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Follicular fluid and serum concentrations of myo-inositol in patients undergoing IVF: relationship with oocyte quality
Abstract
BACKGROUND: The follicular microenvironment is an important determinant of oocyte development. The aim of this study was to examine whether the myo-inositol (MI) content in human follicular fluid (FF) was associated with better oocyte quality. METHODS: A total of 53 patients treated with IVF was recruited to a prospective observational study. FF and serum samples collected were divided into two groups: group A consisted of FF associated with matured and fertilized oocytes, whilst group B was from follicles with immature and unfertilized oocytes. RESULTS: Patient's age, total ampoules of HMG used, days of stimulation, basal levels of FSH, estradiol (E(2)) levels on the day of HCG, and serum MI content were not significantly different between the two groups. FF volume and its MI content were significantly higher in group A compared with group B (P < 0.05). The levels of MI in FF were positively correlated with the amount of E(2) in their corresponding FF samples and also correlated with embryo quality. CONCLUSIONS: We propose that higher concentrations of MI and E(2) in human FF appear to play a role in follicular maturity and provide a marker of good quality oocytes.
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Inositol trisphosphate and calcium signalling
Berridge, M. J. (1993) · Nature · doi:10.1038/361315a0 · Cited by 6,545
Cited by
Follicular fluid content and oocyte quality: from single biochemical markers to metabolomics
Revelli, A., Piane, L. D., Casano, S., Molinari, E., Massobrio, M., & Rinaudo, P. (2009) · Reproductive Biology and Endocrinology · doi:10.1186/1477-7827-7-40 · Cited by 640
Evaluation of oocyte quality: morphological, cellular and molecular predictors
Wang, Q., & Sun, Q.-Y. (2006) · Reproduction, Fertility and Development · doi:10.1071/rd06103 · Cited by 306
Genazzani, A. D., Lanzoni, C., Ricchieri, F., & Jasonni, V. M. (2008) · Gynecological Endocrinology · doi:10.1080/09513590801893232 · Cited by 221
Effects of myo-inositol in women with PCOS: a systematic review of randomized controlled trials
Unfer, V., Carlomagno, G., Dante, G., & Facchinetti, F. (2012) · Gynecological Endocrinology · doi:10.3109/09513590.2011.650660 · Cited by 201
Papaleo, E., Unfer, V., Baillargeon, J.-P., Fusi, F., Occhi, F., & De Santis, L. (2009) · Fertility and Sterility · doi:10.1016/j.fertnstert.2008.01.088 · Cited by 197
Retracted
Metadata
- Authors
- Chiu, T. T. Y., Rogers, M. S., Law, E. L. K., Briton-Jones, C. M., Cheung, L. P., & Haines, C. J.
- Venue
- Human Reproduction
- Publisher
- Oxford University Press (OUP)
- Published
- 2002-06
- Volume
- 17
- Issue
- 6
- Pages
- 1591-1596
- ISSN
- 0268-1161 (ISSN-L)
- 1460-2350
- OpenAlex
- W2156191286
- Cited by
- 182
- References
- 1
- FWCI
- 0.67
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Follicular fluid and serum concentrations of myo-inositol in patients undergoing IVF: relationship with oocyte quality. https://app.cochat.ai/papers/10.1093/humrep/17.6.1591
- The paper
- Chiu, T. T. Y., Rogers, M. S., Law, E. L. K., Briton-Jones, C. M., Cheung, L. P., & Haines, C. J. (2002). Follicular fluid and serum concentrations of myo-inositol in patients undergoing IVF: relationship with oocyte quality. Human Reproduction. https://doi.org/10.1093/humrep/17.6.1591
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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