Modeling familial Alzheimer's disease with induced pluripotent stem cells

Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors

Takahashi, K., Tanabe, K., Ohnuki, M., Narita, M., Ichisaka, T., Tomoda, K., & Yamanaka, S. (2007) · Cell · doi:10.1016/j.cell.2007.11.019 · Cited by 20,221

The Amyloid Hypothesis of Alzheimer’s Disease: Progress and Problems on the Road to Therapeutics

Hardy, J., & Selkoe, D. J. (2002) · Science · doi:10.1126/science.1072994 · Cited by 13,864

Induced Pluripotent Stem Cell Lines Derived from Human Somatic Cells

Yu, J., Vodyanik, M. A., Smuga-Otto, K., Antosiewicz-Bourget, J., Frane, J. L., Tian, S., Nie, J., Jonsdottir, G. A., Ruotti, V., Stewart, R., et al. (2007) · Science · doi:10.1126/science.1151526 · Cited by 10,310

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

Sherrington, R., Rogaev, E. I., Liang, Y., Rogaeva, E. A., Levesque, G., Ikeda, M., Chi, H., Lin, C., Li, G., Holman, K., et al. (1995) · Nature · doi:10.1038/375754a0 · Cited by 4,051

Secreted amyloid β–protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

Scheuner, D., Eckman, C., Jensen, M., Song, X., Citron, M., Suzuki, N., Bird, T. D., Hardy, J., Hutton, M., Kukull, W., et al. (1996) · Nature Medicine · doi:10.1038/nm0896-864 · Cited by 2,599

Candidate gene for the chromosome 1 familial Alzheimer’s disease locus

Levy-Lahad, E., Wasco, W., Poorkaj, P., Romano, D. M., Oshima, J., Pettingell, W. H., Yu, C.-E., Jondro, P. D., Schmidt, S. D., Wang, K., et al. (1995) · Science · doi:10.1126/science.7638622 · Cited by 2,577

Disease-Specific Induced Pluripotent Stem Cells.

Park, I.-H., Arora, N., Huo, H., Maherali, N., Ahfeldt, T., Shimamura, A., Lensch, M. W., Cowan, C., Hochedlinger, K., & Daley, G. Q. (2008) · Cell · doi:10.1016/j.cell.2008.07.041 · Cited by 2,196

Decreased Clearance of CNS β-Amyloid in Alzheimer’s Disease

Mawuenyega, K. G., Sigurdson, W., Ovod, V., Munsell, L., Kasten, T., Morris, J. C., Yarasheski, K. E., & Bateman, R. J. (2010) · Science · doi:10.1126/science.1197623 · Cited by 2,078

Induced Pluripotent Stem Cells Generated from Patients with ALS Can Be Differentiated into Motor Neurons

Dimos, J. T., Rodolfa, K. T., Niakan, K. K., Weisenthal, L. M., Mitsumoto, H., Chung, W. K., Croft, G. F., Saphier, G., Leibel, R. L., Goland, R., et al. (2008) · Science · doi:10.1126/science.1158799 · Cited by 2,019

Twenty years of the Alzheimer's disease amyloid hypothesis: a genetic perspective

Tanzi, R. E., & Bertram, L. (2005) · Cell · doi:10.1016/j.cell.2005.02.008 · Cited by 1,849

Single cell transcriptomic profiling of a neuron-astrocyte assembloid tauopathy model

Rickner, H., Jiang, L., Hong, R., O’Neill, N. K., Mojica, C. A., Snyder, B. J., Zhang, L., Shaw, D., Medalla, M., Wolozin, B. L., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-34005-1 · Cited by 43

Human iPSC application in Alzheimer’s disease and tau-related neurodegenerative diseases

TCW, J. (2019) · Neuroscience Letters · doi:10.1016/j.neulet.2019.01.043 · Cited by 39

Alzheimer's Disease Modeling: Ups, Downs, and Perspectives for Human Induced Pluripotent Stem Cells

Wojda, U., & Kuźnicki, J. (2013) · Journal of Alzheimer s Disease · doi:10.3233/jad-121984 · Cited by 40

PSEN1 and PSEN2 Gene Expression in Alzheimer's Disease Brain: A New Approach

Delabio, R., Rasmussen, L. T., Mizumoto, I., Viani, G.-A., Chen, E., Villares, J., Costa, I.-B., Turecki, G., Drigo, S. A., Smith, M. D. A. C., et al. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-140033 · Cited by 39

Using induced pluripotent stem cell neuronal models to study neurodegenerative diseases

Zhang, X., Hu, D., Shang, Y., & Qi, X. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2019.03.004 · Cited by 36

Harnessing cerebral organoids for Alzheimer's disease research

Bubnys, A., & Tsai, L. (2021) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2021.10.003 · Cited by 41

Induced Pluripotent Stem Cells in Drug Discovery and Neurodegenerative Disease Modelling

Beghini, D. G., Kasai-Brunswick, T. H., & Henriques‐Pons, A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25042392 · Cited by 37

Regeneration of the damaged central nervous system through reprogramming technology: Basic concepts and potential application for cell replacement therapy

Matsui, T. K., Akamatsu, W., Nakamura, M., & Okano, H. (2012) · Experimental Neurology · doi:10.1016/j.expneurol.2012.09.016 · Cited by 38

Recent Advances: Decoding Alzheimer’s Disease With Stem Cells

Fang, Y., Gao, T., Zhang, B., & Pu, J. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00077 · Cited by 39

Beyond animal models: revolutionizing neurodegenerative disease modeling using 3D in vitro organoids, microfluidic chips, and bioprinting

Teli, P., Kale, V. P., & Vaidya, A. (2023) · Cell and Tissue Research · doi:10.1007/s00441-023-03821-2 · Cited by 37

Melanoma-Derived iPCCs Show Differential Tumorigenicity and Therapy Response

Bernhardt, M., Novak, D., Assenov, Y., Orouji, E., Knappe, N., Weina, K., Reith, M., Larribère, L., Gebhardt, C., Plass, C., et al. (2017) · Stem Cell Reports · doi:10.1016/j.stemcr.2017.03.007 · Cited by 37

Human fibroblast and stem cell resource from the Dominantly Inherited Alzheimer Network

the Dominantly Inherited Alzheimer Network (DIAN), Karch, C. M. M., Hernández, D., Wang, J., Marsh, J. A., Hewitt, A. W., Hsu, S., Norton, J. B., Levitch, D., Donahue, T. A., et al. (2018) · Alzheimer s Research & Therapy · doi:10.1186/s13195-018-0400-0 · Cited by 39

Modelling Sporadic Alzheimer’s Disease Using Induced Pluripotent Stem Cells

Rowland, H. A., Hooper, N. M., & Kellett, K. A. B. (2018) · Neurochemical Research · doi:10.1007/s11064-018-2663-z · Cited by 38

Modeling Alzheimer’s disease with human iPS cells: advancements, lessons, and applications

Essayan-Perez, S., Zhou, B., Nabet, A. M., Wernig, M., & Huang, Y. A. (2019) · Neurobiology of Disease · doi:10.1016/j.nbd.2019.104503 · Cited by 40

Human Induced Pluripotent Stem Cells : Clinical Significance and Applications in Neurologic Diseases

Chang, E.-A., Jin, S.-W., Nam, M., & Kim, S.-D. (2019) · Journal of Korean Neurosurgical Society · doi:10.3340/jkns.2018.0222 · Cited by 39

miRNA-Based Rapid Differentiation of Purified Neurons from hPSCs Advancestowards Quick Screening for Neuronal Disease Phenotypes In Vitro

Ishikawa, M., Aoyama, T., Shibata, S., Sone, T., Miyoshi, H., Watanabe, H., Nakamura, M., Morota, S., Uchino, H., Yoo, A. S., et al. (2020) · Cells · doi:10.3390/cells9030532 · Cited by 36

Induced Pluripotent Stem Cells and Organoids in Advancing Neuropathology Research and Therapies

Pazzin, D. B., Previato, T. T. R., Gonçalves, J. I. B., Zanirati, G., Xavier, F. A. C., DaCosta, J. C., & Marinowic, D. R. (2024) · Cells · doi:10.3390/cells13090745 · Cited by 36

Strategies for modeling aging and age-related diseases

Jothi, D., & Kulka, L. A. M. (2024) · npj Aging · doi:10.1038/s41514-024-00161-5 · Cited by 39

Cell and Gene Therapy in Alzheimer's Disease

Glat, M. J., & Offen, D. (2013) · Stem Cells and Development · doi:10.1089/scd.2012.0633 · Cited by 39

Genetic validation of a therapeutic target in a mouse model of ALS

de Boer, A. S., Koszka, K., Kiskinis, E., Suzuki, N., Davis‐Dusenbery, B. N., & Eggan, K. C. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3009351 · Cited by 35

Human Neural Tissue Construct Fabrication Based on Scaffold‐Free Tissue Engineering

Takahashi, H., Itoga, K., Shimizu, T., Yamato, M., & Okano, T. (2016) · Advanced Healthcare Materials · doi:10.1002/adhm.201600197 · Cited by 37

Early onset of inflammation during ontogeny of bipolar disorder: the NLRP2 inflammasome gene distinctly differentiates between patients and healthy controls in the transition between iPS cell and neural stem cell stages

Vizlin‐Hodzic, D., Zhai, Q., Illes, S., Södersten, K., Truvé, K., Parris, T. Z., Sobhan, P. K., Salmela, S., Kosalai, S. T., Kanduri, C., et al. (2017) · Translational Psychiatry · doi:10.1038/tp.2016.284 · Cited by 35

Patient-Specific Induced Pluripotent Stem Cells for Disease Modeling and Phenotypic Drug Discovery

Tang, S., Xie, M., Cao, N., & Ding, S. (2015) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.5b00789 · Cited by 37

Modeling Cancer with Pluripotent Stem Cells

Gingold, J. A., Zhou, R., Lemischka, I. R., & Lee, D. (2016) · Trends in cancer · doi:10.1016/j.trecan.2016.07.007 · Cited by 35

Stem Cell Therapy: A Prospective Treatment for Alzheimer's Disease

Lee, J. H., Oh, I., & Lim, H. K. (2016) · Psychiatry Investigation · doi:10.4306/pi.2016.13.6.583 · Cited by 35

Alzheimer's disease mechanisms in peripheral cells: Promises and challenges

Trushina, E. V. (2019) · Alzheimer s & Dementia Translational Research & Clinical Interventions · doi:10.1016/j.trci.2019.06.008 · Cited by 35

Human Pluripotent Stem Cell-Derived Neural Cells as a Relevant Platform for Drug Screening in Alzheimer’s Disease

García‐León, J. A., Cáceres-Palomo, L., Sánchez‐Mejías, E., Mejias‐Ortega, M., Nuñez‐Diaz, C., Fernandez-Valenzuela, J. J., Sanchez-Varo, R. M., Dávila, J. C., Vitórica, J., & Gutiérrez, A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21186867 · Cited by 35

Human Pluripotent Stem Cells: Applications and Challenges in Neurological Diseases

Hibaoui, Y., & Féki, A. (2012) · Frontiers in Physiology · doi:10.3389/fphys.2012.00267 · Cited by 35

Human induced pluripotent stem cells as a research tool in Alzheimer's disease

Robbins, J. P., & Price, J. (2017) · Psychological Medicine · doi:10.1017/s0033291717002124 · Cited by 34

Representing Diversity in the Dish: Using Patient-Derived in Vitro Models to Recreate the Heterogeneity of Neurological Disease

Ghaffari, L., Starr, A., Nelson, A. T., & Sattler, R. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00056 · Cited by 35

Stem cells as a promising therapeutic approach for Alzheimer’s disease: a review

Fouad, G. I. (2019) · Bulletin of the National Research Centre/Bulletin of the National Research Center · doi:10.1186/s42269-019-0078-x · Cited by 34

A microfiber scaffold-based 3D in vitro human neuronal culture model of Alzheimer's disease

Ranjan, V., Qiu, L., Lee, J. W. L., Chen, X., Jang, S. E., Chai, C., Lim, K., Tan, E., Zhang, Y., Huang, W., et al. (2020) · Biomaterials Science · doi:10.1039/d0bm00833h · Cited by 33

Modelling Alzheimer's disease: Insights fromin vivotoin vitrothree-dimensional culture platforms

Ranjan, V., Qiu, L., Tan, E., Zeng, L., & Zhang, Y. (2018) · Journal of Tissue Engineering and Regenerative Medicine · doi:10.1002/term.2728 · Cited by 41

Alzheimer’s in a dish – induced pluripotent stem cell-based disease modeling

de Leeuw, S., & Tackenberg, C. (2019) · Translational Neurodegeneration · doi:10.1186/s40035-019-0161-0 · Cited by 31

Building the brain from scratch: Engineering region-specific brain organoids from human stem cells to study neural development and disease

Jacob, F., Schnoll, J. G., Song, H., & Ming, G. (2021) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/bs.ctdb.2020.12.011 · Cited by 34

Neurons Derived from Induced Pluripotent Stem Cells of Patients with Down Syndrome Reproduce Early Stages of Alzheimer’s Disease Type Pathology in vitro

Dashinimaev, E. B., Artyuhov, A., Bolshakov, A. P., Vorotelyak, E. A., & Vasiliev, A. V. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-160945 · Cited by 32

Recent advances of induced pluripotent stem cells application in neurodegenerative diseases

Amin, N., Tan, X., Ren, Q., Zhu, N., Botchway, B. O. A., Hu, Z., & Fang, M. (2019) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2019.109674 · Cited by 36

Induced pluripotent stem cell-derived and directly reprogrammed neurons to study neurodegenerative diseases: The impact of aging signatures

Aversano, S., Caiazza, C., & Caiazzo, M. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.1069482 · Cited by 33

Stem Cells and Organoids: A Paradigm Shift in Preclinical Models Toward Personalized Medicine

Luce, E., & Duclos‐Vallée, J. (2025) · Pharmaceuticals · doi:10.3390/ph18070992 · Cited by 34

Induced pluripotent stem cells as a cellular model for studying Down Syndrome

Brigida, A., & Siniscalco, D. (2016) · Journal of Stem Cells and Regenerative Medicine · doi:10.46582/jsrm.1202009 · Cited by 20

BMS-708163 and Nilotinib restore synaptic dysfunction in human embryonic stem cell-derived Alzheimer’s disease models

Nishioka, H., Tooi, N., Isobe, T., Nakatsuji, N., & Aiba, K. (2016) · Scientific Reports · doi:10.1038/srep33427 · Cited by 30

Patient-derived iPSCs show premature neural differentiation and neuron type-specific phenotypes relevant to neurodevelopment

Yeh, E., Dao, D. Q., Wu, Z. Y., Kandalam, S., Camacho, F. M., Tom, C., Zhang, W., Krencik, R., Rauen, K. A., Ullian, E. M., et al. (2017) · Molecular Psychiatry · doi:10.1038/mp.2017.238 · Cited by 32

Neural Differentiation of Human Pluripotent Stem Cells for Nontherapeutic Applications: Toxicology, Pharmacology, andIn VitroDisease Modeling

Yap, M. S., Nathan, K. G., Yeo, Y., Lim, L. W., Poh, C. L., Richards, M., Lim, W. L., Othman, I., & Heng, B. C. (2015) · Stem Cells International · doi:10.1155/2015/105172 · Cited by 31

Mesenchymal-epithelial transition regulates initiation of pluripotency exit before gastrulation

Hamidi, S., Nakaya, Y., Nagai, H., Alev, C., Kasukawa, T., Chhabra, S., Lee, A., Niwa, H., Warmflash, A., Shibata, T., et al. (2020) · Development · doi:10.1242/dev.184960 · Cited by 30

Impact of Four Common Hydrogels on Amyloid-β (Aβ) Aggregation and Cytotoxicity: Implications for 3D Models of Alzheimer’s Disease

Simpson, L. W., Szeto, G. L., Boukari, H., Good, T. A., & Leach, J. B. (2020) · ACS Omega · doi:10.1021/acsomega.0c02046 · Cited by 32

Native PLGA nanoparticles regulate APP metabolism and protect neurons against β-amyloid toxicity: Potential significance in Alzheimer's disease pathology

Wu, Q., Karthivashan, G., Nakhaei‐Nejad, M., Anand, B. G., Giuliani, F., & Kar, S. (2022) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2022.08.148 · Cited by 30

Alzheimer's disease and synapse Loss: What can we learn from induced pluripotent stem Cells?

Rodríguez-Jiménez, F. J., Ureña‐Peralta, J. R., Jendelová, P., & Erceg, S. (2023) · Journal of Advanced Research · doi:10.1016/j.jare.2023.01.006 · Cited by 33

Mechanisms and models of endoplasmic reticulum stress in chondrodysplasia

Patterson, S. E., & Dealy, C. N. (2014) · Developmental Dynamics · doi:10.1002/dvdy.24131 · Cited by 30

Induced Pluripotent Stem Cells

Chang, C.-Y., Ting, H.-C., Liu, C.-A., Su, H.-L., Chiou, T., Harn, H., & Lin, S. (2018) · Cell Transplantation · doi:10.1177/0963689718775406 · Cited by 31

Being human: The role of pluripotent stem cells in regenerative medicine and humanizing Alzheimer's disease models

Sproul, A. A. (2015) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2015.06.007 · Cited by 31

Disease modelling using human iPSCs

Chamberlain, S. J. (2016) · Human Molecular Genetics · doi:10.1093/hmg/ddw209 · Cited by 28

A new era of disease modeling and drug discovery using induced pluripotent stem cells

Suh, W. (2016) · Archives of Pharmacal Research · doi:10.1007/s12272-016-0871-0 · Cited by 29

Use of Human Pluripotent Stem Cell-Derived Cells for Neurodegenerative Disease Modeling and Drug Screening Platform

García‐León, J. A., Vitórica, J., & Gutiérrez, A. (2019) · Future Medicinal Chemistry · doi:10.4155/fmc-2018-0520 · Cited by 30

LncRNA H19 Suppresses Osteosarcomagenesis by Regulating snoRNAs and DNA Repair Protein Complexes

Xu, A., Huang, M.-F., Zhu, D., Gingold, J. A., Bazer, D. A., Chang, B., Wang, D., Lai, C., Lemischka, I. R., Zhao, R., et al. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2020.611823 · Cited by 28

The Path to Progress Preclinical Studies of Age-Related Neurodegenerative Diseases: A Perspective on Rodent and hiPSC-Derived Models

MacDougall, G., Brown, L. Y., Kantor, B., & Chiba‐Falek, O. (2021) · Molecular Therapy · doi:10.1016/j.ymthe.2021.01.001 · Cited by 31

Emerging hiPSC Models for Drug Discovery in Neurodegenerative Diseases

Trudler, D., Ghatak, S., & Lipton, S. A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22158196 · Cited by 30

In Vitro Methodologies to Study the Role of Advanced Glycation End Products (AGEs) in Neurodegeneration

Chrysanthou, M., Estruch, I. M., Rietjens, I. M. C. M., Wichers, H. J., & Hoppenbrouwers, T. (2022) · Nutrients · doi:10.3390/nu14020363 · Cited by 31

Cognitive Enhancers (Nootropics). Part 3: Drugs Interacting with Targets other than Receptors or Enzymes. Disease-modifying Drugs

Froestl, W., Pfeifer, A., & Muhs, A. (2013) · Journal of Alzheimer s Disease · doi:10.3233/jad-121729 · Cited by 27

Modeling axonal defects in hereditary spastic paraplegia with human pluripotent stem cells

Denton, K. R., Xu, C., Shah, H., & Li, X. J. (2016) · Frontiers in Biology · doi:10.1007/s11515-016-1416-0 · Cited by 30

Exploiting pluripotent stem cell technology for drug discovery, screening, safety, and toxicology assessments

McGivern, J. V., & Ebert, A. D. (2013) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2013.11.012 · Cited by 29

The Importance of Non-neuronal Cell Types in hiPSC-Based Disease Modeling and Drug Screening

Gonzalez, D. M., Gregory, J. K., & Brennand, K. (2017) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2017.00117 · Cited by 26

Tumour necrosis factor induces increased production of extracellular amyloid-β- and α-synuclein-containing aggregates by human Alzheimer’s disease neurons

Whiten, D. R., Brownjohn, P. W., Moore, S., De, S., Strano, A., Zuo, Y., Haneklaus, M., Klenerman, D., & Livesey, F. J. (2020) · Brain Communications · doi:10.1093/braincomms/fcaa146 · Cited by 28

Animal and Cellular Models of Alzheimer’s Disease: Progress, Promise, and Future Approaches

Trujillo‐Estrada, L., Sánchez‐Mejías, E., Sanchez-Varo, R. M., García‐León, J. A., Nuñez‐Diaz, C., Dávila, J. C., Vitórica, J., LaFerla, F. M., Moreno‐González, I., Gutiérrez, A., et al. (2021) · The Neuroscientist · doi:10.1177/10738584211001753 · Cited by 30

Advances in Modeling Alzheimer's Disease In Vitro

Sharma, N. S., Karan, A., Lee, D.-H., Yan, Z., & Xie, J. (2021) · Advanced NanoBiomed Research · doi:10.1002/anbr.202100097 · Cited by 31

Developmental Pb exposure increases AD risk via altered intracellular Ca2+ homeostasis in hiPSC-derived cortical neurons

Xie, J., Wu, S., Szadowski, H., Min, S., Yang, Y., Bowman, A. B., Rochet, J., Freeman, J. L., & Yuan, C. (2023) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2023.105023 · Cited by 27

Stem cells and the treatment of Parkinson's disease

Ali, F. R., Stott, S., & Barker, R. A. (2013) · Experimental Neurology · doi:10.1016/j.expneurol.2012.12.017 · Cited by 29

Promising Therapies for Alzheimer';s Disease

Confaloni, A., Tosto, G., & Tata, A. M. (2016) · Current Pharmaceutical Design · doi:10.2174/1381612822666160215154218 · Cited by 29

Single-cell multimodal transcriptomics to study neuronal diversity in human stem cell-derived brain tissue and organoid models

van den Hurk, M., & Bardy, C. (2019) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2019.108350 · Cited by 28

The role of mycotoxins in neurodegenerative diseases: current state of the art and future perspectives of research

Nguyen, V. T. T., König, S., Eggert, S., Endres, K., & Kins, S. (2021) · Biological Chemistry · doi:10.1515/hsz-2021-0214 · Cited by 28

The Breakthroughs and Caveats of Using Human Pluripotent Stem Cells in Modeling Alzheimer’s Disease

Bendtsen, K. M., & Hall, V. J. (2023) · Cells · doi:10.3390/cells12030420 · Cited by 30

Induced Pluripotent Stem Cells to Model and Treat Neurogenetic Disorders

Wang, H., & Doering, L. C. (2012) · Neural Plasticity · doi:10.1155/2012/346053 · Cited by 26

Early‐stage development of human induced pluripotent stem cell‐derived neurons

Ohara, Y., Koganezawa, N., Yamazaki, H., Roppongi, R. T., Sato, K., Sekino, Y., & Shirao, T. (2015) · Journal of Neuroscience Research · doi:10.1002/jnr.23666 · Cited by 26

Exploratory Analysis of iPSCS-Derived Neuronal Cells as Predictors of Diagnosis and Treatment of Alzheimer Disease

Cavalli, E., Battaglia, G., Basile, M. S., Bruno, V., Petralia, M. C., Lombardo, S. D., Pennisi, M., Kalfin, R. E., Tancheva, L. P., Fagone, P., et al. (2020) · Brain Sciences · doi:10.3390/brainsci10030166 · Cited by 26

Potential use of iPSCs for disease modeling, drug screening, and cell-based therapy for Alzheimer’s disease

Marei, H. E. S., Khan, M. U. A., & Hasan, A. (2023) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-023-00504-2 · Cited by 27

Familial Alzheimer’s disease modelling using induced pluripotent stem cell technology

Mohamet, L. (2014) · World Journal of Stem Cells · doi:10.4252/wjsc.v6.i2.239 · Cited by 25

Toward pluripotency by reprogramming: mechanisms and application

Wang, T., Warren, S. T., & Jin, P. (2013) · Protein & Cell · doi:10.1007/s13238-013-3074-1 · Cited by 26

Advances in Reprogramming-Based Study of Neurologic Disorders

Nityanandam, A., & Baldwin, K. K. (2015) · Stem Cells and Development · doi:10.1089/scd.2015.0044 · Cited by 25

A Commentary on iPS Cells: Potential Applications in Autologous Transplantation, Study of Illnesses and Drug Screening

Romano, G., Morales, F., Marino, I. R., & Giordano, A. (2013) · Journal of Cellular Physiology · doi:10.1002/jcp.24437 · Cited by 25

Cell reprogramming: Therapeutic potential and the promise of rejuvenation for the aging brain

López-León, M., Outeiro, T. F., & Goya, R. G. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2017.09.002 · Cited by 27

Microfluidic Platforms to Unravel Mysteries of Alzheimer’s Disease: How Far Have We Come?

Prasanna, P., Rathee, S., Rahul, V., Mandal, D., Goud, M. S. C., Yadav, P., Hawthorne, S. J., Sharma, A., Gupta, P. K., Ojha, S. K., et al. (2021) · Life · doi:10.3390/life11101022 · Cited by 25

Complexity of Sex Differences and Their Impact on Alzheimer’s Disease

Kadlecová, M., Freude, K., & Haukedal, H. (2023) · Biomedicines · doi:10.3390/biomedicines11051261 · Cited by 27

3D bioprinting patient-derived induced pluripotent stem cell models of Alzheimer’s disease using a smart bioink

Benwood, C., Walters-Shumka, J., Scheck, K., & Willerth, S. (2023) · Bioelectronics in Medicine · doi:10.1186/s42234-023-00112-7 · Cited by 26

Astrocytic transporters in Alzheimer's disease

Ugbode, C., Hu, Y., Whalley, B., Peers, C., Rattray, M., & Dallas, M. L. (2017) · Biochemical Journal · doi:10.1042/bcj20160505 · Cited by 25

Modeling Alzheimer’s Disease with Induced Pluripotent Stem Cells: Current Challenges and Future Concerns

Zhang, W., Jiao, B., Zhou, M., Zhou, T., & Shen, L. H. (2016) · Stem Cells International · doi:10.1155/2016/7828049 · Cited by 26

iPS Cells—The Triumphs and Tribulations

Sharma, R. (2016) · Dentistry Journal · doi:10.3390/dj4020019 · Cited by 24

The Use of Patient-Derived Induced Pluripotent Stem Cells for Alzheimer’s Disease Modeling

Lee, C., Willerth, S. M., & Nygaard, H. B. (2020) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2020.101804 · Cited by 24

Modeling Alzheimer’s Disease Using Human Brain Organoids

Karmirian, K., Holubiec, M. I., Goto‐Silva, L., Bessone, I. F., Vitória, G., Mello, B., Alloatti, M., Vanderborght, B., Falzone, T. L., & Rehen, S. K. (2022) · Methods in molecular biology · doi:10.1007/978-1-0716-2655-9_7 · Cited by 25

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Wang, R., Zhu, Y., Qin, L.-F., Xu, Z., Gao, X.-R., Liu, C., Xu, G., & Chen, Y. (2023) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000528886 · Cited by 24

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Devalle, S., Sartore, R., Paulsen, B. S., Borges, H. L., Martins, R. A. P., & Rehen, S. K. (2012) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2012.00036 · Cited by 24

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Xie, Y., & Zhang, R. X. (2014) · Neurological Sciences · doi:10.1007/s10072-014-1989-9 · Cited by 24

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Massa, M., Gisevius, B., Hirschberg, S., Hinz, L., Schmidt, M., Gold, R., Prochnow, N., & Haghikia, A. (2016) · PLoS ONE · doi:10.1371/journal.pone.0155274 · Cited by 22

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Yagi, T., Ito, D., Okada, Y., Akamatsu, W., Nihei, Y., Okano, H., & Suzuki, N. (2012) · Rinsho Shinkeigaku · doi:10.5692/clinicalneurol.52.1134 · Cited by 25

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Paulsen, B. D. S., Silveira, M. S., Galina, A., & Rehen, S. K. (2012) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2012.10.009 · Cited by 23

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Kang, J.-F., Tang, B., & Guo, J. (2016) · Stem Cells International · doi:10.1155/2016/4126214 · Cited by 24

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Liang, Q., Inoue, K., & Abeliovich, A. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.10.027 · Cited by 22

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Livesey, F. J. (2014) · Human Molecular Genetics · doi:10.1093/hmg/ddu302 · Cited by 22

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Mahairaki, V., Ryu, J., Peters, A., Chang, Q., Li, T., Park, T. S., Burridge, P. W., Talbot, C. C., Asnaghi, L., Martin, L. J., et al. (2014) · Stem Cells and Development · doi:10.1089/scd.2013.0511 · Cited by 120

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Sproul, A. A., Jacob, S., Nestor, M. W., Keilani, S., Jean, Y., Kahler, D. J., Santa‐María, I., Steele, J., Crary, J. F., Troy, C. M., et al. (2012) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2012.05.1945 · Cited by 4