Vitamin D and the epigenome

Chromatin modifications and their function

Kouzarides, T. (2007) · Cell · doi:10.1016/j.cell.2007.02.005 · Cited by 10,883 · see citing works

DNA methylation patterns and epigenetic memory

Bird, A. (2002) · Genes & Development · doi:10.1101/gad.947102 · Cited by 7,124 · see citing works

DNA Methyltransferases Dnmt3a and Dnmt3b Are Essential for De Novo Methylation and Mammalian Development

Okano, M., Bell, D. W., Haber, D. A., & Li, E. (1999) · Cell · doi:10.1016/s0092-8674(00)81656-6 · Cited by 6,143 · see citing works

The Epigenomics of Cancer

Jones, P. A., & Baylin, S. B. (2007) · Cell · doi:10.1016/j.cell.2007.01.029 · Cited by 4,515 · see citing works

Histone demethylation mediated by the nuclear amine oxidase homolog LSD1

Shi, Y., Lan, F., Matson, C., Mulligan, P., Whetstine, J. R., Cole, P. A., Casero, R. A., & Shi, Y. (2004) · Cell · doi:10.1016/j.cell.2004.12.012 · Cited by 4,051 · see citing works

Epigenetics in Cancer

Esteller, M. (2008) · New England Journal of Medicine · doi:10.1056/nejmra072067 · Cited by 3,681 · see citing works

CpG islands in vertebrate genomes.

Gardiner-Garden, M., & Frommer, M. (1987) · Journal of Molecular Biology · doi:10.1016/0022-2836(87)90689-9 · Cited by 3,462 · see citing works

Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex

Nan, X., Ng, H.-H., Johnson, C. A., Laherty, C. D., Turner, B. M., Eisenman, R. N., & Bird, A. (1998) · Nature · doi:10.1038/30764 · Cited by 3,440 · see citing works

Gene Silencing in Cancer in Association with Promoter Hypermethylation

Herman, J. G., & Baylin, S. B. (2003) · New England Journal of Medicine · doi:10.1056/nejmra023075 · Cited by 3,425 · see citing works

A decade of exploring the cancer epigenome—biological and translational implications

Baylin, S. B., & Jones, P. A. (2011) · Nature Reviews Cancer · doi:10.1038/nrc3130 · Cited by 2,871 · see citing works

DNA methylation and human disease

Robertson, K. D. (2005) · Nature Reviews Genetics · doi:10.1038/nrg1655 · Cited by 2,864 · see citing works

Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription

Jones, P. L., Veenstra, G. J. C., Wade, P. A., Vermaak, D., Kass, S. U., Landsberger, N., Strouboulis, J., & Wolffe, A. P. (1998) · Nature Genetics · doi:10.1038/561 · Cited by 2,734 · see citing works

The Nuclear DNA Base 5-Hydroxymethylcytosine Is Present in Purkinje Neurons and the Brain

Kriaucionis, S., & Heintz, N. (2009) · Science · doi:10.1126/science.1169786 · Cited by 2,700 · see citing works

The many roles of histone deacetylases in development and physiology: implications for disease and therapy

Haberland, M., Montgomery, R. L., & Olson, E. N. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2485 · Cited by 2,541 · see citing works

Genome-scale DNA methylation maps of pluripotent and differentiated cells

Meissner, A., Mikkelsen, T. S., Gu, H., Wernig, M., Hanna, J., Sivachenko, A., Zhang, X., Bernstein, B. E., Nusbaum, C., Jaffe, D. B., et al. (2008) · Nature · doi:10.1038/nature07107 · Cited by 2,536 · see citing works

Histone methylation: a dynamic mark in health, disease and inheritance

Greer, E. L., & Shi, Y. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3173 · Cited by 2,241 · see citing works

Histone demethylation by a family of JmjC domain-containing proteins

Tsukada, Y.-I., Fang, J., Erdjument‐Bromage, H., Warren, M., Borchers, C. H., Tempst, P., & Zhang, Y. (2005) · Nature · doi:10.1038/nature04433 · Cited by 2,171 · see citing works

Histone deacetylases and cancer: causes and therapies

Marks, P. A., Rifkind, R. A., Richon, V. M., Breslow, R., Miller, T., & Kelly, W. K. (2001) · Nature reviews. Cancer · doi:10.1038/35106079 · Cited by 1,866 · see citing works

Vitamin D and Human Health: Lessons from Vitamin D Receptor Null Mice

Bouillon, R., Carmeliet, G., Verlinden, L., van Etten, E., Verstuyf, A., Luderer, H. F., Lieben, L., Mathieu, C., & Demay, M. (2008) · Endocrine Reviews · doi:10.1210/er.2008-0004 · Cited by 1,783 · see citing works

LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription

Metzger, E., Wissmann, M., Yin, N., Müller, J. M., Schneider, R., Peters, A. H. F. M., Günther, T., Buettner, R., & Schüle, R. (2005) · Nature · doi:10.1038/nature04020 · Cited by 1,741 · see citing works

Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferases

Okano, M., Xie, S., & Li, E. (1998) · Nature Genetics · doi:10.1038/890 · Cited by 1,643 · see citing works

Chromosomal Instability and Tumors Promoted by DNA Hypomethylation

Eden, A., Gaudet, F., Waghmare, A., & Jaenisch, R. (2003) · Science · doi:10.1126/science.1083557 · Cited by 1,401 · see citing works

Specific activation of microRNA-127 with downregulation of the proto-oncogene BCL6 by chromatin-modifying drugs in human cancer cells

Saito, Y., Liang, G., Egger, G., Friedman, J. M., Chuang, J. C., Coetzee, G. A., & Jones, P. A. (2006) · Cancer Cell · doi:10.1016/j.ccr.2006.04.020 · Cited by 1,328 · see citing works

Cloning and characterization of chi-1: a developmentally regulated member of a novel class of the ionotropic glutamate receptor family

Ciabarra, A., Sullivan, J., Gahn, L. G., Pecht, G., Heinemann, S., & Sevarino, K. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-10-06498.1995 · Cited by 1,254 · see citing works

DNMT1 and DNMT3b cooperate to silence genes in human cancer cells

Rhee, I. P., Bachman, K. E., Park, B. H., Jair, K.-W., Yen, R.-W. C., Schuebel, K. E., Cui, H., Feinberg, A. P., Christoph Lengauer, C., Kinzler, K. W., et al. (2002) · Nature · doi:10.1038/416552a · Cited by 1,243 · see citing works

DNA methylation and the frequency of CpG in animal DNA

Bird, A. P. (1980) · Nucleic Acids Research · doi:10.1093/nar/8.7.1499 · Cited by 1,175 · see citing works

Dynamic regulation of 5-hydroxymethylcytosine in mouse ES cells and during differentiation

Ficz, G., Branco, M. R., Seisenberger, S., Santos, F., Krueger, F., Hore, T. A., Marques, C. J., Andrews, S., & Reik, W. (2011) · Nature · doi:10.1038/nature10008 · Cited by 1,123 · see citing works

Reversal of Histone Lysine Trimethylation by the JMJD2 Family of Histone Demethylases

Whetstine, J. R., Nottke, A. C., Lan, F., Huarte, M., Smolikov, S., Chen, Z., Spooner, E., Li, E., Zhang, G., Colaiácovo, M. P., et al. (2006) · Cell · doi:10.1016/j.cell.2006.03.028 · Cited by 1,046 · see citing works

TET1 and hydroxymethylcytosine in transcription and DNA methylation fidelity

Williams, K., Christensen, J., Pedersen, M. T., Johansen, J. V., Cloos, P. A. C., Rappsilber, J., & Helin, K. (2011) · Nature · doi:10.1038/nature10066 · Cited by 1,021 · see citing works

Noncalcemic Actions of Vitamin D Receptor Ligands

Nagpal, S., Na, S., & Rathnachalam, R. (2005) · Endocrine Reviews · doi:10.1210/er.2004-0002 · Cited by 960 · see citing works

Ensembl 2014

Flicek, P., Amode, M., Barrell, D., Beal, K., Billis, K., Brent, S., Carvalho-Silva, D., Clapham, P., Coates, G., Fitzgerald, S., et al. (2013) · Nucleic Acids Res. · doi:10.1093/nar/gkt1196 · Cited by 926 · see citing works

A direct link between core histone acetylation and transcriptionally active chromatin.

Hebbes, T. R., Thorne, A. W., & Crane‐Robinson, C. (1988) · The EMBO Journal · doi:10.1002/j.1460-2075.1988.tb02956.x · Cited by 921 · see citing works

Germline DNA Demethylation Dynamics and Imprint Erasure through 5-hydroxymethylcytosine

Hackett, J. A., Sengupta, R., Żylicz, J. J., Murakami, K., Lee, C., Down, T., & Surani, M. (2012) · Science · doi:10.1126/science.1229277 · Cited by 762 · see citing works

Molecular Mechanisms of Vitamin D Action

Haussler, M. R., Whitfield, G. K., Kaneko, I., Haussler, C. A., Hsieh, D., Hsieh, J.-C., & Jurutka, P. W. (2013) · Calcified Tissue International · doi:10.1007/s00223-012-9619-0 · Cited by 759 · see citing works

Gadd45a promotes epigenetic gene activation by repair-mediated DNA demethylation

Barreto, G., Schäfer, A., Marhold, J., Stach, D., Swaminathan, S. K., Handa, V., Doederlein, G., Maltry, N., Wu, W., Lyko, F., et al. (2007) · Nature · doi:10.1038/nature05515 · Cited by 758 · see citing works

The putative oncogene GASC1 demethylates tri- and dimethylated lysine 9 on histone H3

Cloos, P. A., Christensen, J., Agger, K., Maiolica, A., Rappsilber, J., Antal, T., Hansen, K. H., & Helin, K. (2006) · Nature · doi:10.1038/nature04837 · Cited by 738 · see citing works

Loss of IGF2 Imprinting: A Potential Marker of Colorectal Cancer Risk

Cui, H., Cruz-Correa, M. R., Giardiello, F. M., Hutcheon, D. F., Kafonek, D. R., Brandenburg, S. A., Wu, Y., He, X., Powe, N. R., & Feinberg, A. P. (2003) · Science · doi:10.1126/science.1080902 · Cited by 735 · see citing works

Epigenetic gene silencing in cancer: the DNA hypermethylome

Esteller, M. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddm018 · Cited by 725 · see citing works

Dynamic Regulation of Histone Lysine Methylation by Demethylases

Shi, Y., & Whetstine, J. R. (2007) · Molecular Cell · doi:10.1016/j.molcel.2006.12.010 · Cited by 710 · see citing works

The X-Linked Mental Retardation Gene SMCX/JARID1C Defines a Family of Histone H3 Lysine 4 Demethylases

Iwase, S., Lan, F., Bayliss, P. E., de la Torre-Ubieta, L., Huarte, M., Qi, H. H., Whetstine, J. R., Bonni, A., Roberts, T. M., & Shi, Y. (2007) · Cell · doi:10.1016/j.cell.2007.02.017 · Cited by 695 · see citing works

The UCSC Genome Browser database: 2014 update

Karolchik, D., Barber, G. P., Casper, J., Clawson, H., Cline, M. S., Diekhans, M., Dreszer, T. R., Fujita, P. A., Guruvadoo, L., Haeussler, M., et al. (2014) · Nucleic Acids Research · doi:10.1093/nar/gkt1168 · Cited by 670 · see citing works

The transcriptional repressor JHDM3A demethylates trimethyl histone H3 lysine 9 and lysine 36

Klose, R. J., Yamane, K., Bae, Y., Zhang, D., Erdjument‐Bromage, H., Tempst, P., Wong, J., & Zhang, Y. (2006) · Nature · doi:10.1038/nature04853 · Cited by 630 · see citing works

Sirtuins in aging and age-related disease

Longo, V. D., & Kennedy, B. K. (2006) · Cell · doi:10.1016/j.cell.2006.07.002 · Cited by 628 · see citing works

DNA Methylation Markers and Early Recurrence in Stage I Lung Cancer

Brock, M. V., Hooker, C. M., Ota-Machida, E., Han, Y. K., Guo, M., Ames, S., Glöckner, S. C., Piantadosi, S., Gabrielson, E. W., Pridham, G., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0706550 · Cited by 594 · see citing works

Reversal of Histone Methylation: Biochemical and Molecular Mechanisms of Histone Demethylases

Mosammaparast, N., & Shi, Y. (2010) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.78.070907.103946 · Cited by 585 · see citing works

Histone deacetylase 3 (HDAC3) and other class I HDACs regulate colon cell maturation and p21 expression and are deregulated in human colon cancer

Wilson, A. J., Byun, D.-S., Popova, N., Murray, L. B., L'Italien, K., Sowa, Y., Arango, D., Velcich, A., Augenlicht, L. H., & Mariadason, J. M. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m510023200 · Cited by 575 · see citing works

Epigenetic changes may contribute to the formation and spontaneous regression of retinoblastoma

Greger, V., Passarge, E., H�pping, W., Messmer, E. P., & Horsthemke, B. (1989) · Human Genetics · doi:10.1007/bf00286709 · Cited by 573 · see citing works

RBP2 Belongs to a Family of Demethylases, Specific for Tri-and Dimethylated Lysine 4 on Histone 3

Christensen, J. F., Agger, K., Cloos, P. A., Pasini, D., Rose, S., Sennels, L., Rappsilber, J., Hansen, K. H., Salcini, A. E., & Helin, K. (2007) · Cell · doi:10.1016/j.cell.2007.02.003 · Cited by 554 · see citing works

Vitamin D controls T cell antigen receptor signaling and activation of human T cells

von Essen, M. R., Kongsbak‐Wismann, M., Schjerling, P., Ølgaard, K., Ødum, N., & Geisler, C. (2010) · Nature Immunology · doi:10.1038/ni.1851 · Cited by 537 · see citing works

DNA Oxidation as Triggered by H3K9me2 Demethylation Drives Estrogen-Induced Gene Expression

Perillo, B., Ombra, M. N., Bertoni, A., Cuozzo, C., Sacchetti, S., Sasso, A., Chiariotti, L., Malorni, A., Abbondanza, C., & Avvedimento, E. V. (2008) · Science · doi:10.1126/science.1147674 · Cited by 529 · see citing works

Induction of HDAC2 expression upon loss of APC in colorectal tumorigenesis

Zhu, P., Martin, E., Mengwasser, J., Schlag, P., Janssen, K., & Göttlicher, M. (2004) · Cancer Cell · doi:10.1016/s1535-6108(04)00114-x · Cited by 527 · see citing works

DNA Methyltransferases, DNA Damage Repair, and Cancer

Jin, B., & Robertson, K. D. (2012) · Advances in experimental medicine and biology · doi:10.1007/978-1-4419-9967-2_1 · Cited by 521 · see citing works

Upregulation and Nuclear Recruitment of HDAC1 in Hormone Refractory Prostate Cancer

Halkidou, K., Gaughan, L., Cook, S., Leung, H. Y., Neal, D. E., & Robson, C. N. (2004) · The Prostate · doi:10.1002/pros.20022 · Cited by 515 · see citing works

PLU-1 Is an H3K4 Demethylase Involved in Transcriptional Repression and Breast Cancer Cell Proliferation

Yamane, K., Tateishi, K., Klose, R. J., Fang, J., Fabrizio, L. A., Erdjument‐Bromage, H., Taylor‐Papadimitriou, J., Tempst, P., & Zhang, Y. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.03.001 · Cited by 493 · see citing works

Depressed expression of calcium receptor in parathyroid gland tissue of patients with hyperparathyroidism

Gogusev, J., Duchambon, P., Hory, B., Giovannini, M., Goureau, Y., Sarfati, E., & Drüeke, T. B. (1997) · Kidney International · doi:10.1038/ki.1997.41 · Cited by 489 · see citing works

Androgen Receptor Coactivators Lysine-Specific Histone Demethylase 1 and Four and a Half LIM Domain Protein 2 Predict Risk of Prostate Cancer Recurrence

Kahl, P., Gullotti, L., Heukamp, L. C., Wolf, S. A., Friedrichs, N., VORREUTHER, R., Solleder, G., Bastian, P. J., Ellinger, J., Metzger, E., et al. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-1570 · Cited by 475 · see citing works

Allele-specific hypermethylation of the retinoblastoma tumor-suppressor gene.

Sakai, T., Toguchida, J., Ohtani, N., Yandell, D. W., Rapaport, J. M., & Dryja, T. P. (1991) · PubMed · Cited by 470 · see citing works

Sirtuins as potential targets for metabolic syndrome

Guarente, L. (2006) · Nature · doi:10.1038/nature05486 · Cited by 468 · see citing works

CpG methylation is maintained in human cancer cells lacking DNMT1

Rhee, I. P., Jair, K., Yen, R.-W. C., Christoph Lengauer, C., Herman, J. G., Kinzler, K. W., Vogelstein, B., Baylin, S. B., & Schuebel, K. E. (2000) · Nature · doi:10.1038/35010000 · Cited by 453 · see citing works

Lysine-Specific Demethylase 1 Is Strongly Expressed in Poorly Differentiated Neuroblastoma: Implications for Therapy

Schulte, J. H., Lim, S., Schramm, A. R., Friedrichs, N., Köster, J., Versteeg, R., Øra, I., Pajtler, K. W., Klein‐Hitpaß, L., Kuhfittig-Kulle, S., et al. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-1735 · Cited by 447 · see citing works

The Retinoblastoma Binding Protein RBP2 Is an H3K4 Demethylase

Klose, R. J., Yan, Q., Tóthová, Z., Yamane, K., Erdjument‐Bromage, H., Tempst, P., Gilliland, D. G., Zhang, Y., & Kaelin, W. G. (2007) · Cell · doi:10.1016/j.cell.2007.02.013 · Cited by 446 · see citing works

Histone Methylation-Dependent Mechanisms Impose Ligand Dependency for Gene Activation by Nuclear Receptors

García-Bassets, I., Kwon, Y., Telese, F., Préfontaine, G. G., Hutt, K. R., Cheng, C. S., Ju, B., Ohgi, K. A., Wang, J., Escoubet‐Lozach, L., et al. (2007) · Cell · doi:10.1016/j.cell.2006.12.038 · Cited by 438 · see citing works

Chromatin proteins and modifications as drug targets

Helin, K., & Dhanak, D. (2013) · Nature · doi:10.1038/nature12751 · Cited by 435 · see citing works

The histone H3K4 demethylase SMCX links REST target genes to X-linked mental retardation

Tahiliani, M., Mei, P., Fang, R., Leonor, T., Rutenberg, M. S., Shimizu, F., Li, J., Rao, A., & Shi, Y. G. (2007) · Nature · doi:10.1038/nature05823 · Cited by 429 · see citing works

The cancer epigenome—components and functional correlatesPreprint

Ting, A. H., McGarvey, K. M., & Baylin, S. B. (2006) · Genes & Development · doi:10.1101/gad.1464906 · Cited by 416 · see citing works

Conserved Metabolic Regulatory Functions of Sirtuins

Schwer, B., & Verdin, E. M. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2007.11.006 · Cited by 415 · see citing works

JARID1B is a histone H3 lysine 4 demethylase up-regulated in prostate cancer

Xiang, Y., Zhu, Z., Han, G., Ye, X., Xu, B., Peng, Z., Ma, Y., Yu, Y., Lin, H., Chen, A. P., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0700735104 · Cited by 395 · see citing works

Histone demethylases in development and disease

Pedersen, M. T., & Helin, K. (2010) · Trends in Cell Biology · doi:10.1016/j.tcb.2010.08.011 · Cited by 394 · see citing works

Jmjd2b antagonizes H3K9 trimethylation at pericentric heterochromatin in mammalian cellsPreprint

Fodor, B. D., Kubicek, S., Yonezawa, M., O’Sullivan, R. J., Sengupta, R., Perez-Burgos, L., Opravil, S., Mechtler, K., Schotta, G., & Jenuwein, T. (2006) · Genes & Development · doi:10.1101/gad.388206 · Cited by 376 · see citing works

Co‐operation and communication between the human maintenance and de novo DNA (cytosine‐5) methyltransferases

Kim, G., Ni, J., Kelesoglu, N., Roberts, R. J., & Pradhan, S. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf401 · Cited by 358 · see citing works

Expression Profile of Histone Deacetylase 1 in Gastric Cancer Tissues

Choi, J., Kwon, H. J., Yoon, B., Kim, J., Han, S., Joo, H. J., & Kim, D.-Y. (2001) · Japanese Journal of Cancer Research · doi:10.1111/j.1349-7006.2001.tb02153.x · Cited by 349 · see citing works

Quantitation of HDAC1 mRNA Expression in Invasive Carcinoma of the Breast*

Zhang, Z., Yamashita, H., Toyama, T., Sugiura, H., Ando, Y., Mita, K., Hamaguchi, M., Hara, Y., Kobayashi, S., & Iwase, H. (2005) · Breast Cancer Research and Treatment · doi:10.1007/s10549-005-6001-1 · Cited by 307 · see citing works

Tet1 controls meiosis by regulating meiotic gene expression

Yamaguchi, S., Hong, K., Liu, R., Shen, L., Inoue, A., Diep, D. H., Zhang, K., & Zhang, Y. (2012) · Nature · doi:10.1038/nature11709 · Cited by 307 · see citing works

Vitamin D for treatment and prevention of infectious diseases: A systematic review of randomized controlled trials

Yamshchikov, A. V., Desai, N. S., Blumberg, H. M., Ziegler, T. R., & Tangpricha, V. (2009) · Endocrine Practice · doi:10.4158/ep09101.orr · Cited by 307 · see citing works

hMLH1 Promoter Hypermethylation Is an Early Event in Human Endometrial Tumorigenesis

Esteller, M., Catasús, L., Matías‐Guiu, X., Mutter, G. L., Prat, J., Baylin, S. B., & Herman, J. G. (1999) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)65492-2 · Cited by 305 · see citing works

Methylation of CpG sequences in eukaryotic DNA

Gruenbaum, Y., Stein, R., Cedar, H., & Razin, A. (1981) · FEBS Letters · doi:10.1016/0014-5793(81)80055-5 · Cited by 301 · see citing works

Cancer epigenetics: linking basic biology to clinical medicine

Tsai, H.-C., & Baylin, S. B. (2011) · Cell Research · doi:10.1038/cr.2011.24 · Cited by 298 · see citing works

Epigenetics provides a new generation of oncogenes and tumour-suppressor genes

Esteller, M. (2006) · British Journal of Cancer · doi:10.1038/sj.bjc.6602918 · Cited by 285 · see citing works

JHDM1B/FBXL10 is a nucleolar protein that represses transcription of ribosomal RNA genes

Frescas, D., Guardavaccaro, D., Bassermann, F., Koyama-Nasu, R., & Pagano, M. (2007) · Nature · doi:10.1038/nature06255 · Cited by 284 · see citing works

Co-evolution of X-chromosome inactivation and imprinting in mammals

Reik, W., & Lewis, A. (2005) · Nature Reviews Genetics · doi:10.1038/nrg1602 · Cited by 267 · see citing works

An evaluation of new criteria for CpG islands in the human genome as gene markers

Wang, Y., & Leung, F. C. (2004) · Bioinformatics · doi:10.1093/bioinformatics/bth059 · Cited by 267 · see citing works

Placenta-specific Methylation of the Vitamin D 24-Hydroxylase Gene

Novakovic, B., Sibson, M., Ng, H. K., Manuelpillai, U., Rakyan, V. K., Down, T. A., Beck, S., Fournier, T., Evain-Brion, D., Dimitriadis, E., et al. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m809542200 · Cited by 238 · see citing works

Sirtuins, melatonin and circadian rhythms: building a bridge between aging and cancer

Jung-Hynes, B. D., Reiter, R. J., & Ahmad, N. (2009) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2009.00729.x · Cited by 234 · see citing works

A Novel Gene (PLU-1) Containing Highly Conserved Putative DNA/Chromatin Binding Motifs Is Specifically Up-regulated in Breast Cancer

Lu, P., Sundquist, K., Baeckström, D., Poulsom, R., Hanby, A. M., Meier‐Ewert, S., Jones, T. A., Mitchell, M., Pitha-Rowe, P. M., Freemont, P. S., et al. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.22.15633 · Cited by 231 · see citing works

Vitamin D nutritional policy needs a vision for the future

Norman, A. W., & Bouillon, R. (2010) · Experimental Biology and Medicine · doi:10.1258/ebm.2010.010014 · Cited by 228 · see citing works

DNA methylation and genomic imprinting: insights from cancer into epigenetic mechanisms

Feinberg, A. P., Cui, H., & OHLSSON, R. I. (2002) · Seminars in Cancer Biology · doi:10.1016/s1044-579x(02)00059-7 · Cited by 219 · see citing works

The Tumor Suppressor p53 and Histone Deacetylase 1 Are Antagonistic Regulators of the Cyclin-Dependent Kinase Inhibitor p21/WAF1/CIP1 Gene

Egger, G., Doetzlhofer, A., Schuettengruber, B., Haidweger, E., Simboeck, E., Tischler, J., Chiocca, S., Suske, G., Rotheneder, H., Wintersberger, E., et al. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.8.2669-2679.2003 · Cited by 214 · see citing works

Dual metabolic pathway of 25‐hydroxyvitamin D3 catalyzed by human CYP24

Sakaki, T., Sawada, N., Komai, K., Shiozawa, S., Yamada, S., Yamamoto, K., Ohyama, Y., & Inouye, K. (2000) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.2000.01680.x · Cited by 186 · see citing works

Localization of 25-hydroxyvitamin D3 1 alpha-hydroxylase and 24-hydroxylase along the rat nephron.

Kawashima, H., Torikai, S., & Kurokawa, K. (1981) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.78.2.1199 · Cited by 186 · see citing works

The Wnt antagonist DICKKOPF-1 gene is induced by 1 ,25-dihydroxyvitamin D3 associated to the differentiation of human colon cancer cells

Aguilera, O., Peña, C., Garcia, J. M., Larriba, M. J., Ordóñez‐Morán, P., Navarro, D., Barbáchano, A., de Silanes, I. L., Ballestar, E., Fraga, M. F., et al. (2007) · Carcinogenesis · doi:10.1093/carcin/bgm094 · Cited by 180 · see citing works

VDR-Alien: a novel, DNA-selective vitamin D3 receptor-corepressor partnership

Polly, P. (2000) · The FASEB Journal · doi:10.1096/fj.14.10.1455 · Cited by 178 · see citing works

LSD1-mediated epigenetic modification contributes to proliferation and metastasis of colon cancer

Ding, J., Zhang, Z.-M., Yi, X., Liao, G.-Q., Pan, Y., Liu, S., Zhang, Y., & Yan, Z.-S. (2013) · British Journal of Cancer · doi:10.1038/bjc.2013.364 · Cited by 178 · see citing works

KDM6B/JMJD3 Histone Demethylase Is Induced by Vitamin D and Modulates Its Effects in Colon Cancer Cells

Pereira, F., Barbáchano, A., Silva, J., Bonilla, F., Campbell, M. J., Muñoz, A., & Larriba, M. J. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr399 · Cited by 177 · see citing works

Histone Deacetylases

Parbin, S., Kar, S., Shilpi, A., Sengupta, D., Deb, M., Rath, S. K., & Patra, S. K. (2013) · Journal of Histochemistry & Cytochemistry · doi:10.1369/0022155413506582 · Cited by 172 · see citing works

HDAC4 represses p21WAF1/Cip1 expression in human cancer cells through a Sp1-dependent, p53-independent mechanism

Mottet, D., Pirotte, S., Lamour, V., Hagedorn, M., Javerzat, S., Bikfalvi, A., Bellahcène, A., Verdin, E. M., & CASTRONOVO, V. (2008) · Oncogene · doi:10.1038/onc.2008.371 · Cited by 156 · see citing works

G2/M Arrest by 1,25-Dihydroxyvitamin D3 in Ovarian Cancer Cells Mediated through the Induction of GADD45 via an Exonic Enhancer

Jiang, F., Li, P., Fornace, A. J., Nicosia, S. V., & Bai, W. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m308430200 · Cited by 148 · see citing works

Fundamentals of vitamin D hormone-regulated gene expression

Pike, J. W., & Meyer, M. B. (2013) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2013.11.004 · Cited by 144 · see citing works

Transcriptional coregulators of the nuclear receptor superfamily: coactivators and corepressors

Lee*, J. W., Lee, Y. C., Na, S.-Y., Jung, D.-J., & Lee, S.-K. (2001) · Cellular and Molecular Life Sciences · doi:10.1007/pl00000856 · Cited by 139 · see citing works

KDM2A represses transcription of centromeric satellite repeats and maintains the heterochromatic state

Frescas, D., Guardavaccaro, D., Kuchay, S., Kato, H., Poleshko, A. S., Basrur, V., Elenitoba‐Johnson, K. S. J., Katz, R. A., & Pagano, M. (2008) · Cell Cycle · doi:10.4161/cc.7.22.7062 · Cited by 136 · see citing works

Vitamin D and Wnt/beta-catenin pathway in colon cancer: role and regulation of DICKKOPF genes.

Pendás-Franco, N., Aguilera, O., Pereira, F., González‐Sancho, J. M., & Múñoz, A. (2008) · PubMed · Cited by 134 · see citing works

MicroRNA-627 Mediates the Epigenetic Mechanisms of Vitamin D to Suppress Proliferation of Human Colorectal Cancer Cells and Growth of Xenograft Tumors in Mice

Padi, S. K. R., Zhang, Q., Rustum, Y. M., Morrison, C., & Guo, B. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.04.012 · Cited by 131 · see citing works

Vitamin D has wide regulatory effects on histone demethylase genes

Pereira, F., Barbáchano, A., Singh, P. K., Campbell, M. J., Múñoz, A., & Larriba, M. J. (2012) · Cell Cycle · doi:10.4161/cc.11.6.19508 · Cited by 124 · see citing works

Regulation of target gene expression by the vitamin D receptor - an update on mechanisms

Pike, J. W., Meyer, M. B., & Bishop, K. A. (2011) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-011-9198-9 · Cited by 123 · see citing works

Members of a family of JmjC domain-containing oncoproteins immortalize embryonic fibroblasts via a JmjC domain-dependent process

Pfau, R., Tzatsos, A., Kampranis, S. C., Serebrennikova, O. B., Bear, S. E., & Tsichlis, P. N. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0711865105 · Cited by 119 · see citing works

Synergistic growth inhibition of prostate cancer cells by 1α,25 Dihydroxyvitamin D3 and its 19-nor-hexafluoride analogs in combination with either sodium butyrate or trichostatin A

Rashid, S. F., Moore, J. S., Walker, E. S., Driver, P. M., Engel, J., Edwards, C. E., Brown, G., Uskoković, M. R., & Campbell, M. J. (2001) · Oncogene · doi:10.1038/sj.onc.1204269 · Cited by 118 · see citing works

1α,25(OH)2D3-Induced Transrepression by Vitamin D Receptor through E-Box-Type Elements in the Human Parathyroid Hormone Gene Promoter

Kim, M. S., Fujiki, R., Murayama, A., Kitagawa, H., Yamaoka, K., Yamamoto, Y., Mihara, M., Takeyama, K.-I., & Kato, S. (2006) · Molecular Endocrinology · doi:10.1210/me.2006-0231 · Cited by 114 · see citing works

Reduced Parathyroid Vitamin D Receptor Messenger Ribonucleic Acid Levels in Primary and Secondary Hyperparathyroidism

Carling, T., Rastad, J., Szabó, E., Westin, G., & Åkerström, G. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.85.5.2000 · Cited by 112 · see citing works

Cyclical Chromatin Looping and Transcription Factor Association on the Regulatory Regions of the p21 (CDKN1A) Gene in Response to 1α,25-Dihydroxyvitamin D3

Saramäki, A., Diermeier, S. D., Kellner, R., Laitinen, H. M., Vaïsänen, S., & Carlberg, C. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m808090200 · Cited by 109 · see citing works

Epigenetic Specificity of Loss of Imprinting of the IGF2 Gene in Wilms Tumors

Bjornsson, H. T., Brown, L. J., Fallin, M. D., Rongione, M. A., Bibikova, M. V., Wickham‐Garcia, E., Fan, J., & Feinberg, A. P. (2007) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djm069 · Cited by 109 · see citing works

A review of dietary factors and its influence on DNA methylation in colorectal carcinogenesis

Arasaradnam, R. P., Commane, D. M., Bradburn, D., & Mathers, J. C. (2008) · Epigenetics · doi:10.4161/epi.3.4.6508 · Cited by 108 · see citing works

A Genome-Wide Methylation Study of Severe Vitamin D Deficiency in African American Adolescents

Zhu, H., Wang, X., Shi, H., Su, S., Harshfield, G. A., Gutin, B., Snieder, H., & Dong, Y. (2012) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2012.10.059 · Cited by 105 · see citing works

Heterochromatin Protein 1a Stimulates Histone H3 Lysine 36 Demethylation by the Drosophila KDM4A Demethylase

Lin, C., Li, B., Swanson, S. K., Zhang, Y., Florens, L. A., Washburn, M. P., Abmayr, S. M., & Workman, J. L. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.11.008 · Cited by 104 · see citing works

Impact of vitamin D metabolism on clinical epigenetics

Karlic, H., & Varga, F. (2011) · Clinical Epigenetics · doi:10.1007/s13148-011-0021-y · Cited by 103 · see citing works

DNA methylation-related vitamin D receptor insensitivity in breast cancer

Marik, R., Fackler, M. J., Gabrielson, E. W., Zeiger, M. A., Sukumar, S. V., Stearns, V., & Umbricht, C. B. (2010) · Cancer Biology & Therapy · doi:10.4161/cbt.10.1.11994 · Cited by 103 · see citing works

Nutritional factors and gender influence age‐related DNA methylation in the human rectal mucosa

Tapp, H. S., Commane, D. M., Bradburn, D. M., Arasaradnam, R. P., Mathers, J. C., Johnson, I. T., & Belshaw, N. J. (2012) · Aging Cell · doi:10.1111/acel.12030 · Cited by 101 · see citing works

Short Chain Fatty Acids and Colon Cancer

Augenlicht, L. H., Mariadason, J. M., Wilson, A., Arango, D., Yang, W., Heerdt, B. G., & Velcich, A. (2002) · Journal of Nutrition · doi:10.1093/jn/132.12.3804s · Cited by 99 · see citing works

Epigenetic Regulation of Vitamin D 24-Hydroxylase/ CYP24A1 in Human Prostate Cancer

Luo, W., Karpf, A. R., Deeb, K. K., Muindi, J. R., Morrison, C. D., Johnson, C. S., & Trump, D. L. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-0617 · Cited by 99 · see citing works

Vitamin D stimulates apoptosis in gastric cancer cells in synergy with trichostatin A /sodium butyrate‐induced and 5‐aza‐2′‐deoxycytidine‐induced PTEN upregulation

Pan, L., Matloob, A. F., Du, J., Pan, H., Dong, Z., Zhao, J., Feng, Y., Zhong, Y., Huang, B., & Lü, J. (2010) · FEBS Journal · doi:10.1111/j.1742-4658.2009.07542.x · Cited by 98 · see citing works

Discovery of novel epigenetic markers in non-Hodgkin's lymphoma

Shi, H., Guo, J., Duff, D. J., Rahmatpanah, F. B., Chitima-Matsiga, R., Al-Kuhlani, M., Taylor, K. H., Sjahputera, O., Andreski, M. W., Wooldridge, J. E., et al. (2006) · Carcinogenesis · doi:10.1093/carcin/bgl092 · Cited by 92 · see citing works

HDAC3 impacts multiple oncogenic pathways in colon cancer cells with effects on Wnt and vitamin D signaling

Godman, C. A., Joshi, R. A., Tierney, B. R., Greenspan, E. J., Rasmussen, T. P., Wang, H., Shin, D., Rosenberg, D. W., & Giardina, C. A. (2008) · Cancer Biology & Therapy · doi:10.4161/cbt.7.10.6561 · Cited by 87 · see citing works

Expressed CpG island sequence tag microarray for dual screening of DNA hypermethylation and gene silencing in cancer cells.

Shi, H., Yan, P. S., Chen, C., Rahmatpanah, F. B., Lofton–Day, C., Caldwell, C. W., & Huang, T. H. ‐. (2002) · PubMed · Cited by 85 · see citing works

Role of Calcium, Vitamin D, and the Extrarenal Vitamin D Hydroxylases in Carcinogenesis

Höbaus, J., Thiem, U., Hummel, D. M., & Kállay, E. (2012) · Anti-Cancer Agents in Medicinal Chemistry · doi:10.2174/187152013804487434 · Cited by 84 · see citing works

1Alpha,25-dihydroxyvitamin D3 induces de novo E-cadherin expression in triple-negative breast cancer cells by CDH1-promoter demethylation.

Lopes, N., Carvalho, J., Durães, C., Sousa, B., Gomes, M., Costa, J. L., Oliveíra, C., Paredes, J., & Schmitt, F. C. (2012) · PubMed · Cited by 82 · see citing works

Vitamin D receptor gene methylation is associated with ethnicity, tuberculosis, and TaqI polymorphism

Andraos, C., Koorsen, G., Knight, J. C., & Bornman, L. (2010) · Human Immunology · doi:10.1016/j.humimm.2010.12.010 · Cited by 81 · see citing works

Transposons Reanimated in Mice

Bestor, T. H. (2005) · Cell · doi:10.1016/j.cell.2005.07.024 · Cited by 74 · see citing works

Increased copy‐number and not DNA hypomethylation causes overexpression of the candidate proto‐oncogene CYP24A1 in colorectal cancer

Höbaus, J., Hummel, D. M., Thiem, U., Fetahu, I. S., Aggarwal, A., Müllauer, L., Heller, G., Egger, G., Mesteri, I., Baumgartner-Parzer, S. M., et al. (2013) · International Journal of Cancer · doi:10.1002/ijc.28143 · Cited by 74 · see citing works

Methyl-CpG-binding proteins in cancer: blaming the DNA methylation messenger

Ballestar, E., & Esteller, M. (2005) · Biochemistry and Cell Biology · doi:10.1139/o05-035 · Cited by 70 · see citing works

Dynamics of 1α,25-dihydroxyvitamin D3-dependent chromatin accessibility of early vitamin D receptor target genes

Seuter, S., Pehkonen, P., Heikkinen, S., & Carlberg, C. (2013) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2013.10.003 · Cited by 69 · see citing works

Involvement of promoter methylation in the regulation of Pregnane X receptor in colon cancer cells

Habano, W., Gamou, T., Terashima, J., Sugai, T., Otsuka, K., Wakabayashi, G., & Ozawa, S. (2011) · BMC Cancer · doi:10.1186/1471-2407-11-81 · Cited by 68 · see citing works

Epigenetic Regulation of BMP2 by 1,25-dihydroxyvitamin D3 through DNA Methylation and Histone Modification

Fu, B., Wang, H., Wang, J., Barouhas, I., Liu, W., Shuboy, A., Bushinsky, D. A., Zhou, D., & Favus, M. J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0061423 · Cited by 59 · see citing works

Epigenetic corruption of VDR signalling in malignancy.

Abedin, S. A., Banwell, C. M., Colston, K. W., Carlberg, C., & Campbell, M. J. (2006) · PubMed · Cited by 59 · see citing works

Persistent Downregulation of Calcium-Sensing Receptor mRNA in Rat Parathyroids when Severe Secondary Hyperparathyroidism Is Reversed by an Isogenic Kidney Transplantation

Lewin, E., Garfia, B., Luque, F., Rodríguez, M., & Ølgaard, K. (2002) · Journal of the American Society of Nephrology · doi:10.1097/01.asn.0000024439.38838.03 · Cited by 59 · see citing works

Vitamin D Intake Is Negatively Associated with Promoter Methylation of the Wnt Antagonist GeneDKK1in a Large Group of Colorectal Cancer Patients

Rawson, J. B., Sun, Z., Dicks, E. L., Daftary, D., Parfrey, P. S., Green, R. C., Gallinger, S., McLaughlin, J. R., Wang, P., Knight, J. A., et al. (2012) · Nutrition and Cancer · doi:10.1080/01635581.2012.711418 · Cited by 58 · see citing works

Global and gene-specific promoter methylation analysis in primary hyperparathyroidism

Sulaiman, L. R., Juhlin, C. C., Nilsson, I., Fotouhi, O., Larsson, C., & Hashemi, J. (2013) · Epigenetics · doi:10.4161/epi.24823 · Cited by 58 · see citing works

Recruitment of NCOR1 to VDR target genes is enhanced in prostate cancer cells and associates with altered DNA methylation patterns

Doig, C. L., Singh, P., Dhiman, V. K., Thorne, J. L., Battaglia, S., Sobolewski, M. D., Maguire, O., O’Neill, L. P., Turner, B. M., McCabe, C. J., et al. (2012) · Carcinogenesis · doi:10.1093/carcin/bgs331 · Cited by 58 · see citing works

Genome-Wide Analysis of Histone H3 Lysine9 Modifications in Human Mesenchymal Stem Cell Osteogenic Differentiation

Tan, J., Lü, J., Huang, W., Dong, Z., Kong, C., Li, L., Gao, L., Guo, J., & Huang, B. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006792 · Cited by 56 · see citing works

The Cancer Epigenome: Its Origins, Contributions to Tumorigenesis, and Translational Implications

Baylin, S. B. (2012) · Proceedings of the American Thoracic Society · doi:10.1513/pats.201201-001ms · Cited by 55 · see citing works

The Vitamin D3 1alpha-Hydroxylase Gene and Its Regulation by Active Vitamin D3

Takeyama, K., & Kato, S. (2011) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.100684 · Cited by 51 · see citing works

PDLIM2 expression is driven by vitamin D and is involved in the pro-adhesion, and anti-migration and -invasion activity of vitamin D

Vanoirbeek, E., Eelen, G., Verlinden, L., Carmeliet, G., Mathieu, C., Bouillon, R., O’Connor, R., Xiao, G., & Verstuyf, A. (2013) · Oncogene · doi:10.1038/onc.2013.123 · Cited by 51 · see citing works

Short-Chain Fatty Acids and Colon Cancer Cells: The Vitamin D Receptor—Butyrate Connection

Gaschott, T., & Stein, J. M. (2003) · Recent results in cancer research/Recent Results in Cancer Research · doi:10.1007/978-3-642-55580-0_18 · Cited by 51 · see citing works

Epigenetic regulation of Vitamin D hydroxylase expression and activity in normal and malignant human prostate cells

Khorchide, M., Lechner, D., & Cross, H. S. (2005) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2004.12.022 · Cited by 47 · see citing works

Vitamin D Receptor is a Novel Drug Target for Ovarian Cancer Treatment

Zhang, X., Nicosia, S. V., & Bai, W. (2006) · Current Cancer Drug Targets · doi:10.2174/156800906776842939 · Cited by 47 · see citing works

25-Hydroxyvitamin D3-24-hydroxylase in rat kidney mitochondria.

Pedersen, J. I., Shobaki, H. H., Holmberg, I., Bergseth, S., & Björkhem, I. (1983) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)33110-7 · Cited by 43 · see citing works

Methylation Status of the CpG Islands in Vitamin D and Calcium-Sensing Receptor Gene Promoters Does Not Explain the Reduced Gene Expressions in Parathyroid Adenomas

Varshney, S., Bhadada, S. K., Sachdeva, N. K., Arya, A. K., Saikia, U. N., Behera, A., & Rao, S. D. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-1699 · Cited by 41 · see citing works

Hypermethylation of the CDKN2A gene promoter is a frequent epigenetic change in periocular sebaceous carcinoma and is associated with younger patient age

Liau, J., Liao, S., Hsiao, C.-H., Lin, M.-C., Chang, H., & Kuo, K. (2013) · Human Pathology · doi:10.1016/j.humpath.2013.10.019 · Cited by 39 · see citing works

Epigenetic regulation of the 1,25-dihydroxyvitamin D3 24-hydroxylase (CYP24A1) in colon cancer cells

Höbaus, J., Fetahu, I. S., Khorchide, M., Manhardt, T., & Kállay, E. (2012) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2012.08.003 · Cited by 38 · see citing works

Integrity of the 1,25-dihydroxyvitamin D3 receptor in bone, lung, and other cancers

Miller, C. W., Roberta Morosetti, A., Campbell, M. J., Mendoza, S., & Koeffler, H. P. (1997) · Molecular Carcinogenesis · doi:10.1002/(sici)1098-2744(199708)19:4 · Cited by 33 · see citing works

1,25-Dihydroxyvitamin D3 induced histone profiles guide discovery of VDR action sites

Meyer, M. B., Benkusky, N. A., & Pike, J. W. (2013) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2013.09.005 · Cited by 30 · see citing works

Epigenetic silencing of CYP24 in the tumor microenvironment

Johnson, C. S., Chung, I., & Trump, D. L. (2010) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2010.03.046 · Cited by 29 · see citing works

VDR hypermethylation and HIV-induced T cell loss

Chandel, N., Husain, M., Goel, H., Salhan, D., Lan, X., Malhotra, A., McGowan, J. P., & Singhal, P. C. (2013) · Journal of Leukocyte Biology · doi:10.1189/jlb.0812383 · Cited by 29 · see citing works

Epigenetic regulation of vitamin D converting enzymes

Wjst, M., Heimbeck, I., Kutschke, D., & Pukelsheim, K. (2010) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2010.03.056 · Cited by 27 · see citing works

PREDICTING DNA METHYLATION SUSCEPTIBILITY USING CpG FLANKING SEQUENCES

KIM, S., Li, M., PAIR, H., Nephew, K. P., Shi, H., Kramer, R., Xu, D. H., & HUANG, T.-H. (2007) · Pacific Symposium on Biocomputing (PSB) · doi:10.1142/9789812776136_0031 · Cited by 26 · see citing works

Regulation of gene expression by the CYP27B1 promoter—study of a transgenic mouse model

Hendrix, I., Anderson, P., May, B. K., & Morris, H. A. (2004) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2004.03.093 · Cited by 26 · see citing works

Expression and function of the vitamin D receptor in malignant germ cell tumour of the testis.

Bremmer, F., Thelen, P., Pottek, T., Behnes, C. L., Radzun, H., & Schweyer, S. (2012) · PubMed · Cited by 24 · see citing works

Sodium butyrate (SB) augments the effects of 1,25 Dihydroxyvitamin D3 (1,25(OH)2D3) on neoplastic and osteoblastic phenotype in clonal rat osteosarcoma cells

Yoneda, T., Aya, S.-I., & SAKUDA, M. (1984) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(84)90748-4 · Cited by 19 · see citing works

Epigenetic distortion to VDR transcriptional regulation in prostate cancer cells

Singh, P. K., Doig, C. L., Dhiman, V. K., Turner, B. M., Smiraglia, D. J., & Campbell, M. J. (2012) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2012.10.002 · Cited by 18 · see citing works

Extensive methylation of CpG island of CYP24 gene in osteoblastic ROS17/2.8 cells

Ohyama, Y., Kusada, T., Yamasaki, T., & Ide, H. (2002) · Nucleic Acids Symposium Series · doi:10.1093/nass/2.1.249 · Cited by 17 · see citing works

Colorectal cancer risk.

Al-Hassan, N. (2006) · PubMed Central · Cited by 15 · see citing works

In silico analysis of the 5′ region of the Vitamin D receptor gene: Functional implications of evolutionary conservation

Halsall, J. A., Osborne, J. E., Hutchinson, P. E., & Pringle, J. H. (2007) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2006.12.046 · Cited by 14 · see citing works

Epigenetic Methylation of ParathyroidCaRandVDRPromoters in Experimental Secondary Hyperparathyroidism

Hofman-Bang, J., Gravesen, E., Ølgaard, K., & Lewin, E. (2012) · International Journal of Nephrology · doi:10.1155/2012/123576 · Cited by 11 · see citing works

EVOLUTION OF X-CHROMOSOME INACTIVATION

Bühler, E. M. (1975) · The Lancet · doi:10.1016/s0140-6736(75)90315-3 · Cited by 6 · see citing works

Maternal plasma folate impacts differential DNA methylation in an epigenome-wide meta-analysis of newborns

Joubert, B. R., den Dekker, H. T., Felix, J. F., Bohlin, J., Ligthart, S., Beckett, E., Tiemeier, H. W., van Meurs, J. B. J., Uitterlinden, A. G., Albert Hofman, D., et al. (2016) · Nature Communications · doi:10.1038/ncomms10577 · Cited by 262 · see citing works

Epigenetics in male reproduction: effect of paternal diet on sperm quality and offspring health

Schagdarsurengin, U., & Steger, K. (2016) · Nature Reviews Urology · doi:10.1038/nrurol.2016.157 · Cited by 222 · see citing works

Vitamin D cell signalling in health and disease

Berridge, M. J. (2015) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2015.01.008 · Cited by 214 · see citing works

Vitamin D Receptor (VDR) Gene Polymorphisms Modify the Response to Vitamin D Supplementation: A Systematic Review and Meta-Analysis

Usategui‐Martín, R., Román, D. A. D. L., Fernández-Gómez, J. M., Ruiz‐Mambrilla, M., & Pérez-Castrillón, J.-L. (2022) · Nutrients · doi:10.3390/nu14020360 · Cited by 201 · see citing works

Regulation of the vitamin D receptor gene by environment, genetics and epigenetics

Saccone, D. S., Asani, F. F., & Bornman, L. (2015) · Gene · doi:10.1016/j.gene.2015.02.024 · Cited by 188 · see citing works

Role of Vitamin D in the Hygiene Hypothesis: The Interplay between Vitamin D, Vitamin D Receptors, Gut Microbiota, and Immune Response

Clark, A. P., & Mach, N. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00627 · Cited by 168 · see citing works

The effects of long-term daily folic acid and vitamin B12 supplementation on genome-wide DNA methylation in elderly subjects

Kok, D. E. G., Dhonukshe-Rutten, R. A. M., Lute, C., Heil, S. G., Uitterlinden, A. G., van der Velde, N., van Meurs, J. B. J., van Schoor, N. M., Hooiveld, G. J. E. J., de Groot, C. P. G. M., et al. (2015) · Clinical Epigenetics · doi:10.1186/s13148-015-0154-5 · Cited by 168 · see citing works

Vitamin D: Newer Concepts of Its Metabolism and Function at the Basic and Clinical Level

Bikle, D. D. (2020) · Journal of the Endocrine Society · doi:10.1210/jendso/bvz038 · Cited by 172 · see citing works

Biology of colorectal cancer

Arvelo, F. A. (2015) · ecancermedicalscience · doi:10.3332/ecancer.2015.520 · Cited by 152 · see citing works

Vitamin D deficiency accelerates ageing and age‐related diseases: a novel hypothesis

Berridge, M. J. (2017) · The Journal of Physiology · doi:10.1113/jp274887 · Cited by 142 · see citing works

Epigenetic-sensitive pathways in personalized therapy of major cardiovascular diseases

Schiano, C., Benincasa, G., Franzese, M., Mura, N. D., Pane, K., Salvatore, M., & Claudio Napoli, A. (2020) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2020.107514 · Cited by 136 · see citing works

Vitamin D, reactive oxygen species and calcium signalling in ageing and disease

Berridge, M. J. (2016) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2015.0434 · Cited by 127 · see citing works

Prenatal epigenetics diets play protective roles against environmental pollution

Li, S.-Z., Chen, M., Li, Y.-Y., & Tollefsbol, T. (2019) · Clinical Epigenetics · doi:10.1186/s13148-019-0659-4 · Cited by 103 · see citing works

Low serum vitamin D is associated with axial length and risk of myopia in young children

Tideman, J. W. L., Polling, J. R., Voortman, T., Jaddoe, V. W. V., Uitterlinden, A. G., Albert Hofman, D., Vingerling, J. R., Franco, O. H., & Klaver, C. C. W. (2016) · European Journal of Epidemiology · doi:10.1007/s10654-016-0128-8 · Cited by 117 · see citing works

Impact of vitamin D on pregnancy-related disorders and on offspring outcome

von Websky, K., Hasan, A. A., Reichetzeder, C., Tsuprykov, O., & Hocher, B. (2017) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2017.11.008 · Cited by 109 · see citing works

Biological Effects of CYP11A1-Derived Vitamin D and Lumisterol Metabolites in the Skin

Slominski, A. T., Kim, T., Janjetović, Z., Slominski, R. M., Li, W., Jetten, A. M., Indra, A. K., Mason, R. S., & Tuckey, R. C. (2024) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2024.04.022 · Cited by 109 · see citing works

Inhibition of the mevalonate pathway affects epigenetic regulation in cancer cells

Karlic, H., Thaler, R., Gerner, C., Grunt, T. W., Proestling, K., Haider, F., & Varga, F. (2015) · Cancer Genetics · doi:10.1016/j.cancergen.2015.03.008 · Cited by 104 · see citing works

Functional genomics analysis of vitamin D effects on CD4+ T cells in vivo in experimental autoimmune encephalomyelitis

Zeitelhofer, M., Adzemovic, M. Z., Gómez-Cabrero, D., Bergman, P., Hochmeister, S., N’diaye, M., Paulson, A., Ruhrmann, S., Almgren, M., Tegner, J. N., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1615783114 · Cited by 102 · see citing works

Vitamin D as a Nutri-Epigenetic Factor in Autoimmunity—A Review of Current Research and Reports on Vitamin D Deficiency in Autoimmune Diseases

Mazur, A., Frączek, P., & Tabarkiewicz, J. (2022) · Nutrients · doi:10.3390/nu14204286 · Cited by 106 · see citing works

Molecular endocrinology of vitamin D on the epigenome level

Carlberg, C. (2017) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2017.03.016 · Cited by 100 · see citing works

Placental uptake and metabolism of 25(OH)vitamin D determine its activity within the fetoplacental unit

Ashley, B., Simner, C., Manousopoulou, A., Jenkinson, C., Hey, F., Frost, J. M., Rezwan, F. I., White, C. H., Lofthouse, E. M., Hyde, E., et al. (2022) · eLife · doi:10.7554/elife.71094 · Cited by 92 · see citing works

Aberrant DNA methylation profile exacerbates inflammation and neurodegeneration in multiple sclerosis patients

Celarain, N., & Tomàs-Roig, J. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1667-1 · Cited by 87 · see citing works

Role of vitamin D in cytotoxic T lymphocyte immunity to pathogens and cancer

Sarkar, S., Hewison, M., Studzinski, G. P., Li, Y. C., & Kalia, V. (2015) · Critical Reviews in Clinical Laboratory Sciences · doi:10.3109/10408363.2015.1094443 · Cited by 89 · see citing works

Vitamin D in obesity and obesity-related diseases: an overview

Barrea, L., Frías-Toral, E., Pugliese, G., Garcia-Velasquez, E., Carignano, M. D. L. A., Savastano, S., Colao, A., & Muscogiuri, G. (2021) · Minerva Endocrinology · doi:10.23736/s2724-6507.20.03299-x · Cited by 87 · see citing works

Recent Findings in Alzheimer Disease and Nutrition Focusing on Epigenetics

Athanasopoulos, D., Karagiannis, G., & Tsolaki, M. (2016) · Advances in Nutrition · doi:10.3945/an.116.012229 · Cited by 81 · see citing works

Nutritive vitamins as epidrugs

Nur, S. M., Rath, S., Ahmad, V., Ahmad, A., Ateeq, B., & Khan, M. I. (2020) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2020.1712674 · Cited by 78 · see citing works

The physiology of vitamin D—far more than calcium and bone

Carlberg, C. (2014) · Frontiers in Physiology · doi:10.3389/fphys.2014.00335 · Cited by 78 · see citing works

Effects of Vitamin D on Fertility, Pregnancy and Polycystic Ovary Syndrome—A Review

Várbı́ró, S., Takács, I., Tűű, L., Nas, K., Sziva, R. E., Hetthéssy, J. R., & Török, M. (2022) · Nutrients · doi:10.3390/nu14081649 · Cited by 84 · see citing works

Glia in the cytokine-mediated onset of depression: fine tuning the immune response

Jo, W. K., Zhang, Y., Emrich, H. M., & Dietrich, D. E. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00268 · Cited by 77 · see citing works

Glutathione deficiency induces epigenetic alterations of vitamin D metabolism genes in the livers of high-fat diet-fed obese mice

Parsanathan, R., & Jain, S. K. (2019) · Scientific Reports · doi:10.1038/s41598-019-51377-5 · Cited by 75 · see citing works

Vitamin D in Neurological Diseases

Plantone, D., Primiano, G., Manco, C., Locci, S., Servidei, S., & Stefano, N. D. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms24010087 · Cited by 77 · see citing works

Malignant Melanoma: An Overview, New Perspectives, and Vitamin D Signaling

Slominski, R. M., Kim, T., Janjetović, Z., Brożyna, A. A., Podgórska, E., Dixon, K. M., Mason, R. S., Tuckey, R. C., Sharma, R., Crossman, D. K., et al. (2024) · Cancers · doi:10.3390/cancers16122262 · Cited by 74 · see citing works

Vitamin D, DNA methylation, and breast cancer

O’Brien, K. M., Sandler, D. P., Xu, Z., Kinyamu, H. K., Taylor, J. A., & Weinberg, C. R. (2018) · Breast Cancer Research · doi:10.1186/s13058-018-0994-y · Cited by 71 · see citing works

Policing Cancer: Vitamin D Arrests the Cell Cycle

Bhoora, S., & Punchoo, R. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21239296 · Cited by 70 · see citing works

The impact of the vitamin D-modulated epigenome on VDR target gene regulation

Nurminen, V., Neme, A., Seuter, S., & Carlberg, C. (2018) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2018.05.006 · Cited by 69 · see citing works

Placental uptake and metabolism of 25(OH)vitamin D determine its activity within the fetoplacental unit

Ashley, B., Simner, C., Manousopoulou, A., Jenkinson, C., Hey, F., Frost, J. M., Rezwan, F. I., White, C., Lofthouse, E. M., Hyde, E., et al. (2021) · Apollo (University of Cambridge) · doi:10.17863/cam.82232 · Cited by 68 · see citing works

Epigenetic Modifications and Therapy in Multiple Sclerosis

Aslani, S., Jafari, N., Javan, M. R., Karami, J., Ahmadi, M., & Jafarnejad, M. (2016) · NeuroMolecular Medicine · doi:10.1007/s12017-016-8422-x · Cited by 67 · see citing works

Vitamin D Resistance as a Possible Cause of Autoimmune Diseases: A Hypothesis Confirmed by a Therapeutic High-Dose Vitamin D Protocol

Lemke, D., Klement, R. J., Schweiger, F., Schweiger, B., & Spitz, J. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.655739 · Cited by 70 · see citing works

Cellular and molecular mechanisms of vitamin D in food allergy

Poole, A., Song, Y., Brown, H., Hart, P. H., & Zhang, G. (2018) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.13607 · Cited by 64 · see citing works

Vitamin D receptor, STAT3, and TET2 cooperate to establish tolerogenesis

Català‐Moll, F., Ferreté-Bonastre, A. G., Godoy‐Tena, G., Morante-Palacios, O., Ciudad, L., Barberà, L., Fondelli, F., Martínez-Cáceres, E. M., Rodríguez‐Ubreva, J., Li, T., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2021.110244 · Cited by 61 · see citing works

Maternal vitamin D deficiency and developmental origins of health and disease (DOHaD)

Ideraabdullah, F., Belenchia, A. M., Rosenfeld, C. S., Kullman, S. W., Knuth, M. M., Mahapatra, D., Bereman, M. S., Levin, E. D., & Peterson, C. A. (2019) · Journal of Endocrinology · doi:10.1530/joe-18-0541 · Cited by 63 · see citing works

Muscle catabolic capacities and global hepatic epigenome are modified in juvenile rainbow trout fed different vitamin levels at first feeding

Panserat, S., Marandel, L., Geurden, I., Véron, V., Dias, K., Plagnes‐Juan, E., Pegourié, G., Arbenoits, E., Santigosa, E., Weber, G. M., et al. (2016) · Aquaculture · doi:10.1016/j.aquaculture.2016.11.021 · Cited by 61 · see citing works

Maternal Vitamin D Deficiency and Fetal Programming - Lessons Learned from Humans and Mice

Reichetzeder, C., Chen, H., Föller, M., Slowinski, T., Li, J., Chen, Y., Lang, F. J. W., & Hocher, B. (2014) · Kidney & Blood Pressure Research · doi:10.1159/000355809 · Cited by 60 · see citing works

Vitamin D: a custodian of cell signalling stability in health and disease

Berridge, M. J. (2015) · Biochemical Society Transactions · doi:10.1042/bst20140279 · Cited by 60 · see citing works

Ancestry Dependent DNA Methylation and Influence of Maternal Nutrition

Mozhui, K., Smith, A. K., & Tylavsky, F. A. (2015) · PLoS ONE · doi:10.1371/journal.pone.0118466 · Cited by 58 · see citing works

Nutrition, Epigenetics, and Major Depressive Disorder: Understanding the Connection

Ortega, M. A., Fraile‐Μartinez, O., Montero, C. G., Álvarez-Mon, M. Á., Lahera, G., Monserrat, J., Llavero-Valero, M., Mora, F., Rodríguez–Jiménez, R., Fernández-Rojo, S., et al. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.867150 · Cited by 57 · see citing works

How do established developmental risk-factors for schizophrenia change the way the brain develops?

Eyles, D. W. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01273-2 · Cited by 55 · see citing works

Vitamin D Every Day to Keep the Infection Away?

Kroner, J. D. C., Sommer, A., & Fabri, M. (2015) · Nutrients · doi:10.3390/nu7064170 · Cited by 53 · see citing works

Race/Ethnicity-Specific Association of Vitamin D and Global DNA Methylation: Cross-Sectional and Interventional Findings

Zhu, H., Bhagatwala, J., Huang, Y., Pollock, N. K., Parikh, S. J., Raed, A., Gutin, B., Harshfield, G. A., & Dong, Y. (2016) · PLoS ONE · doi:10.1371/journal.pone.0152849 · Cited by 53 · see citing works

Gestational Vitamin D Supplementation Leads to Reduced Perinatal RXRA DNA Methylation: Results From the MAVIDOS Trial

Curtis, E. M., Krstic, N., Cook, E., D’Angelo, S., Crozier, S., Moon, R. J., Murray, R. J. S., Garratt, E. S., Costello, P. M., Cleal, J. K., et al. (2018) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.3603 · Cited by 53 · see citing works

Epigenetic Clock and Leukocyte Telomere Length Are Associated with Vitamin D Status but not with Functional Assessments and Frailty in the Berlin Aging Study II

Vetter, V. M., Spira, D., Banszerus, V. L., & Demuth, I. (2020) · The Journals of Gerontology Series A · doi:10.1093/gerona/glaa101 · Cited by 53 · see citing works

Increased vitamin D levels at birth and in early infancy increase offspring allergy risk—evidence for involvement of epigenetic mechanisms

Junge, K. M., Bauer, T., Geißler, S., Hirche, F., Thürmann, L., Bauer, M., Trump, S., Bieg, M., Weichenhan, D., Gu, L., et al. (2015) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2015.06.040 · Cited by 52 · see citing works

Serum folate predicts muscle strength: a pilot cross-sectional study of the association between serum vitamin levels and muscle strength and gait measures in patients >65 years old with diabetes mellitus in a primary care setting

Wee, A. K. H. (2016) · Nutrition Journal · doi:10.1186/s12937-016-0208-3 · Cited by 51 · see citing works

1α,25(OH) 2 D 3 reverses exhaustion and enhances antitumor immunity of human cytotoxic T cells

Li, P., Zhu, X., Cao, G., Wu, R., Li, K., Yuan, W., Chen, B., Sun, G., Xia, X., Zhang, H., et al. (2022) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2021-003477 · Cited by 50 · see citing works

Adipose tissue inflammation and VDR expression and methylation in colorectal cancer

Castellano‐Castillo, D., Morcillo, S., Clemente‐Postigo, M., Crujeiras, A. B., Fernández‐García, J. C., Torres, E., Tinahones, F. J., & Macías‐González, M. (2018) · Clinical Epigenetics · doi:10.1186/s13148-018-0493-0 · Cited by 50 · see citing works

Merging Data from Genetic and Epigenetic Approaches to Better Understand Autistic Spectrum Disorder

Grayson, D. R., & Guidotti, A. (2015) · Epigenomics · doi:10.2217/epi.15.92 · Cited by 49 · see citing works

Neonatal vitamin D status is not associated with later risk of type 1 diabetes: results from two large Danish population-based studies

Jacobsen, R., Thorsen, S. U., Cohen, A. S., Lundqvist, M., Frederiksen, P., Pipper, C. B., Pociot, F., Thygesen, L. C., Ascherio, A., Svensson, J., et al. (2016) · Diabetologia · doi:10.1007/s00125-016-4002-8 · Cited by 49 · see citing works

Vitamin D as A Protector of Arterial Health: Potential Role in Peripheral Arterial Disease Formation

Krishna, S. M. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20194907 · Cited by 49 · see citing works

Placental Epigenome Impacts Fetal Development: Effects of Maternal Nutrients and Gut Microbiota

Basak, S., Mallick, R., Boga, N. S., & Duttaroy, A. K. (2024) · Nutrients · doi:10.3390/nu16121860 · Cited by 53 · see citing works

Relationship between methylation status of vitamin D-related genes, vitamin D levels, and methyl-donor biochemistry

Beckett, E., Duesing, K., Martin, C., Jones, P. R., Furst, J. E., King, K., Niblett, S. H., Yates, Z. R., Veysey, M. J., & Lucock, M. D. (2016) · Journal of Nutrition & Intermediary Metabolism · doi:10.1016/j.jnim.2016.04.010 · Cited by 47 · see citing works

Increased DNA methylation of SLFN12 in CD4+ and CD8+ T cells from multiple sclerosis patients

Rhead, B. L., Brorson, I. S., Berge, T., Adams, C., Quach, H., Moen, S. M., Berg‐Hansen, P., Celius, E. G., Sangurdekar, D. P., Bronson, P. G., et al. (2018) · PLoS ONE · doi:10.1371/journal.pone.0206511 · Cited by 45 · see citing works

Vitamins D2 and D3 Have Overlapping But Different Effects on the Human Immune System Revealed Through Analysis of the Blood Transcriptome

Durrant, L. R., Bucca, G., Hesketh, A. R., Möller‐Levet, C. S., Tripkovic, L., Wu, H., Hart, K. H., Mathers, J. C., Elliott, R. M., Lanham-New, S. A., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.790444 · Cited by 45 · see citing works

The role of vitamin D on redox regulation and cellular senescence

Sosa-Díaz, E., Cruz, E. Y. H., & Pedraza‐Chaverrí, J. (2022) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2022.10.003 · Cited by 43 · see citing works

Post-SSRI Sexual Dysfunction (PSSD): Biological Plausibility, Symptoms, Diagnosis, and Presumed Risk Factors

Peleg, L. C., Rabinovitch, D., Lavie, Y., Rabbie, D. M., Horowitz, I., Fruchter, E., & Gruenwald, I. (2021) · Sexual Medicine Reviews · doi:10.1016/j.sxmr.2021.07.001 · Cited by 41 · see citing works

Application of vitamin D and vitamin D analogs in acute myelogenous leukemia

Cao, H. L., Xu, Y., de Necochea-Campion, R., Baylink, D. J., Payne, K. J., Tang, X., Ratanatharathorn, C., Ji, Y., Mirshahidi, S., & Chen, C.-S. (2017) · Experimental Hematology · doi:10.1016/j.exphem.2017.01.007 · Cited by 39 · see citing works

Vitamin D deficiency exacerbates bleomycin-induced pulmonary fibrosis partially through aggravating TGF-β/Smad2/3-mediated epithelial-mesenchymal transition

Li, S.-R., Tan, Z.-X., Chen, Y., Hu, B., Zhang, C., Wang, H., Zhao, H., & Xu, D. (2019) · Respiratory Research · doi:10.1186/s12931-019-1232-6 · Cited by 40 · see citing works

Vitamin D and Immune Response: Implications for Prostate Cancer in African Americans

Batai, K., Murphy, A. B., Nonn, L., & Kittles, R. A. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00053 · Cited by 39 · see citing works

Low penetrance genetic polymorphisms as potential biomarkers for colorectal cancer predisposition

Tan, S. C. (2018) · The Journal of Gene Medicine · doi:10.1002/jgm.3010 · Cited by 39 · see citing works

Obesity-Associated Vitamin D Deficiency Correlates with Adipose Tissue DNA Hypomethylation, Inflammation, and Vascular Dysfunction

Mirza, I., Mohamed, A., Deen, H., Balaji, S., Elsabbahi, D., Munasser, A., Naquiallah, D., Abdulbaseer, U., Hassan, C., Masrur, M. A., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232214377 · Cited by 38 · see citing works

Role of Vitamin D Deficiency in Extraskeletal Complications: Predictor of Health Outcome or Marker of Health Status?

Guessous, I. (2015) · BioMed Research International · doi:10.1155/2015/563403 · Cited by 37 · see citing works

Epigenetics in Food Allergy and Immunomodulation

Cañas, J. A., Núñez, R., Cruz‐Amaya, A., Gómez, F., Torres, M. J., Palomares, F., & Mayorga, C. (2021) · Nutrients · doi:10.3390/nu13124345 · Cited by 37 · see citing works

Methylation of the Vitamin D Receptor (VDR) Gene, Together with Genetic Variation, Race, and Environment Influence the Signaling Efficacy of the Toll-Like Receptor 2/1-VDR Pathway

Meyer, V., Saccone, D. S., Tugizimana, F., Asani, F. F., Jeffery, T. J., & Bornman, L. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01048 · Cited by 36 · see citing works

Immunomodulatory Agents Combat Multidrug-Resistant Tuberculosis by Improving Antimicrobial Immunity

Muvva, J. R., Ahmed, S., Rekha, R. S., Kalsum, S., Groenheit, R., Schön, T., Agerberth, B., Bergman, P., & Brighenti, S. (2021) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiab100 · Cited by 36 · see citing works

The evolution of human skin pigmentation: A changing medley of vitamins, genetic variability, and UV radiation during human expansion

Lucock, M. D. (2022) · American Journal of Biological Anthropology · doi:10.1002/ajpa.24564 · Cited by 35 · see citing works

Common and personal target genes of the micronutrient vitamin D in primary immune cells from human peripheral blood

Hänel, A., Neme, A., Malinen, M., Hämäläinen, E., Malmberg, H.-R., Etheve, S., Tuomainen, T., Virtanen, J. K., Bendik, I., & Carlberg, C. (2020) · Scientific Reports · doi:10.1038/s41598-020-78288-0 · Cited by 37 · see citing works

25-Hydroxyvitamin D in pregnancy and genome wide cord blood DNA methylation in two pregnancy cohorts (MoBa and ALSPAC)

Suderman, M. J., Stene, L. C., Bohlin, J., Page, C. M., Holvik, K., Parr, C. L., Magnus, M. C., Håberg, S. E., Joubert, B. R., Wu, M. C., et al. (2016) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2016.03.005 · Cited by 34 · see citing works

Epigenetic regulation of pediatric and neonatal immune responses

Bermick, J., & Schaller, M. A. (2021) · Pediatric Research · doi:10.1038/s41390-021-01630-3 · Cited by 32 · see citing works

Nutrition during Pregnancy and Lactation: Epigenetic Effects on Infants’ Immune System in Food Allergy

Costanzo, M. D., Paulis, N. D., Capra, M. E., & Biasucci, G. (2022) · Nutrients · doi:10.3390/nu14091766 · Cited by 35 · see citing works

DNA methylation and the social gradient of osteoporotic fracture: A conceptual model

Brennan-Olsen, S. L., Page, R. S., Berk, M., Riancho, J. A., Leslie, W. D., Wilson, S. G., Saban, K. L., Janusek, L. W., Pasco, J. A., Hodge, J. M., et al. (2015) · Bone · doi:10.1016/j.bone.2015.12.015 · Cited by 32 · see citing works

Association between variation of circulating 25-OH vitamin D and methylation of secreted frizzled-related protein 2 in colorectal cancer

Boughanem, H., Cabrera-Mulero, A., Hernández‐Alonso, P., Clemente‐Postigo, M., Casanueva, F. F., Tinahones, F. J., Morcillo, S., Crujeiras, A. B., & Macías‐González, M. (2020) · Clinical Epigenetics · doi:10.1186/s13148-020-00875-9 · Cited by 32 · see citing works

Vitamin D receptor gene is epigenetically altered and transcriptionally up-regulated in multiple sclerosis

Ayuso, T., Aznar, P., Soriano, L., Olaskoaga, A., Roldán, M., Otaño, M., Ajuria-Morentin, I., Soriano, G., Lacruz, F., & Mendióroz, M. (2017) · PLoS ONE · doi:10.1371/journal.pone.0174726 · Cited by 31 · see citing works

Vitamin D and its Effects on DNA Methylation in Development, Aging, and Disease

Ong, L. T. C., Booth, D. R., & Parnell, G. P. (2020) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202000437 · Cited by 33 · see citing works

Nucleotide Excision Repair and Vitamin D—Relevance for Skin Cancer Therapy

Pawłowska, E., Wysokiński, D., & Błasiak, J. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17040372 · Cited by 31 · see citing works

Methylation Status of Vitamin D Receptor Gene Promoter in Benign and Malignant Adrenal Tumors

Pilon, C., Rebellato, A., Urbanet, R., Guzzardo, V., Cappellesso, R., Sasano, H., Fassina, A., & Fallo, F. (2015) · International Journal of Endocrinology · doi:10.1155/2015/375349 · Cited by 30 · see citing works

Advances in Nutritional Epigenetics—A Fresh Perspective for an Old Idea. Lessons Learned, Limitations, and Future Directions

Sedley, L. (2020) · Epigenetics Insights · doi:10.1177/2516865720981924 · Cited by 29 · see citing works

Vitamin D deficiency during pregnancy affects the function of Th1/Th2 cells and methylation of IFN-γ gene in offspring rats

Jiao, X., Wang, L., Wei, Z., Liu, B., Liu, X., & Yu, X. (2019) · Immunology Letters · doi:10.1016/j.imlet.2019.06.012 · Cited by 29 · see citing works

Low serum vitamin D levels are associated with shorter survival after first-line azacitidine treatment in patients with myelodysplastic syndrome and secondary oligoblastic acute myeloid leukemia

Radujkovic, A., Schnitzler, P., Ho, A. D., Dreger, P., & Luft, T. (2016) · Clinical Nutrition · doi:10.1016/j.clnu.2016.01.021 · Cited by 28 · see citing works

Vitamin D receptor variants and uncontrolled asthma

Hutchinson, K., Kerley, C. P., Faul, J. L., Greally, P., Coghlan, D., Louw, M. A., Elnazir, B., & Rochev, Y. A. (2018) · European Annals of Allergy and Clinical Immunology · doi:10.23822/eurannaci.1764-1489.46 · Cited by 28 · see citing works

Epigenetic alterations in aging tooth and the reprogramming potential

Hodjat, M., Khan, F., & Saadat, K. A. S. M. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101140 · Cited by 27 · see citing works

Epigenetic Modulation of Human Podocyte Vitamin D Receptor in HIV Milieu

Chandel, N., Ayasolla, K., Lan, X., Sultana-Syed, M., Chawla, A. K., Lederman, R., Vethantham, V., Saleem, M. A., Chander, P. N., Malhotra, A., et al. (2015) · Journal of Molecular Biology · doi:10.1016/j.jmb.2015.07.011 · Cited by 26 · see citing works

Vitamin D and the Immune System

Khorasanizadeh, M. H., Eskian, M., Camargo, C. A., & Rezaei, N. (2019) · Springer eBooks · doi:10.1007/978-3-030-16073-9_2 · Cited by 25 · see citing works

Promoter hypermethylation regulates vitamin D receptor (VDR) expression in colorectal cancer-A study from Kashmir valley

Afshan, F. U., Masood, A., Nissar, B., Chowdri, N. A., Naykoo, N. A., Majid, M., & Ganai, B. A. (2021) · Cancer Genetics · doi:10.1016/j.cancergen.2021.01.002 · Cited by 24 · see citing works

The Combined Beneficial Effects of Postbiotic Butyrate on Active Vitamin D3-Orchestrated Innate Immunity to Salmonella Colitis

Huang, F., & Huang, S. (2021) · Biomedicines · doi:10.3390/biomedicines9101296 · Cited by 26 · see citing works

The Role of Maternal Vitamin D Deficiency in Offspring Obesity: A Narrative Review

Wu, Y., Zeng, Y., Zhang, Q., & Xiao, X. (2023) · Nutrients · doi:10.3390/nu15030533 · Cited by 24 · see citing works

Epigenetic Pathways Regulating Bone Homeostasis: Potential Targeting for Intervention of Skeletal Disorders

Gordon, J. A. R., Montecino, M. A., Aqeilan, R. I., Stein, J. L., Stein, G. S., & Lian, J. B. (2014) · Current Osteoporosis Reports · doi:10.1007/s11914-014-0240-1 · Cited by 24 · see citing works

Vitamin D Enhances Alveolar Development in Antenatal Lipopolysaccharide-Treated Rats through the Suppression of Interferon-γ Production

Liu, C., Chen, Z., Li, W., Huang, L., & Zhang, Y. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01923 · Cited by 24 · see citing works

Vitamin D as a modulator of molecular pathways involved in CVDs: Evidence from preclinical studies

Sudharma, A. A., Dutta, S., Aboo, S., & Ismail, A. (2024) · Life Sciences · doi:10.1016/j.lfs.2024.123062 · Cited by 23 · see citing works

Effects of Diet-Induced Obesity and Deficient in Vitamin D on Spermatozoa Function and DNA Integrity in Sprague-Dawley Rats

Merino, O., Sánchez, R., Gregório, B. M., Sampaio, F. J. B., & Risopatrón, J. (2018) · BioMed Research International · doi:10.1155/2018/5479057 · Cited by 23 · see citing works

Insight into the roles of vitamins C and D against cancer: Myth or truth?

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