Cited by 599Alzheimer's disease research and treatmentsPluripotent Stem Cells ResearchDementia and Cognitive Impairment Research

The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.

Modeling familial Alzheimer's disease with induced pluripotent stem cells

Yagi, Takuya, Ito, Daisuke, Okada, Yohei, Akamatsu, Wado, Nihei, Yoshihiro, Yoshizaki, Takahito, Yamanaka, Shinya, Okano, Hideyuki, Suzuki, Norihiro·2011·Human Molecular Genetics

DOI 10.1093/hmg/ddr394

Open this paper in CoChat — free account

Abstract

Alzheimer's disease (AD) is the most common form of age-related dementia, characterized by progressive memory loss and cognitive disturbance. Mutations of presenilin 1 (PS1) and presenilin 2 (PS2) are causative factors for autosomal-dominant early-onset familial AD (FAD). Induced pluripotent stem cell (iPSC) technology can be used to model human disorders and provide novel opportunities to study cellular mechanisms and establish therapeutic strategies against various diseases, including neurodegenerative diseases. Here we generate iPSCs from fibroblasts of FAD patients with mutations in PS1 (A246E) and PS2 (N141I), and characterize the differentiation of these cells into neurons. We find that FAD-iPSC-derived differentiated neurons have increased amyloid β42 secretion, recapitulating the molecular pathogenesis of mutant presenilins. Furthermore, secretion of amyloid β42 from these neurons sharply responds to γ-secretase inhibitors and modulators, indicating the potential for identification and validation of candidate drugs. Our findings demonstrate that the FAD-iPSC-derived neuron is a valid model of AD and provides an innovative strategy for the study of age-related neurodegenerative diseases.

Integrity signals

Registry

Crossref · 10.1093/hmg/ddr394

Cites

45 of 45 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors
Takahashi, K., Tanabe, K., Ohnuki, M., Narita, M., Ichisaka, T., Tomoda, K., & Yamanaka, S. (2007) · Cell · doi:10.1016/j.cell.2007.11.019 · Cited by 20,221
Self-citation
The Amyloid Hypothesis of Alzheimer’s Disease: Progress and Problems on the Road to Therapeutics
Hardy, J., & Selkoe, D. J. (2002) · Science · doi:10.1126/science.1072994 · Cited by 13,864
Induced Pluripotent Stem Cell Lines Derived from Human Somatic Cells
Yu, J., Vodyanik, M. A., Smuga-Otto, K., Antosiewicz-Bourget, J., Frane, J. L., Tian, S., Nie, J., Jonsdottir, G. A., Ruotti, V., Stewart, R., et al. (2007) · Science · doi:10.1126/science.1151526 · Cited by 10,310
Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease
Sherrington, R., Rogaev, E. I., Liang, Y., Rogaeva, E. A., Levesque, G., Ikeda, M., Chi, H., Lin, C., Li, G., Holman, K., et al. (1995) · Nature · doi:10.1038/375754a0 · Cited by 4,051
Secreted amyloid β–protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease
Scheuner, D., Eckman, C., Jensen, M., Song, X., Citron, M., Suzuki, N., Bird, T. D., Hardy, J., Hutton, M., Kukull, W., et al. (1996) · Nature Medicine · doi:10.1038/nm0896-864 · Cited by 2,599
Self-citation
Candidate gene for the chromosome 1 familial Alzheimer’s disease locus
Levy-Lahad, E., Wasco, W., Poorkaj, P., Romano, D. M., Oshima, J., Pettingell, W. H., Yu, C.-E., Jondro, P. D., Schmidt, S. D., Wang, K., et al. (1995) · Science · doi:10.1126/science.7638622 · Cited by 2,577
Disease-Specific Induced Pluripotent Stem Cells.
Park, I.-H., Arora, N., Huo, H., Maherali, N., Ahfeldt, T., Shimamura, A., Lensch, M. W., Cowan, C., Hochedlinger, K., & Daley, G. Q. (2008) · Cell · doi:10.1016/j.cell.2008.07.041 · Cited by 2,196
Decreased Clearance of CNS β-Amyloid in Alzheimer’s Disease
Mawuenyega, K. G., Sigurdson, W., Ovod, V., Munsell, L., Kasten, T., Morris, J. C., Yarasheski, K. E., & Bateman, R. J. (2010) · Science · doi:10.1126/science.1197623 · Cited by 2,078
Induced Pluripotent Stem Cells Generated from Patients with ALS Can Be Differentiated into Motor Neurons
Dimos, J. T., Rodolfa, K. T., Niakan, K. K., Weisenthal, L. M., Mitsumoto, H., Chung, W. K., Croft, G. F., Saphier, G., Leibel, R. L., Goland, R., et al. (2008) · Science · doi:10.1126/science.1158799 · Cited by 2,019
Twenty years of the Alzheimer's disease amyloid hypothesis: a genetic perspective
Tanzi, R. E., & Bertram, L. (2005) · Cell · doi:10.1016/j.cell.2005.02.008 · Cited by 1,849

Flagged first, then by citations

Show all 45 references

Sorted by citations

Items 101–200 of 599

Establishment of Induced Pluripotent Stem Cells from Centenarians for Neurodegenerative Disease Research
Yagi, T., Kosakai, A., Ito, D., Okada, Y., Akamatsu, W., Nihei, Y., Nabetani, A., Ishikawa, F., Arai, Y., Hirose, N., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0041572 · Cited by 84
Self-citation
Extracellular Forms of Aβ and Tau from iPSC Models of Alzheimer’s Disease Disrupt Synaptic Plasticity
Hu, N., Corbett, G. T., Moore, S., Klyubin, I. V., O’Malley, T. T., Walsh, D. M., Livesey, F. J., & Rowan, M. J. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.04.040 · Cited by 84
Stem Cell Transplantation Therapy and Neurological Disorders: Current Status and Future Perspectives
Rahman, M. M., Islam, M. R., Islam, M. T., Harun-Or-Rashid, M., Islam, M., Abdullah, S., Uddin, M., Das, S. K., Rahaman, M. S., Ahmed, M., et al. (2022) · Biology · doi:10.3390/biology11010147 · Cited by 82
Human induced pluripotent stem cell-derived neurons improve motor asymmetry in a 6-hydroxydopamine-induced rat model of Parkinson's disease.
Han, F., Wang, W., Chen, B.-X., Chen, C., Li, S., Lu, X.-J., Duan, J., Zhang, Y., Zhang, Y., Guo, W., et al. (2015) · Cytotherapy · doi:10.1016/j.jcyt.2015.02.001 · Cited by 76
Concise Review: Drug Discovery in the Age of the Induced Pluripotent Stem Cell
Ko, H. C., & Gelb, B. D. (2014) · Stem Cells Translational Medicine · doi:10.5966/sctm.2013-0162 · Cited by 80
Culture Variabilities of Human iPSC-Derived Cerebral Organoids Are a Major Issue for the Modelling of Phenotypes Observed in Alzheimer’s Disease
Hernández, D., Rooney, L. A., Daniszewski, M., Gulluyan, L. M., Liang, H. H., Cook, A. L., Hewitt, A. W., & Pébay, A. (2021) · Stem Cell Reviews and Reports · doi:10.1007/s12015-021-10147-5 · Cited by 79
Precision Modulation of Neurodegenerative Disease-Related Gene Expression in Human iPSC-Derived Neurons
Heman-Ackah, S. M., Bassett, A. R., & Wood, M. J. A. (2016) · Scientific Reports · doi:10.1038/srep28420 · Cited by 77
Modeling Neurodegenerative Microenvironment Using Cortical Organoids Derived from Human Stem Cells
Yan, Y., Song, L., Bejoy, J., Zhao, J., Kanekiyo, T., Bu, G., Zhou, Y., & Li, Y. (2018) · Tissue Engineering Part A · doi:10.1089/ten.tea.2017.0423 · Cited by 84
Experimental models of Alzheimer's disease for deciphering the pathogenesis and therapeutic screening (Review)
Li, X., Bao, X., & Wang, R. (2015) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2015.2428 · Cited by 78
Neurotrophin Signaling and Stem Cells—Implications for Neurodegenerative Diseases and Stem Cell Therapy
Pramanik, S., Sulistio, Y. A., & Heese, K. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-0214-7 · Cited by 77
Opportunities and challenges for the use of induced pluripotent stem cells in modelling neurodegenerative disease
Wu, Y., Chiu, F., Yeh, C.-S., & Kuo, H. (2019) · Open Biology · doi:10.1098/rsob.180177 · Cited by 78
Low-Level Light in Combination with Metabolic Modulators for Effective Therapy of Injured Brain
Dong, T., Zhang, Q., Hamblin, M. R., & Wu, M. X. (2015) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2015.87 · Cited by 75
Classification of Hydrogels Based on Their Source: A Review and Application in Stem Cell Regulation
Khansari, M. M., Sorokina, L. V., Mukherjee, P., Mukhtar, F., Shirdar, M. R., Shahidi, M., & Shokuhfar, T. (2017) · JOM · doi:10.1007/s11837-017-2412-9 · Cited by 73
The use of fibroblasts as a valuable strategy for studying mitochondrial impairment in neurological disorders
Olesen, M. A., Villavicencio-Tejo, F., & Quintanilla, R. A. (2022) · Translational Neurodegeneration · doi:10.1186/s40035-022-00308-y · Cited by 80
The role of mutations associated with familial neurodegenerative disorders on blood–brain barrier function in an iPSC model
Katt, M. E., Mayo, L. N., Ellis, S., Mahairaki, V., Rothstein, J. D., Cheng, L., & Searson, P. C. (2019) · Fluids and Barriers of the CNS · doi:10.1186/s12987-019-0139-4 · Cited by 69
Human Pluripotent Stem Cells in Neurodegenerative Diseases: Potentials, Advances and Limitations
Kolagar, T. A., Farzaneh, M., Nikkar, N., & Khoshnam, S. E. (2019) · Current Stem Cell Research & Therapy · doi:10.2174/1574888x14666190823142911 · Cited by 71
Disease modeling and cell based therapy with iPSC: future therapeutic option with fast and safe application
Kim, C. (2014) · Blood Research · doi:10.5045/br.2014.49.1.7 · Cited by 74
Towards Advanced iPSC-based Drug Development for Neurodegenerative Disease
Pasteuning-Vuhman, S., de Jongh, R., Timmers, A., & Pasterkamp, R. J. (2020) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2020.09.013 · Cited by 72
Induced pluripotent stem cells: a tool for modeling Parkinson’s disease
Bose, A., Petsko, G. A., & Studer, L. (2022) · Trends in Neurosciences · doi:10.1016/j.tins.2022.05.001 · Cited by 74
Human induced pluripotent stem cells and neurodegenerative disease
Jung, Y. W., Hysolli, E., Kim, K., Tanaka, Y., & Park, I. (2012) · Current Opinion in Neurology · doi:10.1097/wco.0b013e3283518226 · Cited by 72
iPSC technology to study human aging and aging-related disorders
Liu, G., Ding, Z., & Belmonte, J. C. I. (2012) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2012.08.014 · Cited by 70
Modeling Human Neurological and Neurodegenerative Diseases: From Induced Pluripotent Stem Cells to Neuronal Differentiation and Its Applications in Neurotrauma
Bahmad, H. F., Hadadeh, O., Chamaa, F., Cheaito, K. A., Darwish, B., Makkawi, A.-K., & Abou-Kheir, W. G. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00050 · Cited by 70
Modeling neurogenesis impairment in down syndrome with induced pluripotent stem cells from Trisomy 21 amniotic fluid cells
Lu, H.-E., Yang, Y.-C., Chen, S.-M., Su, H.-L., Huang, P.-C., Tsai, M.-S., Wang, T.-H., Tseng, C.-P., & Hwang, S.-M. (2013) · Experimental Cell Research · doi:10.1016/j.yexcr.2012.09.017 · Cited by 74
Stem‐Cell Challenges in the Treatment of Alzheimer's Disease: A Long Way from Bench to Bedside
Fan, X., Sun, D., Tang, X., Cai, Y., Yin, Z. Q., & Xu, H. (2014) · Medicinal Research Reviews · doi:10.1002/med.21309 · Cited by 66
Disease modeling and drug screening for neurological diseases using human induced pluripotent stem cells
Xu, X., & Zhong, Z. (2013) · Acta Pharmacologica Sinica · doi:10.1038/aps.2013.63 · Cited by 67
Congenital amegakaryocytic thrombocytopenia iPS cells exhibit defective MPL-mediated signaling
Hirata, S., Takayama, N., Ohnishi, R., Endo, H., Nakamura, S., Dohda, T., Nishi, M., Hamasaki, Y., Ishii, E., Kaneko, S., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci64721 · Cited by 66
Phenotypic Screening Identifies Modulators of Amyloid Precursor Protein Processing in Human Stem Cell Models of Alzheimer’s Disease
Brownjohn, P. W., Smith, J. C., Portelius, E., Serneels, L., Kvartsberg, H., Strooper, B. D., Blennow, K., Zetterberg, H., & Livesey, F. J. (2017) · Stem Cell Reports · doi:10.1016/j.stemcr.2017.02.006 · Cited by 68
Potential for Stem Cells Therapy in Alzheimer’s Disease: Do Neurotrophic Factors Play Critical Role?
Bali, P., Lahiri, D. K., Banik, A., Nehru, B., & Anand, A. (2016) · Current Alzheimer Research · doi:10.2174/1567205013666160314145347 · Cited by 64
Increased susceptibility to Aβ toxicity in neuronal cultures derived from familial Alzheimer’s disease (PSEN1-A246E) induced pluripotent stem cells
Armijo, E., González, C., Shahnawaz, M., Flores, A., Davis, B. R., & Soto, C. A. (2016) · Neuroscience Letters · doi:10.1016/j.neulet.2016.12.060 · Cited by 61
Nobiletin Reduces Intracellular and Extracellular β-Amyloid in iPS Cell-Derived Alzheimer’s Disease Model Neurons
Kimura, J., Shimizu, K., Kajima, K., Yokosuka, A., Mimaki, Y., Oku, N., & Ohizumi, Y. (2018) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b17-00364 · Cited by 62
Recent Expansions on Cellular Models to Uncover the Scientific Barriers Towards Drug Development for Alzheimer’s Disease
Dubey, S. K., Munnangi, S. R., Krishna, K. V., Saha, R. N., Singhvi, G., Agrawal, M., Ajazuddin, M., Saraf, S., Saraf, S., & Alexander, A. (2019) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-019-00653-z · Cited by 64
The Use of Stem Cells as a Potential Treatment Method for Selected Neurodegenerative Diseases: Review
Cecerska‐Heryć, E., Pękała, M., Serwin, N. M., Gliźniewicz, M., Grygorcewicz, B., Michalczyk, A., Heryć, R., Budkowska, M., & Dołęgowska, B. (2023) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-023-01344-6 · Cited by 71
Modeling Alzheimer’s disease: from past to future
Saraceno, C., Musardo, S., Marcello, E. E., Pelucchi, S., & Luca, M. D. (2013) · Frontiers in Pharmacology · doi:10.3389/fphar.2013.00077 · Cited by 62
Concise Review: Can Stem Cells be Used to Treat or Model Alzheimer's Disease?
Chen, W. W., & Blurton-Jones, M. M. (2012) · Stem Cells · doi:10.1002/stem.1240 · Cited by 62
Remodeling neurodegeneration: somatic cell reprogramming-based models of adult neurological disorders
Qiang, L., Fujita, R., & Abeliovich, A. (2013) · Neuron · doi:10.1016/j.neuron.2013.06.002 · Cited by 59
Human pluripotent stem cells as tools for neurodegenerative and neurodevelopmental disease modeling and drug discovery
Corti, S. P., Faravelli, I., Cardano, M., & Conti, L. (2015) · Expert Opinion on Drug Discovery · doi:10.1517/17460441.2015.1037737 · Cited by 65
iPSC technology-Powerful hand for disease modeling and therapeutic screen
Kim, C. (2015) · BMB Reports · doi:10.5483/bmbrep.2015.48.5.100 · Cited by 63
Enhanced Neuronal Activity and Asynchronous Calcium Transients Revealed in a 3D Organoid Model of Alzheimer’s Disease
Yin, J., & VanDongen, A. M. J. (2020) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.0c01583 · Cited by 63
Stem Cells on the Brain: Modeling Neurodevelopmental and Neurodegenerative Diseases Using Human Induced Pluripotent Stem Cells
Srikanth, P., & Young‐Pearse, T. L. (2014) · Journal of Neurogenetics · doi:10.3109/01677063.2014.881358 · Cited by 61
Alzheimer's disease in a dish: promises and challenges of human stem cell models
Young, J. E., & Goldstein, L. S. B. (2012) · Human Molecular Genetics · doi:10.1093/hmg/dds319 · Cited by 57
Early pathogenic event of Alzheimer’s disease documented in iPSCs from patients with PSEN1 mutations
Yang, J., Zhao, H., Ma, Y., Shi, G., Song, J. H., Tang, Y., Li, S., Li, T., Liu, N., Tang, F., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.13776 · Cited by 58
Using stem cell–derived neurons in drug screening for neurological diseases
Little, D., Ketteler, R., Gissen, P., & Devine, M. J. (2019) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2019.02.008 · Cited by 56
Hypothesis review: Alzheimer's overture guidelines
Ferrer, I. (2022) · Brain Pathology · doi:10.1111/bpa.13122 · Cited by 55
Back and forth in time: Directing age in iPSC-derived lineages
Cornacchia, D., & Studer, L. (2017) · Brain Research · doi:10.1016/j.brainres.2015.11.013 · Cited by 56
Super-Obese Patient-Derived iPSC Hypothalamic Neurons Exhibit Obesogenic Signatures and Hormone Responses
Rajamani, U., Gross, A. R., Hjelm, B. E., Sequeira, A., Vawter, M. P., Tang, J., Gangalapudi, V., Wang, Y., Andres, A. M., Gottlieb, R. A., et al. (2018) · Cell stem cell · doi:10.1016/j.stem.2018.03.009 · Cited by 60
Dissecting Alzheimer's disease pathogenesis in human 2D and 3D models
Cenini, G., Hebisch, M., Iefremova, V., Flitsch, L. J., Breitkreuz, Y., Tanzi, R. E., Kim, D. Y., Peitz, M., & Brüstle, O. (2020) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2020.103568 · Cited by 60
Emerging Brain‐Pathophysiology‐Mimetic Platforms for Studying Neurodegenerative Diseases: Brain Organoids and Brains‐on‐a‐Chip
Bang, S., Lee, S., Choi, N., & Kim, H. N. (2021) · Advanced Healthcare Materials · doi:10.1002/adhm.202002119 · Cited by 57
Promoting Alzheimer’s disease research and therapy with stem cell technology
Cao, Z., Kong, F., Ding, J., Chen, C., He, F., & Deng, W. (2024) · Stem Cell Research & Therapy · doi:10.1186/s13287-024-03737-w · Cited by 60
Neural stem/progenitor cells in Alzheimer's disease.
Tincer, G., Mashkaryan, V., Bhattarai, P., & Kızıl, Ç. (2016) · Europe PMC (PubMed Central) · Cited by 56
Modeling neurodegenerative diseases with patient-derived induced pluripotent cells: Possibilities and challenges
Poon, A., Zhang, Y., Chandrasekaran, A., Phanthong, P., Schmid, B., Nielsen, T. T., & Freude, K. (2017) · New Biotechnology · doi:10.1016/j.nbt.2017.05.009 · Cited by 54
Modeling Brain Disorders Using Induced Pluripotent Stem CellsPreprint
Vadodaria, K. C., Jones, J. R., Linker, S. B., & Gage, F. H. (2019) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a035659 · Cited by 52
The Age of Brain Organoids: Tailoring Cell Identity and Functionality for Normal Brain Development and Disease Modeling
Porciúncula, L. O., Goto‐Silva, L., Ledur, P. F., & Rehen, S. K. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.674563 · Cited by 54
Li–Fraumeni Syndrome Disease Model: A Platform to Develop Precision Cancer Therapy Targeting Oncogenic p53
Zhou, R., Xu, A., Gingold, J. A., Strong, L. C., Zhao, R., & Lee, D. (2017) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2017.07.004 · Cited by 52
Utility of Scalp Hair Follicles as a Novel Source of Biomarker Genes for Psychiatric Illnesses
Maekawa, M., Yamada, K., Toyoshima, M., Ohnishi, T., Iwayama, Y., Shimamoto, C., Toyota, T., Nozaki, Y., Balan, S., Matsuzaki, H., et al. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.07.025 · Cited by 52
Self-citation
Toxicity testing and drug screening using iPSC-derived hepatocytes, cardiomyocytes, and neural cells
Csöbönyeiová, M., Polák, Š., & Danišovič, Ľ. (2016) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2015-0459 · Cited by 54
Cardiovascular Disease Modeling Using Patient-Specific Induced Pluripotent Stem Cells
Tanaka, A., Yuasa, S., Node, K., & Fukuda, K. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms160818894 · Cited by 52
Enhanced Aggregation of Androgen Receptor in Induced Pluripotent Stem Cell-derived Neurons from Spinal and Bulbar Muscular Atrophy
Nihei, Y., Ito, D., Okada, Y., Akamatsu, W., Yagi, T., Yoshizaki, T., Okano, H., & Suzuki, N. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.408211 · Cited by 52
Self-citation
Genome-editing applications of CRISPR–Cas9 to promote in vitro studies of Alzheimer’s disease
Giau, V. V., Lee, H., Shim, K. H., Bagyinszky, E., & An, S. S. A. (2018) · Clinical Interventions in Aging · doi:10.2147/cia.s155145 · Cited by 53
Common proteomic profiles of induced pluripotent stem cell-derived three-dimensional neurons and brain tissue from Alzheimer patients
Chen, M., Lee, H. K., Moo, L. R., Hanlon, E. B., Stein, T. D., & Xia, W. (2018) · Journal of Proteomics · doi:10.1016/j.jprot.2018.04.032 · Cited by 53
Induced pluripotent stem cells as a discovery tool for Alzheimer׳s disease
Sullivan, S. E., & Young-Pearse, T. L. (2017) · Brain Research · doi:10.1016/j.brainres.2015.10.005 · Cited by 50
Probing disorders of the nervous system using reprogramming approaches
Ichida, J. K., & Kiskinis, E. (2015) · The EMBO Journal · doi:10.15252/embj.201591267 · Cited by 51
Modelling Human Disease with Pluripotent Stem Cells
Siller, R., Greenhough, S., Park, I., & Sullivan, G. J. (2013) · Current Gene Therapy · doi:10.2174/1566523211313020004 · Cited by 53
Induced pluripotent stem cell-based organ-on-a-chip as personalized drug screening tools: A focus on neurodegenerative disorders
Fanizza, F., Campanile, M., Forloni, G., Giordano, C., & Albani, D. (2022) · Journal of Tissue Engineering · doi:10.1177/20417314221095339 · Cited by 55
Personalized therapeutic strategies for patients with retinitis pigmentosa
Zheng, A., Li, Y., & Tsang, S. H. (2015) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.2015.1006192 · Cited by 50
A next-generation iPSC-derived forebrain organoid model of tauopathy with tau fibrils by AAV-mediated gene transfer
Shimada, H., Sato, Y., Sasaki, T., Shimozawa, A., Imaizumi, K., Shindo, T., Miyao, S., Kiyama, K., Kondo, T., Shibata, S., et al. (2022) · Cell Reports Methods · doi:10.1016/j.crmeth.2022.100289 · Cited by 50
Self-citation
Comparison of different protocols for neural differentiation of human induced pluripotent stem cells
Salimi, A., Nadri, S., Ghollasi, M., Khajeh, K., & Soleimani, M. (2014) · Molecular Biology Reports · doi:10.1007/s11033-014-3020-1 · Cited by 48
Human stem cell models of neurodegeneration: a novel approach to study mechanisms of disease development
Hargus, G., Ehrlich, M., Hallmann, A.-L., & Kuhlmann, T. (2013) · Acta Neuropathologica · doi:10.1007/s00401-013-1222-6 · Cited by 54
Stem Cell Treatment for Alzheimer’s Disease
Li, M., Guo, K., & Ikehara, S. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms151019226 · Cited by 49
Induced pluripotent stem cells as tools for disease modelling and drug discovery in Alzheimer’s disease
Ooi, L., Sidhu, K., Poljak, A., Sutherland, G. T., O’Connor, M. D., Sachdev, P. S., & Münch, G. W. (2012) · Journal of Neural Transmission · doi:10.1007/s00702-012-0839-2 · Cited by 49
iPSCs: On the Road to Reprogramming Aging
Soria‐Valles, C., & López-Otı́n, C. (2016) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2016.05.010 · Cited by 49
Accelerating progress in induced pluripotent stem cell research for neurological diseases
Ito, D., Okano, H., & Suzuki, N. (2012) · Annals of Neurology · doi:10.1002/ana.23596 · Cited by 49
Self-citation
Stem Cell Therapy for Alzheimer's Disease.
Han, F., Bi, J.-Z., Qiao, L.-Y., & Arancio, O. (2020) · Advances in Experimental Medicine and Biology · doi:10.1007/978-981-15-4370-8_4 · Cited by 19
Human disease modeling with induced pluripotent stem cells
Trounson, A. O., Shepard, K. A., & DeWitt, N. D. (2012) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2012.07.004 · Cited by 49
Stem cell therapy: a revolutionary cure or a pandora's box
Marei, H. E. S. (2025) · Stem Cell Research & Therapy · doi:10.1186/s13287-025-04334-1 · Cited by 56
Modeling Keratoconus Using Induced Pluripotent Stem Cells
Joseph, R., Srivastava, O. P., & Pfister, R. R. (2016) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.16-19105 · Cited by 47
Current Perspectives regarding Stem Cell-Based Therapy for Alzheimer’s Disease
Kwak, K.-A., Lee, S., Yang, J.-Y., & Park, Y. (2018) · Stem Cells International · doi:10.1155/2018/6392986 · Cited by 50
A Three-Dimensional Alzheimer’s Disease Cell Culture Model Using iPSC-Derived Neurons Carrying A246E Mutation in PSEN1
Hernández-Sapiéns, M. A., Reza-Zaldívar, E. E., Cevallos, R. R., Márquez-Aguirre, A. L., Gazarian, K. G., & Canales-Aguirre, A. A. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.00151 · Cited by 46
Optimization of cerebral organoids: a more qualified model for Alzheimer’s disease research
Bi, F.-C., Yang, X.-H., Cheng, X.-Y., Deng, W.-B., Guo, X.-L., Yang, H., Wang, Y., Li, J., & Yao, Y. (2021) · Translational Neurodegeneration · doi:10.1186/s40035-021-00252-3 · Cited by 49
Current progress of cerebral organoids for modeling Alzheimer's disease origins and mechanisms
Sreenivasamurthy, S., Laul, M., Zhao, N., Kim, T., & Zhu, D. (2022) · Bioengineering & Translational Medicine · doi:10.1002/btm2.10378 · Cited by 49
CRISPR and iPSCs: Recent Developments and Future Perspectives in Neurodegenerative Disease Modelling, Research, and Therapeutics
Sen, T., & Thummer, R. P. (2022) · Neurotoxicity Research · doi:10.1007/s12640-022-00564-w · Cited by 52
The evolving field of induced pluripotency: Recent progress and future challenges
Sommer, C., & Mostoslavsky, G. (2012) · Journal of Cellular Physiology · doi:10.1002/jcp.24155 · Cited by 46
Microfluidics-Based Systems in Diagnosis of Alzheimer’s Disease and Biomimetic Modeling
Li, Y., Li, D., Zhao, P., Nandakumar, K., Wang, L., & Song, Y. (2020) · Micromachines · doi:10.3390/mi11090787 · Cited by 45
Understanding stem cells and its pivotal role in regenerative medicine
Sarkar, A., Saha, S., Paul, A., Maji, A., Roy, P., & Maity, T. K. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.119270 · Cited by 47
In vitro neuroprotective effects of farnesene sesquiterpene on alzheimer’s disease model of differentiated neuroblastoma cell line
Arslan, M. E., Türkez, H., & Mardinoğlu, A. (2020) · International Journal of Neuroscience · doi:10.1080/00207454.2020.1754211 · Cited by 43
Alzheimer’s as a Systems-Level Disease Involving the Interplay of Multiple Cellular Networks
Castrillo, J. I., & Oliver, S. G. (2016) · Methods in Molecular Biology · doi:10.1007/978-1-4939-2627-5_1 · Cited by 44
Small Molecule Screening in Human Induced Pluripotent Stem Cell-derived Terminal Cell Types
Engle, S. J., & Vincent, F. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.r113.529156 · Cited by 48
mRNA transfection-based, feeder-free, induced pluripotent stem cells derived from adipose tissue of a 50-year-old patient
Heng, B. C., Heinimann, K., Miny, P., Iezzi, G., Glatz, K., Scherberich, A., Zulewski, H., & Fussenegger, M. (2013) · Metabolic Engineering · doi:10.1016/j.ymben.2013.02.004 · Cited by 45
Paving the Way Toward Complex Blood-Brain Barrier Models Using Pluripotent Stem Cells
Lauschke, K., Frederiksen, L., & Hall, V. J. (2017) · Stem Cells and Development · doi:10.1089/scd.2017.0003 · Cited by 46
Rapid generation of sub-type, region-specific neurons and neural networks from human pluripotent stem cell-derived neurospheres
Begum, A. N., Guoynes, C. D., Cho, J., Hao, J., Lutfy, K., & Hong, Y. (2015) · Stem Cell Research · doi:10.1016/j.scr.2015.10.014 · Cited by 43
Induced pluripotent stem cells for modeling neurological disorders
Russo, F. B. (2015) · World Journal of Transplantation · doi:10.5500/wjt.v5.i4.209 · Cited by 43
The potential of induced pluripotent stem cells as a translational model for neurotoxicological risk
Kumar, K. K., Aboud, A. A., & Bowman, A. B. (2012) · NeuroToxicology · doi:10.1016/j.neuro.2012.02.005 · Cited by 42
Drug discovery using induced pluripotent stem cell models of neurodegenerative and ocular diseases
Hung, S. S. C., Khan, S., Lo, C. Y.-W., Hewitt, A. W., & Wong, R. C. B. (2017) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2017.02.026 · Cited by 47
Using human induced pluripotent stem cells (hiPSCs) to investigate the mechanisms by which Apolipoprotein E (APOE) contributes to Alzheimer’s disease (AD) risk
Raman, S., Brookhouser, N., & Brafman, D. A. (2020) · Neurobiology of Disease · doi:10.1016/j.nbd.2020.104788 · Cited by 41
Application of human induced pluripotent stem cells for modeling and treating neurodegenerative diseases
Payne, N. L., Sylvain, A., O’Brien, C., Herszfeld, D., Sun, G., & Bernard, C. C. A. (2014) · New Biotechnology · doi:10.1016/j.nbt.2014.05.001 · Cited by 41
Induced Pluripotent Stem Cell Potential in Medicine, Specifically Focused on Reproductive Medicine
Botman, O., & Wyns, C. (2014) · Frontiers in Surgery · doi:10.3389/fsurg.2014.00005 · Cited by 41
iPSCs and small molecules: a reciprocal effort towards better approaches for drug discovery
Zhang, R., Zhang, L., & Xie, X. (2013) · Acta Pharmacologica Sinica · doi:10.1038/aps.2013.21 · Cited by 42
Presence of a mutation in PSEN1 or PSEN2 gene is associated with an impaired brain endothelial cell phenotype in vitro
Raut, S., Patel, R., & Al-Ahmad, A. J. (2021) · Fluids and Barriers of the CNS · doi:10.1186/s12987-020-00235-y · Cited by 42
Applications of induced pluripotent stem cells in studying the neurodegenerative diseases
Wan, W., Cao, L., Kalionis, B., Xia, S., & Tai, X. (2015) · Stem Cells International · doi:10.1155/2015/382530 · Cited by 40
Materials for Neural Differentiation, Trans‐Differentiation, and Modeling of Neurological Disease
Gong, L., Cao, L., Shen, Z., Shao, L., Gao, S., Zhang, C., Lü, J., & Li, W. (2018) · Advanced Materials · doi:10.1002/adma.201705684 · Cited by 40
Presenilin mutations and their impact on neuronal differentiation in Alzheimer’s disease
Canales-Aguirre, A. A., Hernández-Sapiéns, M. A., Reza-Zaldívar, E. E., Márquez-Aguirre, A. L., Gómez‐Pinedo, U., Matías‐Guiu, J., Cevallos, R. R., Mateos‐Díaz, J. C., & Sánchez-González, V. (2021) · Neural Regeneration Research · doi:10.4103/1673-5374.313016 · Cited by 41

Authors: Yagi, T., Ito, D., Okada, Y., Akamatsu, W., Nihei, Y., Yoshizaki, T., Yamanaka, S., Okano, H., & Suzuki, N.
Affiliations: Keio University (JP)
ORCID: Yagi, Takuya
Ito, Daisuke
Okada, Yohei
Akamatsu, Wado
Nihei, Yoshihiro
Yamanaka, Shinya
Okano, Hideyuki
Suzuki, Norihiro
Venue: Human Molecular Genetics
Publisher: Oxford University Press (OUP)
Published: 2011-09-07
Volume: 20
Issue: 23
Pages: 4530-4539
ISSN: 0964-6906 (ISSN-L)
1460-2083
DOI: 10.1093/hmg/ddr394
OpenAlex: W2157073241
Cited by: 599
References: 45
Citations by year: 2026: 8 · 2025: 22 · 2024: 26 · 2023: 20 · 2022: 38 · 2021: 43 · 2020: 49 · 2019: 45 · 2018: 47 · 2017: 42 · 2016: 62 · 2015: 50 · 2014: 57 · 2013: 52 · 2012: 36
FWCI: 32.06
Type: journal article
Language: en
Open access: closed
Locations: Human Molecular Genetics (publishedVersion)
PubMed (publishedVersion)
Funders: Japan Society for the Promotion of Science (23591254, 23650194, 23689017, 19002014)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords: familial Alzheimer's disease, induced pluripotent stem cells, presenilin 1, presenilin 2, iPSC-derived neurons, gamma-secretase inhibitors, γ-secretase modulators, disease modeling, drug screening, neurodegeneration
MeSH terms: Alzheimer Disease, Animals, Cell Differentiation, Fibroblasts, Humans, Models, Biological, Mutation, Neurons, Protease Inhibitors, Teratoma, Amyloid beta-Peptides, Mice, SCID, Mice, Presenilin-1, Presenilin-2, Amyloid Precursor Protein Secretases, Induced Pluripotent Stem Cells

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Modeling familial Alzheimer's disease with induced pluripotent stem cells

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks