Cited by 1,070Schizophrenia research and treatmentGenetic Associations and EpidemiologyGenetic Mapping and Diversity in Plants and Animals

Identification of loci associated with schizophrenia by genome-wide association and follow-up

Molecular Genetics of Schizophrenia Collaboration, O'Donovan, Michael C, Craddock, Nicholas, Norton, Nadine, Williams, Hywel, Peirce, Timothy, Moskvina, Valentina, Nikolov, Ivan +41 more·2008·Nature Genetics

Abstract

We carried out a genome-wide association study of schizophrenia (479 cases, 2,937 controls) and tested loci with P < 10(-5) in up to 16,726 additional subjects. Of 12 loci followed up, 3 had strong independent support (P < 5 x 10(-4)), and the overall pattern of replication was unlikely to occur by chance (P = 9 x 10(-8)). Meta-analysis provided strongest evidence for association around ZNF804A (P = 1.61 x 10(-7)) and this strengthened when the affected phenotype included bipolar disorder (P = 9.96 x 10(-9)).

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Crossref · 10.1038/ng.201

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  • Common susceptibility genes for both BD and psychosis have been identified, including ZNF804A on chromosome 2q32.

    “Common susceptibility genes for both disorders have also been identified. The first of such commonalities identified included zinc finger–binding protein 804A gene (ZNF804A) on chromosome 2q32 (185).”
  • For SCZ and BIP, sign tests comparing the consistency of association tests from discovery GWAS and replication samples for sets of top signals are usually highly significant even if most loci do not meet genome-wide significance.

    “For SCZ and BIP, sign tests comparing the consistency of association tests from discovery GWAS and replication samples for sets of top signals are usually highly significant even if most loci do not meet genome-wide significance. 58,59,174”

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Authors
Molecular Genetics of Schizophrenia Collaboration, O'Donovan, M. C., Craddock, N., Norton, N., Williams, H., Peirce, T., Moskvina, V., Nikolov, I., Hamshere, M., Carroll, L., Georgieva, L., Dwyer, S., Holmans, P., Marchini, J. L., Spencer, C. C. A., Howie, B., Leung, H.-T., Hartmann, A. M., Möller, H.-J., Morris, D. W., Shi, Y., Feng, G., Hoffmann, P., Propping, P., Vasilescu, C., Maier, W., Rietschel, M., Zammit, S., Schumacher, J., Quinn, E. M., Schulze, T. G., Williams, N. M., Giegling, I., Iwata, N., Ikeda, M., Darvasi, A., Shifman, S., He, L., Duan, J., Sanders, A. R., Levinson, D. F., Gejman, P. V., Cichon, S., Nöthen, M. M., Gill, M., Corvin, A., Rujescu, D., Kirov, G., & Owen, M. J.
Affiliations
  • Cardiff University (GB)
  • University of Oxford (GB)
  • University of Cambridge (GB)
  • Ludwig-Maximilians-Universität München (DE)
  • Trinity College Dublin (IE)
  • Shanghai Jiao Tong University (CN)
  • University of Bonn (DE)
  • Central Institute of Mental Health (DE)
  • National Institutes of Health (US)
  • Fujita Health University (JP)
  • Hebrew University of Jerusalem (IL)
  • Northwestern University (US)
  • Stanford Medicine (US)
  • Louisiana State University (US)
  • Emory University (US)
  • University of Iowa (US)
  • University of California, San Francisco (US)
Corresponding author
Owen, Michael J
Venue
Nature Genetics
Published
2008-07-30
Volume
40
Issue
9
Pages
1053-1055
ISSN
  • 1061-4036 (ISSN-L)
  • 1546-1718
OpenAlex
W2023171821
Cited by
1,070
References
11
Citations by year
2026: 8 · 2025: 16 · 2024: 21 · 2023: 15 · 2022: 28 · 2021: 28 · 2020: 33 · 2019: 37 · 2018: 34 · 2017: 58 · 2016: 52 · 2015: 74 · 2014: 88 · 2013: 90 · 2012: 104
FWCI
89.01
Type
journal article
Language
en
Open access
closed
Locations
  • Nature Genetics (publishedVersion)
  • PubMed (publishedVersion)
  • Bristol Research (University of Bristol) (publishedVersion)
  • UCL Discovery (University College London) (submittedVersion)
Funders
  • Wellcome Trust
  • Health Research Board
  • National Institute of Mental Health (R01MH060879)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Mapping and Diversity in Plants and Animals
Keywords
schizophrenia, ZNF804A, genetic susceptibility loci, genome-wide association study, replication, bipolar disorder, genetic association meta-analysis
MeSH terms
Bipolar Disorder, Chromosome Mapping, Follow-Up Studies, Humans, Schizophrenia, Case-Control Studies, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide, Kruppel-Like Transcription Factors, Genome-Wide Association Study

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