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KDM6B/JMJD3 histone demethylase is induced by vitamin D and modulates its effects in colon cancer cells
Open accessAbstract
KDM6B/JMJD3 is a histone H3 lysine demethylase with an important gene regulatory role in development and physiology. Here, we show that human JMJD3 expression is induced by the active vitamin D metabolite 1α,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)) and that JMJD3 modulates the gene regulatory action of this hormone. 1,25(OH)(2)D(3) activates the JMJD3 gene promoter and increases the level of JMJD3 RNA in human cancer cells. JMJD3 upregulation was strictly dependent on vitamin D receptor (VDR) expression and was abolished by cycloheximide. In SW480-ADH colon cancer cells, JMJD3 knockdown or expression of an inactive mutant JMJD3 fragment decreased the induction by 1,25(OH)(2)D(3) of several target genes and of an epithelial adhesive phenotype. Moreover, JMJD3 knockdown upregulated the epithelial-to-mesenchymal transition inducers SNAIL1 and ZEB1 and the mesenchymal markers fibronectin and LEF1, while it downregulated the epithelial proteins E-cadherin, Claudin-1 and Claudin-7. Additionally, JMJD3 knockdown abolished the nuclear export of β-catenin and the inhibition of β-catenin transcriptional activity caused by 1,25(OH)(2)D(3). Importantly, the expression of JMJD3 correlated directly with that of VDR and inversely with that of SNAI1 in a series of 96 human colon tumours. Our results indicate for the first time that an epigenetic gene coding for a histone demethylase such as JMJD3 is a VDR co-target that partially mediates the effects of 1,25(OH)(2)D(3) on human colon.
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“Regarding epigenetic mechanisms, vitamin D, through its interaction with the vitamin D receptor (VDR), can modulate the activity of chromatin-modifying enzymes, including DNA methyltransferases (DNMTs), histone acetyltransferases (HATs), and histone deacetylases (HDACs).”
From Maternal Overnutrition and Fetal Programming: Long-Term Metabolic, Cognitive, and Epigenetic Consequences (2026) · cites this paper as [152]
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1 retracted
DNA demethylation in hormone-induced transcriptional derepression
Kim, M. S., Kondo, T., Takada, I., Youn, M., Yamamoto, Y., Takahashi, S., Μatsumoto, T., Fujiyama, S., Shirode, Y., Yamaoka, I., et al. (2009) · Nature · doi:10.1038/nature08456 · Cited by 242
RetractedNorman, A. W. (1979) · Cited by 3,769
The Role of Chromatin during Transcription
Li, B., Carey, M., & Workman, J. L. (2007) · Cell · doi:10.1016/j.cell.2007.01.015 · Cited by 3,503
Snail, Zeb and bHLH factors in tumour progression: An alliance against the epithelial phenotype?
Peinado, H., Olmeda, D., & Cano, A. (2007) · Nature reviews. Cancer · doi:10.1038/nrc2131 · Cited by 3,121
Vitamin D signalling pathways in cancer: potential for anticancer therapeutics
Deeb, K. K., Trump, D. L., & Johnson, C. S. (2007) · Nature reviews. Cancer · doi:10.1038/nrc2196 · Cited by 1,419
UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development
Agger, K., Cloos, P. A., Christensen, J. F., Pasini, D., Rose, S., Rappsilber, J., Issaeva, I., Canaani, E., Salcini, A. E., & Helin, K. (2007) · Nature · doi:10.1038/nature06145 · Cited by 1,392
Schlesinger, Y., Straussman, R., Keshet, I., Farkash, S., Hecht, M., Zimmerman, J., Eden, E., Yakhini, Z., Ben-Shushan, E., Reubinoff, B. E., et al. (2007) · Nature Genetics · doi:10.1038/ng1950 · Cited by 1,226 · cited 1×
“The presence of H3K27me3 at transcriptional sites usually correlates with gene repression (7,11,12), and Polycomb-mediated H3K27 methylation premarks genes for DNA methylation and silencing in cancer (13).”
BackgroundSystematic sequencing of renal carcinoma reveals inactivation of histone modifying genes
Dalgliesh, G. L., Furge, K., Greenman, C., Chen, L., Bignell, G., Butler, A., Davies, H., Edkins, S., Hardy, C., Latimer, C., et al. (2010) · Nature · doi:10.1038/nature08672 · Cited by 1,173 · cited 1×
“Several KDMs have been implicated in development, differentiation or stem cell renewal, and their mutation or deregulation have been linked to cancer and other diseases (2-7).”
BackgroundCovalent histone modifications — miswritten, misinterpreted and mis-erased in human cancers
Chi, P., Allis, C. D., & Wang, G. G. (2010) · Nature reviews. Cancer · doi:10.1038/nrc2876 · Cited by 1,131
Norman, A. W. (2008) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/88.2.491s · Cited by 1,090
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Lu, W., & Kang, Y. (2019) · Developmental Cell · doi:10.1016/j.devcel.2019.04.010 · Cited by 1,039
Inhibitors of Protein Methyltransferases and Demethylases
Kanıskan, H. Ü., Martini, M. L., & Jin, J. J. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.6b00801 · Cited by 327
Fetahu, I. S., Höbaus, J., & Kállay, E. (2014) · Frontiers in Physiology · doi:10.3389/fphys.2014.00164 · Cited by 313
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Saponaro, F., Saba, A., & Zucchi, R. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21186573 · Cited by 339
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Vitamin D and Cancer: An Historical Overview of the Epidemiology and Mechanisms
Múñoz, A., & Grant, W. B. (2022) · Nutrients · doi:10.3390/nu14071448 · Cited by 247
Raiten, D. J., Ashour, F. A. S., Ross, A. C., Meydani, S. N., Dawson, H. D., Stephensen, C. B., Brabin, B. J., Suchdev, P. S., & van Ommen, B. (2015) · The Journal of Nutrition · doi:10.3945/jn.114.194571 · Cited by 234
Chang, S., Yim, S., & Park, H. (2019) · Experimental & Molecular Medicine · doi:10.1038/s12276-019-0230-6 · Cited by 228
Ogino, S., Lochhead, P. J., Chan, A. T., Nishihara, R., Cho, E., Wolpin, B. M., Meyerhardt, J. A., Meissner, A., Schernhammer, E. S., Fuchs, C. S., et al. (2013) · Modern Pathology · doi:10.1038/modpathol.2012.214 · Cited by 214
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Meyer, M. B., Goetsch, P. D., & Pike, J. W. (2011) · Molecular Endocrinology · doi:10.1210/me.2011-1109 · Cited by 201
Carlberg, C. (2019) · Nutrients · doi:10.3390/nu11030676 · Cited by 211
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Zhang, Y., Wu, S., & Sun, J. (2013) · Tissue Barriers · doi:10.4161/tisb.23118 · Cited by 164
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Pereira, F., Larriba, M. J., & Múñoz, A. (2012) · Endocrine Related Cancer · doi:10.1530/erc-11-0388 · Cited by 136
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Mazur, A., Frączek, P., & Tabarkiewicz, J. (2022) · Nutrients · doi:10.3390/nu14204286 · Cited by 106
Szic, K. S. V., de Beeck, K. O., Ratman, D., Wouters, A., Beck, I. M. E., Declerck, K., Heyninck, K., Fransén, E., Bracke, M., Bosscher, K. D., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0087850 · Cited by 104
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Self-citationImplications of gut microbiota-mediated epigenetic modifications in intestinal diseases
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Li, Q., Wang, H. Y., Chepelev, I., Zhu, Q., Wei, G., Zhao, K., & Wang, R.-F. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004524 · Cited by 56
Luo, T., Dunphy, P. S., Lina, T. T., & McBride, J. W. (2015) · Infection and Immunity · doi:10.1128/iai.01289-15 · Cited by 53
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Zhang, P.-P., Wang, X.-L., Zhao, W., Qi, B., Yang, Q., Wan, H.-Y., Shuang, Z.-Y., Liu, M., Li, X., Li, S., et al. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.567818 · Cited by 48
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Self-citationLiang, S., Yao, Q., Wei, D., Liu, M., Geng, F., Wang, Q., & Wang, Y. (2018) · Journal of Cellular Biochemistry · doi:10.1002/jcb.27405 · Cited by 41
RetractedVitamin D3 insufficiency and colorectal cancer
Rosa, M. D., Malaguarnera, M., Zanghì, A., Passaniti, A., & Malaguarnera, L. (2013) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2013.07.016 · Cited by 39
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Xun, J., Wang, D., Shen, L., Gong, J., Gao, R., Du, L., Chang, A., Song, X., Xiang, R., & Tan, X. (2017) · Oncotarget · doi:10.18632/oncotarget.15747 · Cited by 37
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Zhang, Y., Shen, L., Stupack, D. G., Bai, N., Xun, J., Ren, G., Han, J., Li, L., Luo, Y., Xiang, R., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.8836 · Cited by 35
Histone demethylase JMJD3 at the intersection of cellular senescence and cancer
Perrigue, P. M., Najbauer, J., & Barciszewski, J. (2016) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2016.03.002 · Cited by 35
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Sánchez, A., Khoufaf, F. Z. H., Idrissou, M., Penault-Llorca, F. M., Bignon, Y., Guy, L., & Bernard-Gallon, D. J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22020968 · Cited by 33
Ma, J., Wang, N., Zhang, Y., Wang, C., Ge, T., Jin, H., Deng, X., Huo, X., Gu, D., Ge, Z., et al. (2015) · Cellular Physiology and Biochemistry · doi:10.1159/000430345 · Cited by 32
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Punnia-Moorthy, G., Hersey, P., Emran, A. A., & Tiffen, J. C. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.680633 · Cited by 32
Yi, T., Weng, J., Siwko, S. K., Luo, J., Li, D., & Liu, M. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.530816 · Cited by 28
Chang, G., Zhang, K., Xu, T., Jin, D., Guo, J., Zhuang, S., & Shen, X. (2015) · PLoS ONE · doi:10.1371/journal.pone.0123942 · Cited by 29
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Qin, M., Han, F., Wu, J., Gao, F., Li, Y., Yan, D.-X., He, X., Long, Y., Tang, X.-P., Ren, D.-L., et al. (2021) · BMC Cancer · doi:10.1186/s12885-021-08282-w · Cited by 21
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Lian, H., Jia, X., Shi, N., Xie, S., Wang, J., Wang, W., Ma, F.-Z., Liu, H., Wang, A., Cheng, X., et al. (2018) · Cancer Management and Research · doi:10.2147/cmar.s178126 · Cited by 21
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Metadata
- Authors
- Pereira, F., Barbáchano, A., Silva, J., Bonilla, F., Campbell, M. J., Muñoz, A., & Larriba, M. J.
- Affiliations
- Consejo Superior de Investigaciones Científicas (ES)
- Hospital Universitario Puerta de Hierro Majadahonda (ES)
- Roswell Park Comprehensive Cancer Center (US)
- Venue
- Human Molecular Genetics
- Publisher
- Oxford University Press (OUP)
- Published
- 2011-09-02
- Volume
- 20
- Issue
- 23
- Pages
- 4655-4665
- ISSN
- 0964-6906 (ISSN-L)
- 1460-2083
- OpenAlex
- W2130478754
- Cited by
- 177
- References
- 57
- Citations by year
- 2026: 5 · 2025: 12 · 2024: 6 · 2023: 7 · 2022: 27 · 2021: 14 · 2020: 11 · 2019: 14 · 2018: 16 · 2017: 12 · 2016: 9 · 2015: 9 · 2014: 14 · 2013: 11 · 2012: 9
- FWCI
- 4.55
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- other-oa
- Locations
- Human Molecular Genetics (publishedVersion)
- PubMed (publishedVersion)
- DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion, other-oa)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Vitamin D Research Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Keywords
- vitamin D, 1,25-dihydroxyvitamin D3, vitamin D receptor, colon cancer, epithelial-mesenchymal transition, SNAI1, ZEB1, E-cadherin, claudin-1, claudin-7, gene expression regulation, epigenetic regulation
- MeSH terms
- Snail Family Transcription Factors, Calcitriol, Colonic Neoplasms, Enzyme Induction, Humans, Transcription Factors, Vitamin D, Transcriptional Activation, Gene Expression Regulation, Neoplastic, Receptors, Calcitriol, Cell Line, Tumor, Cell Proliferation, Gene Knockdown Techniques, Jumonji Domain-Containing Histone Demethylases, Epithelial-Mesenchymal Transition, Wnt Signaling Pathway
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