Cited by 152Per- and polyfluoroalkyl substances researchEffects and risks of endocrine disrupting chemicalsHypothalamic control of reproductive hormones

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Long-term effects of prenatal exposure to perfluoroalkyl substances on female reproduction

Kristensen, S. L., Ramlau-Hansen, C. H., Ernst, E., Olsen, S. F., Bonde, J. P., Vested, A., Halldorsson, T. I., Becher, G., Haug, L. S., Toft, G.·2013·Human Reproduction

DOI 10.1093/humrep/det382

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Abstract

Study question Does prenatal exposure to perfluoroalkyl substances (PFASs) have long-term effects on female reproductive function?. Summary answer Our results suggest an association between in utero exposure to perfluorooctanoic acid (PFOA) and delay in age of menarche. What is known already Previous cross-sectional studies have reported possible effects of PFASs on female reproduction including reduced fecundity, delayed puberty and accelerated age at menopause. Only limited data exist from follow-up studies on long-term implications of prenatal exposure to PFASs. Study design, size, duration In this study we used data from a Danish population-based cohort established in 1988-1989. Of 1212 eligible pregnant women, 965 participated. Follow-up was initiated in 2008 on the female offspring at ∼20 years of age. Three hundred and sixty seven (84%) daughters answered a questionnaire and 267 (61%) daughters furthermore attended clinical examinations which were conducted in 2008-2009. Participants/materials, setting, methods The final study population consisted of 343 daughters of which 254 had attended the clinical examinations and 89 had answered the questionnaire only. Levels of PFASs in maternal serum from pregnancy week 30 were used as a measure of prenatal exposure and related to age of menarche, menstrual cycle length, levels of reproductive hormones and follicle number of the daughters. Data were divided into three groups according to tertiles of maternal concentrations of P…

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“However, even for a time span of decades, recollection of age of menarche has been demonstrated to be both precise and without bias (Must et al., 2002).”
Background
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Authors: Kristensen, S. L., Ramlau-Hansen, C. H., Ernst, E., Olsen, S. F., Bonde, J. P., Vested, A., Halldorsson, T. I., Becher, G., Haug, L. S., & Toft, G.
Affiliations: Aarhus University Hospital (DK)
Aarhus University (DK)
Statens Serum Institut (DK)
University of Copenhagen (DK)
Norwegian Institute of Public Health (NO)
Corresponding author: Kristensen, S. L.
ORCID: Ernst, E.
Olsen, S. F.
Bonde, J. P.
Vested, A.
Halldorsson, T. I.
Haug, L. S.
Toft, G.
Venue: Human Reproduction
Publisher: Oxford University Press (OUP)
Published: 2013-10-15
Volume: 28
Issue: 12
Pages: 3337-3348
ISSN: 0268-1161 (ISSN-L)
1460-2350
DOI: 10.1093/humrep/det382
OpenAlex: W2114076003
Cited by: 151
References: 44
Citations by year: 2026: 16 · 2025: 13 · 2024: 18 · 2023: 17 · 2022: 10 · 2021: 14 · 2020: 10 · 2019: 9 · 2018: 10 · 2017: 11 · 2016: 7 · 2015: 13 · 2014: 3
FWCI: 6.09
Type: journal article
Language: en
Open access: closed
Locations: Human Reproduction (publishedVersion)
PubMed (publishedVersion)
HighWire Press Open Archive (submittedVersion)
Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
Hirsla (Landspítali University Hospital) (submittedVersion)
Funders: Norwegian Institute of Public Health
Topics: Physical Sciences › Environmental Science › Environmental Chemistry › Per- and polyfluoroalkyl substances research
Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Keywords: perfluorinated compounds, perfluorooctanoic acid, prenatal exposure, female reproduction, age at menarche, delayed menarche, menstrual cycle length, reproductive hormones, ovarian follicle count, placental transfer, endocrine disruptors, puberty onset, age at menopause
MeSH terms: Adolescent, Caprylates, Female, Fluorocarbons, Follow-Up Studies, Humans, Menarche, Pregnancy, Prenatal Exposure Delayed Effects, Reproduction, Young Adult

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Long-term effects of prenatal exposure to perfluoroalkyl substances on female reproduction

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