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Breaking the chains: structure and function of the deubiquitinases

Komander, David, Clague, Michael J., Urbé, Sylvie·2009·Nature Reviews Molecular Cell Biology
DOI 10.1038/nrm2731
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Abstract

Ubiquitylation is a reversible protein modification that is implicated in many cellular functions. Recently, much progress has been made in the characterization of a superfamily of isopeptidases that remove ubiquitin: the deubiquitinases (DUBs; also known as deubiquitylating or deubiquitinating enzymes). Far from being uniform in structure and function, these enzymes display a myriad of distinct mechanistic features. The small number (<100) of DUBs might at first suggest a low degree of selectivity; however, DUBs are subject to multiple layers of regulation that modulate both their activity and their specificity. Due to their wide-ranging involvement in key regulatory processes, these enzymes might provide new therapeutic targets.

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  • Certain DUBs exhibit specificity in hydrolyzing non-K48-linked ubiquitin chains.

    “However, certain DUBs have been shown to exhibit specificity in hydrolyzing non-K48-linked Ub chains (Komander et al, 2009a;Reyes-Turcu et al, 2009;Mevissen et al, 2013).”

    From USP8 regulates mitophagy by removing K6‐linked ubiquitin conjugates from parkin (2014) · cites this paper as Komander et al, 2009a

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Metadata

Authors
Komander, D., Clague, M. J., & Urbé, S.
Venue
Nature Reviews Molecular Cell Biology
Publisher
Springer Science and Business Media LLC
Published
2009-08
Volume
10
Issue
8
Pages
550-563
ISSN
  • 1471-0072
  • 1471-0080
DOI
10.1038/nrm2731
Cited by
1,969
References
2
Language
en
Licence
www.springer.com/tdm (tdm)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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