Cited by 346Reproductive System and PregnancyReproductive Biology and FertilityReproductive Health and Technologies

Endometrial receptivity is affected in women with high circulating progesterone levels at the end of the follicular phase: a functional genomics analysis

Labarta, E., Martinez-Conejero, J. A., Alama, P., Horcajadas, J. A., Pellicer, A., Simon, C., Bosch, E.·2011·Human Reproduction

Abstract

BACKGROUND: Elevated serum progesterone levels at the end of the follicular phase in controlled ovarian stimulation (COS) leads to a poorer ongoing pregnancy rate in IVF cycles due to reduced endometrial receptivity. The objective of this study was to use microarray technology to compare endometrial gene expression profiles at the window of implantation according to the levels of circulating progesterone. METHODS: For this prospective cohort study, microarray data were obtained from endometrial biopsies from 12 young healthy oocyte donors undergoing COS with pituitary suppression by either gonadotrophin-releasing hormone (GnRH) agonists or antagonists, and recombinant FSH. On the day of recombinant chorionic gonadotrophin (rCG) administration, six women had serum progesterone levels (P) >1.5 ng/ml (study group) and six had serum P levels <1.5 ng/ml (control group). Endometrial samples were collected using a Pipelle catheter 7 days after the rCG injection. RESULTS: Using the parametric test, we identified 140 genes significantly dysregulated (64 up- and 76 down-regulated) in the study group endometria compared with the control endometria, regardless of the GnRH analogue employed. These genes are related to cell adhesion, developmental processes, the immune system and others, which are all required for normal endometrial function development. Of the 25 gene targets previously proposed as markers for endometrial receptivity, 13 appeared over-regulated in the study group. CONCLUSIONS: Our results reveal that elevated progesterone levels on the day of rCG administration can induce significant alterations in the gene expression profile of the endometrium.

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Crossref · 10.1093/humrep/der126

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  • In the virilizing forms of CAH, excess adrenal sex steroids can lead to hypogonadotropic hypogonadism and increased progesterone can interfere with endometrial implantation.

    “In the virilizing forms of CAH, excess adrenal sex steroids can lead to hypogonadotropic hypogonadism 106,107 and increased progesterone can interfere with endometrial implantation.108,109”

    From Congenital adrenal hyperplasia (2017) · cites this paper as [108]

  • Increased progesterone can interfere with endometrial implantation.

    “increased progesterone can interfere with endometrial implantation.108,109”

    From Congenital adrenal hyperplasia (2017) · cites this paper as [108]

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Authors
Labarta, E., Martinez-Conejero, J. A., Alama, P., Horcajadas, J. A., Pellicer, A., Simon, C., & Bosch, E.
Affiliations
  • Universitat de València (ES)
  • Igenomix (ES)
Corresponding author
Labarta, E.
Venue
Human Reproduction
Published
2011-05-02
Volume
26
Issue
7
Pages
1813-1825
ISSN
  • 0268-1161 (ISSN-L)
  • 1460-2350
OpenAlex
W2153214140
Cited by
346
References
67
Citations by year
2026: 16 · 2025: 14 · 2024: 19 · 2023: 20 · 2022: 31 · 2021: 30 · 2020: 25 · 2019: 37 · 2018: 30 · 2017: 34 · 2016: 17 · 2015: 26 · 2014: 17 · 2013: 13 · 2012: 11
FWCI
6.38
Type
journal article
Language
en
Open access
closed
Locations
  • Human Reproduction (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
  • Health Sciences › Medicine › Reproductive Medicine › Reproductive Health and Technologies
Keywords
endometrial receptivity, serum progesterone, endometrial gene expression, implantation window, controlled ovarian stimulation, oocyte donors, GnRH agonist, GnRH antagonist, recombinant FSH, human chorionic gonadotropin, implantation failure
MeSH terms
Adult, Endometrium, Female, Follicular Phase, Gene Expression Regulation, Humans, Ovulation Induction, Embryo Implantation, Pregnancy, Progesterone, Prospective Studies, Oligonucleotide Array Sequence Analysis, Gene Expression Profiling, Genomics

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