Androgen and follicle stimulating hormone interactions in primate ovarian follicle development
Abstract
We have previously shown that androgens stimulate early stages of follicular development and that granulosal androgen receptor (AR) gene expression is positively correlated with follicular growth. The present study was aimed at elucidating potential interactions between FSH and androgens in follicular development. Study groups included eight normal cycling rhesus monkeys (five follicular and three luteal-phase), eight testosterone (T)-treated, and four FSH-treated animals. Examination of sequential ovary sections revealed selective colocalization of AR and FSH receptor (FSHR) messenger RNAs (mRNAs) in healthy, growing follicles. Moreover, individual follicles demonstrate a highly significant (P < 0.001) positive correlation between FSHR and AR mRNA levels in all study groups. Androgen treatment significantly increased granulosa cell FSHR mRNA abundance (by approximately 50-100%, depending on follicle size). FSH treatment increased granulosa AR mRNA levels only in primary follicles. The finding that T augments follicular FSHR expression suggests that androgens promote follicular growth and estrogen biosynthesis indirectly, by amplifying FSH effect, and may partially explain the enhanced responsiveness to gonadotropin stimulation noted in women with polycystic ovary syndrome.
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Several recent publications support a role for androgens in the stimulation of follicular growth in primates through amplification of FSH receptor gene expression.
“Several recent publications support a role for androgens in the stimulation of follicular growth in primates through amplification of FSH receptor gene expression (22)(23)(24).”
From A randomized double-blind comparison of the effects of clomiphene citrate and the aromatase inhibitor letrozole on ovulatory function in normal women (2002) · cites this paper as [22]
Testosterone augments follicular FSH receptor expression in primates.
“Testosterone was found to augment follicular FSH receptor expression in primates suggesting that follicular growth may be improved by amplification of FSH effects (18 -20).”
From Aromatase inhibition improves ovarian response to follicle-stimulating hormone in poor responders (2002) · cites this paper as [18]
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- Authors
- Weil, S., Vendola, K., Zhou, J., & Bondy, C. A.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Bondy, Carolyn A.
- ORCID
- Zhou, Jian
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 1999-08
- Volume
- 84
- Issue
- 8
- Pages
- 2951-2956
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2015159617
- Cited by
- 592
- References
- 24
- Citations by year
- 2026: 2 · 2025: 11 · 2024: 17 · 2023: 16 · 2022: 26 · 2021: 17 · 2020: 21 · 2019: 29 · 2018: 18 · 2017: 55 · 2016: 23 · 2015: 45 · 2014: 34 · 2013: 26 · 2012: 36
- FWCI
- 7.52
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Reproductive biology and impacts on aquatic species
- Keywords
- androgens, follicle-stimulating hormone, ovarian follicle development, androgen receptor, FSH receptor, granulosa cells, testosterone, rhesus monkeys, polycystic ovary syndrome, estrogen synthesis, gonadotropin response
- MeSH terms
- Androgens, Animals, Aromatase, Female, Follicle Stimulating Hormone, Ovarian Follicle, Macaca mulatta, Ovulation, Polycystic Ovary Syndrome, Receptors, Androgen, Receptors, FSH, RNA, Messenger
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