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The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.

The deubiquitinase USP15 antagonizes Parkin-mediated mitochondrial ubiquitination and mitophagy

Cornelissen, Tom, Haddad, Dominik, Wauters, Fieke, Van Humbeeck, Cindy, Mandemakers, Wim, Koentjoro, Brianada, Sue, Carolyn, Gevaert, Kris, De Strooper, Bart, Verstreken, Patrik, Vandenberghe, Wim·2014·Human Molecular Genetics
DOI 10.1093/hmg/ddu244
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Crossref · 10.1093/hmg/ddu244

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9 of 9 references verified0 citation errors · 0 not checkable

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  • Knockdown of USP15 and USP30 increased the rate of mitophagy but had no discernible effect on parkin recruitment.

    “knockdown of these DUBs increased the rate of mitophagy but had no discernible effect on parkin recruitment.”

    From USP8 regulates mitophagy by removing K6‐linked ubiquitin conjugates from parkin (2014) · cites this paper as Cornelissen et al, 2014

    The 'Knockdown of USP15 enhances mitophagy' section reports increased Parkin-dependent mitophagy after USP15 knockdown. The 'USP15 antagonizes Parkin-mediated mitochondrial ubiquitination' section reports no effect on Parkin translocation, but that experiment tested USP15 overexpression, not knockdown. The copy does not report the claimed mitophagy or recruitment effects for USP30 knockdown. (LLM, conf=0.88)

    Experimental — accuracy not yet measured

  • Two recent studies identified a role for USP15 and USP30 in parkin-mediated mitophagy.

    “two recent studies identified a role for USP15 and the mitochondrial DUB USP30 in parkin-mediated mitophagy”

    From USP8 regulates mitophagy by removing K6‐linked ubiquitin conjugates from parkin (2014) · cites this paper as Cornelissen et al, 2014

  • Overexpression of USP15 and USP30 leads to deubiquitination of parkin substrates on mitochondria, which slows mitochondrial clearance by autophagy.

    “overexpression of these DUBs leads to deubiquitination of parkin substrates on mitochondria, which in turn slowed the rate of mitochondrial clearance by autophagy.”

    From USP8 regulates mitophagy by removing K6‐linked ubiquitin conjugates from parkin (2014) · cites this paper as Cornelissen et al, 2014

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Citations

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Research works printed but not linked: 46

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  19. 2004, De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-κB signalling, Nature, 430, 694, 10.1038/nature02794 · DOI
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  22. 2012, USP15 stabilizes TGF-β receptor I and promotes oncogenesis through the activation of TGF-β signaling in glioblastoma, Nat. Med., 18, 429, 10.1038/nm.2619 · DOI · Paper page
  23. 2006, Diverse effects of pathogenic mutations of Parkin that catalyze multiple monoubiquitylation in vitro, J. Biol. Chem., 281, 3204, 10.1074/jbc.M510393200 · DOI · Paper page
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  25. 2006, Biochemical analysis of Parkinson's disease-causing variants of Parkin, an E3 ubiquitin-protein ligase with monoubiquitylation capacity, Hum. Mol. Genet., 15, 2059, 10.1093/hmg/ddl131 · DOI
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Metadata

Authors
Cornelissen, T., Haddad, D., Wauters, F., Van Humbeeck, C., Mandemakers, W., Koentjoro, B., Sue, C., Gevaert, K., De Strooper, B., Verstreken, P., & Vandenberghe, W.
Venue
Human Molecular Genetics
Publisher
Oxford University Press (OUP)
Published
2014-05-22
Volume
23
Issue
19
Pages
5227-5242
ISSN
  • 0964-6906
  • 1460-2083
DOI
10.1093/hmg/ddu244
Cited by
327
References
9
Language
en

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