The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Zinc for the treatment of diarrhoea: effect on diarrhoea morbidity, mortality and incidence of future episodes
Open accessAbstract
BACKGROUND: Zinc supplementation for the treatment of diarrhoea has been shown to decrease the duration and severity of the diarrhoeal episode, diarrhoea hospitalization rates and, in some studies, all-cause mortality. Using multiple outcome measures, we sought to estimate the effect of zinc for the treatment of diarrhoea on diarrhoea mortality and subsequent pneumonia mortality. METHODS: We conducted a systematic review of efficacy and effectiveness studies. We used a standardized abstraction and grading format and performed meta-analyses for all outcomes with >or=2 data points. The estimated effect on diarrhoea mortality was determined by applying the standard Child Health Epidemiology Reference Group rules for multiple outcomes. RESULTS: We identified 13 studies for abstraction. Zinc supplementation decreased the proportion of diarrhoeal episodes which lasted beyond 7 days, risk of hospitalization, all-cause mortality and diarrhoea mortality. Using diarrhoea hospitalizations as the closest and most conservative possible proxy for diarrhoea mortality, zinc for the treatment of diarrhoea is estimated to decrease diarrhoea mortality by 23%. CONCLUSION: Zinc is an effective therapy for diarrhoea and will decrease diarrhoea morbidity and mortality when introduced and scaled-up in low-income countries.
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Cites
Grading quality of evidence and strength of recommendations
(2004) · BMJ · doi:10.1136/bmj.328.7454.1490 · Cited by 8,477
Bhutta, Z. A., Black, R. E., Brown, K. H., Gardner, J. M., Gore, S., Hidayat, A., Khatun, F., Martorell, R., Ninh, N. X., Penny, M. E., et al. (1999) · The Journal of Pediatrics · doi:10.1016/s0022-3476(99)70086-7 · Cited by 731
Self-citationZinc Supplementation in Young Children with Acute Diarrhea in India
Sazawal, S., Black, R. E., Bhan, M. K., Bhandari, N., Sinha, A., & Jalla, S. (1995) · New England Journal of Medicine · doi:10.1056/nejm199509283331304 · Cited by 383
Self-citationStandards for CHERG reviews of intervention effects on child survival
Walker, N., Fischer-Walker, C., Bryce, J., Bahl, R., Cousens, S., & Effects, W. F. T. C. R. G. O. I. (2010) · International Journal of Epidemiology · doi:10.1093/ije/dyq036 · Cited by 182
Cited by
Bhutta, Z. A., Das, J. K., Rizvi, A., Gaffey, M. F., Walker, N., Horton, S., Webb, P., Lartey, A., & Black, R. E. (2013) · The Lancet · doi:10.1016/s0140-6736(13)60996-4 · Cited by 3,093
Self-citationPerry, H. B., Zulliger, R., & Rogers, M. M. (2014) · Annual Review of Public Health · doi:10.1146/annurev-publhealth-032013-182354 · Cited by 944
Bhutta, Z. A., Das, J. K., Walker, N., Rizvi, A., Campbell, H., Rudan, I., & Black, R. E. (2013) · The Lancet · doi:10.1016/s0140-6736(13)60648-0 · Cited by 675
Self-citationA Guide to Human Zinc Absorption: General Overview and Recent Advances of In Vitro Intestinal Models
Maares, M., & Haase, H. (2020) · Nutrients · doi:10.3390/nu12030762 · Cited by 367
Zinc signals and immune function
Haase, H., & Rink, L. (2014) · BioFactors · doi:10.1002/biof.1114 · Cited by 297
Metadata
- Authors
- Walker, C. L. F., & Black, R. E.
- Venue
- International Journal of Epidemiology
- Publisher
- Oxford University Press (OUP)
- Published
- 2010-03-26
- Volume
- 39
- Issue
- Supplement 1
- Pages
- i63-i69
- ISSN
- 0300-5771 (ISSN-L)
- 1464-3685
- OpenAlex
- W2150020023
- Cited by
- 212
- References
- 4
- FWCI
- 16.11
- Type
- journal article
- Language
- en
- Open access
- hybrid
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