The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Role of sperm chromatin abnormalities and DNA damage in male infertility
Abstract
Sperm DNA integrity is essential for the accurate transmission of genetic information. It has a highly compact and complex structure and is capable of decondensation-features that must be present in order for a spermatozoon to be considered fertile. Any form of sperm chromatin abnormalities or DNA damage may result in male infertility. In support of this conclusion, it was reported that in-vivo fecundity decreases progressively when > 30% of the spermatozoa are identified as having DNA damage. Several methods are used to assess sperm chromatin/DNA, which is considered an independent measure of sperm quality that may yield better diagnostic and prognostic approaches than standard sperm parameters (concentration, motility and morphology). The clinical significance of this assessment lies in its association not only with natural conception rates, but also with assisted reproduction success rates. Also, it has a serious impact on the offspring and is highly prognostic in the assessment of fertility in cancer patients. Therefore, screening for sperm DNA damage may provide useful information in cases of male idiopathic infertility and in those men pursuing assisted reproduction. Treatment should include methods for prevention of sperm DNA damage.
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Citations
Cites
EVENSON, D. P., LARSON, K. L., & JOST, L. K. (2002) · Journal of Andrology · doi:10.1002/j.1939-4640.2002.tb02599.x · Cited by 1,072 · cited 2×
“Environmental stress, gene mutations and chromosomal abnormalities can disturb the highly re®ned biochemical events that occur during spermatogenesis, and this can ultimately lead to an abnormal chromatin structure that is incompatible with fertility (Evenson et al., 2002).”
BackgroundDonnelly, E. T. (2001) · Human Reproduction · doi:10.1093/humrep/16.6.1191 · Cited by 263
Cited by
Oxidative stress, DNA damage and apoptosis in male infertility: A clinical approach
Agarwal, A., & Said, T. M. (2005) · BJU International · doi:10.1111/j.1464-410x.2005.05328.x · Cited by 472
Self-citationFunction of sperm chromatin structural elements in fertilization and development
Ward, W. S. (2010) · Molecular Human Reproduction · doi:10.1093/molehr/gap080 · Cited by 395
Male infertility testing: reactive oxygen species and antioxidant capacity
Ko, E. Y., Sabanegh, E. S., & Agarwal, A. (2014) · Fertility and Sterility · doi:10.1016/j.fertnstert.2014.10.020 · Cited by 329
Self-citationSperm chromatin structure and male fertility: biological and clinical aspects
Erenpreiss, J., Spano, M., Erenpreisa, J., Bungum, M., & Giwercman, A. (2006) · Asian Journal of Andrology · doi:10.1111/j.1745-7262.2006.00112.x · Cited by 304
Antioxidants for male subfertility
Showell, M. G., Mackenzie-Proctor, R., Brown, J., Yazdani, A., Stankiewicz, M. T., & Hart, R. J. (2014) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007411.pub3 · Cited by 285
Metadata
- Authors
- Agarwal, A.
- Venue
- Human Reproduction Update
- Publisher
- Oxford University Press (OUP)
- Published
- 2003-07-01
- Volume
- 9
- Issue
- 4
- Pages
- 331-345
- ISSN
- 1355-4786 (ISSN-L)
- 1460-2369
- OpenAlex
- W2131135711
- Cited by
- 857
- References
- 2
- FWCI
- 20.55
- Type
- journal article
- Language
- en
- Open access
- closed
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- Agarwal, A. (2003). Role of sperm chromatin abnormalities and DNA damage in male infertility. Human Reproduction Update. https://doi.org/10.1093/humupd/dmg027
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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