Antibiotics for the treatment of dysentery in children.
Open accessAbstract
BACKGROUND: Ciprofloxacin, ceftriaxone and pivmecillinam are the antibiotics currently recommended by the World Health Organization (WHO) for the treatment of dysentery in children; yet there have been no reviews of the clinical effectiveness of these antibiotics in recent years. METHODS: We reviewed all literature reporting the effect of ciprofloxacin, ceftriaxone and pivmecillinam for the treatment of dysentery in children in the developing countries. We used a standardized abstraction and grading format and performed meta-analyses to determine the effect of treatment with these antibiotics on rates of treatment failure, bacteriological failure and bacteriological relapse. The CHERG Standard Rules were applied to determine the final effect of treatment with these antibiotics on diarrhoea mortality. RESULTS: Eight papers were selected for abstraction. Treatment with ciprofloxacin, ceftriaxone or pivmecillinam resulted in a cure rate of >99% while assessing clinical failure, bacteriological failure and bacteriological relapse. CONCLUSIONS: The antibiotics recommended by the WHO--ciprofloxacin, ceftriaxone and pivmecillinam--are effective in reducing the clinical and bacteriological signs and symptoms of dysentery and thus can be expected to decrease diarrhoea mortality attributable to dysentery.
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A significant proportion of episodes of bloody diarrhea caused by Shigella is associated with considerable mortality and should be treated with antibiotic therapy.
“In contrast, a significant proportion of episodes of bloody diarrhea caused by Shigella is associated with considerable mortality and should be treated with antibiotic therapy 25.”
From Antibiotic treatment of acute gastroenteritis in children (2018) · cites this paper as [25]
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Bhutta, Z. A., Das, J. K., Walker, N., Rizvi, A., Campbell, H., Rudan, I., & Black, R. E. (2013) · The Lancet · doi:10.1016/s0140-6736(13)60648-0 · Cited by 675 · see citing works
Self-citationAntibiotic treatment of acute gastroenteritis in children
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Guarino, A., & Giannattasio, A. (2011) · Current Opinion in Gastroenterology · doi:10.1097/mog.0b013e3283413750 · Cited by 36 · see citing works
- Authors
- Traa, B. S., Walker, C. L. F., Munos, M., & Black, R. E.
- Affiliations
- Johns Hopkins University (US)
- Corresponding author
- Walker, C. L. F.
- Venue
- International Journal of Epidemiology
- Publisher
- Oxford University Press (OUP)
- Published
- 2010-03-26
- Volume
- 39
- Issue
- Supplement 1
- Pages
- i70-i74
- ISSN
- 0300-5771 (ISSN-L)
- 1464-3685
- PMC
- PMC2845863
- OpenAlex
- W2137819797
- Cited by
- 81
- References
- 18
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 6 · 2023: 5 · 2022: 6 · 2021: 4 · 2020: 4 · 2019: 6 · 2018: 6 · 2017: 3 · 2016: 3 · 2015: 5 · 2014: 7 · 2013: 5 · 2012: 7
- FWCI
- 11.29
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc
- Locations
- International Journal of Epidemiology (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Funders
- Bill and Melinda Gates Foundation
- UNICEF
- National Institutes of Health
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (T32HD046405)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Salmonella and Campylobacter epidemiology
- Life Sciences › Immunology and Microbiology › Applied Microbiology and Biotechnology › Antibiotic Use and Resistance
- Life Sciences › Immunology and Microbiology › Microbiology › Bacterial Infections and Vaccines
- Keywords
- dysentery, children, ciprofloxacin, ceftriaxone, pivmecillinam, antibiotic therapy, treatment failure, bacteriological relapse, diarrhea mortality, developing countries
- MeSH terms
- Amdinocillin Pivoxil, Anti-Bacterial Agents, Ceftriaxone, Child, Preschool, Ciprofloxacin, Dysentery, Dysentery, Bacillary, Female, Humans, Infant, Male, Salmonella Infections, Shigella dysenteriae, Randomized Controlled Trials as Topic, Treatment Outcome
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