Oocyte competence in women with polycystic ovary syndrome

Palomba, Stefano; Daolio, Jessica; La Sala, Giovanni Battista

doi:10.1016/j.tem.2016.11.008

Cited by 296Ovarian function and disordersReproductive Biology and FertilityReproductive Health and Technologies

Oocyte competence in women with polycystic ovary syndrome

Palomba, Stefano, Daolio, Jessica, La Sala, Giovanni Battista·2017·Trends in Endocrinology & Metabolism

DOI 10.1016/j.tem.2016.11.008

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Abstract

Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of reproductive age and affects fertility and pregnancy in cases of oligoanovulation. Ovulation induction is often used to treat anovulatory patients with PCOS, but many of these women fail to conceive and resort to assisted reproductive technologies. Alterations in oocyte competence (OC) are considered potential causative factors for subfertility in women with PCOS. In this review we present and critically assess all recent clinical and experimental data regarding OC in women with PCOS. Our analysis demonstrates that the contribution of OC to reproductive potential in women with PCOS varies and largely depends on the PCOS phenotype and comorbidities associated with PCOS.

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Persistent hyperandrogenism is associated with impaired hypothalamic-pituitary feedback, LH hypersecretion, premature granulosa cell luteinization, aberrant oocyte maturation, and premature arrest of activated primary follicles.
“The persistent hyperandrogenism is associated with impaired hypothalamic–pituitary feedback, LH hypersecretion, premature granulosa cell luteinization, aberrant oocyte maturation, and premature arrest of activated primary follicles [4].”
From Polycystic Ovary Syndrome: Pathophysiology, Presentation, and Treatment With Emphasis on Adolescent Girls (2019) · cites this paper as [4]

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Petersons, C. J., Mangelsdorf, B. L., Thompson, C. H., & Burt, M. G. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-4305 · Cited by 54 · see citing works
Is polycystic ovarian morphology related to a poor oocyte quality after controlled ovarian hyperstimulation for intracytoplasmic sperm injection? Results from a prospective, comparative study
Sigala, J., Sifer, C., Dewailly, D., Robin, G., Bruyneel, A., Ramdane, N., Lefebvre‐Khalil, V., Mitchell, V. A., & Decanter, C. (2014) · Fertility and Sterility · doi:10.1016/j.fertnstert.2014.09.040 · Cited by 52 · see citing works
N-Acetylcysteine improves oocyte and embryo quality in polycystic ovary syndrome patients undergoing intracytoplasmic sperm injection: an alternative to metformin
Cheraghi, E., Mehranjani, M. S., Shariatzadeh, S. M. A., Nasr‐Esfahani, M. H., & Ebrahimi, Z. (2014) · Reproduction Fertility and Development · doi:10.1071/rd14182 · Cited by 52 · see citing works
Evidence for Decreased Expression of ADAMTS-1 Associated With Impaired Oocyte Quality in PCOS Patients
Xiao, S., Li, Y., Li, T., Chen, M., Xu, Y., Wen, Y., & Zhou, C. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-4177 · Cited by 47 · see citing works
Is the fertile window extended in women with polycystic ovary syndrome? Utilizing the Society for Assisted Reproductive Technology registry to assess the impact of reproductive aging on live-birth rate
Kalra, S. K., Ratcliffe, S. J., & Dokras, A. (2013) · Fertility and Sterility · doi:10.1016/j.fertnstert.2013.02.055 · Cited by 47 · see citing works
Low aneuploidy rate in early pregnancy loss abortuses from patients with polycystic ovary syndrome
Wang, Q., Luo, L., Lei, Q., Lin, M., Huang, X., Chen, M.-H., Zeng, Y., & Zhou, C. (2016) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2016.04.006 · Cited by 42 · see citing works
Androgens as double-edged swords: Induction and suppression of follicular development
Pan, J., Zhang, J., Ke, Z.-H., Wang, F., Barry, J. A., Hardiman, P. J., & Qu, F. (2015) · HORMONES · doi:10.14310/horm.2002.1580 · Cited by 41 · see citing works
Proteomics and polycystic ovary syndrome
Insenser, M. R., & Escobar-Morreale, H. F. (2013) · Expert Review of Proteomics · doi:10.1586/14789450.2013.837665 · Cited by 36 · see citing works
Age-related normogram for antral follicle count in women with polycystic ovary syndrome
Wiser, A., Shalom‐Paz, E., Hyman, J. H., Sokal-Arnon, T., Bantan, N., Holzer, H. E. G., & Tulandi, T. (2013) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2013.06.016 · Cited by 30 · see citing works
Effects of Upregulation of Hsp27 Expression on Oocyte Development and Maturation Derived from Polycystic Ovary Syndrome
Cai, L., Ma, X., Liu, S., Liu, J., Wang, W. T., Cui, Y., Ding, W., Mao, Y., Chen, H., Huang, J., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0083402 · Cited by 30 · see citing works
Pregnancy complications in spontaneous and assisted conceptions of women with infertility and subfertility factors. A comprehensive review
Palomba, S., Santagni, S., Gibbins, K. J., Sala, G. B. L., & Silver, R. M. (2016) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2016.08.007 · Cited by 30 · see citing works
Comparison of follicular vascularization in normal versus polycystic ovaries during in vitro fertilization as measured using 3-dimensional power Doppler ultrasonography
Järvelä, I. Y., Sladkevicius, P., Kelly, S. M., Ojha, K., Campbell, S. C., & Nargund, G. (2004) · Fertility and Sterility · doi:10.1016/j.fertnstert.2004.04.048 · Cited by 27 · see citing works
Is there a role for diet in ameliorating the reproductive sequelae associated with chronic low-grade inflammation in polycystic ovary syndrome and obesity?
Riley, J. K., & Jungheim, E. S. (2016) · Fertility and Sterility · doi:10.1016/j.fertnstert.2016.07.1069 · Cited by 27 · see citing works
Prospective Randomized Study on the Influence of Myoinositol in PCOS Women Undergoing IVF in the Improvement of Oocyte Quality, Fertilization Rate, and Embryo Quality
Lesoine, B., & Regidor, P. (2016) · International Journal of Endocrinology · doi:10.1155/2016/4378507 · Cited by 26 · see citing works
Use of gonadotropin-releasing hormone agonist trigger during in vitro fertilization is associated with similar endocrine profiles and oocyte measures in women with and without polycystic ovary syndrome
O’Neill, K. E., Senapati, S., & Dokras, A. (2014) · Fertility and Sterility · doi:10.1016/j.fertnstert.2014.09.042 · Cited by 23 · see citing works
Study on the zona pellucida 4 (ZP4) gene sequence and its expression in the ovaries of patients with polycystic ovary syndrome
Męczekalski, B., Nawrot, R., Nowak, W., Czyzyk, A., Kedzia, H., & Gozdzicka-Jozefiak, A. (2015) · Journal of Endocrinological Investigation · doi:10.1007/s40618-015-0260-4 · Cited by 21 · see citing works
Dependence of Mean Levels of Circulating Luteinizing Hormone upon Pulsatile Amplitude and Frequency*
Kazer, R. R., LIU, C. H., & Yen, S. S. C. (1987) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-65-4-796 · Cited by 19 · see citing works
Are Patients with Polycystic Ovarian Syndrome Ideal Candidates for Oocyte Donation?
Vaz, G. Q., Evangelista, A. V., Sartorio, C. A. P., Cardoso, M. C. A., Erthal, M. C., Gallo, P., & Oliveira, M. A. P. (2016) · BioMed Research International · doi:10.1155/2016/5701609 · Cited by 14 · see citing works
Confocal Microscopic Analysis of the Spindle and Chromosome Configurations of in vitro-Matured Oocytes from Different Types of Polycystic Ovary Syndrome Patients
Zhu, L., Han, C., Cao, Z.-L., Wang, Z., Han, R.-G., Wang, B., & Sun, Q. (2015) · Gynecologic and Obstetric Investigation · doi:10.1159/000376578 · Cited by 9 · see citing works
Association of G22A and A4223C ADA1 gene polymorphisms and ADA activity with PCOS
Salehabadi, M., Farimani, M. S., Tavilani, H., Ghorbani, M., Poormonsefi, F., Poorolajal, J., Shafiee, G., Ghasemkhani, N., & Khodadadi, I. (2016) · Systems Biology in Reproductive Medicine · doi:10.3109/19396368.2016.1143055 · Cited by 7 · see citing works
Intrafollicular nerve growth factor concentration in patients with polycystic ovary syndrome: a case-control study.
Gulino, F. A., Giuffrida, E., Leonardi, E., Marilli, I., & Palumbo, M. A. (2016) · PubMed · Cited by 7 · see citing works

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Obesity and female infertility: potential mediators of obesity's impact
Broughton, D. E., & Moley, K. H. (2017) · Fertility and Sterility · doi:10.1016/j.fertnstert.2017.01.017 · Cited by 845 · see citing works
Polycystic Ovary Syndrome: Pathophysiology, Presentation, and Treatment With Emphasis on Adolescent Girls
Witchel, S. F., Oberfield, S. E., & Peña, A. S. (2019) · Journal of the Endocrine Society · doi:10.1210/js.2019-00078 · Cited by 653 · see citing works
Endometrial function in women with polycystic ovary syndrome: a comprehensive review
Palomba, S., Piltonen, T., & Giudice, L. C. (2020) · Human Reproduction Update · doi:10.1093/humupd/dmaa051 · Cited by 385 · see citing works
Animal Models to Understand the Etiology and Pathophysiology of Polycystic Ovary Syndrome
Stener‐Victorin, E., Padmanabhan, V., Walters, K. A., Campbell, R. E., Benrick, A., Giacobini, P., Dumesic, D. A., & Abbott, D. H. (2020) · Endocrine Reviews · doi:10.1210/endrev/bnaa010 · Cited by 378 · see citing works
Chronic low-grade inflammation and ovarian dysfunction in women with polycystic ovarian syndrome, endometriosis, and aging
Orisaka, M., Mizutani, T., Miyazaki, Y., Shirafuji, A., Tamamura, C., Fujita, M., Tsuyoshi, H., & Yoshida, Y. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1324429 · Cited by 203 · see citing works
Mitochondrial and glucose metabolic dysfunctions in granulosa cells induce impaired oocytes of polycystic ovary syndrome through Sirtuin 3
Zhang, Q., Ren, J. T., Wang, F., Pan, M., Cui, L., Li, M., & Qu, F. (2022) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2022.05.010 · Cited by 148 · see citing works
Is fertility reduced in ovulatory women with polycystic ovary syndrome? An opinion paper
Palomba, S. (2021) · Human Reproduction · doi:10.1093/humrep/deab181 · Cited by 148 · see citing works
Therapeutic potentials of Quercetin in management of polycystic ovarian syndrome using Letrozole induced rat model: a histological and a biochemical study
Jahan, S., Abid, A., Khalid, S., Afsar, T., Ain, Q. U., Shaheen, G., Almajwal, A. M., & Razak, S. (2018) · Journal of Ovarian Research · doi:10.1186/s13048-018-0400-5 · Cited by 140 · see citing works
Lipid metabolism and endometrial receptivity
Yang, T., Zhao, J., Liu, F., & Li, Y. (2022) · Human Reproduction Update · doi:10.1093/humupd/dmac026 · Cited by 126 · see citing works
Curtailing PCOS
Witchel, S. F., Teede, H. J., & Peña, A. S. (2019) · Pediatric Research · doi:10.1038/s41390-019-0615-1 · Cited by 129 · see citing works
Oxidative stress and mitochondrial dysfunction of granulosa cells in polycystic ovarian syndrome
Gao, Y., Zou, Y., Wu, G., & Zheng, L. (2023) · Frontiers in Medicine · doi:10.3389/fmed.2023.1193749 · Cited by 120 · see citing works
lnc-MAP3K13-7:1 Inhibits Ovarian GC Proliferation in PCOS via DNMT1 Downregulation-Mediated CDKN1A Promoter Hypomethylation
Geng, X., Zhao, J., Huang, J., Li, S., Chu, W., Wang, W., Chen, Z., & Du, Y. (2020) · Molecular Therapy · doi:10.1016/j.ymthe.2020.11.018 · Cited by 110 · see citing works
Role of androgens in the ovary
Walters, K. A., & Handelsman, D. J. (2017) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2017.06.026 · Cited by 95 · see citing works
Evidence from animal models on the pathogenesis of PCOS
Walters, K. A., Bertoldo, M. J., & Handelsman, D. J. (2018) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2018.03.008 · Cited by 96 · see citing works
Women with PCOS who undergo IVF: a comprehensive review of therapeutic strategies for successful outcomes
Kotlyar, A. M., & Seifer, D. B. (2023) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-023-01120-7 · Cited by 88 · see citing works
The role of Notch signalling in ovarian angiogenesis
Xie, Q., Cheng, Z., Chen, X., Lobe, C. G., & Liu, J. (2017) · Journal of Ovarian Research · doi:10.1186/s13048-017-0308-5 · Cited by 79 · see citing works
Regulated nuclear accumulation of a histone methyltransferase times the onset of heterochromatin formation in C. elegans embryos
Mutlu, B., Chen, H.-M., Moresco, J. J., Orelo, B. D., Yang, B., Gaspar, J. M., Keppler‐Ross, S., Yates, J. R., Hall, D. H., Maine, E. M., et al. (2018) · Science Advances · doi:10.1126/sciadv.aat6224 · Cited by 77 · see citing works
A review of the hormones involved in the endocrine dysfunctions of polycystic ovary syndrome and their interactions
Emanuel, R. H. K., Roberts, J., Docherty, P. D., Lunt, H., Campbell, R. E., & Möller, K. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.1017468 · Cited by 83 · see citing works
The expression of small RNAs in exosomes of follicular fluid altered in human polycystic ovarian syndrome
Hu, J., Tang, T., Zeng, Z., Wu, J., Tan, X., & Yan, J. (2020) · PeerJ · doi:10.7717/peerj.8640 · Cited by 72 · see citing works
Disturbed Follicular Microenvironment in Polycystic Ovary Syndrome: Relationship to Oocyte Quality and Infertility
Dai, M., Hong, L., Yin, T., & Liu, S. (2024) · Endocrinology · doi:10.1210/endocr/bqae023 · Cited by 72 · see citing works
NMR metabolic profiling of follicular fluid for investigating the different causes of female infertility: a pilot study
Morelli, M. A. C., Iuliano, A., Schettini, S. C. A., Petruzzi, D., Ferri, A., Colucci, P., Viggiani, L., Cuviello, F., & Ostuni, A. (2019) · Metabolomics · doi:10.1007/s11306-019-1481-x · Cited by 71 · see citing works
A Narrative Review of Placental Contribution to Adverse Pregnancy Outcomes in Women With Polycystic Ovary Syndrome
Kelley, A. S., Smith, Y. R., & Padmanabhan, V. (2019) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2019-00383 · Cited by 73 · see citing works
Identifying pleiotropic variants and candidate genes for fertility and reproduction traits in Holstein cattle via association studies based on imputed whole-genome sequence genotypes
Chen, S., Schenkel, F. S., de Melo, A. L. P., de Oliveira, H. R., Pedrosa, V. B., Araujo, A. C., Melka, M. G., & Brito, L. F. (2022) · BMC Genomics · doi:10.1186/s12864-022-08555-z · Cited by 62 · see citing works
Follicular Fluid: A Powerful Tool for the Understanding and Diagnosis of Polycystic Ovary Syndrome
Brinca, A. T., Ramalhinho, A. C., Sousa, Â., Oliani, A. H., Breitenfeld, L., Passarinha, L. A., & Gallardo, E. (2022) · Biomedicines · doi:10.3390/biomedicines10061254 · Cited by 63 · see citing works
Canagliflozin combined with metformin versus metformin monotherapy for endocrine and metabolic profiles in overweight and obese women with polycystic ovary syndrome: A single-center, open-labeled prospective randomized controlled trial
Zhang, J., Xing, C., Cheng, X., & He, B. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.1003238 · Cited by 60 · see citing works
Low oxygen tension increases mitochondrial membrane potential and enhances expression of antioxidant genes and implantation protein of mouse blastocyst cultured in vitro
Ma, Y.-Y., Chen, H., & Tzeng, C. (2017) · Journal of Ovarian Research · doi:10.1186/s13048-017-0344-1 · Cited by 57 · see citing works
Alternative treatment of polycystic ovary syndrome: pre-clinical and clinical basis for using plant-based drugs
Malik, S., Saeed, S., Saleem, A., Khan, M. I., Khan, A., & Akhtar, M. F. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1294406 · Cited by 57 · see citing works
Polycystic ovary syndrome and thyroid disorder: a comprehensive narrative review of the literature
Palomba, S., Colombo, C. M., Busnelli, A., Caserta, D., & Vitale, G. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1251866 · Cited by 52 · see citing works
Follicular fluid composition and reproductive outcomes of women with polycystic ovary syndrome undergoing in vitro fertilization: A systematic review
Moreira, M. V., Vale-Fernandes, E., Albergaria, I. C., Alves, M. G., & Monteiro, M. P. (2023) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-023-09819-z · Cited by 51 · see citing works
A Hyperandrogenic Environment Causes Intrinsic Defects That Are Detrimental to Follicular Dynamics in a PCOS Mouse Model
Bertoldo, M. J., Caldwell, A. S. L., Riepsamen, A. H., Lin, D., Gonzalez, M. B., Robker, R. L., Ledger, W. J., Gilchrist, R. B., Handelsman, D. J., & Walters, K. A. (2019) · Endocrinology · doi:10.1210/en.2018-00966 · Cited by 52 · see citing works
Methylglyoxal-Dependent Glycative Stress and Deregulation of SIRT1 Functional Network in the Ovary of PCOS Mice
Emidio, G. D., Placidi, M., Rea, F., Rossi, G., Falone, S., Cristiano, L., Nottola, S. A., D’Alessandro, A. M., Amicarelli, F., Palmerini, M. G., et al. (2020) · Cells · doi:10.3390/cells9010209 · Cited by 46 · see citing works
Protein Lysine Acetylation in Ovarian Granulosa Cells Affects Metabolic Homeostasis and Clinical Presentations of Women With Polycystic Ovary Syndrome
Min, Z., Long, X., Zhao, H., Zhen, X., Li, R., Li, M., Fan, Y., Yu, Y., Zhao, Y., & Qiao, J. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.567028 · Cited by 43 · see citing works
Chronic hyperandrogenemia in the presence and absence of a western-style diet impairs ovarian and uterine structure/function in young adult rhesus monkeys
Bishop, C. V., Mishler, E., Takahashi, D. L., Reiter, T. E., Bond, K., True, C. A., Slayden, O. D., & Stouffer, R. L. (2017) · Human Reproduction · doi:10.1093/humrep/dex338 · Cited by 39 · see citing works
Does metformin improve reproduction outcomes for non-obese, infertile women with polycystic ovary syndrome? Meta-analysis and systematic review
Magzoub, R., Kheirelseid, E. A. H., Perks, C. M., & Lewis, S. J. (2022) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2022.01.025 · Cited by 41 · see citing works
Chinese herbal medicine alleviates the pathogenesis of polycystic ovary syndrome by improving oxidative stress and glucose metabolism via mitochondrial Sirtuin 3 signaling
Zhang, Q., Ren, J. T., Wang, F., Li, M., Pan, M., Zhang, H., & Qu, F. (2022) · Phytomedicine · doi:10.1016/j.phymed.2022.154556 · Cited by 38 · see citing works
Association between hyperandrogenism and adverse pregnancy outcomes in patients with different polycystic ovary syndrome phenotypes undergoing in vitro fertilization/intracytoplasmic sperm injection: a systematic review and meta-analysis
Ma, L., Cao, Y., Ma, Y., & Zhai, J. (2021) · Gynecological Endocrinology · doi:10.1080/09513590.2021.1897096 · Cited by 38 · see citing works
GLP-1/GLP-1R Signaling Regulates Ovarian PCOS-Associated Granulosa Cells Proliferation and Antiapoptosis by Modification of Forkhead Box Protein O1 Phosphorylation Sites
Sun, Z., Li, P., Wang, X., Lai, S., Qiu, H., Chen, Z., Hu, S., Yao, J., & Shen, J. (2020) · International Journal of Endocrinology · doi:10.1155/2020/1484321 · Cited by 37 · see citing works
“PCOS is the most frequent cause of female anovulatory infertility [3].”
Background
The boosting effects of melatonin on the expression of related genes to oocyte maturation and antioxidant pathways: a polycystic ovary syndrome- mouse model
Nikmard, F., Hosseini, E., Bakhtiyari, M., Ashrafi, M., Amidi, F., & Aflatoonian, R. (2022) · Journal of Ovarian Research · doi:10.1186/s13048-022-00946-w · Cited by 37 · see citing works
Astaxanthin treatment ameliorates ER stress in polycystic ovary syndrome patients: a randomized clinical trial
Jabarpour, M., Aleyasin, A., Nashtaei, M. S., Lotfi, S., & Amidi, F. (2023) · Scientific Reports · doi:10.1038/s41598-023-28956-8 · Cited by 39 · see citing works
Roles of the Notch Signaling Pathway in Ovarian Functioning
Guo, S., Quan, S., & Zou, S. (2021) · Reproductive Sciences · doi:10.1007/s43032-021-00610-6 · Cited by 37 · see citing works
Prevalence of polycystic ovary syndrome in patients with type 2 diabetes: A systematic review and meta-analysis
Long, C., Feng, H., Duan, W., Chen, X., Zhao, Y., Lan, Y., & Yue, R. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.980405 · Cited by 37 · see citing works
Underlying mechanisms of acupuncture therapy on polycystic ovary syndrome: Evidences from animal and clinical studies
Yang, Y., Zhou, C.-C., Hu, H., Fukuzawa, I., & Zhang, H. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.1035929 · Cited by 38 · see citing works
Altered redox status may contribute to aberrant folliculogenesis and poor reproductive outcomes in women with polycystic ovary syndrome
Naigaonkar, A., Dadachanji, R., Hinduja, I. N., & Mukherjee, S. (2021) · Journal of Assisted Reproduction and Genetics · doi:10.1007/s10815-021-02241-x · Cited by 35 · see citing works
Chronically elevated androgen and/or consumption of a Western-style diet impairs oocyte quality and granulosa cell function in the nonhuman primate periovulatory follicle
Bishop, C. V., Reiter, T. E., Erikson, D. W., Hanna, C. B., Daughtry, B. L., Chavez, S. L., Hennebold, J. D., & Stouffer, R. L. (2019) · Journal of Assisted Reproduction and Genetics · doi:10.1007/s10815-019-01497-8 · Cited by 32 · see citing works
Selenium Nanoparticles Modulate Steroidogenesis-Related Genes and Improve Ovarian Functions via Regulating Androgen Receptors Expression in Polycystic Ovary Syndrome Rat Model
Abdallah, A. B. E., El-Ghannam, M. A., Hasan, A. A., Mohammad, L. G., Mesalam, N. M., & Al-sayed, R. M. (2023) · Biological Trace Element Research · doi:10.1007/s12011-023-03616-0 · Cited by 32 · see citing works
Metformin improves ovarian follicle dynamics by reducing theca cell proliferation and CYP-17 expression in an androgenized rat model
Mahamed, R. R., Maganhin, C. C., Sasso, G. R. D. S., Simões, M. D. J., Baracat, M. C. P., Baracat, E. C., & Soares, J. M. (2018) · Journal of Ovarian Research · doi:10.1186/s13048-018-0392-1 · Cited by 31 · see citing works
Association between maternal polycystic ovarian syndrome undergoing assisted reproductive technology and pregnancy complications and neonatal outcomes: a systematic review and meta-analysis
Ban, M., Sun, Y., Chen, X., Zhou, X., Zhang, Y., & Cui, L. (2024) · Journal of Ovarian Research · doi:10.1186/s13048-023-01331-x · Cited by 30 · see citing works
Quantitative mass spectrometric analysis to unravel glycoproteomic signature of follicular fluid in women with polycystic ovary syndrome
Patil, K., Yelamanchi, S. D., Kumar, M., Hinduja, I. N., Prasad, T. S. K., Gowda, H., & Mukherjee, S. (2019) · PLoS ONE · doi:10.1371/journal.pone.0214742 · Cited by 30 · see citing works
Importance of lipid metabolism on oocyte maturation and early embryo development: Can we apply what we know to buffalo?
Marín, D. F. D., da Costa, N. N., Santana, P. D. P. B., de Souza, E. B., & Ohashi, O. M. (2019) · Animal Reproduction Science · doi:10.1016/j.anireprosci.2019.106220 · Cited by 30 · see citing works
Quercetin and polycystic ovary syndrome
Ma, C., Xiang, Q., Song, G., & Wang, X. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.1006678 · Cited by 30 · see citing works
Quantitative Proteomics Reveals That a Prognostic Signature of the Endometrium of the Polycystic Ovary Syndrome Women Based on Ferroptosis Proteins
Zhang, J., Ding, N., Xin, W., Yang, X., & Wang, F. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.871945 · Cited by 29 · see citing works
A PCOS Paradox: Does Inositol Therapy Find a Rationale in All the Different Phenotypes?
Unfer, V., Dinicola, S., & Russo, M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24076213 · Cited by 29 · see citing works
Anti-Müllerian hormone a surrogate of follicular fluid oxidative stress in polycystic ovary syndrome?
Vale-Fernandes, E., Moreira, M. V., Rodrigues, B., Pereira, S. S., Leal, C., Barreiro, M., Tomé, A., & Monteiro, M. P. (2024) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2024.1408879 · Cited by 28 · see citing works
Polycystic ovary syndrome: Criteria, phenotypes, race and ethnicity
Baba, T. (2025) · Reproductive Medicine and Biology · doi:10.1002/rmb2.12630 · Cited by 28 · see citing works
Food restriction during pregnancy and female offspring fertility: adverse effects of reprogrammed reproductive lifespan
Harrath, A. H., Alrezaki, A., Mansour, L. A., Alwasel, S. H., & Palomba, S. (2017) · Journal of Ovarian Research · doi:10.1186/s13048-017-0372-x · Cited by 28 · see citing works
Expression Level of ADAMTS1 in Granulosa Cells of PCOS Patients Is Related to Granulosa Cell Function, Oocyte Quality, and Embryo Development
Yang, G., Yao, G., Xu, Z., Fan, H., Liu, X., He, J. H., Kong, Y., Kong, D., Bai, Y., He, Q., et al. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.647522 · Cited by 28 · see citing works
Frozen embryo transfer outcomes decline with increasing female body mass index in female but not male factor infertility: analysis of 56,564 euploid blastocyst transfers
Bakkensen, J. B., Strom, D. E., & Boots, C. E. (2023) · Fertility and Sterility · doi:10.1016/j.fertnstert.2023.07.027 · Cited by 26 · see citing works
Association between obesity in women with polycystic ovary syndrome and adverse obstetric outcomes
Peeva, M., Badeghiesh, A. M., Baghlaf, H. A., & Dahan, M. H. (2022) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2022.02.007 · Cited by 24 · see citing works
Cannabinoids and PPAR Ligands: The Future in Treatment of Polycystic Ovary Syndrome Women with Obesity and Reduced Fertility
Przybycień, P., Gąsior‐Perczak, D., & Placha, W. (2022) · Cells · doi:10.3390/cells11162569 · Cited by 26 · see citing works
Elevated serum uric acid level is associated with adverse reproductive outcomes in women with polycystic ovary syndrome undergoing in vitro fertilization or intracytoplasmic sperm injection embryo transfer cycles: a retrospective cohort study
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Embryos from polycystic ovary syndrome patients with hyperandrogenemia reach morula stage faster than controls
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Polycystic Ovary Syndrome Phenotypes and Infertility Treatment
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Authors: Palomba, S., Daolio, J., & La Sala, G. B.
Affiliations: Santa Maria Nuova Hospital (IT)
Corresponding author: Palomba, Stefano
ORCID: Palomba, Stefano
Daolio, Jessica
Venue: Trends in Endocrinology & Metabolism
Publisher: Elsevier BV
Published: 2017-03
Volume: 28
Issue: 3
Pages: 186-198
ISSN: 1043-2760 (ISSN-L)
DOI: 10.1016/j.tem.2016.11.008
OpenAlex: W2563202669
Cited by: 294
References: 100
Citations by year: 2026: 32 · 2025: 40 · 2024: 49 · 2023: 56 · 2022: 59 · 2021: 15 · 2020: 18 · 2019: 10 · 2018: 6 · 2017: 9
FWCI: 1.20
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Trends in Endocrinology and Metabolism (publishedVersion)
PubMed (publishedVersion)
IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
Topics: Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
Health Sciences › Medicine › Reproductive Medicine › Reproductive Health and Technologies
Keywords: polycystic ovary syndrome, oocyte developmental competence, subfertility, anovulation, ovulation induction, assisted reproduction, PCOS phenotypes, comorbidities, female fertility
MeSH terms: Female, Humans, Infertility, Female, Oocytes, Ovulation Induction, Polycystic Ovary Syndrome, Pregnancy

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Oocyte competence in women with polycystic ovary syndrome

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