The DOI matches its Crossref record; 223 of the 223 references it cites were found in a registry or an index.
Uterine fibroid management: from the present to the future
Open accessAbstract
Uterine fibroids (also known as leiomyomas or myomas) are the most common form of benign uterine tumors. Clinical presentations include abnormal bleeding, pelvic masses, pelvic pain, infertility, bulk symptoms and obstetric complications.Almost a third of women with leiomyomas will request treatment due to symptoms. Current management strategies mainly involve surgical interventions, but the choice of treatment is guided by patient's age and desire to preserve fertility or avoid 'radical' surgery such as hysterectomy. The management of uterine fibroids also depends on the number, size and location of the fibroids. Other surgical and non-surgical approaches include myomectomy by hysteroscopy, myomectomy by laparotomy or laparoscopy, uterine artery embolization and interventions performed under radiologic or ultrasound guidance to induce thermal ablation of the uterine fibroids.There are only a few randomized trials comparing various therapies for fibroids. Further investigations are required as there is a lack of concrete evidence of effectiveness and areas of uncertainty surrounding correct management according to symptoms. The economic impact of uterine fibroid management is significant and it is imperative that new treatments be developed to provide alternatives to surgical intervention.There is growing evidence of the crucial role of progesterone pathways in the pathophysiology of uterine fibroids due to the use of selective progesterone receptor modulators (SPRMs) such as ulipristal acetate (UPA). The efficacy of long-term intermittent use of UPA was recently demonstrated by randomized controlled studies.The need for alternatives to surgical intervention is very real, especially for women seeking to preserve their fertility. These options now exist, with SPRMs which are proven to treat fibroid symptoms effectively. Gynecologists now have new tools in their armamentarium, opening up novel strategies for the management of uterine fibroids.
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“among new drugs, selective progesterone receptor modulators (SPRMs) are not an option as they induce progesterone modulator-associated endometrial changes (PAECs) in ectopic foci and their efficacy is limited [89,90,91].”
From Endometriosis and Medical Therapy: From Progestogens to Progesterone Resistance to GnRH Antagonists: A Review (2021) · cites this paper as [89]
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Items 201–223 of 223
Bouchard, P. (2014) · Gynecological Endocrinology · doi:10.3109/09513590.2014.950647 · Cited by 24
Practical Applications of 3D Sonography in Gynecologic Imaging
Andreotti, R. F., & Fleischer, A. C. (2014) · Radiologic Clinics of North America · doi:10.1016/j.rcl.2014.07.001 · Cited by 24
Selective progesterone receptor modulators 2: use in reproductive medicine
Benagiano, G., Bastianelli, C., & Farris, M. (2008) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.9.14.2473 · Cited by 24
Sydney Contained in Bag Morcellation for Laparoscopic Myomectomy
Kanade, T., McKenna, J. B., Choi, S., et al. (2014) · Journal of Minimally Invasive Gynecology · doi:10.1016/j.jmig.2014.07.005 · Cited by 23
Uterine Artery Embolization for Heavy Menstrual Bleeding
Moss, J. G., & Christie, A. (2016) · Women s Health · doi:10.2217/whe.15.78 · Cited by 23
Surgical Treatment of Uterine Fibroids Within a Containment System and Without Power Morcellation
Kho, K. A., & Brown, D. (2015) · Clinical Obstetrics & Gynecology · doi:10.1097/grf.0000000000000168 · Cited by 23
The potential of selective progesterone receptor modulators for the treatment of uterine fibroids
Bestel, E., & Donnez, J. (2013) · Expert Review of Endocrinology & Metabolism · doi:10.1586/17446651.2014.862495 · Cited by 22
Self-citationBarlow, D. H., Lumsden, M.-A., Fauser, B. C. J. M., et al. (2014) · Human Reproduction · doi:10.1093/humrep/det467 · Cited by 22
Robot-assisted laparoscopy for infertility treatment: current views
Carbonnel, M., Goetgheluck, J., Frati, A., et al. (2014) · Fertility and Sterility · doi:10.1016/j.fertnstert.2014.01.020 · Cited by 21
Exacoustós, C., Zupi, E., Marconi, D., et al. (2005) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.1861 · Cited by 20
Chromothripsis in Uterine Leiomyomas
Mehine, M., Kaasinen, E., & Aaltonen, L. A. (2013) · New England Journal of Medicine · doi:10.1056/nejmc1310230 · Cited by 20
Lee, M. M. H., & Matsuzono, T. (2016) · Hong Kong Medical Journal · doi:10.12809/hkmj154600 · Cited by 19
Fischer, K., McDannold, N., Tempany, C., et al. (2015) · Dove Medical Press (Taylor and Francis Group) · Cited by 18
Bosteels, J., Weyers, S., Mathieu, C., Mol, B. W., & D’Hooghe, T. (2010) · Europe PMC (PubMed Central) · Cited by 16
Uterine fibroids at routine second-trimester ultrasound survey and risk of sonographic short cervix
Blitz, M. J., Rochelson, B. L., Augustine, S., Greenberg, M., Sison, C. P., & Vohra, N. (2015) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.3109/14767058.2015.1131261 · Cited by 16
Uterine Artery Occlusion: What Is the Evidence?
Vilos, G. A., Hollett-Caines, J., & Burbank, F. H. (2006) · Clinical Obstetrics & Gynecology · doi:10.1097/01.grf.0000211950.74583.f5 · Cited by 15
Three cases of complications after high-intensity focused ultrasound treatment in unmarried women
Kim, H. K., Kim, D., Lee, M.-K., et al. (2015) · Obstetrics & Gynecology Science · doi:10.5468/ogs.2015.58.6.542 · Cited by 15
What is the Future of Open Intraperitoneal Power-Morcellation of Fibroids?
Parker, W. H., Pritts, E. A., & Olive, D. L. (2015) · Clinical Obstetrics & Gynecology · doi:10.1097/grf.0000000000000166 · Cited by 14
Stamatellos, I., & Bontis, J. N. (2007) · European Clinics in Obstetrics and Gynaecology · doi:10.1007/s11296-007-0061-1 · Cited by 10
Marsh, E. E., Chibber, S., Ju, W., Siegersma, K., Kim, J. J., & Bulun, S. E. (2015) · Fertility and Sterility · doi:10.1016/j.fertnstert.2015.12.004 · Cited by 8
Liang, T., & Tsai, C. (2013) · New England Journal of Medicine · doi:10.1056/nejmicm1213254 · Cited by 8
Pereira, N., Bender, J. L., Hancock, K., et al. (2015) · Journal of Minimally Invasive Gynecology · doi:10.1016/j.jmig.2015.07.014 · Cited by 6
Elger, W. A. G., Ivell, R., Nandy, A. K., Rasch, A. C., Triller, A., & Chwalisz, K. (2004) · Fertility and Sterility · doi:10.1016/j.fertnstert.2004.07.851 · Cited by 5
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Donnez, J., & Dolmans, M.-M. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10051085 · Cited by 182
Self-citationGonadotropin-releasing hormone antagonist (linzagolix): A new therapy for uterine adenomyosis
Donnez, O., & Donnez, J. (2020) · Fertility and Sterility · doi:10.1016/j.fertnstert.2020.04.017 · Cited by 58
Self-citationDonnez, J., & Dolmans, M.-M. (2020) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2020.05.017 · Cited by 50
Self-citationDonnez, J., & Dolmans, M.-M. (2020) · Fertility and Sterility · doi:10.1016/j.fertnstert.2020.07.028 · Cited by 20
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Metadata
- Authors
- Donnez, J., & Dolmans, M.-M.
- Affiliations
- UCLouvain (BE)
- Cliniques Universitaires Saint-Luc (BE)
- Corresponding author
- Donnez, Jacques
- Venue
- Human Reproduction Update
- Publisher
- Oxford University Press (OUP)
- Published
- 2016-07-27
- Volume
- 22
- Issue
- 6
- Pages
- 665-686
- ISSN
- 1355-4786 (ISSN-L)
- 1460-2369
- PMC
- PMC5853598
- OpenAlex
- W2496662864
- Cited by
- 780
- References
- 223
- Citations by year
- 2026: 76 · 2025: 86 · 2024: 77 · 2023: 109 · 2022: 89 · 2021: 92 · 2020: 94 · 2019: 48 · 2018: 54 · 2017: 45 · 2016: 9
- FWCI
- 9.19
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- cc-by
- Locations
- Human Reproduction Update (publishedVersion)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Digital Access to Libraries (Université catholique de Louvain (UCL), l'Université de Namur (UNamur) and the Université Saint-Louis (USL-B)) (submittedVersion)
- Funders
- Gedeon Richter
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Uterine Myomas and Treatments
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Health and Contraception
- Health Sciences › Medicine › Obstetrics and Gynecology › Gynecological conditions and treatments
- Keywords
- uterine fibroids, leiomyoma, fibroid management, myomectomy, uterine artery embolization, thermal ablation, selective progesterone receptor modulators, ulipristal acetate, fertility preservation, hysterectomy alternative
- MeSH terms
- Contraceptive Agents, Female, Humans, Hysterectomy, Leiomyoma, Magnetic Resonance Imaging, Norpregnadienes, Progesterone, Risk Factors, Uterine Neoplasms, Randomized Controlled Trials as Topic, Pelvic Pain, Uterine Artery
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