The DOI matches its Crossref record; 223 of the 223 references it cites were found in a registry or an index.
Inhibins, activins and follistatin in reproduction
Abstract
The regulation of reproductive processes involves a complex network of communication systems between the brain, endocrine organs, the gonads and other reproductive tissues. Classically, our understanding has focused on the role of endocrine hormones, but more recently interest has also dwelt on the paracrine and autocrine regulation of these cell systems. In this review, the structure and physiology of the inhibins, activins and follistatin are discussed in terms of the evidence supporting their role as endocrine hormones, and how they might function as paracrine factors within the pituitary, gonad and associated tissues. With the advent of more specific techniques and assays for their measurement, the potential of inhibins, activins and follistatin as clinical markers of reproductive function and in the screening of various pathologies is also evaluated.
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“FST acts as a multi-faceted hepatokine that is involved in reproduction [181], muscle growth [182], cancer development [183], and metabolism [184].”
From Hepatokines and metabolism: Deciphering communication from the liver (2021) · cites this paper as [181]
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Items 201–223 of 223
Badonnel, Y., Barbé, F., Legagneur, H., et al. (1994) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1994.tb02524.x · Cited by 23
Tena‐Sempere, M., Kero, J. T., Rannikko, A. S., Yan, W., & Huhtaniemi, I. T. (1999) · Endocrinology · doi:10.1210/endo.140.12.7193 · Cited by 23
Lockwood, G. M., Ledger, W. J., Barlow, D. H., et al. (1998) · American Journal of Reproductive Immunology · doi:10.1111/j.1600-0897.1998.tb00058.x · Cited by 22
The measurement of activin/EDF in mouse serum: Evidence for extragonadal production
Sakai, R., Shiozaki, M., Tabuchi, M., & Eto, Y. (1992) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(92)91143-e · Cited by 21
de Winter, J. P. (1994) · Endocrinology · doi:10.1210/en.135.2.759 · Cited by 21
Dalkin, A. C. (1996) · Endocrinology · doi:10.1210/en.137.12.5230 · Cited by 21
Phillips, D. J. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.85.7.2411 · Cited by 21
Expression of Activin A and Follistatin Core Proteins by Human Prostate Tumor Cell Lines
McPherson, S. J. (1999) · Endocrinology · doi:10.1210/en.140.11.5303 · Cited by 21
Zhang, Z., Zheng, J., Zhao, Y., et al. (1997) · International Journal of Oncology · doi:10.3892/ijo.11.4.727 · Cited by 20
Tilbrook, A. J., de Kretser, D., & Clarke, I. J. (1999) · Journal of Endocrinology · doi:10.1677/joe.0.1610219 · Cited by 20
Stouffer, R. L. (1993) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.77.1.241 · Cited by 20
Wongprasartsuk, S., Jenkin, G., McFarlane, J. R., et al. (1994) · Journal of Endocrinology · doi:10.1677/joe.0.1410219 · Cited by 19
Feto-Placental Hypoxemia Regulates the Release of Fetal Activin A and Prostaglandin E2
Jenkin, G. (2001) · Endocrinology · doi:10.1210/en.142.2.963 · Cited by 15
Studies in sheep examining plasma follistatin elevations due to frequent blood sampling or surgery
Klein, R., Robertson, D., & Clarke, I. J. (1996) · Reproduction Fertility and Development · doi:10.1071/rd9960273 · Cited by 12
Tilbrook, A. J., de Kretser, D. M., & Clarke, I. J. (2001) · Biology of Reproduction · doi:10.1095/biolreprod64.2.473 · Cited by 9
Are serum inhibin concentrations new markers of placental tumours in the course of chemotherapy?
Pautier, P., Ghione, S., Brailly‐Tabard, S., et al. (2001) · Human Reproduction · doi:10.1093/humrep/16.11.2434 · Cited by 8
Serum inhibin A and activin A are elevated prior to the onset of pre-eclampsia
Muttukrishna, S., North, R. A., Morris, J., et al. (2001) · Human Reproduction · doi:10.1093/oxfordjournals.humrep.a002025 · Cited by 8
New developments in the biology of inhibins, activins and follistatins
Phillips, D. J. (2001) · Trends in Endocrinology and Metabolism · doi:10.1016/s1043-2760(01)00376-9 · Cited by 7
Testicular activin--too hot to handle?
Fh, D. J. (1997) · European Journal of Endocrinology · doi:10.1530/eje.0.1370448 · Cited by 7
Pituitary FSH Is Released by a Heterodimer of the β-Subunits from the Two Forms of Inhibin
LING, N. C., Ying, S., Ueno, N., et al. (1987) · Obstetrical & Gynecological Survey · doi:10.1097/00006254-198742020-00015 · Cited by 7
The Uterine Myometrium Is a Target for Increased Levels of Activin A during Pregnancy
Draper, L. B. (1997) · Endocrinology · doi:10.1210/en.138.7.3042 · Cited by 7
Developmental expression of heat shock protein 60 (HSP60) in the rat testis and ovary
Paranko, J., Seitz, J., & Meinhardt, A. (1996) · Differentiation · doi:10.1007/s002580050146 · Cited by 4
Inhibin: A new circulating marker of hydatidiform mole?
Yohkaichiya, T., Fukaya, T., Hoshiai, H., et al. (1990) · International Journal of Gynecology & Obstetrics · doi:10.1016/0020-7292(90)90209-4 · Cited by 2
Cited by
Sorted by citations
Regulation of Muscle Mass by Follistatin and Activins
Lee, S.-J., Lee, Y.-S., Zimmers, T. A., Soleimani, A., Matzuk, M. M., Tsuchida, K., Cohn, R. D., & Barton, E. R. (2010) · Molecular Endocrinology · doi:10.1210/me.2010-0127 · Cited by 273
Hepatokines and metabolism: Deciphering communication from the liver
Jensen-Cody, S. O., & Potthoff, M. J. (2021) · Molecular Metabolism · doi:10.1016/j.molmet.2020.101138 · Cited by 252
Allaway, H. C. M., Southmayd, E. A., & De Souza, M. J. (2016) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2015-0053 · Cited by 89
Role of exercise-induced hepatokines in metabolic disorders
Ennequin, G., Sirvent, P., & Whitham, M. (2019) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00433.2018 · Cited by 54
Dalcq, J., Pasque, V., Ghaye, A., Larbuisson, A., Motte, P., Martial, J. A., & Muller, M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0050140 · Cited by 52
Metadata
- Authors
- de Kretser, D. M.
- Venue
- Human Reproduction Update
- Publisher
- Oxford University Press (OUP)
- Published
- 2002-11-01
- Volume
- 8
- Issue
- 6
- Pages
- 529-541
- ISSN
- 1355-4786 (ISSN-L)
- 1460-2369
- OpenAlex
- W2166390226
- Cited by
- 211
- References
- 223
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 2 · 2023: 4 · 2022: 2 · 2021: 8 · 2020: 11 · 2019: 12 · 2018: 8 · 2017: 7 · 2016: 10 · 2015: 9 · 2014: 3 · 2013: 12 · 2012: 13
- FWCI
- 1.22
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Human Reproduction Update (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Biology and Fertility
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- inhibin, activin, follistatin, reproductive control, paracrine signaling, autocrine regulation, endocrine hormones, pituitary gland, gonads
- MeSH terms
- Animals, Female, Follicle Stimulating Hormone, Humans, Inhibins, Male, Ovary, Pregnancy, Reproduction, Testis, Activins, Follistatin
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