Anti-Müllerian hormone promotes pre-antral follicle growth, but inhibits antral follicle maturation and dominant follicle selection in primates
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STUDY QUESTION: What are the direct effects and physiological role of anti-Müllerian hormone (AMH) during primate follicular development and function at specific stages of folliculogenesis? SUMMARY ANSWER: AMH actions in the primate ovary may be stage-dependent, directly promoting pre-antral follicle growth while inhibiting antral follicle maturation and dominant follicle selection. WHAT IS KNOWN ALREADY: AMH is expressed in the adult ovary, particularly in developing follicles. Studies in mice suggest that AMH suppresses pre-antral follicle growth in vitro, and inhibits primordial follicle recruitment and FSH-stimulated antral follicle steroidogenesis. STUDY DESIGN, SIZE, DURATION: For in vitro study, secondary follicles were isolated from ovaries of 12 rhesus macaques and cultured for 5 weeks. For in vivo study, intraovarian infusion was conducted on five monkeys for the entire follicular phase during two spontaneous menstrual cycles. PARTICIPANTS/MATERIALS, SETTING, METHODS: For in vitro study, individual follicles were cultured in a 5% O2 environment, in alpha minimum essential medium supplemented with recombinant human FSH. Follicles were randomly assigned to treatments of recombinant human AMH protein or neutralizing anti-human AMH antibody (AMH-Ab). Follicle survival, growth, steroid production, steroidogenic enzyme expression, and oocyte maturation were assessed. For in vivo study, ovaries were infused with control vehicle or AMH-Ab during the follicular phase of the menstrual cycle. Cycle length, serum steroid levels, and antral follicle growth were evaluated. MAIN RESULTS AND THE ROLE OF CHANCE: AMH exposure during culture weeks 0-3 (pre-antral stage) promoted, while AMH-Ab delayed, antrum formation of growing follicles compared with controls. AMH treatment during culture weeks 3-5 (antral stage) decreased (P < 0.05) estradiol (E2) production, as well as the mRNA expression of cytochrome P450 family 19 subfamily A polypeptide 1, by antral follicles relative to controls, whereas AMH-Ab increased (P < 0.05) follicular mRNA levels of the enzyme. Intraovarian infusion of AMH-Ab during the follicular phase of the menstrual cycle increased (P < 0.05) the average levels of serum E2 compared with those of the control cycles. Three of the five AMH-Ab-treated ovaries displayed multiple (n = 2-9) medium-to-large (2-8 mm) antral follicles at the mid-cycle E2 peak, whereas only one large (4-7 mm) antral follicle was observed in all monkeys during their control cycles. The average levels of serum progesterone were higher (P < 0.05) during the luteal phase of cycles following the AMH-Ab infusion relative to the vehicle infusion. LIMITATIONS, REASONS FOR CAUTION: The in vitro study of AMH actions on cultured individual macaque follicles was limited to the interval from the secondary to small antral stage. A sequential study design was used for in vivo experiments, which may limit the power of the study. WIDER IMPLICATIONS OF THE FINDINGS: The current study provides novel information on direct actions and role of AMH during primate follicular development, and selection of a dominant follicle by the late follicular phase of the menstrual cycle. We hypothesize that AMH acts positively on follicular growth during the pre-antral stage in primates, but negatively impacts antral follicle maturation, which is different from what is reported in the mouse model. STUDY FUNDING/COMPETING INTERESTS: NIH NICHD R01HD082208, NIH ORWH/NICHD K12HD043488 (BIRCWH), NIH OD P51OD011092 (ONPRC), Collins Medical Trust. There are no conflicts of interest. TRIAL REGISTRATION NUMBER: Not applicable.
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AMH appears to have a dual role: whereas AMH promotes preantral follicle survival, it negatively impacts later stages of antral follicle maturation.
“Hence, AMH appears to have a dual role: whereas AMH promotes preantral follicle survival, it negatively impacts later stages of antral follicle maturation [12].”
From Polycystic Ovary Syndrome: Pathophysiology, Presentation, and Treatment With Emphasis on Adolescent Girls (2019) · cites this paper as [12]
AMH appears to promote growth of preantral follicles to the antral stage in nonhuman primate ovaries, in contrast to mice where AMH inhibits preantral follicle growth and antral follicle maturation.
“In contrast to mice where AMH inhibits preantral follicle growth and antral follicle maturation, AMH appears to promote growth of preantral follicles to the antral stage in nonhuman primate (NHP) ovaries [11, 12].”
From Polycystic Ovary Syndrome: Pathophysiology, Presentation, and Treatment With Emphasis on Adolescent Girls (2019) · cites this paper as [12]
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Cites
The Diagnosis of Polycystic Ovary Syndrome during Adolescence
Witchel, S. F., Oberfield, S., Rosenfield, R. L., Codner, E., Bonny, A., Ibáñez, L., Pena, A., Horikawa, R., Gomez-Lobo, V., Joel, D., et al. (2015) · Hormone Research in Paediatrics · doi:10.1159/000375530 · Cited by 3,113 · see citing works
Regulation of ovarian follicular development in primates: facts and hypotheses
GOUGEON, A. (1996) · Endocrine Reviews · doi:10.1210/edrv-17-2-121 · Cited by 1,497 · see citing works
Weenen, C. (2004) · Molecular Human Reproduction · doi:10.1093/molehr/gah015 · Cited by 1,285 · see citing works
TGF-β superfamily members and ovarian follicle development
KNIGHT, P. G., & Glister, C. (2006) · Reproduction · doi:10.1530/rep.1.01074 · Cited by 1,201 · see citing works
The physiology and clinical utility of anti-Müllerian hormone in women
Dewailly, D., Andersen, C. Y., Balen, A. H., Broekmans, F. J., Dilaver, N., Fanchin, R. R. F., Griesinger, G., Kelsey, T., Marca, A. L., Lambalk, C. B., et al. (2014) · Human Reproduction Update · doi:10.1093/humupd/dmt062 · Cited by 1,056 · see citing works
Anti-Mullerian Hormone Attenuates the Effects of FSH on Follicle Development in the Mouse Ovary
Durlinger, A. L. L., Gruijters, M. J. G., Kramer, P., Karels, B., Kumar, T. R., Matzuk, M. M., Rose, U. M., de Jong, F. H., Uilenbroek, J. T. J., Grootegoed, J. A., et al. (2001) · Endocrinology · doi:10.1210/endo.142.11.8486 · Cited by 772 · see citing works
Regulation of ovarian function: the role of anti-Mullerian hormone
Durlinger, A. L. L., Visser, J. A., & Themmen, A. P. N. (2002) · Reproduction · doi:10.1530/rep.0.1240601 · Cited by 766 · see citing works
Münsterberg, A., & Lovell-Badge, R. H. (1991) · Development · doi:10.1242/dev.113.2.613 · Cited by 483 · see citing works
Baarends, W. M., Uilenbroek, J. T. J., Kramer, P. F., Hoogerbrugge, J. W., van Leeuwen, E. C. M., Themmen, A. P. N., & Grootegoed, J. A. (1995) · Endocrinology · doi:10.1210/endo.136.11.7588229 · Cited by 462 · see citing works
Anti-Müllerian hormone and folliculogenesis
Visser, J. A., & Themmen, A. P. N. (2005) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2004.09.008 · Cited by 462 · see citing works
Jeppesen, J. V., Anderson, R. A., Kelsey, T., Christiansen, S. L., Kristensen, S. G., Jayaprakasan, K., Raine‐Fenning, N. J., Campbell, B. K., & Andersen, C. Y. (2013) · Molecular Human Reproduction · doi:10.1093/molehr/gat024 · Cited by 374 · see citing works
Pellatt, L. J., Rice, S., Dilaver, N., Heshri, A., Galea, R. P., Brincat, M., Brown, K. A., Simpson, E. R., & Mason, H. D. (2011) · Fertility and Sterility · doi:10.1016/j.fertnstert.2011.08.015 · Cited by 277 · see citing works
Andersen, C. Y., Schmidt, K. T., Kristensen, S. G., Rosendahl, M., Byskov, A. G., & Ernst, E. (2010) · Human Reproduction · doi:10.1093/humrep/deq019 · Cited by 200 · see citing works
In Vitro Fertilization and Embryo Transfer in the Rhesus Monkey1
Wolf, D. P., VandeVoort, C. A., Meyer-Haas, G. R., Zelinski, M. B., Hess, D. L., Baughman, W. L., & Stouffer, R. L. (1989) · Biology of Reproduction · doi:10.1095/biolreprod41.2.335 · Cited by 166 · see citing works
BÉZARD, J., Vigier, B., Tran, D., MAULÉON, P., & Josso, N. (1987) · Reproduction · doi:10.1530/jrf.0.0800509 · Cited by 135 · see citing works
Xu, J., Bernuci, M. P., Lawson, M. S., Yeoman, R. R., Fisher, T. E., Zelinski, M. B., & Stouffer, R. L. (2010) · Reproduction · doi:10.1530/rep-10-0284 · Cited by 134 · see citing works
Self-citationCampbell, B. K., Clinton, M., & WEBB, R. (2012) · Endocrinology · doi:10.1210/en.2012-1158 · Cited by 134 · see citing works
di Clemente, N., Goxe, B., Rémy, J., Cate, R. L., Josso, N., Vigier, B., & Salesse, R. (1994) · HAL · Cited by 132 · see citing works
Xu, J., Lawson, M. S., Yeoman, R. R., Molskness, T. A., Ting, A. Y., Stouffer, R. L., & Zelinski, M. B. (2013) · Human Reproduction · doi:10.1093/humrep/det093 · Cited by 131 · see citing works
Self-citationMullerian Inhibitory Substance Induces Growth of Rat Preantral Ovarian Follicles1
McGee, E. A., Smith, R., Spears, N., Nachtigal, M. W., Ingraham, H. A., & Hsueh, A. J. W. (2001) · Biology of Reproduction · doi:10.1095/biolreprod64.1.293 · Cited by 125 · see citing works
Duffy, D. M., & Stouffer, R. L. (2002) · Human Reproduction · doi:10.1093/humrep/17.11.2825 · Cited by 122 · see citing works
Anti-Müllerian hormone initiates growth of human primordial follicles in vitro
Schmidt, K. L. T., Kryger‐Baggesen, N., Byskov, A. G., & Andersen, C. Y. (2005) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2004.12.010 · Cited by 117 · see citing works
Baarends, W. M. (1995) · Endocrinology · doi:10.1210/en.136.11.4951 · Cited by 104 · see citing works
Dynamics of the transcriptome in the primate ovulatory follicle
Xu, F., Stouffer, R. L., Müller, J., Hennebold, J. D., Wright, J., Bahar, A., Leder, G., Peters, M., Thorne, M., Sims, M. N., et al. (2010) · Molecular Human Reproduction · doi:10.1093/molehr/gaq089 · Cited by 83 · see citing works
Self-citationCollection and quality of rhesus monkey semen
Lanzendorf, S. E., Gliessman, P. M., Archibong, A. E., Alexander, M., & Wolf, D. P. (1990) · Molecular Reproduction and Development · doi:10.1002/mrd.1080250111 · Cited by 69 · see citing works
Rodrigues, J. K., Navarro, P. A., Zelinski, M. B., Stouffer, R. L., & Xu, J. (2015) · Human Reproduction · doi:10.1093/humrep/deu335 · Cited by 66 · see citing works
Self-citationNielsen, M. E., Rasmussen, I. A., Fukuda, M., Westergaard, L. G., & Andersen, C. Y. (2010) · Molecular Human Reproduction · doi:10.1093/molehr/gaq001 · Cited by 53 · see citing works
Primate Follicular Development and Oocyte Maturation In Vitro
Xu, J., Xu, M., Bernuci, M. P., Fisher, T. E., Shea, L. D., Woodruff, T. K., Zelinski, M. B., & Stouffer, R. L. (2013) · Advances in experimental medicine and biology · doi:10.1007/978-1-4614-8214-7_5 · Cited by 50 · see citing works
Self-citationThomas, F. H., Telfer, E. E., & Fraser, H. M. (2007) · Endocrinology · doi:10.1210/en.2006-1501 · Cited by 50 · see citing works
Zelinski, M. B., & Stouffer, R. L. (1990) · Biology of Reproduction · doi:10.1095/biolreprod43.3.507 · Cited by 46 · see citing works
McNatty, K. P., Makris, A., Osathanondh, R., & Ryan, K. J. (1980) · Steroids · doi:10.1016/0039-128x(80)90067-7 · Cited by 40 · see citing works
Bishop, C. V., Sparman, M. L., Stanley, J. E., Bahar, A., Zelinski, M. B., & Stouffer, R. L. (2009) · American Journal of Primatology · doi:10.1002/ajp.20664 · Cited by 38 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Witchel, S. F., Oberfield, S. E., & Peña, A. S. (2019) · Journal of the Endocrine Society · doi:10.1210/js.2019-00078 · Cited by 653 · see citing works
Oocyte competence in women with polycystic ovary syndrome
Palomba, S., Daolio, J., & La Sala, G. B. (2017) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2016.11.008 · Cited by 294 · see citing works
AMH/MIS as a contraceptive that protects the ovarian reserve during chemotherapy
Kano, M., Sosulski, A., Zhang, L., Saatcioglu, H. D., Wang, D., Nagykery, N. G., Sabatini, M. E., Gao, G., Donahoe, P. K., & Pépin, D. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1620729114 · Cited by 209 · see citing works
Growth Hormone and Insulin-Like Growth Factor Action in Reproductive Tissues
Ipsa, E., Cruzat, V. F., Kagize, J., Yovich, J. L., & Keane, K. N. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00777 · Cited by 198 · see citing works
Silva, M. S. B., & Giacobini, P. (2020) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03576-x · Cited by 131 · see citing works
Potential factors result in diminished ovarian reserve: a comprehensive review
Zhu, Q., Li, Y., Ma, J., Ma, H., & Liang, X. (2023) · Journal of Ovarian Research · doi:10.1186/s13048-023-01296-x · Cited by 127 · see citing works
Junior, J. B., Dellaqua, T. T., Canto, M. D., Marca, A. L., Carone, D., Renzini, M. M., & WEBB, R. (2021) · Human Reproduction Update · doi:10.1093/humupd/dmab044 · Cited by 90 · see citing works
Xu, J., Lawson, M. S., Xu, F., Du, Y., Tkachenko, O. Y., Bishop, C. V., Pejovic-Nezhat, L., Seifer, D. B., & Hennebold, J. D. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.01600 · Cited by 73 · see citing works
Self-citationXu, F., Lawson, M. S., Bean, Y. T., Ting, A. Y., Pejovic, T. B., Geest, K. D., Moffitt, M. N., Mitalipov, S. M., & Xu, J. (2021) · Human Reproduction · doi:10.1093/humrep/deab003 · Cited by 72 · see citing works
Self-citationZhang, T., Yan, D., Yang, Y., Ma, A., Li, L., Wang, Z., Pan, Q., & Sun, Z. (2016) · Regulatory Toxicology and Pharmacology · doi:10.1016/j.yrtph.2016.09.002 · Cited by 61 · see citing works
Xu, J., Xu, F., Lawson, M. S., Tkachenko, O. Y., Ting, A. Y., Kahl, C. A., Park, B. S., Stouffer, R. L., & Bishop, C. V. (2017) · Biology of Reproduction · doi:10.1093/biolre/iox181 · Cited by 54 · see citing works
Self-citationXu, J., Hennebold, J. D., & Seifer, D. B. (2016) · Fertility and Sterility · doi:10.1016/j.fertnstert.2016.08.037 · Cited by 53 · see citing works
Self-citationDias, J. A., & Ulloa‐Aguirre, A. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.636038 · Cited by 43 · see citing works
Bertoldo, M. J., Walters, K. A., Ledger, W. J., Gilchrist, R. B., Mermillod, P., & Locatelli, Y. (2018) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2018.01.014 · Cited by 42 · see citing works
Polycystic Ovary Syndrome and Hyperandrogenic States
Chang, R. J., & Dumesic, D. A. (2019) · Elsevier eBooks · doi:10.1016/b978-0-323-47912-7.00021-4 · Cited by 41 · see citing works
Bishop, C. V., Mishler, E., Takahashi, D. L., Reiter, T. E., Bond, K., True, C. A., Slayden, O. D., & Stouffer, R. L. (2017) · Human Reproduction · doi:10.1093/humrep/dex338 · Cited by 39 · see citing works
Self-citationFujibe, Y., Baba, T., Nagao, S., Adachi, S., Ikeda, K., 森下, 美., Kuno, Y., Suzuki, M., Mizuuchi, M., Honnma, H., et al. (2019) · Journal of Ovarian Research · doi:10.1186/s13048-019-0505-5 · Cited by 36 · see citing works
Baba, T., Ting, A. Y., Tkachenko, O. Y., Xu, J., & Stouffer, R. L. (2017) · Human Reproduction · doi:10.1093/humrep/dex322 · Cited by 36 · see citing works
Self-citationAnti-Müllerian hormone overexpression restricts preantral ovarian follicle survival.
Pankhurst, M., Kelley, R., Sanders, R. L., Woodcock, S. R., Oorschot, D., & Batchelor, N. J. (2018) · Journal of Endocrinology · doi:10.1530/joe-18-0005 · Cited by 27 · see citing works
Zhou, Y., Richard, S., Batchelor, N. J., Oorschot, D. E., Anderson, G. M., & Pankhurst, M. W. (2022) · Human Reproduction · doi:10.1093/humrep/deac204 · Cited by 31 · see citing works
Xu, J., Xu, F., Letaw, J., Park, B. S., Searles, R. P., & Ferguson, B. M. (2016) · Journal of Assisted Reproduction and Genetics · doi:10.1007/s10815-016-0804-3 · Cited by 30 · see citing works
Self-citationAcetylcholine and necroptosis are players in follicular development in primates
Du, Y., Bagnjuk, K., Lawson, M. S., Xu, J., & Mayerhofer, A. (2018) · Scientific Reports · doi:10.1038/s41598-018-24661-z · Cited by 29 · see citing works
Self-citationLiu, X., Yang, Y. J., Tang, C. L., Wang, K., Chen, J.-J., Teng, X., Ruan, Y. C., & Yang, J. Z. (2018) · Fertility and Sterility · doi:10.1016/j.fertnstert.2018.09.022 · Cited by 29 · see citing works
Vale-Fernandes, E., Carrageta, D. F., Moreira, M. V., Guerra‐Carvalho, B., Rodrigues, B., Sousa, D., Brandão, R., Leal, C., Barreiro, M., Tomé, A., et al. (2025) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2025.112536 · Cited by 27 · see citing works
Feng, Y., Tamadon, A., & Hsueh, A. J. W. (2018) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2018.02.006 · Cited by 27 · see citing works
Mamsen, L. S., Bøtkjær, J. A., Kristensen, S. G., Pors, S. E., Jeppesen, J. V., Kumar, A., Kalra, B., Ernst, E., & Andersen, C. Y. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.617523 · Cited by 26 · see citing works
The functional role of lncRNAs as ceRNAs in both ovarian processes and associated diseases
Usman, M., Ai, L., Wu, D., Qinyan, Y., Yi, L. X., He, G., & Lü, H. (2023) · Non-coding RNA Research · doi:10.1016/j.ncrna.2023.11.008 · Cited by 25 · see citing works
Afradiasbagharani, P., Hosseini, E., Allahveisi, A., & Bazrafkan, M. (2022) · Middle East Fertility Society Journal · doi:10.1186/s43043-022-00119-1 · Cited by 24 · see citing works
Oocyte quality following in vitro follicle development
Xu, J., & Zelinski, M. B. (2021) · Biology of Reproduction · doi:10.1093/biolre/ioab242 · Cited by 22 · see citing works
Self-citationXu, J., Lawson, M. S., Mitalipov, S. M., Park, B. S., & Xu, F. (2018) · Fertility and Sterility · doi:10.1016/j.fertnstert.2018.07.006 · Cited by 20 · see citing works
Self-citationKOIZUMI, M., & Kadokawa, H. (2017) · Journal of Reproduction and Development · doi:10.1262/jrd.2016-088 · Cited by 20 · see citing works
AMH regulates granulosa cell function via ESR2/ p38-MAPK signaling pathway in sheep
Xu, H., Cai, Y., Yang, H., Zhang, C., Liu, W., Zhao, B., Wang, F., & Zhang, Y. (2025) · Communications Biology · doi:10.1038/s42003-025-08259-6 · Cited by 19 · see citing works
AMH in PCOS: Controlling the ovary, placenta, or brain?
Moolhuijsen, L. M. E., & Visser, J. A. (2020) · Current Opinion in Endocrine and Metabolic Research · doi:10.1016/j.coemr.2020.04.006 · Cited by 19 · see citing works
Marca, A. L., Longo, M., Sighinolfi, G., Grisendi, V., Imbrogno, M. G., & Giulini, S. (2023) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2023.103369 · Cited by 19 · see citing works
The Role of Anti-Müllerian Hormone in Ovarian Function
Yildiz, S., Moolhuijsen, L. M. E., & Visser, J. A. (2024) · Seminars in Reproductive Medicine · doi:10.1055/s-0044-1786732 · Cited by 17 · see citing works
Key signalling pathways underlying the aetiology of polycystic ovary syndrome
Walters, K. A., Moreno-Asso, A., Stepto, N. K., Pankhurst, M. W., Paris, V. R., & Rodgers, R. J. (2022) · Journal of Endocrinology · doi:10.1530/joe-22-0059 · Cited by 17 · see citing works
2,3,5,4′-Tetrahydroxystilbene-2-O-β-D-Glucoside improves female ovarian aging
Lin, H., Yang, Y., Chen, Y., Huang, T.-Y., Crawford, D. R., Chuang, H., Chin, Y., Chu, H.-R., Li, Z., Shih, Y.-J., et al. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.862045 · Cited by 15 · see citing works
Hagen, C. P., Fischer, M. B., Mola, G., Mikkelsen, T. B., Cleemann, L. H., Gravholt, C. H., Viuff, M. H., Juul, A., Pedersen, A. T., & Main, K. M. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1173600 · Cited by 16 · see citing works
Fabbri, R., Zamboni, C., Vicenti, R., Macciocca, M., Paradisi, R., & Seracchioli, R. (2018) · Minerva Obstetrics and Gynecology · doi:10.23736/s0026-4784.18.04273-9 · Cited by 15 · see citing works
Aguiar, F. L. N., Gastal, G. D. A., Alves, K. A., Alves, B. G., Figueiredo, J. R., & Gastal, E. L. (2020) · Theriogenology · doi:10.1016/j.theriogenology.2020.06.043 · Cited by 15 · see citing works
Ovarian Fragmentation and AKT Stimulation for Expansion of Fertile Lifespan
Vo, K., & Kawamura, K. (2021) · Frontiers in Reproductive Health · doi:10.3389/frph.2021.636771 · Cited by 14 · see citing works
Biomarkers of reproductive health in wildlife and techniques for their assessment
Ghosal, R., Edwards, K. L., Chiarelli, T. L., Fanson, K. V., Ganswindt, A., Keeley, T., Koester, D. C., Roberts, B. M., Majelantle, T. L., Wauters, J., et al. (2023) · Theriogenology Wild · doi:10.1016/j.therwi.2023.100052 · Cited by 15 · see citing works
Effect of controlled ovarian hyperstimulation on puberty and estrus in mice offspring
Ding, J., Tan, X., Song, K., Ma, W., Xiao, J., & Zhang, M. (2017) · Reproduction · doi:10.1530/rep-16-0572 · Cited by 14 · see citing works
Villarroel, C., Salinas, A., López, P. V., Kohen, P., Rencoret, G., Devoto, L., & Ethel Codner, D. (2017) · Gynecological Endocrinology · doi:10.1080/09513590.2017.1359824 · Cited by 14 · see citing works
Interrelationships among reproductive hormones and antral follicle count in human menstrual cycles
Robertson, D. M., Lee, C. H., & Baerwald, A. (2016) · Endocrine Connections · doi:10.1530/ec-16-0077 · Cited by 13 · see citing works
Man, L., Guahmich, N. L., Kallinos, E., Caiazza, B., Khan, M., Liu, Z.-Y., Patel, R., Torres, C., Pépin, D., Yang, H. S., et al. (2022) · Science Advances · doi:10.1126/sciadv.abi7315 · Cited by 13 · see citing works
Xu, F., Lawson, M. S., Campbell, S., Tkachenko, O. Y., Park, B. S., Bishop, C. V., & Xu, J. (2020) · F&S Science · doi:10.1016/j.xfss.2020.10.005 · Cited by 11 · see citing works
Self-citationSwelum, A. A., Abdelnour, S. A., Sheiha, A. M., Hashem, N. M., Taha, A. E.-S., Khafaga, A. F., Attia, Y. A., Al-Mutary, M. G., El-Bar, M. M. A., Ohran, H., et al. (2021) · Annals of Animal Science · doi:10.2478/aoas-2021-0054 · Cited by 11 · see citing works
Jones, A. S. K., Bernabé, B. P., Padmanabhan, V., Li, J. Z., & Shikanov, A. (2021) · Scientific Reports · doi:10.1038/s41598-021-92036-y · Cited by 11 · see citing works
Guo, Y., Chen, P., Li, T., Jia, L., Zhou, Y. J., Huang, J., Liang, X., Zhou, C., & Fang, C. (2021) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-021-00818-w · Cited by 11 · see citing works
Characterization of Anti-Müllerian Hormone (AMH) Gene in Buffaloes and Goats
Gautam, D., Vats, A., Pal, P., Haldar, A., & De, S. (2021) · Frontiers in Veterinary Science · doi:10.3389/fvets.2021.627094 · Cited by 10 · see citing works
Stocker, W. A., Howard, J. A., Maskey, S., Luan, H., Harrison, S. G., Hart, K. N., Hok, L., Thompson, T. B., Walton, K. L., & Harrison, C. A. (2023) · The FASEB Journal · doi:10.1096/fj.202301335rr · Cited by 10 · see citing works
Liu, X., Wu, X., & Yang, S. (2019) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-019-05332-4 · Cited by 10 · see citing works
Anti-Müllerian Hormone: A Molecular Key to Unlocking Polycystic Ovary Syndrome?
Abbott, D. H., Hutcherson, B. A., & Dumesic, D. A. (2024) · Seminars in Reproductive Medicine · doi:10.1055/s-0044-1787525 · Cited by 9 · see citing works
Huang, Y., Li, S., Tan, Y., Xu, C., Huang, X., & Yin, Z. (2024) · Frontiers in Physiology · doi:10.3389/fphys.2024.1358682 · Cited by 8 · see citing works
Zhang, S., Di, N., Tayier, B., Guan, L., Wang, G., Lu, H., Yan, F., & Mu, Y. (2020) · Biomaterials Science · doi:10.1039/d0bm01125h · Cited by 8 · see citing works
TGF-β Signaling in the Pathophysiology of the Ovary: A Double-Edged Regulator
Bertani, N. N., Alteri, A., Cacciottola, L., D’Addato, G., Sala, G. L., Lozanoska‐Ochser, B., Massimiani, M., Parrella, E., Reggio, A., Russo, E., et al. (2026) · Biomolecules · doi:10.3390/biom16010130 · Cited by 7 · see citing works
Calcaterra, V., Nappi, R. E., Pelizzo, G., Silvestri, A. D., Albertini, R., AMICI, M. D., Tenuta, E., Vinci, F., Mameli, C., & Zuccotti, G. (2021) · Gynecological Endocrinology · doi:10.1080/09513590.2021.1940127 · Cited by 7 · see citing works
Rodgers, R. J., Abbott, J. A., Walters, K. A., & Ledger, W. J. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.689532 · Cited by 7 · see citing works
Detti, L., Mari, M. C., Diamond, M. P., & Saed, G. M. (2025) · Journal of Assisted Reproduction and Genetics · doi:10.1007/s10815-025-03473-x · Cited by 7 · see citing works
Stocker, W. A., Olenick, L. K., Maskey, S., Skrombolas, D., Luan, H., Harrison, S. G., Wilson, M., Traas, A. M., Heffernan, M., Busfield, S. J., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-56924-5 · Cited by 6 · see citing works
Kristensen, S. G., & Duncan, F. E. (2021) · Human Reproduction · doi:10.1093/humrep/deab052 · Cited by 5 · see citing works
Chen, Y., Deng, M., Chen, Z., Han, S., Chen, J., Zhang, H., Wang, Q., Jin, X., Liu, W., & Zhang, Z. (2022) · Journal of Ovarian Research · doi:10.1186/s13048-022-01052-7 · Cited by 5 · see citing works
Grand Challenges in Reproductive Endocrinology
Andersen, C. Y. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2016.00169 · Cited by 5 · see citing works
Godin, P., Nagykery, N. G., Sicher, N., Barnes, J. L., Miller, A. G., Bunner, C., Thompson, A. K., Kano, M., Gao, G., Wang, D., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-65780-2 · Cited by 4 · see citing works
Li, J., Zhu, W., Bu, Y., Li, L., Wei, H., & Zhang, S. (2026) · Communications Biology · doi:10.1038/s42003-026-10273-1 · Cited by 4 · see citing works
Ovarian Dysfunction in Polycystic Ovary Syndrome (PCOS)
Mason, H. D., Dilaver, N., & Rice, S. (2022) · Springer eBooks · doi:10.1007/978-3-030-92589-5_6 · Cited by 3 · see citing works
Shaping up the function of anti-Müllerian hormone in ovaries of mono-ovulatory species
Visser, J. A. (2016) · Human Reproduction · doi:10.1093/humrep/dew101 · Cited by 3 · see citing works
Redhead, A. K. (2017) · doi:10.33915/etd.6489 · Cited by 3 · see citing works
Friedman-Gohas, M., Orvieto, R., Michaeli, A., Aizer, A., Kirshenbaum, M., & Cohen, Y. (2021) · Scientific Reports · doi:10.1038/s41598-021-93489-x · Cited by 2 · see citing works
Proteolytic activation of anti-Müllerian hormone is suppressed in adolescent girls
Pankhurst, M. W., Dillingham, P. W., & Peña, A. S. (2022) · Endocrine · doi:10.1007/s12020-021-02955-z · Cited by 2 · see citing works
AMH regulates ovary size by counteracting ovarian follicle cluster effects.Preprint
Lim, C., Yiew, L., Anderson, N. J., Smith, P. R., Quirke, L. D., Carne, A., Sarma, U. C., Rose, R., Nicholson, M., Jasoni, C. L., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.08.15.607694 · Cited by 2 · see citing works
Berkel, Ç. (2025) · Reproductive Sciences · doi:10.1007/s43032-025-01815-9 · Cited by 1 · see citing works
Liao, C., Lee, C., & Li, J. (2025) · International Journal of Gynecology & Obstetrics · doi:10.1002/ijgo.70380 · Cited by 1 · see citing works
Current Status of In Vitro Oocyte Growth and Development in Mammals
Hirao, Y. (2025) · Reproductive Medicine and Biology · doi:10.1002/rmb2.12669 · Cited by 1 · see citing works
Lim, C., Yiew, L., Anderson, N. J., Smith, P. R., Quirke, L. D., Carne, A., Sarma, U. C., Rose, R., Nicholson, M., Jasoni, C. L., et al. (2026) · Human Reproduction · doi:10.1093/humrep/deag022 · Cited by 3 · see citing works
Polycystic Ovary Syndrome: Pathophysiology, Presentation and Treatment a Mini-Review Article
Simic, D., Stefanovic, K., Djurić, D., & Turnić, T. N. (2021) · Serbian Journal of Experimental and Clinical Research · doi:10.2478/sjecr-2020-0053 · Cited by 1 · see citing works
Kallen, A. N. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-823344-3.00002-9 · Cited by 1 · see citing works
Begum, R. F., Mohan, S., Chitra, V., & Devi, S. (2022) · The Thai Journal of Pharmaceutical Sciences · doi:10.56808/3027-7922.2632 · Cited by 1 · see citing works
LH prevents AMH action via receptor downregulation in human primary granulosa lutein cells
Liuzzi, F., Lazzaretti, C., Carlini, S. D., Michelini, A., Simoni, M., Casarini, L., & Marca, A. L. (2025) · Journal of Assisted Reproduction and Genetics · doi:10.1007/s10815-025-03635-x · Cited by 1 · see citing works
Anti-Mullerian hormone as a marker of oocyte quantity, developmental potential, and fetal sex
Carter, A. S. (2016) · The Atrium (University of Guelph)
Energy status and ovarian follicular development
Meng, L. (2016) · doi:10.18174/389440
The Role of Antimullerian Hormone in Assisted Reproduction
Tal, R., & Seifer, D. B. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-813209-8.00025-x
The elusive function of AMH signaling in folliculogenesis
Pankhurst, M. W. (2025) · Journal of Assisted Reproduction and Genetics · doi:10.1007/s10815-025-03657-5
Varra, M., Sejian, V., Kumar, V. G., Kumar, B. S., & Nagalingam, R. S. (2025) · Buffalo Bulletin · doi:10.56825/bufbu.2025.4434286
Fertility in Polycystic Ovary Syndrome—The Spark and the Fire!
Shah, D., & Rasool, S. (2025) · Fertility & Reproduction · doi:10.1142/s2661318225300053
Single-oocyte mRNA sequencing reveals that AMH-overexpression alters oocyte gene expression
Hore, T. A., & Pankhurst, M. W. (2026) · Reproduction Fertility and Development · doi:10.1071/rd25190
Maskey, S., Stocker, W. A., Alesi, L. R., Pankhurst, M. W., Herron-Vellacott, H. W. G., Harrison, S. G., Spiller, C. M., Hagg, A., Winship, A., Harrison, C. A., et al. (2026) · Endocrinology · doi:10.1210/endocr/bqag016
Zhao, W., Liu, X., Guo, Y., Li, T., Zeng, H., Fang, C., Liang, X., Li, Y., & Li, J. (2026) · Human Reproduction · doi:10.1093/humrep/deag117
Jia, Q., Zhang, S., Zhang, L., Zhao, G., Zhu, Q., & 葛红山 (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1879713
- Authors
- Xu, J., Bishop, C. V., Lawson, M. S., Park, B. S., & Xu, F.
- Affiliations
- Oregon National Primate Research Center (US)
- Oregon Health & Science University (US)
- Corresponding author
- Xu, J.
- ORCID
- Venue
- Human Reproduction
- Publisher
- Oxford University Press (OUP)
- Published
- 2016-05-09
- Volume
- 31
- Issue
- 7
- Pages
- 1522-1530
- ISSN
- 0268-1161 (ISSN-L)
- 1460-2350
- PMC
- PMC4901882
- OpenAlex
- W2411075777
- Cited by
- 90
- References
- 32
- Citations by year
- 2026: 7 · 2025: 12 · 2024: 4 · 2023: 6 · 2022: 10 · 2021: 15 · 2020: 5 · 2019: 5 · 2018: 9 · 2017: 9 · 2016: 8
- FWCI
- 10.25
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Human Reproduction (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Funders
- National Institutes of Health
- NIH
- Eunice Kennedy Shriver National Institute of Child Health & Human Development (NI CHD) (R01HD082208)
- Office of Research on Women's Health/NICHD (K12HD043488)
- Office of the Director (P51OD011092)
- Collins Medical Trust
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Life Sciences › Agricultural and Biological Sciences › Agronomy and Crop Science › Reproductive Physiology in Livestock
- Keywords
- anti-Müllerian hormone, folliculogenesis, dominant follicle selection, rhesus monkeys, steroidogenesis, CYP19A1, estradiol, oocyte maturation, follicle survival, primordial follicle recruitment, menstrual cycle
- MeSH terms
- Cytochrome P450 Family 19, Animals, Estradiol, Female, Ovarian Follicle, Macaca mulatta, Progesterone, Random Allocation, RNA, Messenger, Tissue Culture Techniques, Anti-Mullerian Hormone, Antibodies, Neutralizing
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