min, Z., Tian, J., Valenzuela, R. K., Guo, T., Tian, L., Zhao, W., & Ma, J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0030237 · Cited by 30 · see citing works
Barrenschee, M., Lange, C., Cossais, F., Egberts, J.-H., Becker, T., Wedel, T., & Böttner, M. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00360 · Cited by 28 · see citing works
Kyogoku, C., Yanagi, M., Nishimura, K., Sugiyama, D., Morinobu, A., Fukutake, M., Maeda, K., Shirakawa, O., Kuno, T., & Kumagai, S. (2011) · Psychiatry Research · doi:10.1016/j.psychres.2009.11.003 · Cited by 20 · see citing works
Suárez-Rama, J. J., Arrojo, M., Sobrino, B., Amigo, J., Brenlla, J., Agra, S., Paz, E., Brión, M., Carracedo, Á., Páramo, M., et al. (2015) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2015.04.013 · Cited by 18 · see citing works
Rare variants are common in schizophrenia
Gratten, J. (2016) · Nature Neuroscience · doi:10.1038/nn.4422 · Cited by 12 · see citing works
- Authors
- Molecular Genetics of Schizophrenia Collaboration, O'Donovan, M. C., Craddock, N., Norton, N., Williams, H., Peirce, T., Moskvina, V., Nikolov, I., Hamshere, M., Carroll, L., Georgieva, L., Dwyer, S., Holmans, P., Marchini, J. L., Spencer, C. C. A., Howie, B., Leung, H.-T., Hartmann, A. M., Möller, H.-J., Morris, D. W., Shi, Y., Feng, G., Hoffmann, P., Propping, P., Vasilescu, C., Maier, W., Rietschel, M., Zammit, S., Schumacher, J., Quinn, E. M., Schulze, T. G., Williams, N. M., Giegling, I., Iwata, N., Ikeda, M., Darvasi, A., Shifman, S., He, L., Duan, J., Sanders, A. R., Levinson, D. F., Gejman, P. V., Cichon, S., Nöthen, M. M., Gill, M., Corvin, A., Rujescu, D., Kirov, G., & Owen, M. J.
- Affiliations
- Cardiff University (GB)
- University of Oxford (GB)
- University of Cambridge (GB)
- Ludwig-Maximilians-Universität München (DE)
- Trinity College Dublin (IE)
- Shanghai Jiao Tong University (CN)
- University of Bonn (DE)
- Central Institute of Mental Health (DE)
- National Institutes of Health (US)
- Fujita Health University (JP)
- Hebrew University of Jerusalem (IL)
- Northwestern University (US)
- Stanford Medicine (US)
- Louisiana State University (US)
- Emory University (US)
- University of Iowa (US)
- University of California, San Francisco (US)
- Corresponding author
- Owen, Michael J
- ORCID
- Norton, Nadine
- Williams, Hywel
- Hamshere, Marian
- Carroll, Liam
- Dwyer, Sarah
- Holmans, Peter
- Marchini, Jonathan L
- Spencer, Chris C A
- Hartmann, Annette M
- Morris, Derek W
- Shi, YongYong
- Hoffmann, Per
- Maier, Wolfgang
- Rietschel, Marcella
- Zammit, Stanley
- Schumacher, Johannes
- Schulze, Thomas G
- Williams, Nigel M
- Giegling, Ina
- Iwata, Nakao
- Ikeda, Masashi
- Shifman, Sagiv
- He, Lin
- Duan, Jubao
- Sanders, Alan R
- Levinson, Douglas F
- Cichon, Sven
- Nöthen, Markus M
- Gill, Michael
- Corvin, Aiden
- Rujescu, Dan
- Kirov, George
- Owen, Michael J
- Venue
- Nature Genetics
- Published
- 2008-07-30
- Volume
- 40
- Issue
- 9
- Pages
- 1053-1055
- ISSN
- 1061-4036 (ISSN-L)
- 1546-1718
- OpenAlex
- W2023171821
- Cited by
- 1,070
- References
- 11
- Citations by year
- 2026: 8 · 2025: 16 · 2024: 21 · 2023: 15 · 2022: 28 · 2021: 28 · 2020: 33 · 2019: 37 · 2018: 34 · 2017: 58 · 2016: 52 · 2015: 74 · 2014: 88 · 2013: 90 · 2012: 104
- FWCI
- 89.01
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Genetics (publishedVersion)
- PubMed (publishedVersion)
- Bristol Research (University of Bristol) (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- Wellcome Trust
- Health Research Board
- National Institute of Mental Health (R01MH060879)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Mapping and Diversity in Plants and Animals
- Keywords
- schizophrenia, ZNF804A, genetic susceptibility loci, genome-wide association study, replication, bipolar disorder, genetic association meta-analysis
- MeSH terms
- Bipolar Disorder, Chromosome Mapping, Follow-Up Studies, Humans, Schizophrenia, Case-Control Studies, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide, Kruppel-Like Transcription Factors, Genome-Wide Association Study
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review