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Cited by 1,467Nitric Oxide and Endothelin EffectsAntioxidant Activity and Oxidative StressRedox biology and oxidative stress

Role of oxidative stress in cardiovascular diseases

Dhalla, Naranjan S., Temsah, Rana M., Netticadan, Thomas·2000·Journal of Hypertension
DOI 10.1097/00004872-200018060-00002
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Abstract

OBJECTIVES: In view of the critical role of intracellular Ca2 overload in the genesis of myocyte dysfunction and the ability of reactive oxygen species (ROS) to induce the intracellular Ca2+-overload, this article is concerned with analysis of the existing literature with respect to the role of oxidative stress in different types of cardiovascular diseases. OBSERVATIONS: Oxidative stress in cardiac and vascular myocytes describes the injury caused to cells resulting from increased formation of ROS and/or decreased antioxidant reserve. The increase in the generation of ROS seems to be due to impaired mitochondrial reduction of molecular oxygen, secretion of ROS by white blood cells, endothelial dysfunction, auto-oxidation of catecholamines, as well as exposure to radiation or air pollution. On the other hand, depression in the antioxidant reserve, which serves as a defense mechanism in cardiac and vascular myocytes, appears to be due to the exhaustion and/or changes in gene expression. The deleterious effects of ROS are mainly due to abilities of ROS to produce changes in subcellular organelles, and induce intracellular Ca2+-overload. Although the cause-effect relationship of oxidative stress with any of the cardiovascular diseases still remains to be established, increased formation of ROS indicating the presence of oxidative stress has been observed in a wide variety of experimental and clinical conditions. Furthermore, antioxidant therapy has been shown to exert beneficial effects in hypertension, atherosclerosis, ischemic heart disease, cardiomyopathies and congestive heart failure. CONCLUSIONS: The existing evidence support the view that oxidative stress may play a crucial role in cardiac and vascular abnormalities in different types of cardiovascular diseases and that the antioxidant therapy may prove beneficial in combating these problems.

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  • Excess superoxide or other ROS in the cell causes modification of different parts of the cellular machinery and is a known player in the genesis and progression of cardiovascular disease.

    “The excess of superoxide, or other ROS, in the cell causes the modification of different parts of the cellular machinery and is a known player in the genesis and progression of cardiovascular disease (227, 408, 409, 570, 672, 700, 893).”

    From Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation (2019) · cites this paper as [227]

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Authors
Dhalla, N. S., Temsah, R. M., & Netticadan, T.
Affiliations
St. Boniface Hospital (CA)
Corresponding author
Dhalla, Naranjan S.
ORCID
Venue
Journal of Hypertension
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2000-06
Volume
18
Issue
6
Pages
655-673
ISSN
0263-6352 (ISSN-L)
DOI
10.1097/00004872-200018060-00002
OpenAlex
W2092685208
Cited by
1,467
References
265
Citations by year
2026: 16 · 2025: 40 · 2024: 40 · 2023: 49 · 2022: 46 · 2021: 83 · 2020: 63 · 2019: 57 · 2018: 70 · 2017: 75 · 2016: 70 · 2015: 69 · 2014: 80 · 2013: 79 · 2012: 69
FWCI
5.32
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Hypertension (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
  • Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Keywords
oxidative stress, reactive oxygen species, cardiovascular disease, intracellular calcium overload, antioxidant reserve, endothelial dysfunction, air pollution, radiation, hypertension, atherosclerosis, ischemic heart disease, cardiomyopathy, congestive heart failure, antioxidant therapy
MeSH terms
Calcium, Cardiovascular Diseases, Humans, Oxidoreductases, Signal Transduction, Gene Expression, Reactive Oxygen Species, Oxidative Stress

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