The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
A randomized single-blind controlled trial of letrozole as a low-cost IVF protocol in women with poor ovarian response: a preliminary report
Abstract
BACKGROUND: Use of letrozole, a selective inhibitor of aromatase, reduces the gonadotrophin dose required to induce follicular maturation. We evaluated whether incorporation of letrozole could be an effective low-cost IVF protocol for poor responders. METHODS: A randomized, controlled, single-blind trial was conducted in the Assisted Reproduction Unit, Institute of Reproductive Medicine, Kolkata, India. Thirty-eight women with a history of poor ovarian response to gonadotrophins were recruited. Thirteen women (Let-FSH group) received letrozole 2.5 mg daily from day 3-7, and recombinant FSH (rFSH) 75 IU/day on days 3 and 8; and 25 women (GnRH-ag-FSH group) underwent long GnRH agonist protocol and stimulated with rFSH (300-450 IU/day). Ovulation was triggered by 10,000 IU of HCG followed by IVF-embryo transfer. The main outcome measures were total dose of rFSH (IU/cycle), terminal estradiol (E2) (pg/ml), numbers of follicles, oocytes retrieved and transferable embryo, endometrial thickness (mm), and pregnancy rate. RESULTS: Compared with the GnRH-ag-FSH group (2865 +/- 228 IU), the Let-FSH group (150 +/- 0 IU) received a significantly (P < 0.001) lower total dose of FSH. Except for terminal E2, which was significantly higher (P < 0.001) in the GnRH-ag-FSH group (380 +/- 46 pg/ml) than the Let-FSH group (227 +/- 45 pg/ml), the treatment outcomes in all other respects, including pregnancy rate, were statistically comparable. CONCLUSIONS: Adjunctive use of letrozole may form an effective means of low-cost IVF protocol in poorly responding women.
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“The combined letrozole and FSH group required a significantly lower total dose of FSH as compared with the GnRH-a and FSH group.”
From A new era in ovulation induction (2006) · cites this paper as [69]
In the citing paper
“Except for the E 2 levels in late follicular phase, which were significantly higher in the GnRH-a and FSH group, the treatment outcomes in all respects, including the pregnancy rates, were statistically comparable.”
From A new era in ovulation induction (2006) · cites this paper as [69]
Citations
Cites
Mitwally, M. F. M., & Casper, R. F. (2001) · Fertility and Sterility · doi:10.1016/s0015-0282(00)01705-2 · Cited by 800 · cited 7×
“Letrozole, a highly selective, non-steroidal aromatase inhibitor, could successfully induce ovulation in women with polycystic ovary syndrome (PCOS) (Mitwally and Casper, 2000), including even those who were resistant to clomiphene citrate (Mitwally and Casper, 2001).”
BackgroundInfluentialLabrie, F., Bélanger, A., Cusan, L., Gomez, J.-L., & Candas, B. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.8.4160 · Cited by 713
Androgen and follicle stimulating hormone interactions in primate ovarian follicle development
Weil, S., Vendola, K., Zhou, J., & Bondy, C. A. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.8.5929 · Cited by 592
Navot, D., Bergh, R. A., Williams, M. C., Garrisi, G. J., Guzman, I., Sandler, B., & Grunfeld, L. (1991) · The Lancet · doi:10.1016/0140-6736(91)93060-m · Cited by 523
Insulin-Like Growth Factors and Ovarian Follicular Development*
Giudice, L. C. (1992) · Endocrine Reviews · doi:10.1210/edrv-13-4-641 · Cited by 521
Toner, J. P., Philput, C. B., Jones, G. S., & Muasher, S. J. (1991) · Fertility and Sterility · doi:10.1016/s0015-0282(16)54249-6 · Cited by 495
Aromatase inhibition improves ovarian response to follicle-stimulating hormone in poor responders
Mitwally, M. F. M., & Casper, R. F. (2002) · Fertility and Sterility · doi:10.1016/s0015-0282(01)03280-0 · Cited by 407
Clinical management of low ovarian response to stimulation for IVF: a systematic review
Tarlatzis, B. C. (2003) · Human Reproduction Update · doi:10.1093/humupd/dmg007 · Cited by 364
Mitwally, M. F. M. (2003) · Human Reproduction · doi:10.1093/humrep/deg311 · Cited by 344
The role of local estrogen Biosynthesis in males and females
Simpson, E., Rubin, G., Clyne, C., Robertson, K., O’Donnell, L., Jones, M., & Davis, S. (2000) · Trends in Endocrinology & Metabolism · doi:10.1016/s1043-2760(00)00254-x · Cited by 249
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Ferraretti, A. P., Marca, A. L., Fauser, B. C. J. M., Tarlatzis, B. C., Nargund, G., Gianaroli, L., & on behalf of the ESHRE working group on Poor Ovarian Response Definition (2011) · Human Reproduction · doi:10.1093/humrep/der092 · Cited by 1,884
Aromatase Inhibitors for Ovulation Induction
Casper, R. F., & Mitwally, M. F. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-1923 · Cited by 272
Pandian, Z., McTavish, A. R., Aucott, L. S., Hamilton, M. P. R., & Bhattacharya, S. (2010) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd004379.pub3 · Cited by 241
Kyrou, D., Kolibianakis, E. M., Venetis, C. A., Papanikolaou, E. G. E., Bontis, J. N., & Tarlatzis, B. C. (2008) · Fertility and Sterility · doi:10.1016/j.fertnstert.2007.12.077 · Cited by 239
Zhang, Y., Zhang, C., Shu, J., Guo, J., Chang, H., Leung, P. C. K., Sheng, J., & Huang, H. (2019) · Human Reproduction Update · doi:10.1093/humupd/dmz046 · Cited by 234
Metadata
- Authors
- Goswami, S. K.
- Affiliations
- Institute of Reproductive Medicine (IN)
- Corresponding author
- Goswami, S.K.
- ORCID
- Goswami, S.K.
- Venue
- Human Reproduction
- Publisher
- Oxford University Press (OUP)
- Published
- 2004-06-24
- Volume
- 19
- Issue
- 9
- Pages
- 2031-2035
- ISSN
- 0268-1161 (ISSN-L)
- 1460-2350
- OpenAlex
- W2105251513
- Cited by
- 372
- References
- 31
- Citations by year
- 2025: 5 · 2024: 3 · 2023: 6 · 2022: 8 · 2021: 12 · 2020: 14 · 2019: 10 · 2018: 5 · 2017: 40 · 2016: 12 · 2015: 44 · 2014: 37 · 2013: 33 · 2012: 36
- FWCI
- 8.53
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Human Reproduction (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Biology and Fertility
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Health and Technologies
- Keywords
- letrozole, poor ovarian response, aromatase inhibitors, recombinant FSH, GnRH agonist protocol, oocyte retrieval, pregnancy rate
- MeSH terms
- Letrozole, Adult, Cost Control, Dose-Response Relationship, Drug, Drug Resistance, Embryo Transfer, Estradiol, Female, Fertilization in Vitro, Follicle Stimulating Hormone, Gonadotropins, Chorionic Gonadotropin, Humans, Gonadotropin-Releasing Hormone, Nitriles, Ovary, Pregnancy, Recombinant Proteins, Triazoles, Single-Blind Method, Treatment Outcome, Pregnancy Rate, Aromatase Inhibitors
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