TBK1 controls autophagosomal engulfment of polyubiquitinated mitochondria through p62/SQSTM1 phosphorylation

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p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death

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PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy

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Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin

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Phosphorylation of the Autophagy Receptor Optineurin Restricts Salmonella Growth

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Mechanistic insights into the interactions of TAX1BP1 with RB1CC1 and mammalian ATG8 family proteins

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The ULK complex–LRRK1 axis regulates Parkin-mediated mitophagy via Rab7 Ser-72 phosphorylation

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OPTN gene therapy increases autophagy and protects mitochondria in SOD1 ‐G93A‐expressing transgenic mice and cells

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PIKfyve, expressed by CD11c-positive cells, controls tumor immunity

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Myositis with sarcoplasmic inclusions in Nakajo–Nishimura syndrome: a genetic inflammatory myopathy

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Impact of Organelle Transport Deficits on Mitophagy and Autophagy in Niemann–Pick Disease Type C

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TBK1 and GABARAP family members suppress Coxsackievirus B infection by limiting viral production and promoting autophagic degradation of viral extracellular vesicles

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SQSTM1/p62 Post-Translational Modifications and Reverse Processes Modulate Disease Pathogenesis via KEAP1-NRF2 Signaling and Selective Autophagy

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Ataxin-3 Links NOD2 and TLR2 Mediated Innate Immune Sensing and Metabolism in Myeloid Cells

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Non-canonical function of FIP200 is required for neural stem cell maintenance and differentiation by limiting TBK1 activation and p62 aggregate formation

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p62/ SQSTM 1 promotes rapid ubiquitin conjugation to target proteins after endosome rupture during xenophagy

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The Interplay Between Autophagy and RNA Homeostasis: Implications for Amyotrophic Lateral Sclerosis and Frontotemporal Dementia

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Slingshot homolog-1 mediates the secretion of small extracellular vesicles containing misfolded proteins by regulating autophagy cargo receptors and actin dynamics

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Inhibition of SQSTM1 S403 phosphorylation facilitates the aggresome formation of ubiquitinated proteins during proteasome dysfunction

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TBK1 is a signaling hub in coordinating stress-adaptive mechanisms in head and neck cancer progression

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Hepatitis B surface antigen hijacks TANK-binding kinase 1 to suppress type I interferon and induce early autophagy

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Emerging Drugs for the Treatment of Amyotrophic Lateral Sclerosis: A Focus on Recent Phase 2 Trials

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UBQLN2 Promotes the Production of Type I Interferon via the TBK1-IRF3 Pathway

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TBK1 variants in Chinese patients with amyotrophic lateral sclerosis

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Functional Characterization of a Familial ALS-Associated Missense TBK1 (p-Arg573Gly) Mutation in Patient-Derived Lymphoblasts

Porras, G., Ruiz, S., Maestro, I., Borrego‐Hernández, D., García‐Redondo, A., Martínez, A., & Martín‐Requero, Á. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24032847 · Cited by 9

ALLO-1- and IKKE-1-dependent positive feedback mechanism promotes the initiation of paternal mitochondrial autophagy

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The Role of Autophagy in Excitotoxicity, Synaptic Mitochondrial Stress and Neurodegeneration

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Caffeic Acid Phenethyl Ester and Caffeamide Derivatives Suppress Oral Squamous Cell Carcinoma Cells

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In vivo selection reveals autophagy promotes adaptation of metastatic ovarian cancer cells to abdominal microenvironment

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Understanding neurodevelopmental proteasomopathies as new rare disease entities: A review of current concepts, molecular biomarkers, and perspectives

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AZI2 mediates TBK1 activation at unresolved selective autophagy cargo receptor complexes with implications for CD8 T-cell infiltration in breast cancer

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Transcriptome Highlights Cannabinol Modulation of Mitophagy in a Parkinson’s Disease In Vitro Model

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Sqstm1-GFP knock-in mice reveal dynamic actions of Sqstm1 during autophagy and under stress conditions in living cells

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Supramolecular Complexes in Cell Death and Inflammation and Their Regulation by Autophagy

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MEKK3-MEK5-ERK5 signaling promotes mitochondrial degradation

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Restriction of intracellular Salmonella typhimurium growth by the small-molecule autophagy inducer A77 1726 through the activation of the AMPK-ULK1 axis

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Molecular targets and approaches to restore autophagy and lysosomal capacity in neurodegenerative disorders

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Slingshot homolog-1 amplifies mitochondrial abnormalities by distinctly impairing health and clearance of mitochondria

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Molecular insights into the immune response of Ruditapes philippinarum under Vibrio anguillarum infection at high temperature

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Molecular features of TNBC govern heterogeneity in the response to radiation and autophagy inhibition

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Hypoxic postconditioning restores mitophagy against transient global cerebral ischemia via Parkin-induced posttranslational modification of TBK1

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TANK-binding kinase 1 alleviates myocardial ischemia/reperfusion injury through regulating apoptotic pathway

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Unveiling the physiological impact of ESCRT-dependent autophagosome closure by targeting the VPS37A ubiquitin E2 variant-like domain

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Adaptor‐Mediated Trafficking of Tank Binding Kinase 1 During Diverse Cellular Processes

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Control of innate immunity and lipid biosynthesis in neurodegeneration

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Recent approaches to target apoptosis in neurological disorders

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Measles virus-imposed remodeling of the autophagy machinery determines the outcome of bacterial coinfection

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iTRAQ-based quantitative proteomics suggests mitophagy involvement after Rice black-streaked dwarf virus acquisition in insect vector small brown planthopper Laodelphax striatellus Fallén

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In Silico Insights: QSAR Modeling of TBK1 Kinase Inhibitors for Enhanced Drug Discovery

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Guanylate-Binding Protein 1 Regulates Infection-Induced Autophagy through TBK1 Phosphorylation

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Carbon disulfide activates p62-Nrf2-keap1 pathway in rat nerve tissues

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Inhibition of Ref(2)P, the Drosophila homologue of the p62/SQSTM1 gene, increases lifespan and leads to a decline in motor function

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Failure of efficient cardiac proteostatic adaptations to chronic cAMP-stress is associated with accelerated heart aging

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TANK-binding kinase 1 protects against MASH progression via mitochondrial quality control

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The master antioxidant defense is activated during EBV latent infection

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Mitochondria Modulating Therapeutic Approaches in the Management of Huntington’s Disease

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OPTN deficiency through CRISPR/Cas9 downregulates autophagy and mitophagy in a SOD1-G93A-expressing transgenic cell line

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Predicting Which Mitophagy Proteins Are Dysregulated in Spinocerebellar Ataxia Type 3 (SCA3) Using the Auto-p2docking Pipeline

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TNIP1 and autophagy receptors regulate STING signaling

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Phosphorylation tunes p62 condensates to drive autophagic degradation of ubiquitinated proteins

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Beyond interferons: Non-canonical roles of MITA/STING

Zhang, L., Zhang, C., & Zhang, J. (2025) · Cell Insight · doi:10.1016/j.cellin.2025.100266 · Cited by 4

Targeting macroautophagy to combat neurodegenerative disease: strategies and considerations

Duncan, G. M., & Yamamoto, A. (2025) · Autophagy Reports · doi:10.1080/27694127.2025.2571940 · Cited by 6

TBK1 inhibitors enhance transfection efficiency by suppressing p62/ SQSTM1 phosphorylation

Tsuchiya, M., Kong, W.-X., Hiraoka, Y., Haraguchi, T., & Ogawa, H. (2022) · Genes to Cells · doi:10.1111/gtc.12987 · Cited by 4

Ubiquitination regulation of mitochondrial homeostasis: a new sight for the treatment of gastrointestinal tumors

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The role of autophagic kinases in regulation of axonal function

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Identification of multifunctionality of grass carp (Ctenopharyngodon idella) TBK1 during bacterial infection

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PTK2 regulates the UPS impairment via p62 phosphorylation in TDP-43 proteinopathyPreprint

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TBK1 Mutations in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia: Mechanistic Insights into Impaired Autophagy and Proteostatic Failure

Manganelli, F., Perfetto, C., Carletta, O., & Gerbino, V. (2026) · Cells · doi:10.3390/cells15050477 · Cited by 4

Post-translational modifications of selective autophagy receptors: orchestrating cellular homeostasis, disease pathogenesis, and therapeutic opportunities

Zhu, W., Wang, X., Li, Q., Jiang, X., & Xu, G. (2026) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-026-00884-1 · Cited by 3

Phosphorylation of Optineurin by protein kinase D regulates Parkin-dependent mitophagy

Weil, R., Laplantine, E., Attailia, M., Oudin, A., Curic, S., Yokota, A., Banide, E., & Génin, P. (2024) · iScience · doi:10.1016/j.isci.2024.111384 · Cited by 3

METTL14 promotes TBK1 mRNA stability through IGF2BP3-recognized m6A modification and enhances mitophagy in BMSCs

Shen, Y., Wang, L., Guo, Z., Wang, J., Zhang, R., Tang, C., & Wu, J. R. (2025) · Cellular Signalling · doi:10.1016/j.cellsig.2025.111873 · Cited by 3

Genetics of primary open-angle glaucoma

Youngblood, H. A., & Liu, Y. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-816222-4.00011-3 · Cited by 3

Ubiquitin-mediated recruitment of the ATG9A-ATG2 lipid transfer complex drives clearance of phosphorylated p62 aggregates

Broadbent, D. G., McEwan, C. M., Jayatunge, D., Kaminsky, E. G., Tsang, T.-M., Poole, D. M., Naylor, B. C., Price, J. C., Schmidt, J. C., & Andersen, J. L. (2024) · Molecular Biology of the Cell · doi:10.1091/mbc.e24-03-0101 · Cited by 3

Microtubule inhibitors identified through nonbiased screening enhance DNA transfection efficiency by delaying p62‐dependent ubiquitin recruitment

Tsuchiya, M., Ogawa, H., Watanabe, K., Koujin, T., Mori, C., Nunomura, K., Lin, B., Tani, A., Hiraoka, Y., & Haraguchi, T. (2021) · Genes to Cells · doi:10.1111/gtc.12881 · Cited by 3

Linear ubiquitination at damaged lysosomes induces local NF-κB activation and controls cell survivalPreprint

Zein, L., Dietrich, M., Balta, D., Bader, V., Scheuer, C., Zellner, S., Weinelt, N., Vandrey, J., Mari, M. C., Behrends, C., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.10.06.560832 · Cited by 3

Functional Role of Hepatitis C Virus NS5A in the Regulation of Autophagy

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Exploring TANK-Binding Kinase 1 in Amyotrophic Lateral Sclerosis: From Structural Mechanisms to Machine Learning-Guided Therapeutics

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Network-based approach for targeting human kinases commonly associated with amyotrophic lateral sclerosis and cancer

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TBK1 regulates autophagic clearance of soluble mutant huntingtin and inhibits aggregation/toxicity in different models of Huntington’s diseasePreprint

Hegde, R. N., Chiki, A., Petricca, L., Martufi, P., Arbez, N., Mouchiroud, L., Auwerx, J., Landles, C., Bates, G., Singh-Bains, M. K., et al. (2019) · bioRxiv · doi:10.1101/869586 · Cited by 2

p62: Intersection of Antioxidant Defense and Autophagy Pathways

Shilovsky, G. A. (2024) · Molecular Biology · doi:10.1134/s0026893324700390 · Cited by 2

Inhibition of TrkB kinase activity impairs autophagy in cervical motor neurons of young but not old mice

Pareja‐Cajiao, M., Gransee, H. M., Jahanian, S., Sieck, G. C., & Mantilla, C. B. (2024) · Experimental Physiology · doi:10.1113/ep092095 · Cited by 1

Selective Autophagy: A Potential Player in Cutaneous Wound Healing

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Tank-binding kinase 1 regulates inflammation and autophagy in glaucoma

Morgan, A. B., & Inman, D. M. (2026) · Frontiers in Neuroscience · doi:10.3389/fnins.2025.1735403 · Cited by 1

The molecular arms race: Xenophagy, pathogen evasion, and emerging host-directed therapies

Ansari, O., Ahmed, F., Siddiquee, N., Mursaleen, A., Rushna, S., Sheikh, J. A., & Shariq, M. (2026) · Microbiological Research · doi:10.1016/j.micres.2026.128460 · Cited by 1

Cutting edge: ESCRT-mediated phagophore closure in mammals

Takahashi, Y., Opozda, D. M., & Wang, H. (2026) · Biochemical Journal · doi:10.1042/bcj20250148 · Cited by 1

Bi-magnolignan suppresses triple-negative breast cancer by triggering TBK1-dependent mitophagy

Chu, T., Yang, D., Zheng, D., Liang, S., Lu, Y., Zhang, K., Yang, Y., & Ma, W. (2026) · Tissue and Cell · doi:10.1016/j.tice.2026.103550 · Cited by 1

Cytosolic DNA inhibits rDNA transcription by retaining the RNA polymerase I transcription machinery

Xu, Y., Wang, Q., Qian, C., Lu, S., He, Z., Liu, W., & Wan, W. (2026) · The EMBO Journal · doi:10.1038/s44318-026-00792-2 · Cited by 1

Molecular switches of SQSTM1: the impact of post-translational modifications on autophagy and neurodegeneration

Abrar, F., & Martin, D. D. O. (2026) · Autophagy · doi:10.1080/15548627.2026.2711593 · Cited by 2

p62/ SQSTM1 : From an autophagy receptor to a condensate organizer of selective autophagy and stress signaling

Sakamaki, J.-I., & Komatsu, M. (2026) · FEBS Journal · doi:10.1111/febs.70689 · Cited by 1

The Role of p62 in Aggregopathies

Cormet‐Boyaka, E., Caution, K., Dakhlallah, D. A., & Amer, A. O. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-812146-7.00003-2 · Cited by 1

Minimized combinatorial CRISPR screens identify genetic interactions in autophagy

Diehl, V. (2022) · Publication Server of Goethe University Frankfurt am Main (Goethe University Frankfurt) · doi:10.21248/gups.67332 · Cited by 1

Age-associated failure of efficient cardiac proteostatic adaptations to chronic cAMP-stress is associated with accelerated heart agingPreprint

Perino, M. G., Calvo‐Rubio, M., Riordon, D. R., Agnetti, G., Parveen, A., Morrell, C. H., Ahmet, I., Chakir, K., Tarasova, Y. S., Qu, J.-H., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.08.13.553128 · Cited by 1

Mutant SQSTM1/p62 Signaling in Paget’s Disease of Bone

Rea, S. L., & Layfield, R. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-805083-5.00005-1

The Effects of Autophagic Deficiencies on the Leukemia Mitochondrial Phenotype and Implications in Strategic Drug Targeting

Rodrigo, R. (2016) · UWSpace (University of Waterloo)

Mechanisms and Roles of Mitophagy

Vigié, P., Bhatia‐Kiššová, I., & Camougrand, N. M. (2017) · Wiley eBooks · doi:10.1002/9780470015902.a0027587

Investigation of a Novel Mitophagy Regulatory Pathway and Chemical Inducer

Craig, J. (2020) · doi:10.21007/etd.cghs.2020.0512

Regulation of intracellular traffic by TBK1 and its relevance to ALS

Villarroel‐Campos, D. (2020) · UCL Discovery (University College London)

Mitochondrial Dysfunction and Mitophagy: Physiological Implications in Cardiovascular Health

Gustafsson, Å. B. (2021) · Advances in biochemistry in health and disease · doi:10.1007/978-3-030-78799-8_11

Publications from Juntendo University Graduate School of Medicine, 2015 [6/6]

(2018) · Juntendō Igaku/Juntendo igaku · doi:10.14789/jmj.2018.64.2-pl

Publications from Juntendo University Graduate School of Medicine, 2015 [2/6]

(2017) · Juntendō Igaku/Juntendo igaku · doi:10.14789/jmj.63.293

Data from MYC- and MIZ1-Dependent Vesicular Transport of Double-Strand RNA Controls Immune Evasion in Pancreatic Ductal Adenocarcinoma

Krenz, B., Gebhardt-Wolf, A., Ade, C. P., Gaballa, A., Roehrig, F., Vendelova, E., Baluapuri, A., Eilers, U., Gallant, P., D’Artista, L., et al. (2023) · doi:10.1158/0008-5472.c.6513463.v1

Data from MYC- and MIZ1-Dependent Vesicular Transport of Double-Strand RNA Controls Immune Evasion in Pancreatic Ductal Adenocarcinoma

Krenz, B., Gebhardt-Wolf, A., Ade, C. P., Gaballa, A., Roehrig, F., Vendelova, E., Baluapuri, A., Eilers, U., Gallant, P., D’Artista, L., et al. (2023) · doi:10.1158/0008-5472.c.6513463

The formation of ubiquitin rich condensates triggers recruitment of the ATG9A lipid transfer complex to initiate basal autophagyPreprint

Broadbent, D. G., McEwan, C. M., Tsang, T., Poole, D., Naylor, B. C., Price, J., Schmidt, J. C., & Andersen, J. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.11.28.569058

Additional file 1 of Inhibition of SQSTM1 S403 phosphorylation facilitates the aggresome formation of ubiquitinated proteins during proteasome dysfunction

Zhang, C., Duan, Y., Huang, C. L., & Li, L. (2023) · Figshare · doi:10.6084/m9.figshare.24425698

Phosphorylation of OPTN by TBK1 enhances its binding to Ub chains and promotes selective autophagy of damaged mitochondria

Richter, B., Sliter, D. A., Herhaus, L., Stolz, A., Wang, C., Beli, P., Zaffagnini, G., Wild, P., Martens, S., Wagner, S. A., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1523926113 · Cited by 755

The PINK1-PARKIN Mitochondrial Ubiquitylation Pathway Drives a Program of OPTN/NDP52 Recruitment and TBK1 Activation to Promote Mitophagy

Heo, J.-M., Ordureau, A., Paulo, J. A., Rinehart, J., & Harper, J. W. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.08.016 · Cited by 906

TBK1 is ubiquitinated by TRIM5α to assemble mitophagy machinery

Saha, B., Olsvik, H. L., Williams, G. L., Oh, S., Evjen, G., Sjøttem, E., & Mandell, M. A. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114294 · Cited by 20

S513 A COMBINATION OF MULTIPLE AUTONOMIC PARAMETERS, RATHER THAN EACH PARAMETER ALONE, YIELDS SIGNIFICANT DIFFERENTIATION BETWEEN HEAT PAIN INTENSITIES

Treister, R., Kliger, M., Zuckerman, G. H., Goor-Aryeh, I., & Eisenberg, E. (2011) · European Journal of Pain Supplements · doi:10.1016/s1754-3207(11)70912-9

Optineurin provides a mitophagy contact site for TBK1 activation

Yamano, K., Sawada, M., Kikuchi, R., Nagataki, K., Kojima, W., Endo, R., Kinefuchi, H., Sugihara, A., Fujino, T., Watanabe, A., et al. (2024) · The EMBO Journal · doi:10.1038/s44318-024-00036-1 · Cited by 68