In-utero stress and mode of conception: impact on regulation of imprinted genes, fetal development and future health
Abstract
Background Genomic imprinting is an epigenetic gene regulatory mechanism; disruption of this process during early embryonic development can have major consequences on both fetal and placental development. The periconceptional period and intrauterine life are crucial for determining long-term susceptibility to diseases. Treatments and procedures in assisted reproductive technologies (ART) and adverse in-utero environments may modify the methylation levels of genomic imprinting regions, including insulin-like growth factor 2 (IGF2)/H19, mesoderm-specific transcript (MEST), and paternally expressed gene 10 (PEG10), affecting the development of the fetus. ART, maternal psychological stress, and gestational exposures to chemicals are common stressors suspected to alter global epigenetic patterns including imprinted genes. Objective and rationale Our objective is to highlight the effect of conception mode and maternal psychological stress on fetal development. Specifically, we monitor fetal programming, regulation of imprinted genes, fetal growth, and long-term disease risk, using the imprinted genes IGF2/H19, MEST, and PEG10 as examples. The possible role of environmental chemicals in genomic imprinting is also discussed. Search methods A PubMed search of articles published mostly from 2005 to 2019 was conducted using search terms IGF2/H19, MEST, PEG10, imprinted genes, DNA methylation, gene expression, and imprinting disorders (IDs). Studies focusing on maternal prenatal stress,…
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Imprinting defects in IGF2 are linked to fetal growth restriction.
“Imprinting defects in IGF2 have been linked to fetal growth restriction (Argyraki et al., 2019).”
From Pregnancy-related maternal physiological adaptations and fetal chemical exposure (2023) · cites this paper as Argyraki et al., 2019
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Pregnancy-related maternal physiological adaptations and fetal chemical exposure
Vinnars, M.-T., Bixo, M., & Damdimopoulou, P. (2023) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2023.112064 · Cited by 32 · see citing works
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- Authors
- Argyraki, M., Damdimopoulou, P., Chatzimeletiou, K., Grimbizis, G. F., Tarlatzis, B. C., Syrrou, M., & Lambropoulos, A.
- Affiliations
- Aristotle University of Thessaloniki (GR)
- Karolinska University Hospital (SE)
- University of Ioannina (GR)
- Corresponding author
- Argyraki, Maria
- ORCID
- Venue
- Human Reproduction Update
- Publisher
- Oxford University Press (OUP)
- Published
- 2019-10-21
- Volume
- 25
- Issue
- 6
- Pages
- 777-801
- ISSN
- 1355-4786 (ISSN-L)
- 1460-2369
- OpenAlex
- W2981795986
- Cited by
- 86
- References
- 10
- Citations by year
- 2026: 8 · 2025: 9 · 2024: 7 · 2023: 15 · 2022: 15 · 2021: 18 · 2020: 13 · 2019: 1
- FWCI
- 7.08
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
- Locations
- Human Reproduction Update (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Syndromes and Imprinting
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Keywords
- genomic imprinting, imprinted genes, MEST, PEG10, DNA methylation, prenatal stress, assisted reproduction, mode of conception, fetal programming, fetal growth, birth weight, imprinting disorders, placental development, environmental chemicals, epigenetics, hypothalamic-pituitary-adrenal axis
- MeSH terms
- Animals, Child, DNA-Binding Proteins, Female, Fertilization, Humans, Hypothalamo-Hypophyseal System, Insulin-Like Growth Factor II, Pituitary-Adrenal System, Placenta, Pregnancy, Proteins, RNA-Binding Proteins, Genomic Imprinting, DNA Methylation, Reproductive Techniques, Assisted, Epigenesis, Genetic, Fetal Development, Apoptosis Regulatory Proteins, RNA, Long Noncoding
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