The DOI matches its Crossref record; 66 of the 66 references it cites were found in a registry or an index.
Inflammatory markers and particulate air pollution: characterizing the pathway to disease
Abstract
BACKGROUND: Increased concentrations of particles in air have been related to changes in inflammatory markers that in turn are hypothesized in mediating the particle effects on cardiovascular disease. The present work examined this association in an elderly cohort in the Greater Boston area and addresses the relative role of particles from different sources. METHODS: The study included 710 subjects, active members of the VA Normative Aging Study cohort with measurements of blood markers. Concentrations of particle number (PN), black carbon (BC), fine particulate matter (PM(2.5)), and sulphates were measured at a central site near the examination site. RESULTS: Positive associations were found between traffic-related particles (PN and BC) and inflammatory markers, but only suggestive associations were found with exposures to PM(2.5) and sulphates. The particle effect on the inflammatory markers was greater among subjects older than 78 years and among obese. A suggestion for a greater effect of particles on inflammatory markers among GSTM1-null subjects and non-users of statin drugs was also seen. CONCLUSIONS: The findings of the study support the hypothesis that particles can induce cardiovascular disease through inflammatory pathways, suggestive of a greater toxicity of traffic-related particles.
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“Subjects who develop COPD, an important cause of respiratory mortality, may have weakened antioxidant defenses (Rahman et al. 1996), and PM2.5 can produce oxidative stress, in part because of lung inflammation (Dagher et al. 2005; Zeka et al. 2006).”
From Differentiating the effects of fine and coarse particles on daily mortality in Shanghai, China (2007) · cites this paper as Zeka et al. 2006
Citations
Cites
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Items 201–204 of 204
Liu, R. A., Wei, Y., Qiu, X., Kosheleva, A., & Schwartz, J. D. (2022) · Figshare · doi:10.6084/m9.figshare.21009497
Junglas, T., Daiber, A., Kuntić, I., Valar, A., Zheng, J., Oelze, M. W., Strohm, L., Ubbens, H., Hahad, O., Jiménez, M. T. B., et al. (2026) · Antioxidants · doi:10.3390/antiox15010106
“As a proof-of-concept, populations with a higher cardiovascular risk without statin medication showed more pronounced inflammation by PM exposure than those taking statins [21,22,68–71].”
Park, H., Jang, H., Lee, H., Kim, C., & Cho, J. (2026) · Clinical Hypertension · doi:10.5646/ch.2026.32.e22
Xu, Y., Zhang, Y., Guo, G., Meng, X., Wei, J., Fan, Y., Cai, J., Wu, C., Cai, Z., Zhao, P., et al. (2026) · Environmental Pollution · doi:10.1016/j.envpol.2026.128840
Metadata
- Authors
- Zeka, A., Sullivan, J. R., Vokonas, P. S., Sparrow, D., & Schwartz, J.
- Affiliations
- Harvard University (US)
- Boston University (US)
- Corresponding author
- Zeka, Ariana
- Venue
- International Journal of Epidemiology
- Publisher
- Oxford University Press (OUP)
- Published
- 2006-07-14
- Volume
- 35
- Issue
- 5
- Pages
- 1347-1354
- ISSN
- 0300-5771 (ISSN-L)
- 1464-3685
- OpenAlex
- W2122623434
- Cited by
- 205
- References
- 66
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 8 · 2023: 4 · 2022: 17 · 2021: 20 · 2020: 14 · 2019: 7 · 2018: 9 · 2017: 7 · 2016: 11 · 2015: 10 · 2014: 10 · 2013: 15 · 2012: 15
- FWCI
- 5.58
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Epidemiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Air Quality and Health Impacts
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Indoor Air Quality and Microbial Exposure
- Physical Sciences › Earth and Planetary Sciences › Atmospheric Science › Atmospheric chemistry and aerosols
- Keywords
- particulate matter, air pollution, inflammatory markers, black carbon, PM2.5, sulfate, cardiovascular disease, older adults, obesity, GSTM1, statin use
- MeSH terms
- Adult, Aged, Aged, 80 and over, Air Pollutants, Air Pollution, Vehicle Emissions, Boston, C-Reactive Protein, Cardiovascular Diseases, Environmental Exposure, Environmental Monitoring, Humans, Male, Middle Aged, Obesity, Biomarkers, Inflammation Mediators
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