The DOI matches its Crossref record; 105 of the 105 references it cites were found in a registry or an index.
Female and male lifestyle habits and IVF: what is known and unknown
Abstract
There is no greater tribute to the importance and efficacy of IVF than the fact that >1 x 10(6) babies have been born to infertile couples since its clinical introduction in 1978. Despite enormous advances regarding the technical aspects of the IVF procedure, the parents' contribution has virtually been ignored when considering aspects that influence success rates. This systematic review focuses on the effects of female and male lifestyle habits (specifically: smoking, alcohol and caffeine use, and psychological stress) on the reproductive endpoints of IVF (i.e. oocyte aspiration, fertilization, embryo transfer, achievement of a pregnancy, live birth delivery, and perinatal outcomes, e.g. low birthweight, multiple gestations). What is currently known in the field of lifestyle habits and IVF? There is compelling evidence that smoking has a negative influence on IVF outcomes, whereas for stress, the evidence is suggestive but insufficient due to the heterogeneity of studies. The evidence for the effects of alcohol and caffeine on IVF is inadequate, and therefore unknown, due to the scarcity of studies.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Moreover, evidence shows that smoking reduces the success of fertility treatments such as IVF and ICSI (Klonoff-Cohen 2005, Mínguez-Alarcón 2018, Practice Committee 2018, Waylen 2008).”
From Preconception lifestyle advice for people with infertility (2021) · cites this paper as Klonoff-Cohen 2005
Citations
Cites
Clinical Epidemiology: A Basic Science for Clinical Medicine.
(1991) · Annals of Internal Medicine · doi:10.7326/0003-4819-114-9-825_9 · Cited by 3,497
Conception to ongoing pregnancy: the 'black box' of early pregnancy loss
Macklon, N. (2002) · Human Reproduction Update · doi:10.1093/humupd/8.4.333 · Cited by 800
Smoking and female infertility: a systematic review and meta-analysis
Augood, C., Duckitt, K., & Templeton, A. A. (1998) · Human Reproduction · doi:10.1093/humrep/13.6.1532 · Cited by 510
Klonoff-Cohen, H. S., Chu, E., Natarajan, L., & Sieber, W. J. (2001) · Fertility and Sterility · doi:10.1016/s0015-0282(01)02008-8 · Cited by 369
Self-citationClinical management of low ovarian response to stimulation for IVF: a systematic review
Tarlatzis, B. C. (2003) · Human Reproduction Update · doi:10.1093/humupd/dmg007 · Cited by 364
Psychological evaluation and support in a program of in vitro fertilization and embryo transfer
Freeman, E. W., Boxer, A. S., Rickels, K., Tureck, R., & Mastroianni, L. (1985) · Fertility and Sterility · doi:10.1016/s0015-0282(16)48316-0 · Cited by 319
Women's experience of IVF: a follow-up study
Hammarberg, K. (2001) · Human Reproduction · doi:10.1093/humrep/16.2.374 · Cited by 308
Wallach, E. E., Stillman, R. J., Rosenberg, M. J., & Sachs, B. P. (1986) · Fertility and Sterility · doi:10.1016/s0015-0282(16)49628-7 · Cited by 305
Smoking and male reproduction: a review
Vine, M. F. (1996) · International Journal of Andrology · doi:10.1111/j.1365-2605.1996.tb00523.x · Cited by 270
Smoking cigarettes is associated with increased sperm disomy in teenage men
Rubeš, J., Lowe, X. R., Moore, D. H., Perreault, S. D., Slott, V. L., Evenson, D. P., Selevan, S. G., & Wyrobek, A. J. (1998) · Fertility and Sterility · doi:10.1016/s0015-0282(98)00261-1 · Cited by 245
Research works printed but not linked: 11
- 1989, Lancet, 1, 731
- 1989, Hum Reprod, 4, 29
- 2001, Cent Eur J Publ Hlth, 9, 64
- 1997, Fertil Steril, 68, 384
- 1995, Rom J Morphol Embryol, 41, 7
- 1978, Fertil Steril, 52, 495
- 2003, Acta Obstet Gynecol Scand, 82, 151
- 1997, Alcohol, 32, 113
- 2003, J Med Assoc Thai, 86, 425
- 2002, Nat Cell Biol, 4, s33
- 1996, Hum Reprod, 11, 95
Cited by
Sorted by citations
Items 101–172 of 172
Mohammadi, H., Golbabaei, F., Dehghan, S. F., Ardakani, S. K., Imani, H., & Tehrani, F. R. (2021) · Toxicology and Industrial Health · doi:10.1177/07482337211006535 · Cited by 11
“The participants were all male, between 20 and 50 years of age (Zitzmann, 2013) and with two or more years of employment (Klonoff-Cohen, 2005).”
BackgroundAssessment of sexual hormones in foundry workers exposed to heat stress and electromagnetic fields
Mohammadi, H., Dehghan, S. F., Moradi, N., Suri, S., Pirposhteh, E. A., Ardakani, S. K., & Golbabaei, F. (2021) · Reproductive Toxicology · doi:10.1016/j.reprotox.2020.12.015 · Cited by 10
Soto, E., & Copperman, A. B. (2011) · doi:10.1002/9781444393958.ch1 · Cited by 8
Lifestyle Related Fertility Disorders in North Jordan: Potential for Improvement
Hamadneh, J., Amarin, Z. O., Hamadneh, S., Obeidat, N. A., Kassab, M. I., & Hani, M. B. (2017) · International Journal of Women s Health and Reproduction Sciences · doi:10.15296/ijwhr.2017.45 · Cited by 7
Fecundidad y fertilidad: aspectos generales
Fuentes, G. A. (2010) · Revista Médica Clínica Las Condes · doi:10.1016/s0716-8640(10)70544-7 · Cited by 7
Kirchner, T., Munoz, D., Forns, M., Peñarrubia, J., & Balasch, J. (2011) · Human Reproduction · doi:10.1093/humrep/der028 · Cited by 7
Blessures dans la filiation et infertilité masculine : étude comparative et psychodynamique
Jaoul, M., Albert, M., Bailly, M., Selva, J., & Gomes, D. M. (2010) · Basic and Clinical Andrology · doi:10.1007/s12610-010-0065-4 · Cited by 7
“D’autres études ont porté sur la source du stress : une étude prospective sur 818 couples a montré que le stress touchant les domaines personnel et conjugal a un poids plus grand sur les résultats des FIV que le stress social [7] ; le stress peut être aussi lié à la situation de stérilité, ou bien même au recours à l’…”
BackgroundSoini, S., Ibarreta, D., Anastasiadou, V., Aymé, S., Braga, S., Cornel, M. C., Coviello, D. A., Evers‐Kiebooms, G., Geraedts, J. P. M., Gianaroli, L., et al. (2006) · ESHRE Monographs · doi:10.1093/humrep/del390 · Cited by 7
Investigation of exposure to lifestyle and environmental factors on cumulus-oocyte complex function
Campen, K. A. (2013) · doi:10.26686/wgtn.17006155 · Cited by 5
“Some of these compounds have also been reported to negatively affect female fertility (Emanuele et al., 2002; Klonoff-Cohen, 2005; Anderson, 2010).”
BackgroundWischmann, T. H. (2010) · Gynäkologische Endokrinologie · doi:10.1007/s10304-009-0345-2 · Cited by 6
Covington, S. N., & Burns, L. H. (2001) · Cambridge University Press eBooks · doi:10.1017/cbo9780511547263.007 · Cited by 6
Zhai, J., Zhang, J., He, J., Li, G., & Hao, G. (2023) · Risk Management and Healthcare Policy · doi:10.2147/rmhp.s422969 · Cited by 5
Influence of social determinants on fertility: a critical review
Rico, P.-M. T., & García-Velasco, J. A. (2020) · Current Opinion in Obstetrics & Gynecology · doi:10.1097/gco.0000000000000673 · Cited by 5
Ramiro‐Cortijo, D., Balbuena, C. S., & Muñoz, M. D. L. F. R. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10235672 · Cited by 5
“The ART could be considered as a stressful event for women, leading to poor obstetrical outcomes [28].”
BackgroundMedication Adherence Among Women Undergoing Infertility Treatment: A Systematic Review
Mahoney, D. E., Russell, C. L., & Cheng, A. (2018) · International Journal of Women s Health and Reproduction Sciences · doi:10.15296/ijwhr.2019.24 · Cited by 4
“Despite the extensive literature on adherence to lifestyle recommendations in women receiving infertility treatment, interest in studies on medication-taking behaviors has been overlooked (6-10,13).”
BackgroundBals‐Pratsch, M., & Bühler, K. (2009) · Journal für Kardiologie (Krause & Pachernegg GmbH) · Cited by 5
Medical Approaches to Ovarian Stimulation for Infertility
Fauser, B. C. J. M. (2019) · Elsevier eBooks · doi:10.1016/b978-0-323-47912-7.00030-5 · Cited by 6
Trial development of the Cognitive Appraisal Scale for Infertility (CASI) (version 1)
Saito, Y., & Matsuo, H. (2008) · Fertility and Sterility · doi:10.1016/j.fertnstert.2008.03.052 · Cited by 4
Medical Approaches to Ovarian Stimulation for Infertility
Fauser, B. C. J. M. (2013) · Elsevier eBooks · doi:10.1016/b978-1-4557-2758-2.00030-5 · Cited by 4
Role of Environmental Factors and Gonadotoxin Exposure in Unexplained Female Infertility
Fujimoto, V. Y., & Bloom, M. S. (2015) · Springer eBooks · doi:10.1007/978-1-4939-2140-9_15 · Cited by 4
The experience of birth and early mothering after assisted conception
Hammarberg, K. (2006) · Minerva Access (University of Melbourne) · Cited by 4
Systematic Review of Reviews: the public health role of the midwife
McNeill, J., Alderdice, F. A., & Lynn, F. A. (2010) · Cited by 3
Cito, G., Pizzarelli, C., Zurkirch, V. P., Basile, V., Ruggiero, M. R., Coccia, M. E., Inaudi, P., & Rossi, P. G. (2022) · Journal of Reproduction & Infertility · doi:10.18502/jri.v23i2.8997 · Cited by 3
Pápay, N., Rigó, A., & Nagy, O. N. (2013) · Magyar Pszichológiai Szemle · doi:10.1556/mpszle.68.2013.3.02 · Cited by 3
Erkek Fertilitesi ve Riskli Yaşam Biçimi Davranışları
Demırcı, N. (2014) · Florence Nightingale Journal of Nursing · doi:10.17672/fnhd.32681 · Cited by 3
Mosalanejad, L., Rasekhjahromi, A., & Sobhanian, S. (2014) · Zahedan Journal of Research in Medical Sciences · Cited by 3
Mohammadi, H., Khoddam, S., Golbabaei, F., & Dehghan, S. F. (2025) · Reproductive Toxicology · doi:10.1016/j.reprotox.2025.108959 · Cited by 3
Mahoney, D. E., & Russell, C. L. (2021) · Journal of Reproduction & Infertility · doi:10.18502/jri.v22i3.6719 · Cited by 2
Infertility Risk Factors and Nurse’s Role
Abiç, A., & Yılmaz, D. V. (2019) · International Journal of Emerging Trends in Health Sciences · doi:10.18844/ijeths.v3i1.4073 · Cited by 2
The Psychological Impact of IVF Treatment
de Klerk, C. (2008) · Cited by 2
Kunicki, M., Łukaszuk, K., Liss, J., Jakiel, G., & Skowrońska, P. (2017) · Annals of Agricultural and Environmental Medicine · doi:10.26444/aaem/78944 · Cited by 2
Carroll, K., Pottinger, A. M., & Jackson, M. (2017) · West Indian Medical Journal · doi:10.7727/wimj.2017.189 · Cited by 2
“While the decline does not necessarily impact fertility rates, it is of concern for men who have borderline fertility potential (2).”
BackgroundKostova, E. P. (2020) · Balkan Journal of Medical Genetics · doi:10.2478/bjmg-2020-0005 · Cited by 2
Ravel, C., Berthaut, I., & Siffroi, J. (2009) · EMC - Endocrinologie - Nutrition · doi:10.1016/s1155-1941(08)50295-2 · Cited by 2
Factors Affecting Female Infertility in the Population of Gujarat (India): A Comprehensive Study
Sanghavi, P., Savsaiya, B., Patel, H. C., Patel, K., & Chandel, D. (2022) · Journal für Gynäkologische Endokrinologie/Österreich · doi:10.1007/s41974-022-00240-z · Cited by 2
Clinical characteristics of patients with violation of the early embryogenesis in IVF programs
Nazarenko, T. A., Krasnopolskaya, K. V., Sesina, N. I., Sanakoeva, A. V., Kulikova, O. R., & Bednik, D. Y. (2019) · Russian Journal of Human Reproduction · doi:10.17116/repro20192502160 · Cited by 2
Nordic and Infertile. A study of options and decisions.
Ólafsdóttir, H. S. (2012) · Diva portal (Dalarna University Library) · Cited by 2
Lifestyle Factors and Reproductive Health
Agarwal, A. K., & Durairajanayagam, D. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-800872-0.00013-5 · Cited by 1
Ovarian issues in human spaceflight
Parada, K. L., & Luderer, U. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-22259-7.00018-7 · Cited by 1
El estrés: ¿en qué momento del tratamiento médico de la infertilidad debe tratarse?
Campagne, D. M. (2008) · Redalyc (Universidad Autónoma del Estado de México) · Cited by 1
Evidenced-Based Approaches to Infertility Counseling
Boivin, J. (2001) · Cambridge University Press eBooks · doi:10.1017/cbo9780511547263.009 · Cited by 1
Impact of Diabetes Mellitus and Obesity on Male Infertility in Iraqi patients
Zamil, G. O. Z. G. O. (2013) · IOSR Journal of Applied Chemistry · doi:10.9790/5736-0430913 · Cited by 1
“Subfertility and subfecundity are also used in some studies as synonyms to infertility [8].”
BackgroundMood and Anxiety Disorders in the Context of Fertility Treatments
Zaig, I. F., Joskowicz, Y., & Bloch, M. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-803592-4.00076-6 · Cited by 1
Infertilité du couple : de l’interrogatoire à l’orientation thérapeutique
Dechanet, C., Brunet, C., Anahory, T., Reyftmann, L., Hedon, B., & Déchaud, H. (2009) · Journal de gynécologie, obstétrique et biologie de la reproduction. Supplément/Journal de gynécologie obstétrique et biologie de la reproduction · doi:10.1016/s0368-2315(09)70227-3 · Cited by 2
Al-Taee, H. A. J., Alkhafaji, Z. H., Abdul, Z., & Almadfai, M. (2012) · Medical Journal of Babylon · Cited by 1
Environmental Factors Affecting Female Infertility
Fujimoto, V. Y., Giudice, L. C., Fujimoto, V. Y., & Giudice, L. C. (2009) · Humana Press eBooks · doi:10.1007/978-1-60327-392-3_1 · Cited by 1
In Vitro Fertilization for the Polycystic Ovary Syndrome
Baakdah, H., Demirtaş, E., Holzer, H. E. G., Buckett, W. M., & Tan, S. L. (2007) · Humana Press eBooks · doi:10.1007/978-1-59745-179-6_36 · Cited by 1
“Although IVF was initially developed to treat tubal factor infertility, it has since become a successful treatment for various forms of infertility including endometriosis, ovulatory dysfunction, cervical factor, luteal defects, immunological causes, male-factor and unexplained infertility ( 4 ).”
BackgroundThe pathway from infertility to motherhood through assisted reproductive technology (ART)
Kuivasaari-Pirinen, P. (2013) · UEF eRepo (University of Eastern Finland) · Cited by 1
Mohammadi, H., Golbabaei, F., Dehghan, S. F., Ardakani, S. K., Imani, H., & Tehrani, F. R. (2020) · Research Square · doi:10.21203/rs.3.rs-49934/v1 · Cited by 1
Overcoming Involuntary Childlessness and Assisted Conception
van den Akker, O. B. (2012) · doi:10.1002/9781119968382.ch10
Variables psicológicas en la infertilidad
Nogueira, D. C. O. A. (2010) · doi:10.14201/gredos.76548
Jacobs, M. B. (2013) · eScholarship (California Digital Library)
Lara, L. A., Ornelas, J. R., Rivera, W. A., Gaviño, F. G., Ambriz, S. G., & García, D. M. (2009) · Redalyc (Universidad Autónoma del Estado de México)
Recent advances in female infertility assessment and treatment
Gillett, W. R. (2007) · Expert Review of Obstetrics & Gynecology · doi:10.1586/17474108.2.4.501
Utor, A. L. G., Moya, M. M., Jiménez, J. F., Navarro, M. L. M., Rivera, J. L. M., Alcalá, J. A. C., Ezequiel, V. M., Villaverde, V. L., Lozano, J. C., Navarro, J. L., et al. (2007) · Dialnet (Universidad de la Rioja)
Smoking rates for men from infertile couples and men with reproductive disorders
Andreeva, M. V., Khayat, S. S., Михайловна, С. Т., Shileyko, L. V., Остроумова, Т. В., & Курило, Л. Ф. (2015) · Andrology and Genital Surgery · doi:10.17650/2070-9781-2015-1-63-68
Generales, A. (2010)
Nutritional counseling impact on assisted reproduction treatment outcomes
Halpern, G., Sardinha, F. A. A., Setti, A. S., Iaconelli, A., & Borges, E. (2013) · JBRA · doi:10.5935/1518-0557.20130001
Braga, D. P. D. A. F., & Borges, E. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-800872-0.00032-9
Gamete quality and assisted reproductive technologies
Racowsky, C. (2008) · CRC Press eBooks · doi:10.3109/9780203091500-47
Андреева, М. В., Sh, S., Михайловна, С. Т., Shileyko, L. V., Остроумова, Т. В., & Курило, Л. Ф. (2015)
Polycystic ovary syndrome, body mass index and outcomes of assisted reproductive
Beydoun, H. A., Stadtmauer, L., Beydoun, M. A., Russell, H., Zhao, Y., & Oehninger, S. (2009)
Jaoul, M., Albert, M., Bailly, M., Selva, J., & Gomes, D. M. (2010)
Psychosocial Predictors of Medically Unexplained Infertility in Urban Working Women
Chakraborty, M., Gupta, P., & Ray, D. (2021) · Journal of Psychosexual Health · doi:10.1177/2631831820987824
Best Practice & Research Clinical Obstetrics and Gynaecology
Tournaye, H. J., & Cohlen, B. J. (2012)
Fatah, B. N. A., & Yahya, B. T. (2021) · Materials Today Proceedings · doi:10.1016/j.matpr.2021.05.692
Retracted(2006) · Current Opinion in Obstetrics & Gynecology · doi:10.1097/01.gco.0000193023.28556.e2
Gamete quality and assisted reproductive technologies
Combelles, C. M. H., & Racowsky, C. (2008) · Reproductive medicine and assisted reproductive techniques series · doi:10.3109/9780203091500.042
Yin, J., Chen, R., Churchill, D., Zou, H., Guo, P., Liang, C., Peng, X., Wang, J., Zhang, Z., Zhou, W., et al. (2025) · Scientific Reports · doi:10.1038/s41598-025-03651-y
“Previous studies have suggested associations of paternal smoking and alcohol consumption with an increased risk of IF 13–16 .”
Peng, M., Wen, M., Jiang, T., Jiang, Y., Lv, H., Chen, T., Ling, X., Li, H., Meng, Q., Boxian, H., et al. (2021) · Figshare · doi:10.6084/m9.figshare.16893244
Graafland, N., Posthumus, A. G., Mulders, A. G. M. G. J., Gaillard, R., Koning, A. H. J., Jaddoe, V. W. V., Steegers, E. A. P., & Rousian, M. (2026) · Human Reproduction · doi:10.1093/humrep/deag125
“Additionally, IVF/ICSI pregnancies may be more susceptible to external exposures due to the techniques involved in assisted reproduction (Klonoff-Cohen, 2005; Berntsen et al. , 2019).”
Metadata
- Authors
- Klonoff-Cohen, H.
- Affiliations
- University of California San Diego (US)
- Corresponding author
- Klonoff-Cohen, H.
- ORCID
- Klonoff-Cohen, H.
- Venue
- Human Reproduction Update
- Publisher
- Oxford University Press (OUP)
- Published
- 2005-03-01
- Volume
- 11
- Issue
- 2
- Pages
- 180-204
- ISSN
- 1355-4786 (ISSN-L)
- 1460-2369
- OpenAlex
- W2151606477
- Cited by
- 173
- References
- 105
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2023: 4 · 2022: 5 · 2021: 15 · 2020: 5 · 2019: 7 · 2018: 6 · 2017: 9 · 2016: 7 · 2015: 9 · 2014: 9 · 2013: 11 · 2012: 12
- FWCI
- 1.67
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Human Reproduction Update (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Health and Technologies
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Assisted Reproductive Technology and Twin Pregnancy
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Biology and Fertility
- Keywords
- in vitro fertilization, lifestyle habits, smoking, alcohol consumption, caffeine consumption, psychological stress, IVF outcomes, oocyte aspiration, fertilisation (biology), embryo transfer, live birth, perinatal outcomes, low birth weight, multiple pregnancy, male infertility, female infertility
- MeSH terms
- Abortion, Spontaneous, Alcohol Drinking, Birth Weight, Caffeine, Embryo Transfer, Female, Fertilization in Vitro, Gestational Age, Humans, Infant, Newborn, Life Style, Male, Oocytes, Pregnancy, Pregnancy, Multiple, Smoking, Stress, Psychological, Multivariate Analysis, Sample Size, Pregnancy Rate
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review