Modeling familial Alzheimer's disease with induced pluripotent stem cells

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Induced Pluripotent Stem Cells Generated from Patients with ALS Can Be Differentiated into Motor Neurons

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The iNs and Outs of Direct Reprogramming to Induced Neurons

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Induced pluripotent stem cell research: A revolutionary approach to face the challenges in drug screening

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Meta-Analysis of Transcriptome Data Related to Hippocampus Biopsies and iPSC-Derived Neuronal Cells from Alzheimer’s Disease Patients Reveals an Association with FOXA1 and FOXA2 Gene Regulatory Networks

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Recapitulating Amyloid ß and Tau Pathology in Human Neural Cell Culture Models—Clinical Implications

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CRISPR Transcriptional Activation Analysis Unmasks an Occult γ-Secretase Processivity Defect in Familial Alzheimer’s Disease Skin Fibroblasts

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Neurological diseases at the blood-brain barrier: Stemming new scientific paradigms using patient-derived induced pluripotent cells

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Beyond Transgenic Mice: Emerging Models and Translational Strategies in Alzheimer’s Disease

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Stem Cells in Neurological Disorders: Emerging Therapy with Stunning Hopes

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Expression of ACE2 and a viral virulence-regulating factor CCN family member 1 in human iPSC-derived neural cells: implications for COVID-19-related CNS disorders

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Urine-derived induced pluripotent/neural stem cells for modeling neurological diseases

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Stem Cell-Derived Neurons as Cellular Models of Sporadic Alzheimer’s Disease

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Patient-specific Induced Pluripotent Stem Cells as a Platform for Disease Modeling, Drug Discovery and Precision Personalized Medicine

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Cell-based regenerative and rejuvenation strategies for treating neurodegenerative diseases

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The Use of Pluripotent Stem Cell-Derived Organoids to Study Extracellular Matrix Development during Neural Degeneration

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Probing the Secrets of Alzheimer's Disease Using Human-induced Pluripotent Stem Cell Technology

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Induced Pluripotent Stem Cells Derived from Alzheimer’s Disease Patients: The Promise, the Hope and the Path Ahead

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Gene delivery methods and genome editing of human pluripotent stem cells

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Pathological manifestation of the induced pluripotent stem cell‐derived cortical neurons from an early‐onset Alzheimer's disease patient carrying a presenilin‐1 mutation (S170F)

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Neural In Vitro Models for Studying Substances Acting on the Central Nervous System

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High-throughput platforms for the screening of new therapeutic targets for neurodegenerative diseases

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Clinical Applications of Induced Pluripotent Stem Cells – Stato Attuale

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A three‐dimensional spheroid co‐culture system of neurons and astrocytes derived from Alzheimer's disease patients for drug efficacy testing

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Data Mining of Microarray Datasets in Translational Neuroscience

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Induced Pluripotent Stem Cells and Their Use in Cardiac and Neural Regenerative Medicine

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Is aging a barrier to reprogramming? Lessons from induced pluripotent stem cells

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Physiological Aβ Concentrations Produce a More Biomimetic Representation of the Alzheimer’s Disease Phenotype in iPSC Derived Human Neurons

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Human Induced Pluripotent Stem Cells and the Modelling of Alzheimer’s Disease: The Human Brain Outside the Dish

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Mutual interaction of neurons and astrocytes derived from iPSCs with APP V717L mutation developed the astrocytic phenotypes of Alzheimer’s disease

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Stemming the Hype: What Can We Learn from iPSC Models of Parkinson's Disease and How Can We Learn It?

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An update on Alzheimer's disease: Immunotherapeutic agents, stem cell therapy and gene editing

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The Role of Gene Editing in Neurodegenerative Diseases

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Inhibition of Histone Methyltransferases EHMT1/2 Reverses Amyloid-β-Induced Loss of AMPAR Currents in Human Stem Cell-Derived Cortical Neurons

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Cell Transdifferentiation and Reprogramming in Disease Modeling: Insights into the Neuronal and Cardiac Disease Models and Current Translational Strategies

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Insights into Human-Induced Pluripotent Stem Cell-Derived Astrocytes in Neurodegenerative Disorders

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Cell models for Down syndrome-Alzheimer’s disease research

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Tackling neurodegeneration in vitro with omics: a path towards new targets and drugs

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Mapping the future of oxidative RNA damage in neurodegeneration: Rethinking the status quo with new tools

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Pluripotent stem cells to model Hutchinson-Gilford progeria syndrome (HGPS): Current trends and future perspectives for drug discovery

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Revisiting Mitochondrial Function and Metabolism in Pluripotent Stem Cells: Where Do We Stand in Neurological Diseases?

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The translational potential of human induced pluripotent stem cells for clinical neurology

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Generation of Cholinergic and Dopaminergic Interneurons from Human Pluripotent Stem Cells as a Relevant Tool for In Vitro Modeling of Neurological Disorders Pathology and Therapy

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Modelling mitochondrial dysfunction in Alzheimer's disease using human induced pluripotent stem cells

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Prospects of Directly Reprogrammed Adult Human Neurons for Neurodegenerative Disease Modeling and Drug Discovery: iN vs. iPSCs Models

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Development of a novel cellular model of Alzheimer’s disease utilizing neurosphere cultures derived from B6C3-Tg(APPswe,PSEN1dE9)85Dbo/J embryonic mouse brain

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An insight into the iPSCs-derived two-dimensional culture and three-dimensional organoid models for neurodegenerative disorders

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Role of small molecules as drug candidates for reprogramming somatic cells into induced pluripotent stem cells: A comprehensive review

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The use of human neurons for novel drug discovery in dementia research

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Deconstructing Alzheimer’s Disease: How to Bridge the Gap between Experimental Models and the Human Pathology?

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Patient-Specific iPSCs-Based Models of Neurodegenerative Diseases: Focus on Aberrant Calcium Signaling

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Effects of cytoprotective antioxidants on lymphocytes from representative mitochondrial neurodegenerative diseases

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Induced pluripotent stem cells (iPSCs) as game‐changing tools in the treatment of neurodegenerative disease: Mirage or reality?

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Proceedings: Consideration of Genetics in the Design of Induced Pluripotent Stem Cell-Based Models of Complex Disease

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Neural Stem Cell Dysfunction in Human Brain Disorders

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Use of induced pluripotent stem cell derived neurons engineered to express BDNF for modulation of stressor related pathology

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A critical overview of therapeutic strategy and advancement for Alzheimer's disease treatment

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Modeling tau pathology in human stem cell derived neurons

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An update on stem cell and stem cell-derived extracellular vesicle-based therapy in the management of Alzheimer’s disease

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Induced Pluripotent Stem Cells and Disorders of the Nervous System

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In vitro models of multiple system atrophy from primary cells to induced pluripotent stem cells

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Human-Induced Pluripotent Stem Cells and Herbal Small-Molecule Drugs for Treatment of Alzheimer’s Disease

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Flexible and Accurate Substrate Processing with Distinct Presenilin/γ-Secretases in Human Cortical Neurons

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Utilization of Human Induced Pluripotent Stem Cells-Derived In vitro Models for the Future Study of Sex Differences in Alzheimer’s Disease

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Advances in Stem Cell Research- A Ray of Hope in Better Diagnosis and Prognosis in Neurodegenerative Diseases

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Modeling Osteosarcoma Using Li-Fraumeni Syndrome Patient-derived Induced Pluripotent Stem Cells

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Therapeutic potential of combined viral transduction and CRISPR/Cas9 gene editing in treating neurodegenerative diseases

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IPSC-Derived Neuronal Cultures Carrying the Alzheimer’s Disease Associated TREM2 R47H Variant Enables the Construction of an Aβ-Induced Gene Regulatory Network

Martins, S., Müller‐Schiffmann, A., Erichsen, L., Bohndorf, M., Wruck, W., Sleegers, K., Broeckhoven, C. V., Korth, C., & Adjaye, J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21124516 · Cited by 14

Current concepts in Alzheimer’s Disease: molecules, models and translational perspectives

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Gamma secretase modulators and BACE inhibitors reduce Aβ production without altering gene expression in Alzheimer’s disease iPSC-derived neurons and mice

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Research models to study lewy body dementia

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Modeling Alzheimer’s Disease: A Review of Gene-Modified and Induced Animal Models, Complex Cell Culture Models, and Computational Modeling

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A plethora of human pluripotent stem cells

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Human pluripotent stem cells on artificial microenvironments: a high content perspective

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Induced pluripotent stem cells from patients with focal cortical dysplasia and refractory epilepsy

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Mass spectrometry analysis of tau and amyloid‐beta in iPSC‐derived models of Alzheimer’s disease and dementia

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Modeling Neurological Disorders by Human Induced Pluripotent Stem Cells

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Important advances in Alzheimer’s disease from the use of induced pluripotent stem cells

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Cancer in a dish: progress using stem cells as a platform for cancer research.

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Stem cells therapy in neurodegenerative and neuroimmune diseases: Current status of treatments and future prospects

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Stem Cell Therapy for Neurodegenerative Diseases

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Direct induction of neural progenitor cells transiently passes through a partially reprogrammed state

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Patient-Derived Stem Cell Models in SPAST HSP: Disease Modelling and Drug Discovery

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Analysis of Technological Developments in the Treatment of Alzheimer’s Disease through Patent Documents

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Current Development of iPSC-Based Modeling in Neurodegenerative Diseases

Guo, X., Wang, X., Wang, J., Ma, M., & Ren, Q. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26083774 · Cited by 15

Modeling placental development and disease using human pluripotent stem cells

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Urine-derived cells from the aged donor for the 2D/3D modeling of neural cells via iPSCs

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Dementia in a Dish

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Human-Derived Brain Models: Windows into Neuropsychiatric Disorders and Drug Therapies

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Stem Cells

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Cell Reprogramming Preserving Epigenetic Age: Advantages and Limitations

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Phenotyping Neurodegeneration in Human iPSCs

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PSEN1 E280A Cholinergic-like Neurons and Cerebral Spheroids Derived from Mesenchymal Stromal Cells and from Induced Pluripotent Stem Cells Are Neuropathologically Equivalent

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Investigating pediatric disorders with induced pluripotent stem cells

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Disease Modeling of Neuropsychiatric Brain Disorders Using Human Stem Cell-Based Neural Models

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Calcilytic NPS 2143 Reduces Amyloid Secretion and Increases sAβPP α Release from PSEN1 Mutant iPSC-Derived Neurons

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Towards a Mechanistic Model of Tau-Mediated Pathology in Tauopathies: What Can We Learn from Cell-Based In Vitro Assays?

Sala‐Jarque, J., Zimkowska, K., Ávila, J., Ferrer, I., & del Río, J. A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231911527 · Cited by 11

Vascular models of Alzheimer's disease: An overview of recent in vitro models of the blood-brain barrier

Takeuchi, L. E., Kalia, L. V., & Simmons, C. A. (2025) · Neurobiology of Disease · doi:10.1016/j.nbd.2025.106864 · Cited by 11

Induced Pluripotent Stem Cells from Familial Alzheimer's Disease Patients Differentiate into Mature Neurons with Amyloidogenic Properties

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iPSC Modeling of Presenilin1 Mutation in Alzheimer's Disease with Cerebellar Ataxia

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P1–091: Modeling Alzheimer's disease using induced pluripotent stem cells from familial and sporadic Alzheimer's disease patients

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Probing sporadic and familial Alzheimer’s disease using induced pluripotent stem cells

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S5‐01‐02: Development of an induced pluripotent stem cell (iPSC) Alzheimer's disease model using PSEN1 mutant fibroblasts

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