Temporal trends in sperm count: a systematic review and meta-regression analysis of samples collected globally in the 20th and 21st centuries

Levine, Hagai, Jørgensen, Niels, Martino-Andrade, Anderson, Mendiola, Jaime, Weksler-Derri, Dan, Jolles, Maya, Pinotti, Rachel, Swan, Shanna H·2023·Human Reproduction Update

Cited by (730)

Items 101–200 of 730

  1. Association of seminal plasma zinc levels with human semen quality and its toxic effects on sperm motility
    Yu Chen, Xiaoyu Wang, Jing Zhou, Ganlin Wang, Tingting Gao, Haiming Wei, Yurui Che, Tianfu Liu, Zhenglin Zhang, Shuxian Wang et al. · 2024 · Ecotoxicology and Environmental Safety
  2. Exploring the association between urinary bisphenol A, S, and F levels and semen quality parameters: Findings from Led-Fertyl cross-sectional study
    María Ángeles Martínez, Albert Salas‐Huetos, María Fernández de la Puente, Cristina Valle‐Hita, Montse Marquès, Claudia Del Egido‐González, Jennifer Estefanía Davila Cordova, Cristina Mestres, Maria Skaalum Petersen, Nancy Babió et al. · 2024 · Environmental Research
  3. Can lifestyle changes significantly improve male fertility: A narrative review?
    Kadir Böcü, Luca Boeri, Asli Metin Mahmutoglu, Paraskevi Vogiatzi · 2024 · Arab Journal of Urology
  4. Polystyrene microplastics induced spermatogenesis disorder via disrupting mitochondrial function through the regulation of the Sirt1-Pgc1α signaling pathway in male mice
    Haibo Jin, Bowen Xue, Xuefang Chen, Tan Ma, Yonggang Ma, Hui Zou, Jiaqiao Zhu, Xishuai Tong, Ruilong Song, Weiqian Meng et al. · 2024 · Environmental Pollution
  5. Microplastics and human health: Exposure pathways, toxicity mechanisms, and future research challenges
    Zhi Wang, Nuo Li, Yongcheng Ding, Na Li, Menghan Su, Congcong Zhang, Yiqun Li, Qing Wang, Chenyan Sha, Bing Xia et al. · 2025 · Journal of environmental chemical engineering
  6. The role of total antioxidant capacity and malondialdehyde of seminal plasma in the association between air pollution and sperm quality
    Lipeng Li, Tengfei Feng, Ruiting Wu, Yaling Zhang, Ning Wang, Mengqi Wu, Sujuan Yang, Sujuan Yang, Aimin Yang, Dengsuo Zhang et al. · 2023 · Environmental Pollution
  7. Exploring the biological roles of DHX36, a DNA/RNA G-quadruplex helicase, highlights functions in male infertility: A comprehensive review
    Li Fu, Qiang Wu, Junjiang Fu · 2024 · International Journal of Biological Macromolecules
  8. The Influence of Lifestyle on Male Fertility in the Context of Insulin Resistance—Identification of Factors That Influence Semen Quality
    Adrianna Zańko, Iwo Martynowicz, Anna Citko, Paulina Konopka, Adam Paszko, Michał Pawłowski, Łukasz Szczerbiński, Katarzyna Siewko, Adam Jacek Kretowski, Waldemar Kuczyński et al. · 2024 · Journal of Clinical Medicine
  9. Human sperm RNA in male infertility
    Rossella Cannarella, Andrea Crafa, Roberto Curto, Laura M. Mongioì, Vincenzo Garofalo, Vittorio Cannarella, Rosita Angela Condorelli, Sandro La Vignera, Aldo Eugenio Calogero · 2024 · Nature Reviews Urology
  10. Repeated measurements of urinary bisphenol A and its analogues in relation to sperm DNA damage
    Yang-Juan Li, A-Xue Liu, Jia-Yue Zeng, Yu Miao, Min Zhang, Xiao-Ying Liu, Wu Yang, Rong Li, Jin-Qin Zhu, Changjiang Liu et al. · 2025 · Journal of Hazardous Materials
  11. Differentiation between nonobstructive azoospermia and obstructive azoospermia: then and now
    Logan C. Hubbard, Amarnath Rambhatla, Giovanni Maria Colpi · 2024 · Asian Journal of Andrology
  12. ESHRE’s key research priorities in infertility: maximizing impact on science, people and society
    Johanna Tassot, Aisling Ahlström, Antonio Capalbo, Ying C Cheong, Giovanni Coticchio, Ilse Delbaere, Christina Fadler, Sofia Gameiro, Mariëtte Goddijn, Jackson Kirkman‐Brown et al. · 2025 · Human Reproduction
  13. Interleukin-17A knockout or self-recovery alleviated autoimmune reaction induced by fluoride in mouse testis
    Panhong Wu, Kaidong Yang, Zilong Sun, Yangfei Zhao, Ram Kumar Manthari, Jundong Wang, Jinling Cao · 2023 · The Science of The Total Environment
  14. The Price of Human Evolution: Cancer-Testis Antigens, the Decline in Male Fertility and the Increase in Cancer
    Jekaterina A. Erenpreisa, Ninel Miriam Vainshelbaum, Marija Lazovska, Roberts Kārkliņš, Kristīne Salmiņa, Pawel Zayakin, Fēlikss Rūmnieks, Inna Inashkina, Dace Pjanova, Juris Ērenpreiss · 2023 · International Journal of Molecular Sciences
  15. Associations between Sperm Epigenetic Age and Semen Parameters: An Evaluation of Clinical and Non-Clinical Cohorts
    S. Sawant, O. Oluwayiose, K. Nowak, DruAnne L. Maxwell, E. Houle, Amanda L. Paskavitz, H. Saddiki, R. Bertolla, J. Pilsner · 2024 · Current Issues in Molecular Biology
  16. The role of p53 in male infertility
    Jinhong Li, Xia Huang, Luo Lei, Jialin Sun, Qie Guo, Xue Yang, Chuanzhou Zhang, Beibei Ni · 2024 · Frontiers in Endocrinology
  17. Circular RNAs and Their Role in Male Infertility: A Systematic Review
    Maria-Anna Kyrgiafini, Zissis Mamuris · 2023 · Biomolecules
  18. Loss of PBX1 function in Leydig cells causes testicular dysgenesis and male sterility
    Fei-Chen Wang, Xiaona Zhang, Shixin Wu, Zhen He, Luyao Zhang, Qi‐En Yang · 2024 · Cellular and Molecular Life Sciences
  19. Recent decline in sperm motility among donor candidates at a sperm bank in Denmark
    Emilie Lassen, Allan Anthony Pacey, Anne‐Bine Skytte, Robert Montgomerie · 2024 · Human Reproduction
  20. Dipeptide metabolite, glutamyl-glutamate mediates microbe-host interaction to boost spermatogenesis
    Balázs Juhász, Krisztina Horváth, Dániel Kuti, Jian Xing Shen, Annette Feuchtinger, Chaoyang Zhang, Ildikó Bata‐Vidács, István Nagy, József Kukolya, Michael A. Witting et al. · 2024 · Scientific Reports
  21. High-Fat Diets Disturb Rat Epididymal Sperm Maturation
    Lorena Ruiz Valderrama, José Edwin Mendoza-Sánchez, Ernesto Rodríguez‐Tobón, Isabel Arrieta‐Cruz, Humberto González‐Márquez, Pablo Arturo Salame-Méndez, Rosario Tarragó-Castellanos, Edith Cortés Barberena, Ahiezer Rodríguez Tobón, Edith Arenas‐Ríos · 2025 · International Journal of Molecular Sciences
  22. Artificial Intelligence in Andrology: A New Frontier in Male Infertility Diagnosis and Treatment
    Joseph Y. Nashed, Kiera Liblik, Ali Dergham, Luke Witherspoon, Ryan Kendrick Flannigan · 2025 · Current Urology Reports
  23. Protective Effect of Curculigo orchioides Gaertn. Extract on Heat Stress-Induced Spermatogenesis Complications in Murine Model
    Thanh-Nhan Bui-Le, Hoàng Tấn Quảng, Huong Hoang-Viet, Bich-Phuong Truong-Thi, Tung Thanh Nguyen · 2023 · Current Issues in Molecular Biology
  24. Is telomere length a biomarker of sperm quality? A systematic review and meta‐analysis of observational studies
    María Fernández de la Puente, Albert Salas‐Huetos, Cristina Valle‐Hita, Nancy Babió, Michelle M. Murphy, Sı́lvia Canudas, Jordi Salas‐Salvadó · 2023 · Andrology
  25. Organophosphate Esters, Sperm Mitochondrial DNA Copy Number, and Semen Quality: A Longitudinal Study with Repeated Measurements
    Yaping Li, Chong Liu, Vicente Mustieles, Yu Zhang, Carmen Messerlian, Audrey Jane Gaskins, Heng‐Gui Chen, Yingjun Chen, Qitong Xu, Xiaoya Zhao et al. · 2025 · Environmental Science & Technology
  26. Deciphering the role of reactive oxygen species in idiopathic asthenozoospermia
    Zilong Wang, Dandan Li, Guoyi Zhou, Zhen Xu, Xinkun Wang, Senbao Tan, Zhenghao Li, Xiaoli Li, Changze Song, Yuan Song · 2025 · Frontiers in Endocrinology
  27. H omo sapiens , industrialisation and the environmental mismatch hypothesis
    Daniel P. Longman, Colin N. Shaw · 2025 · Biological reviews/Biological reviews of the Cambridge Philosophical Society
  28. Perinatal exposure to polystyrene microplastics induces multigenerational impairment of male reproduction via disrupted steroidogenesis and proteostasis
    Mengling Jiang, Shuxin Wang, Huilin Zeng, Bowen Tan, Yuqi Qin, Qi Zhou, Xiaojing Lv, Jian Wan, Mingqing Chen · 2026 · Environment International
  29. Temporal trends in equine sperm progressive motility: a systematic review and meta-regression
    Imogen Thea Harris, C Maddock, Mark James Farnworth, Kathryn J. Nankervis, Jodie Perrett, Alison Z. Pyatt, Rebecca Nicole Blanchard · 2023 · Reproduction
  30. TERT transcription and translocation into mitochondria regulate benzo[a]pyrene/BPDE-induced senescence and mitochondrial damage in mouse spermatocytes
    Haonan Cui, Yang Wang, Shi-Jun He, Zili Chai, Lihong Wang, Guowei Zhang, Peng Zou, Lei Sun, Huan Yang, Qing Chen et al. · 2023 · Toxicology and Applied Pharmacology
  31. Impact of semen microbiota on the composition of seminal plasma
    David Baud, Arnaud Zuber, A. Peric, Nicola Pluchino, Nicolas R. Vulliémoz, Miloš Stojanov · 2024 · Microbiology Spectrum
  32. Exposure to toxicologically relevant atrazine concentrations impair the glycolytic function of mouse Sertoli cells through the downregulation of lactate dehydrogenase
    Daniela Gomes-Andrade, Bárbara Guerra‐Carvalho, David F. Carrageta, Raquel L. Bernardino, Patrícia C. Braga, Pedro Fontes Oliveira, Maria de Lourdes Pereira, Marco Gouveia Alves · 2024 · Toxicology and Applied Pharmacology
  33. Sperm epigenetics and sperm RNAs as drivers of male infertility: truth or myth?
    Loredana Leggio, Greta Paternò, Fabrizio Cavallaro, Marco Falcone, Silvia Vivarelli, Claudio Manna, Aldo Eugenio Calogero, Rossella Cannarella, Nunzio Iraci · 2024 · Molecular and Cellular Biochemistry
  34. Association between spectrum of mycotoxins and semen quality: A cross-sectional study in Beijing, China
    Chen Yang, Ning Xiao, Baojun Wang, Tian Tian, Yongyan Chen, Le Ma, Linlin Wang · 2024 · Journal of Hazardous Materials
  35. Association between mental health and male fertility: depression, rather than anxiety, is linked to decreased semen quality
    Yi Zhang, Bei Chen, Yaqin Wang, Cong Liu, Jiayi Sun, Zhimo Zhang, Liangzi Guan, Xiao Ke, Zhonghai Zhu, Jin Jun Luo · 2024 · Frontiers in Endocrinology
  36. Vers une stratégie nationale de lutte contre l'infertilité
    S. Hamamah · 2023 · Elsevier eBooks
  37. Food, nutrition, and fertility: from soil to fork
    Melissa Maitin‐Shepard, Erika F. Werner, Larry A. Feig, Jorge E. Chavarro, Sunni L. Mumford, Blair Johnson Wylie, Oliver J. Rando, Audrey Jane Gaskins, Denny Sakkas, Manish Arora et al. · 2023 · American Journal of Clinical Nutrition
  38. Exposure to ambient ozone and sperm quality among adult men in China
    Yadi Shi, Yangchang Zhang, Kun Yuan, Ze‐Guang Han, Shi Zhao, Zhenyu Zhang, Wangnan Cao, Yufeng Li, Qiang Zeng, Shengzhi Sun · 2024 · Ecotoxicology and Environmental Safety
  39. ATF3 as a response factor to regulate Cd-induced reproductive damage by activating the NRF2/HO-1 ferroptosis pathway
    Sisi Li, Sheng Ma, Lirui Wang, Dian Zhan, Shengyao Jiang, Zhenyang Zhang, Manyi Xiong, Yanping Jiang, Qixian Huang, Jian Zhang et al. · 2024 · Ecotoxicology and Environmental Safety
  40. Microplastic exposure is associated with male reproductive health
    Weijia Liu, Zhi Qu, Xuemei Wang, Huai-Liang Feng, Shaohua Ma, Y.K. Zheng, Guimiao Lin, Suli Huang, Qiming Yang, Xihua Feng et al. · 2024 · Medical Review
  41. Reproductive and Metabolic Health Following Exposure to Environmental Chemicals: Mechanistic Insights from Mammalian Models
    Michelle Bellingham, Neil P. Evans, Richard G. Lea, Vasantha Padmanabhan, Kevin D. Sinclair · 2024 · Annual Review of Animal Biosciences
  42. Perceived stress in relation to testicular function markers among men attending a fertility center
    Akshay G. Reddy, Paige L. Williams, Irene C. Souter, Jennifer B. Ford, Ramace Dadd, Ramy Abou Ghayda, Russ B. Hauser, Jorge E. Chavarro, Lidia Mínguez‐Alarcón · 2025 · Fertility and Sterility
  43. Melatonin alleviates ferroptosis triggered by cadmium via regulating ferritinophagy and iron metabolism in spermatogonia
    Didi Jia, Wei Huang, Qizi Yin, Han Wang, Ziyue Wang, Mingming Zhang, Wenjing Gong, Rong Wang, Yan Zhu, Yanli Ji · 2025 · Scientific Reports
  44. The effects of radiofrequency radiation on male reproductive health and potential mechanisms
    Hava Bektaş, Süleyman Daşdağ · 2025 · Electromagnetic Biology and Medicine
  45. Role of Mediterranean Diet and Ultra-Processed Foods on Sperm Parameters: Data from a Cross-Sectional Study
    Gabriel Cosmin Petre, Francesco Francini‐Pesenti, Luca De Toni, Andrea Di Nisio, Asia Mingardi, Ilaria Cosci, Nicola Passerin, Alberto Ferlin, Andrea Garolla · 2025 · Nutrients
  46. Diet and recreational drug use in relation to male reproductive health
    Sarah LaPointe, Akanksha Mehta, Audrey Jane Gaskins · 2023 · Fertility and Sterility
  47. A Possible Role for Nerve Growth Factor and Its Receptors in Human Sperm Pathology
    Anna Maria Stabile, Alessandra Pistilli, Elena Moretti, Desirée Bartolini, Mariangela Ruggirello, Mario Rende, Cesare Castellini, Simona Mattioli, Rosetta Ponchia, Sergio Antonio Tripodi et al. · 2023 · Biomedicines
  48. More equitable preconception health: paternal life course opportunities for better pregnancy, child, and family outcomes
    Jonathan Yinhao Huang, Felicia M. Low, Michelle Z. L. Kee, Lorenzo N. Hopper, Ka Kei Sum, Gerard Chung, Joseph Keawe‘aimoku Kaholokula, Judith Stephenson, Danielle A. J. M. Schoenaker, Keith M. Godfrey · 2026 · The Lancet
  49. Effect of obstructive sleep apnea on semen quality
    Zehao Wang, Qingfeng Zhang, Jinli Ding, Sisi Yan, Wenyi Jin, Lingbo Luo, Shiqian Zha, Qing Liu, Zongyue Zhang, Hao Chen et al. · 2023 · Sleep And Breathing
  50. The effect of an educational animation on knowledge of testicular health and fertility of adolescents
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  51. Next-Generation Sequencing to Elucidate the Semen Microbiome in Male Reproductive Disorders
    Rhianna Davies, Suks Minhas, Channa Nalin Jayasena · 2023 · Medicina
  52. Taste receptor type 1 member 3 is required for the fertility of male mice
    Woo-Jeong Shon, Hobin Seong, Jae Won Song, Dong‐Mi Shin · 2024 · Heliyon
  53. A systematic review of interventions to improve male knowledge of fertility and fertility-related risk factors
    Srinithy Krishnan, Michael P. Daly, Ruth Kipping, China Harrison · 2024 · Human Fertility
  54. Impact of Season Variation on Semen Quality: A Comprehensive Retrospective Analysis of Data From Patients at an Eastern Iranian Tertiary Care Fertility Center Over a Decade
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  55. Spermbots and Their Applications in Assisted Reproduction: Current Progress and Future Perspectives
    Yiaobo Zhang, Min Wang, Ting Zhang, Honghua Wang, Ying Chen, Tao Zhou, Rui Yang · 2024 · International Journal of Nanomedicine
  56. Metabolomics analysis of human spermatozoa reveals impaired metabolic pathways in asthenozoospermia
    Bárbara Guerra‐Carvalho, David F. Carrageta, Tatiana Maurício, Sara C. Pereira, Alberto Barros, Rui A. Carvalho, Marco Gouveia Alves, Pedro M. Domingues, Pedro Fontes Oliveira · 2024 · European Journal of Clinical Investigation
  57. Generation of mouse testicular organoids with highly compartmentalized tubular lumen structure and their cryopreservation
    Jia Tan, Jiahui Li, Chun-Yan Lin, N. Ye, Hui Zhang, Chenxi Liu, Sha Han, Zheng Li, Xinli Zhou · 2024 · Life Sciences
  58. Dietary supplementation of male mice with inorganic, organic or nanoparticle selenium preparations: evidence supporting a putative gut-thyroid-male fertility axis
    Albaraa Mojadadi, A. Au, Tamara Ortíz, Yu‐Hsuan Joni Shao, T. O’Neil, Kim S. Bell-Anderson, J. W. Andersen, J. Leyden Webb, Wesam Salah, Gulfam Ahmad et al. · 2025 · Redox Report
  59. Epidemiology of falling fertility: the contribution of social, environmental, and genetic forces
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  60. HFPO homologues, the novel alternatives to PFOA, impair male reproduction in mice through inducing mitochondrial dysfunction
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  61. Current progress and open challenges for applying artificial intelligence across the in vitro fertilization cycle
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  62. Developmental exposure to a real-life environmental chemical mixture alters testicular transcription factor expression in neonatal and pre-pubertal rams, with morphological changes persisting into adulthood
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  63. Effects of Benzo[a]pyrene on Human Sperm Functions: An In Vitro Study
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  64. THC and sperm: Impact on fertilization capability, pre-implantation in vitro development and epigenetic modifications
    Alexander G. Kuzma-Hunt, Reem Sabry, Ola S. Davis, Vivien B. Truong, Jibran Younis Khokhar, Laura A. Favetta · 2024 · PLoS ONE
  65. Fertility in High-Income Countries: Trends, Patterns, Determinants, and Consequences
    Bloom, David E., Kuhn, Michael, Prettner, Klaus · 2023
  66. Loss of Nuclear/DNA Integrity in Mouse Epididymal Spermatozoa after Short-Term Exposure to Low Doses of Dibutyl Phthalate or Bisphenol AF and Its Mitigation by Oral Antioxidant Supplementation
    Elisa Hug, Pauline Villeneuve, Stéphanie Bravard, Areski Chorfa, Christelle Damon‐Soubeyrand, Stephen G. Somkuti, Aron Moazamian, R. John Aitken, Parviz Gharagozloo, Joël R. Drevet et al. · 2023 · Antioxidants
  67. The association between ambient temperature and semen quality in a Northern Peninsular Province, China
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  68. Machine learning approach to assess the association between anthropometric, metabolic, and nutritional status and semen parameters
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  69. Lead and calcium crosstalk tempted acrosome damage and hyperpolarization of spermatozoa: signaling and ultra-structural evidences
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  70. Acupuncture in the Treatment of Male Infertility: A Review
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  71. Comparative Efficacy of Swim-Up, Density-Gradient Centrifugation, and Microfluidic Sorting in Sperm Preparation, and the Impact on Motility, Morphology, and DNA Integrity
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  72. Evolution of the incidence of male fertility disorders over the last decades
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  73. An update on the role and potential mechanisms of clock genes regulating spermatogenesis: A systematic review of human and animal experimental studies
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  74. A dataset of hidden small non-coding RNA in the testis of heat-stressed models revealed by Pandora-seq
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  75. Integrated transcriptomic and metabolomic analysis reveals the underlying mechanisms for male reproductive toxicity of polystyrene nanoplastics in mouse spermatocyte-derived GC-2spd(ts) cells
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  76. Resveratrol: potential application in safeguarding testicular health
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  77. Lectin Functionalised Iron Magnetic Nanoparticle‐Based Sperm Selection: A Potential Technique to Improve Bull Sperm Quality In Vitro
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  78. Exploring the Biological Effects of Polystyrene Nanoplastics on Spermatogenesis: Insights From Transcriptomic Analysis in Mouse Spermatocytes
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  79. Temporal trends in serum testosterone and luteinizing hormone levels indicate an ongoing resetting of hypothalamic-pituitary-gonadal function in healthy men: a systematic review
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  80. A functionally tunable magnetic nanochains platform for N-glycoproteomic analysis of extracellular vesicles from ultratrace biofluids
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  81. From gut to gamete: how the microbiome influences fertility and preconception health
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  82. Associations between PM2.5 components, temperature, and semen quality: Insights from seminal plasma metabolome
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  83. Evidence that declining human fecundity contributes to the fertility crisis
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  84. Deep learning-based approach for sperm morphology analysis
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  85. Trimethylamine-N-oxide disrupts spermatogenesis by inducing mitochondrial oxidative stress injury through Hippo signaling
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  86. Adolescent exposure to polystyrene nanoplastics induces male reproductive damage via the microbiome-gut-testis axis
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  87. PBA alleviates cadmium-induced mouse spermatogonia apoptosis by suppressing endoplasmic reticulum stress
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  88. Impact of Fetal Exposure to Endocrine Disrupting Chemical Mixtures on FOXA3 Gene and Protein Expression in Adult Rat Testes
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  89. Effects of preconception exposure to phthalates on mouse sperm capacitation parameters
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  90. WNK1 is required during male pachynema to sustain fertility
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  91. Transgenerational Epigenetic DNA Methylation Editing and Human Disease
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  93. Association between diurnal temperature range and sperm quality: Evidence from a prospective cohort in Central China
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  94. A detection model of testis‐derived circular RNAs in serum for predicting testicular sperm retrieval rate in non‐obstructive azoospermia patients
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  95. A preconception cohort study of sugar‐sweetened beverage consumption and semen quality
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  96. Testicular ultrasonic microvascular density in assessing spermatogenesis and predicting successful sperm retrieval
    Jun Cui, Wei Fu, Yongsheng Song · 2024 · Quantitative Imaging in Medicine and Surgery
  97. Why couple infertility is historically a female‐driven problem?
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  98. Healthy and unhealthy dietary patterns and sperm quality from the Led‐Fertyl study
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  99. Chronic psychological stress induces testicular oxidative stress affecting reproductive behavior in rats
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  100. Transcriptomic analysis of the HPT axis in a model of oligoasthenozoospermia induced by Adenine in rats
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