Temporal trends in sperm count: a systematic review and meta-regression analysis of samples collected globally in the 20th and 21st centuries

Levine, Hagai, Jørgensen, Niels, Martino-Andrade, Anderson, Mendiola, Jaime, Weksler-Derri, Dan, Jolles, Maya, Pinotti, Rachel, Swan, Shanna H·2023·Human Reproduction Update

DOI 10.1093/humupd/dmac035

Cited by (730)

Items 201–300 of 730

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Machine learning–based personalized prediction of sperm retrieval in patients with non‐obstructive azoospermia prior to microdissection testicular sperm extraction: A multi‐center cohort study
Xi Yu, Bailing Zhang, Yun Zhang, Lianming Zhao, Defeng Liu, Jiaming Mao, Wenhao Tang, Haitao Zhang, Haocheng Lin, Xiaoyan Wang et al. · 2025 · Andrology
Exposure to Bisphenol B and S Increases the Risk of Male Reproductive Dysfunction in Middle Age
Sen Zhao, Heliang Ni, Yuan Xiao, Jing Du, Yudong Han, Wenying Wang, Shuang Tang, Mingxi Yu · 2025 · International Journal of Molecular Sciences
Platinum single atom alloy-based catalysts for oxygen reduction reaction in proton exchange membrane fuel cells
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Understanding the Secular Decline in Testosterone: Mechanisms, Consequences, and Clinical Perspectives
Oscar Fraile‐Μartinez, Miguel Angel Ortega, Cielo García Montero · 2026 · International Journal of Molecular Sciences
Stability of epigenetic transgenerational inheritance of adult-onset disease and parturition abnormalities
Alexandra A. Korolenko, Eric E. Nilsson, Sarah De Santos, Michael K. Skinner · 2026 · Proceedings of the National Academy of Sciences
Mitochondrial perspectives on environmental pollutant-induced male reproductive toxicity
Qiujian Feng, Zhuozhi Gong, Bin Yan, Boda Guo, Jun Guo, ShengJing Liu · 2026 · Toxicology
A ripple effect? The impact of obesity on sperm quality and function
Maria Inês Alfaiate, Renata Santos Tavares, João Ramalho‐Santos · 2024 · Reproduction Fertility and Development
One out of two idiopathic infertile men has pathologic sperm DNA fragmentation values: Potential implications for clinical practice
Luca Boeri, Edoardo Pozzi, Federico Belladelli, Christian Corsini, Simone Cilio, Alessandro Bertini, Francesco Lanzaro, Luigi Candela, Massimiliano Raffo, Fausto Negri et al. · 2024 · Clinical Endocrinology
Behind the Genetics: The Role of Epigenetics in Infertility-Related Testicular Dysfunction
Andrea Crafa, Rossella Cannarella, Aldo Eugenio Calogero, Sezgin Ozgur Gunes, Ashok Kumar Agarwal · 2024 · Life
Hexavalent chromium reduces testosterone levels by impairing lipophagy and disrupting lipid metabolism homeostasis: Based on a metabolomic analysis
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Prenatal exposure to environmentally relevant levels of PAHs inhibits spermatogenesis in adult mice and the mechanism involved
Kunlin Ou, Siqi Zhang, Xinxing Lei, Xiao Liu, Ningfang Zhang, Chonggang Wang, Xiaopeng Yuan · 2024 · Environmental Pollution
Inhibition of Mitochondrial Uncoupling Proteins Arrests Human Spermatozoa Motility without Compromising Viability
David F. Carrageta, Laís Freire‐Brito, Bárbara Guerra‐Carvalho, João C. Ribeiro, Bruno S. Monteiro, Alberto Barros, Pedro Fontes Oliveira, Mariana Pereira Monteiro, Marco Gouveia Alves · 2023 · Antioxidants
Low-polarity untargeted metabolomic profiling as a tool to gain insight into seminal fluid
Eulàlia Olesti, Julien Boccard, Rita Rahban, Sergey Girel, Natalia E. Moskaleva, Fanny Zufferey, Michel Florian Rossier, Serge Nef, Serge L. Rudaz, Víctor González‐Ruiz · 2023 · Metabolomics
Semen Cryopreservation for Men Banking for Oligozoospermia, Cancers, and Other Conditions: 24 Years’ Experience of an Italian Bank
Sara Marchiani, Selene Degl’Innocenti, Sara Dabizzi, Lara Tamburrino, Maria Grazia Fino, Giulia Traini, Costanza Calamai, Mario Maggi, Linda Vignozzi, Elisabetta Baldi et al. · 2023 · Journal of Clinical Medicine
Antioxidants in Male Infertility—If We Want to Get This Right We Need to Take the Bull by the Horns: A Pilot Study
Usha R. Punjabi, I Goovaerts, Kris Peeters, Diane De Neubourg · 2023 · Antioxidants
Effects of Calorie Restriction on Preserving Male Fertility Particularly in a State of Obesity
Mohammad Ishraq Zafar, Xiao Chen · 2024 · Current Obesity Reports
Male Infertility: From Genes to Genomes 2022
Maria-Anna Kyrgiafini, Zissis Mamuris · 2023 · Genes
Exploring the evolving function of soluble intercellular adhesion molecule-1 in junction dynamics during spermatogenesis
Xiang Xiao, Yating Han, Qin Li, Dongwang Zheng, C. Yan Cheng, Ya Ni · 2024 · Frontiers in Endocrinology
Environmental interference and declining male fertility
Richard G. Lea · 2025 · Reproduction Fertility and Development
Efficacy and Safety of Visible and Near-Infrared Photobiomodulation Therapy on Astenospermic Human Sperm: Wavelength-Dependent Regulation of Nitric Oxide Levels and Mitochondrial Energetics
Matilde Balbi, Rachele Lai, Sara Stigliani, Claudia Massarotti, Matteo Bozzo, Paola Scaruffi, Silvia Ravera, Andrea Amaroli · 2025 · Biology
Cistanche total glycoside capsule promotes sperm maturation and fertility by activating the NELL2 Lumicrine pathway in a male reproductive impairment model
Li Guo, Panyu Xu, Yuan Li, Yuan Li, Siqi Li, Siqi Li, Na Lin, Ying Xu · 2025 · Journal of Ethnopharmacology
Linggui formula improves asthenozoospermia by modulating seminal plasma exosomes Wnt signaling via the LRP6/GSK3/Septin4 pathway
Shengjing Liu, Qiujian Feng, Zhuozhi Gong, Xiaojing An, Elena Colonnello, Bin Yan, Fu Wang, Jun Guo · 2025 · Journal of Ethnopharmacology
Emerging principles and models of human primordial germ cell development
Navin B. Ramakrishna, João Pedro Alves-Lopes, Wolfram H. Gruhn · 2025 · Development
Trends in male infertility burden in South Asia: a 30-year analysis of DALYs, prevalence, and future projections based on GBD 2021
Kaleem Maqsood, Tahir Mehmood, Humayoun Huma Maqbool, Ali Afzal, Muhammad Faisal Maqbool, Mahnoor Fatima, Tayyba Jan, Samina Ashraf, Muhammad Babar Khawar, Chatchai Muanprasat · 2025 · Frontiers in Reproductive Health
Tetrabromobisphenol S (TBBPS) Causes Non-Negligible and Multigenerational Reproductive Toxicity in Zebrafish
Wenhui Qiu, Shuai Liu, Xinyuan Kang, Yu Liu, Bentuo Xu, Chenyuan Pan, Jason T. Magnuson, Xin Yang, Jing Zheng, Chunmiao Zheng et al. · 2025 · Environmental Science & Technology
Improved sperm DNA fragmentation levels in infertile men following very short abstinence of 3–4 hours
Gilad Karavani, Tristan Juvet, Susan Abdullah Lau, Katherine Lajkosz, Brendan M. Mullen, Kirk C. Lo, Ethan D. Grober, Bader Akroof, Mohamed S. Kattan, Keith Allen Jarvi · 2023 · Translational Andrology and Urology
The role of Sertoli cells-secreted factors in different stages of germ cells development in mice exposed to BDE-209
Yue Zhang, Xiangyang Li, Leqiang Gao, Xiaomin Dong, Jinglong Xue, Moxuan Zhao, Junhong Xie, Aliekram Niyaz, Lihua Ren, Xianqing Zhou · 2024 · Environmental Pollution
Decline in reproductive health and its transgenerational lag effect
Rui Feng, Cuiyu Yang, Yinli Zhang, Bin Chen · 2024 · The Science of The Total Environment
Sperm concentration remains stable among fertile American men: a systematic review and meta-analysis
Kieran Lewis, Rossella Cannarella, Fangzhou Liu, Bradley Roth, Leila Bushweller, Jack Millot, Sohei Kuribayashi, Shinnosuke Kuroda, Diego Aguilar Palacios, Sarah Coleman Vij et al. · 2024 · Fertility and Sterility
Can nutraceuticals counteract the detrimental effects of the environment on male fertility? A parallel systematic review and expert opinion
Tommaso Cai, Luca Boeri, Carlos Miacola, Fabrizio Palumbo, Giancarlo Albo, Pasquale Ditonno, Vito Racanelli, Alessandro Palmieri, Truls E. Bjerklund Johansen, Antônio Aversa · 2024 · Minerva Endocrinology
A core outcome set for future male infertility research: development of an international consensus
Michael P. Rimmer, Ruth Howie, Richard A. Anderson, Christopher L. R. Barratt, Kurt Thomas Barnhart, Yusuf Beebeejaun, Ricardo Pimenta Bertolla, Pietro E. Bortoletto, Robert E. Brannigan, Astrid EP Cantineau et al. · 2025 · Human Reproduction
Impact of BPA and its analogs on sperm hyperactivity, acrosome reaction, epigenetic profiles and in vitro embryo development
Ola S. Davis, Olivia L M Scandlan, Erica A Potestio, Catherine Robinson, Katie D. Hickey, M. L. Ross, Laura A. Favetta · 2025 · Molecular and Cellular Endocrinology
Yi-Jing Decoction Ameliorates Oligoasthenozoospermia by Inhibiting the Oxidative Stress-p38 Mitogen-Activated Protein Kinase-Mediated Mitochondrial Apoptosis Pathway in Leydig and Sertoli Cells
Dezhong Cao, Xiao Min, Liang Su, Chenglong Luo, Haoyang Cheng, Sizheng Zhang, Jin-Ming Jia, Yong‐Zheng Jiao · 2025 · Integrative Medicine in Nephrology and Andrology
Dietary fat and fatty acid consumptions and the odds of asthenozoospermia: a case–control study in China
Jun-Qi Zhao, Xiao-Bin Wang, Xu Leng, Yifan Wei, Donghui Huang, Jia-Le Lv, Qiang Du, Ren-Hao Guo, Bochen Pan, Qi‐Jun Wu et al. · 2023 · Human Reproduction Open
Preventing/Reversing Adverse Effects of Endocrine Disruption on Mouse Testes by Normalizing Tissue Resident VSELs
Ankita Kaushik, Siddhanath Metkari, Subhan Ali, Deepa Bhartiya · 2023 · Stem Cell Reviews and Reports
Predictive role of 17α-hydroxy-progesterone serum levels of response to follicle-stimulating hormone in patients with abnormal sperm parameters
Rossella Cannarella, Rosita Angela Condorelli, Carmelo Gusmano, Vincenzo Garofalo, Antônio Aversa, Aldo Eugenio Calogero, Sandro La Vignera · 2023 · Fertility and Sterility
SperMD: the expression atlas of sperm maturation
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Changes in environmental exposures over decades may influence the genetic architecture of severe spermatogenic failure
Miriam Cerván‐Martín, Sara González‐Muñoz, Andrea Guzmán‐Jiménez, Inmaculada Higueras-Serrano, José Antonio Castilla, Nicolás Garrido, Saturnino Luján, L. Bassas, Susana Seixas, João Gonçalves et al. · 2024 · Human Reproduction
Deteriorating Semen Quality: The Role of the Environment
Helena E. Virtanen, Wiwat Rodprasert, Jorma Toppari · 2023 · Seminars in Reproductive Medicine
Impact of metabolic syndrome factors on sperm DNA fragmentation in males from infertile couples: A systematic review and meta-analysis
Intan Chaharunia Mulya, Muhammad Hasan, Muhammad Iqhrammullah · 2024 · Journal of Gynecology Obstetrics and Human Reproduction
Effects of chitosan on restoring spermatogenesis in mice: Insights from gut microbiota and multi-omics analysis
Guitian He, Boqi Zhang, Tong Chen, Caomeihui Shen, Nan Wang, Yang Jun-jun, Fuqiang Chang, Yue Sui, Xuanqi Yin, Yueying Wang et al. · 2025 · Food Research International
A core outcome set for future male infertility research: development of an international consensus
Michael P. Rimmer, Ruth Howie, Richard A. Anderson, Christopher L. R. Barratt, Kurt Thomas Barnhart, Yusuf Beebeejaun, Ricardo Pimenta Bertolla, Pietro E. Bortoletto, Robert E. Brannigan, Astrid EP Cantineau et al. · 2025 · Fertility and Sterility
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Lu Yuan, Tingting Ge, Ling Yang, Wenhua Xu, Guanghua Li, Linwei Xu, Yichun Zhao, Cheng Xu, Wenting Lu, Shiqi Meng et al. · 2025 · Communications Biology
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Construction of testicular organoids and their applications in the field of toxicology
Shidi Gao, Xin Fang, Li Guo · 2025 · Archives of Toxicology
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Heeyon Kim, So-Yeong Park, Yebon Kim, Yun Soo Chung, Jin Kyung Baek, Jeongmi Yoon, Chungsoon Ryu, Bo Hyon Yun, Young Sik Choi, Daewoo Pak et al. · 2025 · Frontiers in Endocrinology
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Sara Hyman, Linda G. Kahn, Whitney Cowell · 2026 · Human Reproduction
Flaxseed oil attenuates PFOS-induced testicular damage by regulating RNA alternative splicing
Jingyi Ren, Jiarui Liu, Jinshi Zuo, Zhenao Zhang, Dan Huang, Xuanyi Liu, Miaomiao Lu, Yadong Zhang, Yang Su, Yuxia Ma · 2024 · Food & Function
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Y. Li, Shikai Wang, Dawen Li, Yueyue Huang, Haifang Liu, Xiao‐Hui Zhang, Jie Qin, Xianbao Mao, Zhengda Li, Liangshi Chen et al. · 2023 · Frontiers in Endocrinology
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Tian Gang Liang, Yangchang Zhang, Wangnan Cao, Yufeng Li, Qiang Zeng, Shengzhi Sun · 2024 · Ecotoxicology and Environmental Safety
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Jing Chen, Guo Jin-ming, Bang-Jian Jiang, F. Sun, Yongcun Qu · 2025 · Asian Journal of Andrology
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Rossella Cannarella, Selahíttín Çayan, Carlo Giulioni, Gökhan Çeker, Keerti Singh, Kareim Mohamed Khalafalla, Amarnath Rambhatla, Raisa Galstyan, Shalaka S Ramgir, Logan C. Hubbard et al. · 2025 · The World Journal of Men s Health
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Sumaiya Safia Irfan, Veronica G Sanchez, Michael S. Bloom, Helen B. Chin, Virginia A. Espina, Jenna R. Krall, Anna Z. Pollack, Lance A. Liotta, Melissa J. Perry · 2025 · Environmental Research
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Weifeng Tang, Xiaoning Liu, Yun Cao, Junxia Liu, Li Zhao, Jin Qiu, Jun Zhang, Xiangfeng Chen, Junjie Ao, Qianlong Zhang · 2025 · Environment International
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Selvakumar Mararajah, Nelli Giribabu, Praveen Kumar Korla, Naguib Salleh · 2026 · Die Naturwissenschaften
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Lu Kong, Geyu Liang, Yán Wāng · 2026 · Cell Biology and Toxicology
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Hongxia Chen, Shenglong He, Zhuoran Zhu, Xia Wang, Zhongji Meng · 2026 · Current Research in Toxicology
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Swati Dhar, Akash Tomar, Anupama Anupama N, Poulomi Chatterjee, Pratik Kumar Chatterjee · 2026 · Reproductive Biology and Endocrinology
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Rachel Lauren Babcock, Allan L. Haynes, Jannette M. Dufour · 2026 · Fertility and Sterility
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Traffic Safety Evaluation of Downstream Intersections on Urban Expressways Based on Analytical Hierarchy Process–Matter-Element Method
Tianjun Feng, Yusong Liu, Chun Chen, Keke Liu, Chongjun Huang · 2024 · Sustainability
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Xuchao Dai, Weikang Chen, Guangyuan Liu, Feidi Li, Shuren Sun, Qi Chen, Gang Chen, Mengqi Zhang, Zhenfeng Wang, Wenyuan Li et al. · 2024 · Environment International
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Zhiheng Shangguan, Kaiqiang Yang, Qi Pan, Hongli Hu, Pan Wang · 2025 · Reproductive Toxicology
Comprehensive characterisation of poly(ADPribosyl)ation in spermatozoa as a novel and early biomarker of sperm health. A preliminary look
Bruno Berman, Gennaro Lettieri, Martina Falace, Carmela Marinaro, Carmen Di Giovanni, Anna Rita Bianchi, Luigi Montano, Marina Piscopo, Anna De Maio · 2025 · Chemico-Biological Interactions
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Ettore Caroppo, Michael L. Eisenberg · 2025 · Human Reproduction
Epigenetics Role in Spermatozoa Function: Implications in Health and Evolution—An Overview
Julia Andreu-Noguera, Andrea López-Botella, Paula Sáez‐Espinosa, María José Gómez‐Torres · 2023 · Life
Annual trends in semen parameters among men attending a fertility center between 2016 and 2022
Igor Alexeyevich Korneyev · 2023 · Urology reports (St - Petersburg)
The Association between Serum Vitamin D Levels and Male Fertility: A Systematic Review and Meta‐Analysis
Teng-Fei Yan, Ju-Ju Qi, Lixin Li, Feng Li · 2023 · Andrologia
Multivariate Statistical and Correlation Analysis between Acoustic and Geotechnical Variables in Soil Compression Tests Monitored by the Acoustic Emission Technique
Gonzalo García Ros, Danny Xavier Villalva-León, Enrique Castro, Juan Francisco Sánchez Pérez, Julio Valenzuela, Manuel Conesa · 2023 · Mathematics
Maternal pre-pregnancy BMI and reproductive health in adult sons: a study in the Danish National Birth Cohort
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Rosmarinic Acid Restored Testicular Function and Steroidogenic Hormone Capacity in Wistar Rats Exposed to Perfluorooctanoic Acid Toxicity
Victoria A. Aluko, Shekins O. Okere, Janet O. Olugbodi, Moses D. Adams · 2024 · Tropical Journal of Natural Product Research
Ejaculate Adjustment in Response to Sperm Competition Risk in Humans
Tara L. DeLecce, Gavin S. Vance, Virgil Zeigler‐Hill, Lisa L. M. Welling, Todd K. Shackelford · 2024 · Archives of Sexual Behavior
The power of 810 nm near-infrared photobiomodulation therapy for human asthenozoospermia
Sara Stigliani, Silvia Ravera, Elena Maccarini, Camilla Rizzo, Claudia Massarotti, Paola Anserini, Matteo Bozzo, Andrea Amaroli, Paola Scaruffi · 2024 · Scientific Reports
Do Delta-9-tetrahydrocannabinol and Cannabidiol have opposed effects on male fertility?
Olivia L M Scandlan, Laura A. Favetta · 2024 · Toxicology Letters
Utilization of artificial intelligence in Men’s Health: Opportunities for innovation and quality improvement
Haley Clark, Nikit Venishetty, Skyler Howell, Nicholas A. Deebel, Akhil Muthigi · 2025 · International Journal of Impotence Research
Decrease of air pollution during lockdown in Tuscany (Italy): An effect on sperm DNA fragmentation?
Costanza Calamai, Oumaïma Ammar, Sara Marchiani, Selene Degl’Innocenti, M. G. Fino, Lorenzo Righi, Sara Dabizzi, Mario Maggi, Elisabetta Baldi, Linda Vignozzi et al. · 2023 · Environmental and Molecular Mutagenesis