Temporal trends in sperm count: a systematic review and meta-regression analysis of samples collected globally in the 20th and 21st centuries

Levine, Hagai, Jørgensen, Niels, Martino-Andrade, Anderson, Mendiola, Jaime, Weksler-Derri, Dan, Jolles, Maya, Pinotti, Rachel, Swan, Shanna H·2023·Human Reproduction Update

Cited by (730)

Items 601–700 of 730

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    Foteini Gkaitatzi, Ilias Tsochantaridis, Olga Pagonopoulou, Georgia-Persephoni Voulgaridou · 2026 · Pharmaceuticals
  2. One-pot assay integrating TdT-mediated poly-A tailing with CRISPR-Cas12a trans-cleavage for amplified detection of sperm DNA damage
    Ziyang Liu, Yong Chen, Zhaoyang Wang, Fan Zhang, Liguo Pei, Yue Zhou, Honghong Wang, Lianghong Ma, Bei Yan, Juan Wang · 2026 · Microchemical Journal
  3. Comprehensive Analysis of Mixed Reproductive Health Effects of Neonicotinoids: Association with Declining Sperm Concentration and Total Sperm Count in Men
    Ruyun Liu, Xun Li, Yilin Xue, Xuanxuan Wang, Cheng Wang, Shulin Yang, Tao Zhang, Dan Hu, Si Liu, Jing Yue et al. · 2026 · Exposure and Health
  4. Associations Between Perceived Stress and Sperm DNA Methylation Among Men Attending a Fertility Center
    Lidia Mínguez‐Alarcón, Karolina Nowak, Akshay G. Reddy, Paige L. Williams, Jennifer B. Ford, Ramace Dadd, Jorge E. Chavarro, Russ B. Hauser, Jonathan Richard Pilsner · 2026 · Andrology
  5. Predictive value of sperm DFI, ROS, and MMP for In Vitro fertilization pregnancy outcomes in asthenozoospermic patients
    Sanhua Wei, Kaili Wang, Hongya Yang, Tao Yang, Kai Gao, Xuhui Ma, Ruonan Li, Zhenhua Chang, Zhenhua Lu, Hai Zhang et al. · 2026 · Frontiers in Endocrinology
  6. Food packaging contaminants and offspring reproductive health: Disease risks and underlying mechanisms
    Huage Liu, Yongfang Xu, Lifeng Xiang, Zhendong Sun, Qunfang Zhou, Guibin Jiang · 2026 · Ecotoxicology and Environmental Safety
  7. Analysis of antisperm antibody assessment results in the ejaculate of men attending a reproductive medicine center
    Igor Alexeyevich Korneyev, O. N. Allakhverdiev · 2026 · Urology reports (St - Petersburg)
  8. Comparing Methods for Sperm DNA Fragmentation Detection
    Monica Muratori, Giulia Pellegrini, Maddalena Pacciani, Giorgio Leter, Lisa Giovannelli, Ettore Caroppo · 2026 · Advances in experimental medicine and biology
  9. Associations between routine systemic biochemical indices and semen quality: a cross-sectional study in men undergoing health examination
    Xihuan Ren, Lin Ni, Yun Fu, Gang An, Xiangqun Fan, Dianliang Lin · 2026 · Scientific Reports
  10. Sperm quality parameters of Swiss army recruits pre- and peri-COVID-19: a cross-sectional, comparative analysis
    Sabine Köppen, Ulrike Held, Nejla Gültekin, Andreas Stettbacher, Zeno Giovanni Stanga, Ismail I. Ülgür, Jeremy Deuel, Patricia Schlagenhauf · 2026 · New Microbes and New Infections
  11. The influence of unhealthy lifestyle on semen quality: results from a cross-sectional study and Mendelian randomization analysis
    Mengyuan Lin, Yangkun Feng, Yun Zhang, Qingwen He, Ninghan Feng · 2026 · Annals of Medicine and Surgery
  12. Paternal Sertoli cell-derived extracellular vesicles transfer mtDNA and microRNA cargo to trigger germ cell oxidative stress and induce metabolic risks in offspring
    Jingxian Deng, L Li, Zhuoying Huang, Xi Wei, Xiaorui Zhang, Sutong Hua, Jiawei Hao, Yanze Zhang, Yuwei Fu, Xuanzhe Cao et al. · 2026 · Cell Communication and Signaling
  13. Persea americana Mill (Lauraceae) Seed Extract Effect on Male Rat Fertility: Sperm Quality and Histomorphological Safety Assessment
    Ifeoma Celestina Orabueze, G.O. Oludare, Khadijat. A. Akinlade, Ogochukwu F. Orabueze, Gaber El‐Saber Batiha, George Awuku Asare · 2026 · Tropical Journal of Natural Product Research
  14. Bibliography
    2026 · Duke University Press eBooks
  15. (DE)Population
    2026 · Duke University Press eBooks
  16. Epilogue
    2026 · Duke University Press eBooks
  17. Introduction
    2026 · Duke University Press eBooks
  18. Breeding Ground
    2026 · Duke University Press eBooks
  19. Notes
    2026 · Duke University Press eBooks
  20. Two Children
    2026 · Duke University Press eBooks
  21. Global research trends on the impact of obesity on male infertility: a bibliometric analysis
    Jiuyuan Wang, Wenjing Huang, Mengchen Tan, Nanqi Xu, Qinghu He, Guixiang Sun · 2026 · Frontiers in Nutrition
  22. On the Culmination of Species
    2026 · Duke University Press eBooks
  23. Identification of Novel Cytogenetic Alterations and Y Chromosome Microdeletions in Infertile Males
    Divya Narayanan, Tapan A. Patel, Joydeep Chakraborty · 2026 · Urology
  24. Exposure to ambient PM2.5 constituents and semen quality in a retrospective cohort study: Windows of susceptibility and modification by greenness
    Ling Yang, Ziwen Hu, Xiyan Wu, Xinghua Yang, Linfei Dou, Yanling Shu, Mingyang Wu · 2026 · International Journal of Hygiene and Environmental Health
  25. Exposure to O3, NO2 and their oxidative potential in relation to decreased fecundability: The potential contribution of inflammatory hematological markers
    Bingxue Wu, Zigao Zhao, Yan Zhang, Cai Kong, Yuyan Li, Yishi Jiang, Zhengyuan Xie, Xiangjing Song, Tao Wang, Yan Che · 2026 · Environmental Research
  26. ZAG and Zn/ZAG Ratio in Seminal Plasma: Dual Roles in Male Semen Quality
    Jin-Bao Ma, 杜美阳, Peipei Deng, Lingyin Kong, Shusong Wang, Fangfang Dai, Jing Ma, Hongzhong Bai · 2026 · Biological Trace Element Research
  27. Evolutionary and epigenetic drivers of the global trajectory of sperm count decline: an integrative framework for male reproductive health
    Enver Kerem Dirican · 2026 · Reproductive BioMedicine Online
  28. Machine learning–driven proteomic profiling reveals seminal plasma biomarkers linking trihalomethane exposure to impaired sperm quality
    Song Xu, Haixia Zhou, Ying-Jun Chen, Heng‐Gui Chen, Bin Sun, Zhong-Hua Lu, Tian-Qing Meng, Chen-Liang Xiong, Yi-Xin Wang, Jie (Jennifer) Zhang · 2026 · Ecotoxicology and Environmental Safety
  29. Oxidative Stress and Male Reproductive Health—First Edition
    R. John Aitken, Joël R. Drevet, Zamira Gibb, Geoffry Nunzio De Iuliis · 2026 · Antioxidants
  30. Modifiable key factors and semen quality in men undergoing preconception evaluation: a cross-sectional study
    Hai-Lin Yao, Tingting Yang, Run Tian, Chang Zhao, F Yang, Zhenmi Liu, Fu-Ping Li · 2026 · Asian Journal of Andrology
  31. Temporal trends in semen parameters among men attending a fertility center in the UAE (2012 – 2022): a retrospective study
    Temidayo S. Omolaoye, Jeyaseelan Lakshmanan, Amin Abu Hijleh, Irfan Aslam, Stefan S. du Plessis · 2026 · Frontiers in Physiology
  32. Estrogen receptors, via paternal epigenome, regulate genes and pathways involved in embryogenesis
    Kushaan Khambata, Sanketa Raut, Nafisa Balasinor · 2026 · Reproduction
  33. Mitochondrial uncoupler BAM15 attenuates cryopreservation-induced damage in human sperm by stabilizing mitochondrial homeostasis
    Bei Chen, Cong Liu, Mengneng Xiong, Ling Xu, Jie Yao, Liangzi Guan, Zhifeng Sun, Qingzhen Xie, Yi Zhang, Yaqin Wang et al. · 2026 · Biology of Reproduction
  34. Comparative Spermatogenic and Androgenic Activity of Aqueous, Methanol, and N-Hexane Seed Extracts of Sphenostylis stenocarpa in Wistar Rats: Implications for Male Fertility
    Ebere Ogbuke, Vincent Chikwendu Ejere, Tesi P. Edesiri, Darlington-Peter Chibuzor Ugoji, Ebele Augustina Orji, Funmilayo Faith Hinmikaiye · 2026 · Research Square
  35. Total glycosides of Cistanche deserticola ameliorate alcohol-induced oligoasthenozoospermia via the modulation of gut microbiota-mediated spermidine metabolism
    Shuo Yuan, Jiaxin Hong, Haitao Zhang, Peng Gao, Ping Yang, Jun Lei, Yan He, Xinlan Fang, Y J Lu, Bin Wang et al. · 2026 · Phytomedicine
  36. Guilu Erxian oral liquid alleviates oligoasthenospermia via the mitochondria-complement-NETs network
    Qingyun Yue, Kejin Tong, Qin Feng, Hetong Chang, Zhen Zhang, Xiangnan Xu, Tiantian Pan, zimeng Xu, Le Chen, Jia Liu et al. · 2026 · Journal of Ethnopharmacology
  37. Semen Quality in a Large Cohort of Males Living in Highly Polluted Areas of Campania Region in Southern Italy with a Focus on the Role of Cadmium Exposure
    Cristina de Angelis, Francesco Garifalos, Davide Menafra, Paolo Chiodini, Giacomo Galdiero, Mariangela Piscopo, Tonia Romano, Nunzia Verde, Antonella Giarra, Marco Trifuoggi et al. · 2026 · Journal of Clinical Medicine
  38. Microplastics as trojan horses: A new perspective on bisphenol toxicity in male infertility and assisted reproduction
    Giovanna Kugel Marraschi, Otávio Galassi Vitale, Cândida Aparecida Leite Kassuya, Bárbara Campos Jorge, Arielle Cristina Arena · 2026 · Reproductive Toxicology
  39. Medically assisted reproduction
    Liv Bente Romundstad, Signe Opdahl · 2026 · Elsevier eBooks
  40. El Teorema de Markov y su relación con el espectro de Lagrange
    Christopher Salvador Martínez Martínez, Alicia Santiago-Santos · 2026 · Revista Digital Matemática Educación e Internet
  41. Intrauterine Growth and Male Reproductive Health: A Follow-up Study From the Danish National Birth Cohort.
    A. Gaml-Sørensen, N. Brix, A. Ernst, S. S. Tøttenborg, Mette Møller Dornfeldt, K. Hougaard, S. E. Håberg, M. Myrskylä, G. Toft, J. P. Bonde et al. · 2026 · Andrology
  42. Decadal Trends in Seminal Parameters: A Retrospective Study from a Tertiary Care Center in South India
    Swathy Yuvaraj, Radha Vembu, Monna Pandurangi, Anusha Ashok · 2026 · International Journal of Infertility & Fetal Medicine
  43. From posthumous-assisted reproduction to early sperm preservation: Israeli men’s perspectives on reproductive decision-making
    Rachel Shvartsur, Talia Eldar‐Geva, Bella Savitsky · 2026 · Reproductive BioMedicine Online
  44. Trimethylamine N-Oxide and Impaired Spermatogenesis in the Gut–Testis Axis: A Focused Review of Current Evidence
    Xinyang Zhang, Jialin Luo, Xiang Zhang, Fang Yang, Xiaojin Zhang, Xujun Yu, Liang Dong · 2026 · Biology
  45. Occupational Heat Exposure and Fertility Stress as Independent Factors of Low Semen Quality: A Multidimensional Analysis
    Ningning Han, Zhijuan Liu, Lijuan He, Rui Han · 2026 · American Journal of Men s Health
  46. Pesticide exposure and male reproductive health: A commentary on emerging toxicological and human studies
    Melissa J. Perry · 2026 · Albanian Journal of Natural and Technical Sciences
  47. Epidemiological trends of primary male infertility and secondary male infertility burden in BRICS from 1990 to 2021 and projections to 2035
    Chaoju Yang, Nan Ding, Jie Wang, Yanqing Tie · 2026 · International Journal of Gynecology & Obstetrics
  48. Male Infertility
    L. Sánchez-Mellado · 2026 · Springer eBooks
  49. Yishen Tongluo formula regulates apoptosis and autophagy in testicular spermatogenic cells of oligoasthenozoospermic rats via the AMPK/mTOR pathway
    Yangdi Chen, Fanggang Bi, Zhong Hua, J Z Chen, Chenxi Li, Mingsan Miao, Zixue Sun · 2026 · Journal of Ethnopharmacology
  50. Exploring cadmium exposure as a contributor to male infertility: insights from the relationship between environmental pollutants and the male reproductive system
    Chenming Zhang, Jing Hu, Sicheng Ma, Yue Wang, Heng Liu, Yinuo Zhang, Wenlin Yu, Yizhe Gao, J Lu · 2026 · Frontiers in Endocrinology
  51. Association of essential element mixtures with semen quality in Shanghai, China
    Zhongxia Zhao, Qi Zheng, Lu He, Zhouchen Yu, Shuya Zhou, Xin Gao, Siju Chen, Junxia Liu, Yan Zhang, Linsheng Yang et al. · 2026 · Environmental Toxicology and Pharmacology
  52. Oxidative Stress and Male Infertility: A Critical Analysis of Current Diagnostic and Therapeutic Methods
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  53. Global estimates of infertility burden and contributions of congenital, endocrine, metabolic and infectious factors
    Jieyan Wang, Chengzi Gan, Zixuan Jia, Zesen Zheng, Youao Zhang, Hui Liang · 2026 · Molecular Medicine
  54. Single-cell transcriptomic analysis reveals upregulation of EGR1, FOSB, and KLF4 in Leydig cells of idiopathic non-obstructive Azoospermia
    Yutao Cai, Xiaojuan Tang, Qiang Xia, Haili Wang, Ling Liu, Chenchen Ye, Bowen Liu, Wending Wang, Peng Duan, Yan Tan · 2026 · Tissue and Cell
  55. Body fat percentage in relation to semen characteristics, testicular volume, and reproductive hormones: a cross-sectional study
    Nis Brix, Andreas Ernst, Anne Gaml‐Sørensen, Linn Håkonsen Arendt, Gunnar Vase Toft, Sandra Søgaard Tøttenborg, Karin Sørig ­Hougaard, Jens Peter Bonde, Cecilia Høst Ramlau‐Hansen · 2026 · Human Reproduction
  56. Ambient air pollutant exposure and semen quality in healthy male undergraduates: A prospective refined multi-window panel study
    Huijun Li, Wenchao Xia, Yujie Li, Jiale Li, Lili Wang, Yongbin Wang, Rongxun Liu, Xinru Bian, Feng Wu, 桂玉明 et al. · 2026 · Ecotoxicology and Environmental Safety
  57. The Reproductive Toxicity of Microplastics: From Environmental Contamination to Organ Distribution and Reproductive Hazards
    Shubhradeep Chakraborty, Abhratanu Ganguly, Satadal Adhikary, Suchandra Bhattacharya, Prem Rajak · 2026 · Environmental Toxicology
  58. Testicular organoid models in male reproductive toxicology: advances, applications, and future perspectives
    Yan Liu, Yuting Sun, Meina Xie · 2026 · Frontiers in Physiology
  59. Micro- and nanoplastics as emerging disruptors of Leydig cell function: A systematic review of experimental evidence
    Isabel Ochando, Laura María Compañ Gabucio, Antonio Urbano, Mariano Andrés, Javier Marco-Lledó, Vanessa Zorrilla-Muñoz, Javier Hernández‐Borges, Pilar Madrigal-Verdú, Jonatan García Campos, Nicanor Morales-Delgado et al. · 2026 · Environmental Toxicology and Pharmacology
  60. Heat shock proteins in male infertility: recent advances and clinical implications
    Zhongnan Wu, Wanting Zhang, Ruqi Han, Huiyu Ping, Linhui Xia, Haoran Ding, Jinxiang Yuan, Xiaomei Wang, Qin Qin · 2026 · Frontiers in Cell and Developmental Biology
  61. Environmental pollutants and testicular toxicity in male reproductive health: Basic evidence and translational prospects — A narrative review
    Andong Guo, Yi Lu, Ye Guo, Hongjun Li · 2026 · Reproductive Toxicology
  62. Exposure to environmentally relevant concentrations of zearalenone disrupts blood-testis barrier via inositol-requiring enzyme 1α-dependent GA binding protein transcription factor α mRNA decay
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  63. Prenatal dexamethasone exposure programs male offspring subfertility via GR/HDAC6/CTSL-mediated spermatogonial autophagic flux blockade
    Shan Jin, Yixue Yao, Lu Zhu, Xiaoqi Zhao, Mengyuan Li, Ping Jiang, Ziyu Kong, Yi Liu, Ying Ao, Hui Wang · 2026 · Chemico-Biological Interactions
  64. Improving Sperm Quality and Hormonal Receptor Expression: N-acetylcysteine Treatment in Testicular Hypoxia
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  65. Reproductive risks of microplastics in assisted reproduction
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  66. Development of a non-terminal technique for sperm collection in Wistar rats to study the influence of environmental factors on reproduction
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  67. Cadmium Toxicity in Testis Organoids: Validation of an In Vitro Model for Testicular Toxicology
    Tat-Chuan Cham, Fahar Ibtisham, Luis Antonio Rico Guerrero, Ahmad N Al-Dissi, Ali Honaramooz · 2026 · Toxicologic Pathology
  68. Father–Son Comparison of Reproductive Traits
    Heidi P. Elamo, Wiwat Rodprasert, Louise Scheutz Henriksen, Niels Jørgensen, Niels E. Skakkebæk, Anders Juul, Helena Ollila, Katharina Maria Main, Jorma Toppari, Helena Virtanen · 2026 · Andrology
  69. Microplastic-induced male reproductive toxicity: animal models, key design parameters, and mechanistic insights
    Qiujian Feng, Zhuozhi Gong, Elena Colonnello, Boda Guo, Shengjing Liu · 2026 · Environmental Sciences Europe
  70. Research and Application of Ecological Logistics Model Based on System Dynamics
    Ye Zhou, Chao Zhou, Hui Mao · 2026 · Automation and Remote Control
  71. AIE-pharmacology-enabled organelle therapeutics for microplastic-induced asthenozoospermia
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  72. Swadamshtradi rasayana attenuates radiofrequency radiation-induced oxidative stress and improves sperm parameters in Swiss albino mice
    V. R. Abdul, M. Sudha, Neenu Prakash Easwaramangalath, Delvin T. Robin, Anusree Dileep, VandanaRani Madhavan · 2026 · Frontiers in Reproductive Health
  73. PFOS-induced mitochondrial ROS impairs male reproductive function by suppressing FTO-dependent m6A RNA demethylation
    Yipeng Pang, Shiqing Yang, Yuenan Wang, Fructueux Modeste Amona, Rong Zhou, Zilu Liu, Chuanbei Tian, Xi Chen · 2026 · Journal of Biological Chemistry
  74. Ultra-processed food intake and male reproductive function: a mini-review
    Jian Huang · 2026 · Frontiers in Nutrition
  75. Reproductive Choices: An Online Survey Among a Convenience Sample of Italian Couples
    Bordin Paolo, Giovanni Marco Campeotto, Pigani Emanuele, Seminara Giuseppina, Francesca Valent, Belletti Francesco, Alessio Fornasin, Lorenza Driul, María Luisa Di Pietro · 2026 · The Family Journal
  76. A Western-style diet exacerbates male infertility in M1ap knockout mice
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  77. Environmental Pollution Exposure and Its Impact on Mental and Reproductive Health: A Review
    Abhinav Sahay, Arundhati Sharma, Upanshu Mishra, Badshah Alam, Rashmi Shekhar, Umesh Kumar · 2026 · Journal of Psychosexual Health
  78. The WHO Sixth Edition: Understanding New Advances in Basic and Advanced Semen Preparation and Analysis
    Missy Savira, Tomer Avidor‐Reiss, Eric Chung, Selahíttín Çayan · 2026 · Springer eBooks
  79. Resveratrol can reverse testicular damage caused by cadmium exposure through miR-26a-5p/COX2
    Hao Xiong, Fei Can, YuJiao Wu, Yanling Yang, Yi Liu, Qi Zhang · 2026 · PharmaNutrition
  80. Global research trends in male fertility and environmental factors (2016-2025): a multi-database bibliometric analysis and cross-validation study
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  81. Copper-induced male reproductive toxicity through ferroptosis-mediated blood–testis barrier disruption
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  82. Seminal Plasma Metabolomics Reveals Potential Metabolic Pathways Linking Organophosphate Flame Retardant Exposure to Impaired Semen Quality
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  83. Hydrolyzed eggshell membrane–calcium chelation complex for enhanced antimicrobial activity, antioxidant defense, and male reproductive homeostasis function
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  84. Unveiling the insidious role of polystyrene nanoplastics in compromising male fertility
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  85. Transmembrane protein 196-mediated regulation of CatSper channel through STAT3 phosphorylation influences sperm motility in mammals
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  87. Don’t judge a sperm by its cover
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  88. Mapping the Global Evidence on Environmental and Climatic Factors Linked to Human Fertility-Related Outcomes: Protocol for a Scoping Review
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  89. Mikroplastik und männliche Urogenitalgesundheit: Aktuelle Evidenz und klinische Implikationen
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  90. A decade of semen quality trends in Libya: nonlinear temporal patterns, age effects, and WHO 2010–2021 reclassification
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  91. Nasal exposure to PM2.5 induces testicular injury and activation of pyroptosis-related signaling in rats: Inhibitor intervention and public transcriptomic analysis
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  92. Sertoli cell oxidative stress as a convergent hazard endpoint for environmental toxicants: A systematic review, meta-analysis, and AOP-based assessment
    Kai Wang · 2026 · Redox Biology
  93. Abdominal Obesity, Testosterone Deficiency and Sedentary Lifestyle in Young Men from the General Population: The Relationship with Semen Quality, Hormonal and Metabolic Status
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  94. From “Seasonal Variation” to “Climate Signals”: Rereading Seasonal Effects on Semen Parameters in a Warming World
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  95. GLP-1 Receptor Agonists and Tirzepatide in Men Seeking Fertility: A Structured Narrative Review and Proposed Clinical Framework
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  96. Androgenetic alopecia drugs and male infertility: Evidence from pharmacovigilance and testicular transcriptomics
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  97. Threat to Masculinity: Introducing a Nursing Diagnosis Grounded in Men's Infertility Experiences
    Mehrdad Abdullahzadeh · 2026 · International Journal of Nursing Knowledge
  98. Molecular Mechanisms and Developmental Effects of Endocrine Disruptors on Male Reproductive Health and Mitigation Strategies to Reduce Their Adverse Effects
    Małgorzata M. Dobrzyńska, Ewa A. Jankowska-Steifer · 2026 · Toxics
  99. Combined assessment of body mass index and triglyceride-glucose index reveals metabolic risk phenotypes associated with semen quality impairment
    Yannan Zhao, Yue Zhao, Yan Zhao, Li Jiang, Shuaishuai Guo, Lihong Jia · 2026 · Frontiers in Endocrinology
  100. Gestational prednisone exposure causes subfertility in male offspring mice: Role of testicular E2f1 N6-methyladenosine modification
    Kaiwen Wang, Wei Chang, Yong-Wei Xiong, Xinyue Wu, Hao Li, Zun-Yu Du, Lan-Lan Wu, Jin Zhang, Hua-Long Zhu, De-Xiang Xu et al. · 2026 · Journal of Hazardous Materials