The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
Long-term effects of prenatal exposure to perfluoroalkyl substances on female reproduction
Abstract
Study question Does prenatal exposure to perfluoroalkyl substances (PFASs) have long-term effects on female reproductive function?. Summary answer Our results suggest an association between in utero exposure to perfluorooctanoic acid (PFOA) and delay in age of menarche. What is known already Previous cross-sectional studies have reported possible effects of PFASs on female reproduction including reduced fecundity, delayed puberty and accelerated age at menopause. Only limited data exist from follow-up studies on long-term implications of prenatal exposure to PFASs. Study design, size, duration In this study we used data from a Danish population-based cohort established in 1988-1989. Of 1212 eligible pregnant women, 965 participated. Follow-up was initiated in 2008 on the female offspring at ∼20 years of age. Three hundred and sixty seven (84%) daughters answered a questionnaire and 267 (61%) daughters furthermore attended clinical examinations which were conducted in 2008-2009. Participants/materials, setting, methods The final study population consisted of 343 daughters of which 254 had attended the clinical examinations and 89 had answered the questionnaire only. Levels of PFASs in maternal serum from pregnancy week 30 were used as a measure of prenatal exposure and related to age of menarche, menstrual cycle length, levels of reproductive hormones and follicle number of the daughters. Data were divided into three groups according to tertiles of maternal concentrations of P…
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“these findings are supported by human epidemiological studies reporting delayed puberty in exposed females.33,34”
From A Never-Ending Story of Per- and Polyfluoroalkyl Substances (PFASs)? (2017) · cites this paper as [33]
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Cites
Buck, R. C., Franklin, J., Berger, U., Conder, J. M., Cousins, I. T., de Voogt, P., Jensen, A. A., Kannan, K., Mabury, S. A., & van Leeuwen, S. P. (2011) · Integrated Environmental Assessment and Management · doi:10.1002/ieam.258 · Cited by 4,641
Perfluoroalkyl Acids: A Review of Monitoring and Toxicological Findings
Lau, C., Anitole, K., Hodes, C., Lai, D., Pfahles-Hutchens, A., & Seed, J. (2007) · Toxicological Sciences · doi:10.1093/toxsci/kfm128 · Cited by 2,620
The Developmental Origins of Adult Disease
Barker, D. J. P. (2004) · Journal of the American College of Nutrition · doi:10.1080/07315724.2004.10719428 · Cited by 1,854
Developmental origins of non-communicable disease: Implications for research and public health
Barouki, R., Gluckman, P. D., Grandjean, P., Hanson, M. A., & Heindel, J. J. (2012) · Environmental Health · doi:10.1186/1476-069x-11-42 · Cited by 788
Perfluorinated Chemicals and Fetal Growth: A Study within the Danish National Birth Cohort
Fei, C., McLaughlin, J. K., Tarone, R. E., & Olsen, J. (2007) · Environmental Health Perspectives · doi:10.1289/ehp.10506 · Cited by 636
Apelberg, B. J., Witter, F. R., Herbstman, J. B., Calafat, A. M., Halden, R. U., Needham, L. L., & Goldman, L. R. (2007) · Environmental Health Perspectives · doi:10.1289/ehp.10334 · Cited by 630
Recent decline in age at breast development: The Copenhagen Puberty Study
Aksglaede, L., Sørensen, K., Petersen, J. H., Skakkebæk, N. E., & Juul, A. (2009) · Pediatrics · doi:10.1542/peds.2008-2491 · Cited by 626
Must, A. (2002) · American Journal of Epidemiology · doi:10.1093/aje/155.7.672 · Cited by 506 · cited 2×
“However, even for a time span of decades, recollection of age of menarche has been demonstrated to be both precise and without bias (Must et al., 2002).”
BackgroundKarapanou, O., & Papadimitriou, A. (2010) · Reproductive Biology and Endocrinology · doi:10.1186/1477-7827-8-115 · Cited by 494
Female reproductive disorders: the roles of endocrine-disrupting compounds and developmental timing
Crain, D. A., Janssen, S. J., Edwards, T. M., Heindel, J., Ho, S.-M., Hunt, P., Iguchi, T., Juul, A., McLachlan, J. A., Schwartz, J., et al. (2008) · Fertility and Sterility · doi:10.1016/j.fertnstert.2008.08.067 · Cited by 465
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EDC-2: the endocrine society's second scientific statement on endocrine-disrupting chemicals
Gore, A. C., Chappell, V. A., Fenton, S. E., Flaws, J. A., Nadal, A., Prins, G. S., Toppari, J., & Zoeller, R. T. (2015) · Endocrine Reviews · doi:10.1210/er.2015-1010 · Cited by 2,407
A Never-Ending Story of Per- and Polyfluoroalkyl Substances (PFASs)?
Wang, Z., DeWitt, J. C., Higgins, C. P., & Cousins, I. T. (2017) · Environmental Science & Technology · doi:10.1021/acs.est.6b04806 · Cited by 1,921
(CONTAM), E. P. O. C. I. T. F. C., Knutsen, H. K., Alexander, J., Barregård, L., Bignami, M., Brüschweiler, B. J., Ceccatelli, S., Cottrill, B., Dinovi, M., Edler, L., et al. (2018) · EFSA Journal · doi:10.2903/j.efsa.2018.5194 · Cited by 549
Self-citationPerfluoroalkyl and polyfluoroalkyl substances (PFAS) and their effects on the ovary
Ding, N., Harlow, S. D., Randolph, J. F., Loch-Caruso, R. K., & Park, S. K. (2020) · Human Reproduction Update · doi:10.1093/humupd/dmaa018 · Cited by 420
Rappazzo, K., Coffman, E., & Hines, E. (2017) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph14070691 · Cited by 405
Metadata
- Authors
- Kristensen, S. L., Ramlau-Hansen, C. H., Ernst, E., Olsen, S. F., Bonde, J. P., Vested, A., Halldorsson, T. I., Becher, G., Haug, L. S., & Toft, G.
- Affiliations
- Aarhus University Hospital (DK)
- Aarhus University (DK)
- Statens Serum Institut (DK)
- University of Copenhagen (DK)
- Norwegian Institute of Public Health (NO)
- Corresponding author
- Kristensen, S. L.
- Venue
- Human Reproduction
- Publisher
- Oxford University Press (OUP)
- Published
- 2013-10-15
- Volume
- 28
- Issue
- 12
- Pages
- 3337-3348
- ISSN
- 0268-1161 (ISSN-L)
- 1460-2350
- OpenAlex
- W2114076003
- Cited by
- 151
- References
- 44
- Citations by year
- 2026: 16 · 2025: 13 · 2024: 18 · 2023: 17 · 2022: 10 · 2021: 14 · 2020: 10 · 2019: 9 · 2018: 10 · 2017: 11 · 2016: 7 · 2015: 13 · 2014: 3
- FWCI
- 6.09
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Human Reproduction (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- Hirsla (Landspítali University Hospital) (submittedVersion)
- Funders
- Norwegian Institute of Public Health
- Topics
- Physical Sciences › Environmental Science › Environmental Chemistry › Per- and polyfluoroalkyl substances research
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- perfluorinated compounds, perfluorooctanoic acid, prenatal exposure, female reproduction, age at menarche, delayed menarche, menstrual cycle length, reproductive hormones, ovarian follicle count, placental transfer, endocrine disruptors, puberty onset, age at menopause
- MeSH terms
- Adolescent, Caprylates, Female, Fluorocarbons, Follow-Up Studies, Humans, Menarche, Pregnancy, Prenatal Exposure Delayed Effects, Reproduction, Young Adult
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