The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
miRNA-34c regulates Notch signaling during bone development
Open accessAbstract
During bone homeostasis, osteoblast and osteoclast differentiation is coupled and regulated by multiple signaling pathways and their downstream transcription factors. Here, we show that microRNA 34 (miR-34) is significantly induced by BMP2 during osteoblast differentiation. In vivo, osteoblast-specific gain of miR-34c in mice leads to an age-dependent osteoporosis due to the defective mineralization and proliferation of osteoblasts and increased osteoclastogenesis. In osteoblasts, miR-34c targets multiple components of the Notch signaling pathway, including Notch1, Notch2 and Jag1 in a direct manner, and influences osteoclast differentiation in a non-cell-autonomous fashion. Taken together, our results demonstrate that miR-34c is critical during osteoblastogenesis in part by regulating Notch signaling in bone homeostasis. Furthermore, miR-34c-mediated post-transcriptional regulation of Notch signaling in osteoblasts is one possible mechanism to modulate the proliferative effect of Notch in the committed osteoblast progenitors which may be important in the pathogenesis of osteosarcomas. Therefore, understanding the functional interaction of miR-34 and Notch signaling in normal bone development and in bone cancer could potentially lead to therapies modulating miR-34 signaling.
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Cites
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Control of translation and mRNA degradation by miRNAs and siRNAs: Table 1.
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The miR-34 family in cancer and apoptosis
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Canonical WNT Signaling Promotes Osteogenesis by Directly Stimulating Runx2 Gene Expression
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Cited by
Yang, X., Yang, J., Lei, P., & Wen, T. (2019) · Aging · doi:10.18632/aging.102264 · Cited by 312
miR-21 deficiency inhibits osteoclast function and prevents bone loss in mice
Hu, C.-H., Sui, B.-D., Du, F.-Y., Shuai, Y., Zheng, C.-X., Zhao, P., Yu, X.-R., & Jin, Y. (2017) · Scientific Reports · doi:10.1038/srep43191 · Cited by 127
Overexpression of MiR-335-5p Promotes Bone Formation and Regeneration in Mice
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Metadata
- Authors
- Bae, Y., Yang, T., Zeng, H.-C., Campeau, P. M., Chen, Y., Bertin, T., Dawson, B. C., Munivez, E., Tao, J., & Lee, B. H.
- Venue
- Human Molecular Genetics
- Publisher
- Oxford University Press (OUP)
- Published
- 2012-04-12
- Volume
- 21
- Issue
- 13
- Pages
- 2991-3000
- ISSN
- 0964-6906 (ISSN-L)
- 1460-2083
- OpenAlex
- W2120307929
- Cited by
- 237
- References
- 6
- FWCI
- 7.32
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Bae, Y., Yang, T., Zeng, H.-C., Campeau, P. M., Chen, Y., Bertin, T., Dawson, B. C., Munivez, E., Tao, J., & Lee, B. H. (2012). miRNA-34c regulates Notch signaling during bone development. Human Molecular Genetics. https://doi.org/10.1093/hmg/dds129
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