The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
A new model of reproductive aging: the decline in ovarian non-growing follicle number from birth to menopause
Open accessAbstract
BACKGROUND: The primary determinant of reproductive age in women is the number of ovarian non-growing (primordial, intermediate and primary) follicles (NGFs). To better characterize the decline in NGF number associated with aging, we have employed modern stereology techniques to determine NGF number in women from birth to menopause. METHODS: Normal human ovaries were collected from 122 women (aged 0-51 years) undergoing elective oophorectomy, organ donation or autopsy. After gross pathologic examination, systematic random sampling was utilized to obtain tissue for analysis by the fractionator/optical disector method. Models to describe the resulting decay curve were constructed and evaluated. RESULTS: NGF decay was best described by a simple power function: log (y) = ax(b) + c, where a, b and c are constants and y = NGF count at age x (R(2) = 0.84, Sums of Squares Error = 28.18 on 119 degrees of freedom). This model implies that follicles decay faster with increasing age. CONCLUSIONS: Unlike previous models of ovarian follicle depletion, our model predicts no sudden change in decay rate, but rather a constantly increasing rate. The model not only agrees well with observed ages of menopause in women, but also is more biologically plausible than previous models. Although the model represents a significant improvement compared with earlier attempts, a considerable percentage of the variation in NGF number between women cannot be explained by age alone.
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Cites
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GOUGEON, A. (1996) · Endocrine Reviews · doi:10.1210/edrv-17-2-121 · Cited by 1,497
Accelerated disappearance of ovarian follicles in mid-life: implications for forecasting menopause
Faddy, M. J., Gosden, R. G., Gougeon, A., Richardson, S. J., & Nelson, J. F. (1992) · Human Reproduction · doi:10.1093/oxfordjournals.humrep.a137570 · Cited by 1,365
Unbiased stereological estimation of the number of neurons in the human hippocampus
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New stereological methods for counting neurons
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Methods for quantifying follicular numbers within the mouse ovary
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Cited by
Ovarian aging: mechanisms and clinical consequences
Broekmans, F. J., Soules, M. R., & Fauser, B. C. (2009) · Endocrine Reviews · doi:10.1210/er.2009-0006 · Cited by 1,248
Self-citationOvarian antral folliculogenesis during the human menstrual cycle: A review
Baerwald, A. R., Adams, G. P., & Pierson, R. A. (2012) · Human Reproduction Update · doi:10.1093/humupd/dmr039 · Cited by 487
Rance, N. E., Dacks, P. A., Mittelman-Smith, M. A., Romanovsky, A. A., & Krajewski-Hall, S. J. (2013) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2013.07.003 · Cited by 380
Delayed childbearing: effects on fertility and the outcome of pregnancy
Balasch, J., & Gratacós, E. (2012) · Current Opinion in Obstetrics & Gynecology · doi:10.1097/gco.0b013e3283517908 · Cited by 253
Rance, N. E. (2009) · Peptides · doi:10.1016/j.peptides.2008.05.016 · Cited by 237
Metadata
- Authors
- Hansen, K. R., Knowlton, N. S., Thyer, A. C., Charleston, J. S., Soules, M. R., & Klein, N. A.
- Venue
- Human Reproduction
- Publisher
- Oxford University Press (OUP)
- Published
- 2008-03-01
- Volume
- 23
- Issue
- 3
- Pages
- 699-708
- ISSN
- 0268-1161 (ISSN-L)
- 1460-2350
- OpenAlex
- W2153143103
- Cited by
- 561
- References
- 40
- FWCI
- 25.11
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Hansen, K. R., Knowlton, N. S., Thyer, A. C., Charleston, J. S., Soules, M. R., & Klein, N. A. (2008). A new model of reproductive aging: the decline in ovarian non-growing follicle number from birth to menopause. Human Reproduction. https://doi.org/10.1093/humrep/dem408
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