Extracellular RNA in aging
Open accessAbstract
Since the discovery of extracellular RNA (exRNA) in circulation and other bodily fluids, there has been considerable effort to catalog and assess whether exRNAs can be used as markers for health and disease. A variety of exRNA species have been identified including messenger RNA and noncoding RNA such as microRNA (miRNA), small nucleolar RNA, transfer RNA, and long noncoding RNA. Age‐related changes in exRNA abundance have been observed, and it is likely that some of these transcripts play a role in aging. In this review, we summarize the current state of exRNA profiling in various body fluids and discuss age‐related changes in exRNA abundance that have been identified in humans and other model organisms. miRNAs, in particular, are a major focus of current research and we will highlight and discuss the potential role that specific miRNAs might play in age‐related phenotypes and disease. We will also review challenges facing this emerging field and various strategies that can be used for the validation and future use of exRNAs as markers of aging and age‐related disease. WIREs RNA 2017, 8:e1385. doi: 10.1002/wrna.1385 This article is categorized under: Regulatory RNAs/RNAi/Riboswitches > Regulatory RNAs RNA in Disease and Development > RNA in Disease RNA in Disease and Development > RNA in Development
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miR-25-3p, miR-92a-3p, miR-93-5p, miR-101-3p, miR-106b-5p, miR-142-5p, miR-151a-3p, and miR-181a-5p tend to be under-represented, whereas miR-21-5p and miR-126-3p are over-represented at older ages.
“Nonetheless, miR-25–3p, miR-92a-3p, miR-93–5p, miR-101–3p, miR-106b-5p, miR-142–5p, miR-151a-3p, and miR-181a-5p tend to be under-represented, whereas miR-21–5p and miR-126–3p are over-represented at older ages47,49,50.”
From Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty (2018) · cites this paper as [49]
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Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty
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- Authors
- Dluzen, D. F., Noren Hooten, N., & Evans, M. K.
- Affiliations
- National Institutes of Health (US)
- Laboratory of Epidemiology and Population Sciences National Institute on Aging, National Institutes of Health Baltimore MD USA
- Corresponding author
- Evans, Michele K.
- Venue
- WIREs RNA
- Publisher
- Wiley
- Published
- 2016-08-17
- Volume
- 8
- Issue
- 2
- ISSN
- 1757-7004 (ISSN-L)
- 1757-7012
- PMC
- PMC5315635
- OpenAlex
- W2513126051
- Cited by
- 31
- References
- 152
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 2 · 2023: 1 · 2022: 5 · 2021: 5 · 2020: 4 · 2019: 3 · 2018: 3 · 2017: 5
- FWCI
- 0.33
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Wiley Interdisciplinary Reviews - RNA (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging Intramural Research Program, National Institutes of Health
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Keywords
- extracellular RNA, aging, microRNA, biological fluids, aging biomarkers, age-related diseases, long non-coding RNA, small nucleolar RNA, tRNA, model organisms
- MeSH terms
- Aging, Cell Communication, Humans, Biomarkers, RNA, Untranslated
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