The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
Long-term effects of prenatal exposure to perfluoroalkyl substances on female reproduction
Abstract
Study question Does prenatal exposure to perfluoroalkyl substances (PFASs) have long-term effects on female reproductive function?. Summary answer Our results suggest an association between in utero exposure to perfluorooctanoic acid (PFOA) and delay in age of menarche. What is known already Previous cross-sectional studies have reported possible effects of PFASs on female reproduction including reduced fecundity, delayed puberty and accelerated age at menopause. Only limited data exist from follow-up studies on long-term implications of prenatal exposure to PFASs. Study design, size, duration In this study we used data from a Danish population-based cohort established in 1988-1989. Of 1212 eligible pregnant women, 965 participated. Follow-up was initiated in 2008 on the female offspring at ∼20 years of age. Three hundred and sixty seven (84%) daughters answered a questionnaire and 267 (61%) daughters furthermore attended clinical examinations which were conducted in 2008-2009. Participants/materials, setting, methods The final study population consisted of 343 daughters of which 254 had attended the clinical examinations and 89 had answered the questionnaire only. Levels of PFASs in maternal serum from pregnancy week 30 were used as a measure of prenatal exposure and related to age of menarche, menstrual cycle length, levels of reproductive hormones and follicle number of the daughters. Data were divided into three groups according to tertiles of maternal concentrations of P…
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“these findings are supported by human epidemiological studies reporting delayed puberty in exposed females.33,34”
From A Never-Ending Story of Per- and Polyfluoroalkyl Substances (PFASs)? (2017) · cites this paper as [33]
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Cites
Buck, R. C., Franklin, J., Berger, U., Conder, J. M., Cousins, I. T., de Voogt, P., Jensen, A. A., Kannan, K., Mabury, S. A., & van Leeuwen, S. P. (2011) · Integrated Environmental Assessment and Management · doi:10.1002/ieam.258 · Cited by 4,641
Perfluoroalkyl Acids: A Review of Monitoring and Toxicological Findings
Lau, C., Anitole, K., Hodes, C., Lai, D., Pfahles-Hutchens, A., & Seed, J. (2007) · Toxicological Sciences · doi:10.1093/toxsci/kfm128 · Cited by 2,620
The Developmental Origins of Adult Disease
Barker, D. J. P. (2004) · Journal of the American College of Nutrition · doi:10.1080/07315724.2004.10719428 · Cited by 1,854
Developmental origins of non-communicable disease: Implications for research and public health
Barouki, R., Gluckman, P. D., Grandjean, P., Hanson, M. A., & Heindel, J. J. (2012) · Environmental Health · doi:10.1186/1476-069x-11-42 · Cited by 788
Perfluorinated Chemicals and Fetal Growth: A Study within the Danish National Birth Cohort
Fei, C., McLaughlin, J. K., Tarone, R. E., & Olsen, J. (2007) · Environmental Health Perspectives · doi:10.1289/ehp.10506 · Cited by 636
Apelberg, B. J., Witter, F. R., Herbstman, J. B., Calafat, A. M., Halden, R. U., Needham, L. L., & Goldman, L. R. (2007) · Environmental Health Perspectives · doi:10.1289/ehp.10334 · Cited by 630
Recent decline in age at breast development: The Copenhagen Puberty Study
Aksglaede, L., Sørensen, K., Petersen, J. H., Skakkebæk, N. E., & Juul, A. (2009) · Pediatrics · doi:10.1542/peds.2008-2491 · Cited by 626
Must, A. (2002) · American Journal of Epidemiology · doi:10.1093/aje/155.7.672 · Cited by 506 · cited 2×
“However, even for a time span of decades, recollection of age of menarche has been demonstrated to be both precise and without bias (Must et al., 2002).”
BackgroundKarapanou, O., & Papadimitriou, A. (2010) · Reproductive Biology and Endocrinology · doi:10.1186/1477-7827-8-115 · Cited by 494
Female reproductive disorders: the roles of endocrine-disrupting compounds and developmental timing
Crain, D. A., Janssen, S. J., Edwards, T. M., Heindel, J., Ho, S.-M., Hunt, P., Iguchi, T., Juul, A., McLachlan, J. A., Schwartz, J., et al. (2008) · Fertility and Sterility · doi:10.1016/j.fertnstert.2008.08.067 · Cited by 465
Haug, L. S., Huber, S., Becher, G., & Thomsen, C. (2011) · Environment International · doi:10.1016/j.envint.2011.01.011 · Cited by 433
Self-citationBinding of Perfluorooctanoic Acid to Rat and Human Plasma Proteins
Han, X., Snow, T. A., Kemper, R. A., & Jepson, G. W. (2003) · Chemical Research in Toxicology · doi:10.1021/tx034005w · Cited by 422
Maternal levels of perfluorinated chemicals and subfecundity
Fei, C., McLaughlin, J. K., Lipworth, L., & Olsen, J. (2009) · Human Reproduction · doi:10.1093/humrep/den490 · Cited by 385
Halldorsson, T. I., Rytter, D., Haug, L. S., Bech, B. H., Danielsen, I., Becher, G., Henriksen, T. B., & Olsen, S. F. (2012) · Environmental Health Perspectives · doi:10.1289/ehp.1104034 · Cited by 353
Self-citationPre- and Postnatal Exposure to Perfluorinated Compounds (PFCs)
Fromme, H., Mosch, C., Morovitz, M., Alba‐Alejandre, I., Boehmer, S., Kiranoglu, M., Faber, F. L., Hannibal, I., Genzel‐Boroviczény, O., Koletzko, B. V., et al. (2010) · Environmental Science & Technology · doi:10.1021/es101184f · Cited by 339
Endocrine disrupting properties of perfluorooctanoic acid
White, S. S., Fenton, S. E., & Hines, E. P. (2011) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2011.03.011 · Cited by 298
Olsen, G. W., Butenhoff, J. L., & Zobel, L. R. (2009) · Reproductive Toxicology · doi:10.1016/j.reprotox.2009.02.001 · Cited by 293
Midasch, O., Drexler, H., Hart, N., Beckmann, M. W., & Angerer, J. (2007) · International Archives of Occupational and Environmental Health · doi:10.1007/s00420-006-0165-9 · Cited by 265
Lopez-Espinosa, M.-J., Fletcher, T., Armstrong, B., Genser, B., Dhatariya, K., Mondal, D., Ducatman, A., & Leonardi, G. (2011) · Environmental Science & Technology · doi:10.1021/es1038694 · Cited by 262
Influence of Medical Conditions and Lifestyle Factors on the Menstrual Cycle
Rowland, A. S., Baird, D. D., Long, S., Wegienka, G., Harlow, S. D., Alavanja, M., & Sandler, D. P. (2002) · Epidemiology · doi:10.1097/00001648-200211000-00011 · Cited by 239
Gützkow, K. B., Haug, L. S., Thomsen, C., Sabaredzovic, A., Becher, G., & Brunborg, G. (2011) · International Journal of Hygiene and Environmental Health · doi:10.1016/j.ijheh.2011.08.011 · Cited by 236
Self-citationDeterminants of Fetal Exposure to Polyfluoroalkyl Compounds in Baltimore, Maryland
Apelberg, B. J., Goldman, L. R., Calafat, A. M., Herbstman, J. B., Kuklenyik, Z., Heidler, J., Needham, L. L., Halden, R. U., & Witter, F. R. (2007) · Environmental Science & Technology · doi:10.1021/es0700911 · Cited by 226
Vested, A., Ramlau‐Hansen, C. H., Olsen, S. F., Bonde, J. P., Kristensen, S. L., Halldorsson, T. I., Becher, G., Haug, L. S., Ernst, E. H., & Toft, G. V. (2013) · Environmental Health Perspectives · doi:10.1289/ehp.1205118 · Cited by 222
Self-citationImplications of Early Menopause in Women Exposed to Perfluorocarbons
Knox, S. S., Jackson, T., Javins, B., Frisbee, S. J., Shankar, A., & DUCATMAN, A. M. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-2401 · Cited by 195
Impact of endocrine disruptor chemicals in gynaecology
Caserta, D., Maranghi, L., Mantovani, A., Marci, R., Maranghi, F., & Moscarini, M. (2007) · Human Reproduction Update · doi:10.1093/humupd/dmm025 · Cited by 191
Persistent Environmental Pollutants and Couple Fecundity: The LIFE Study
Louis, G. M. B., Sundaram, R., Schisterman, E. F., Sweeney, A., Lynch, C. D.-J., Gore‐Langton, R. E., Maisog, J. M., Kim, S., Chen, Z., & Barr, D. B. (2012) · Environmental Health Perspectives · doi:10.1289/ehp.1205301 · Cited by 189
Haug, L. S., Thomsen, C., & Becher, G. (2008) · Journal of Chromatography A · doi:10.1016/j.chroma.2008.10.113 · Cited by 188
Self-citationPhysiologic changes in pregnancy and their effect on drug disposition
Frederiksen, M. C. (2001) · Seminars in Perinatology · doi:10.1053/sper.2001.24565 · Cited by 172
Critical windows of exposure for children's health: the reproductive system in animals and humans.
Pryor, J., Hughes, C. L., Foster, W. G., Hales, B. F., & Robaire, B. (2000) · Environmental Health Perspectives · doi:10.1289/ehp.00108s3491 · Cited by 164
Validity of Self-Reported Menstrual Cycle Length
Small, C. M., Manatunga, A. K., & Marcus, M. (2006) · Annals of Epidemiology · doi:10.1016/j.annepidem.2006.05.005 · Cited by 162
Perfluorinated Compounds and Subfecundity in Pregnant Women
Whitworth, K. W., Haug, L. S., Baird, D. D., Becher, G., Hoppin, J. A., Skjærven, R., Thomsen, C., Eggesbø, M. Å., Travlos, G. S., Wilson, R., et al. (2011) · Epidemiology · doi:10.1097/ede.0b013e31823b5031 · Cited by 146
Self-citationWhite, S., Stanko, J., Kato, K., Calafat, A., Hines, E., & Fenton, S. (2011) · Environmental Health Perspectives · doi:10.1289/ehp.1002741 · Cited by 138
Gestation length and birth weight in relation to intake of marinen-3 fatty acids
Olsen, S. F., Hansen, H. S., Secher, N. J., Jensen, B., & Sandström, B. (1995) · British Journal Of Nutrition · doi:10.1079/bjn19950042 · Cited by 103
Self-citationKristensen, S. L., Ramlau-Hansen, C. H., Ernst, E., Olsen, S. F., Bonde, J. P., Vested, A., & Toft, G. (2010) · Human Reproduction · doi:10.1093/humrep/deq273 · Cited by 102
Self-citationVestergaard, S., Nielsen, F., Andersson, A., Hjøllund, N. H., Grandjean, P., Andersen, H. R., & Jensen, T. K. (2012) · Human Reproduction · doi:10.1093/humrep/der450 · Cited by 88
Yang, C., Tan, Y., Harkema, J. R., & Haslam, S. Z. (2008) · Reproductive Toxicology · doi:10.1016/j.reprotox.2008.10.003 · Cited by 87
Christensen, K. L. Y., Maisonet, M., Rubin, C., Holmes, A. K., Calafat, A. M., Kato, K., Flanders, W. D., Heron, J., McGeehin, M. A., & Marcus, M. (2010) · Environment International · doi:10.1016/j.envint.2010.08.007 · Cited by 82
Erythrocyte levels compared with reported dietary intake of marinen-3 fatty acids in pregnant women
Olsen, S. F., Hansen, H. S., Sandström, B., & Jensen, B. (1995) · British Journal Of Nutrition · doi:10.1079/bjn19950041 · Cited by 79
Self-citationErnst, A., Kristensen, S. L., Toft, G. V., Thulstrup, A. M., Håkonsen, L. B., Olsen, S. F., & Ramlau‐Hansen, C. H. (2012) · Human Reproduction · doi:10.1093/humrep/des337 · Cited by 65
Self-citationDixon, D., Reed, C. E., Moore, A. B., Gibbs-Flournoy, E. A., Hines, E. P., Wallace, E. A., Stanko, J. P., Lu, Y., Jefferson, W. N., Newbold, R. R., et al. (2011) · Reproductive Toxicology · doi:10.1016/j.reprotox.2011.10.011 · Cited by 50
Zhao, Y. M., Tan, Y., Strynar, M. J., Perez, G. I., Haslam, S. Z., & Yang, C. (2012) · Reproductive Toxicology · doi:10.1016/j.reprotox.2012.02.004 · Cited by 48
A halt in the secular trend towards earlier menarche in Denmark
Helm, P., & Grønlund, L. (1998) · Acta Obstetricia Et Gynecologica Scandinavica · doi:10.1034/j.1600-0412.1998.770213.x · Cited by 45
Magnesium intake and status and pregnancy outcome in a Danish population
Skajaa, K., Dørup, I., & Sandström, B. (1991) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.1991.tb13515.x · Cited by 38
Fei, C., Weinberg, C. R., & Olsen, J. (2012) · Epidemiology · doi:10.1097/ede.0b013e3182467608 · Cited by 21
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EDC-2: the endocrine society's second scientific statement on endocrine-disrupting chemicals
Gore, A. C., Chappell, V. A., Fenton, S. E., Flaws, J. A., Nadal, A., Prins, G. S., Toppari, J., & Zoeller, R. T. (2015) · Endocrine Reviews · doi:10.1210/er.2015-1010 · Cited by 2,407
A Never-Ending Story of Per- and Polyfluoroalkyl Substances (PFASs)?
Wang, Z., DeWitt, J. C., Higgins, C. P., & Cousins, I. T. (2017) · Environmental Science & Technology · doi:10.1021/acs.est.6b04806 · Cited by 1,921
(CONTAM), E. P. O. C. I. T. F. C., Knutsen, H. K., Alexander, J., Barregård, L., Bignami, M., Brüschweiler, B. J., Ceccatelli, S., Cottrill, B., Dinovi, M., Edler, L., et al. (2018) · EFSA Journal · doi:10.2903/j.efsa.2018.5194 · Cited by 549
Self-citationPerfluoroalkyl and polyfluoroalkyl substances (PFAS) and their effects on the ovary
Ding, N., Harlow, S. D., Randolph, J. F., Loch-Caruso, R. K., & Park, S. K. (2020) · Human Reproduction Update · doi:10.1093/humupd/dmaa018 · Cited by 420
Rappazzo, K., Coffman, E., & Hines, E. (2017) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph14070691 · Cited by 405
Metadata
- Authors
- Kristensen, S. L., Ramlau-Hansen, C. H., Ernst, E., Olsen, S. F., Bonde, J. P., Vested, A., Halldorsson, T. I., Becher, G., Haug, L. S., & Toft, G.
- Affiliations
- Aarhus University Hospital (DK)
- Aarhus University (DK)
- Statens Serum Institut (DK)
- University of Copenhagen (DK)
- Norwegian Institute of Public Health (NO)
- Corresponding author
- Kristensen, S. L.
- Venue
- Human Reproduction
- Publisher
- Oxford University Press (OUP)
- Published
- 2013-10-15
- Volume
- 28
- Issue
- 12
- Pages
- 3337-3348
- ISSN
- 0268-1161 (ISSN-L)
- 1460-2350
- OpenAlex
- W2114076003
- Cited by
- 151
- References
- 44
- Citations by year
- 2026: 16 · 2025: 13 · 2024: 18 · 2023: 17 · 2022: 10 · 2021: 14 · 2020: 10 · 2019: 9 · 2018: 10 · 2017: 11 · 2016: 7 · 2015: 13 · 2014: 3
- FWCI
- 6.09
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Human Reproduction (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- Hirsla (Landspítali University Hospital) (submittedVersion)
- Funders
- Norwegian Institute of Public Health
- Topics
- Physical Sciences › Environmental Science › Environmental Chemistry › Per- and polyfluoroalkyl substances research
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- perfluorinated compounds, perfluorooctanoic acid, prenatal exposure, female reproduction, age at menarche, delayed menarche, menstrual cycle length, reproductive hormones, ovarian follicle count, placental transfer, endocrine disruptors, puberty onset, age at menopause
- MeSH terms
- Adolescent, Caprylates, Female, Fluorocarbons, Follow-Up Studies, Humans, Menarche, Pregnancy, Prenatal Exposure Delayed Effects, Reproduction, Young Adult
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