Parvalbumin Interneurons of Central Amygdala Regulate the Negative Affective States and the Expression of Corticotrophin-Releasing Hormone During Morphine Withdrawal
Open accessAbstract
The central nucleus of the amygdala (CeA) is a crucial component of the neuronal circuitry mediating aversive emotion. Its role in the negative affective states during drug withdrawal includes changes in opioidergic, GABAergic, and corticotropin-releasing factor neurotransmission. However, the modulation of the neurobiological interconnectivity in the CeA and its effects in the negative reinforcement of drug dependents are poorly understood. We performed electrophysiological recordings to assess the membrane excitability of parvalbumin (PV)+ interneurons in the CeA during chronic morphine withdrawal. We tested the morphine withdrawal–induced negative affective states, such as the aversive (assessed by conditioned place aversion), anxiety (assessed by elevated plus maze), and anhedonic-like (assessed by saccharin preference test) behaviors, as well as the mRNA level of corticotropin-releasing hormone (CRH) via optogenetic inhibition or activation of PV+ interneurons in the CeA. Chronic morphine withdrawal increased the firing rate of CeA PV+ interneurons. Optogenetic inhibition of the activity of CeA PV+ interneurons attenuated the morphine withdrawal–induced negative affective states, such as the aversive, anxiety, and anhedonic-like behaviors, while direct activation of CeA PV+ interneurons could trigger those negative affective-like behaviors. Optogenetic inhibition of the CeA PV+ interneurons during the morphine withdrawal significantly attenuated the elevated CRH mRNA level in the CeA. The activity of PV+ interneurons in the CeA was up-regulated during chronic morphine withdrawal. The activation of PV+ interneurons during morphine withdrawal was crucial for the induction of the negative emotion and the up-regulation of CRH mRNA levels in the CeA.
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Early intervention during the prepubertal period may prevent PV-IN loss in the MAM rat model of ventral hippocampal PV-IN loss.
“Interestingly, early intervention during the prepubertal period might prevent loss of PV-INs, as shown in the methylazoxymethanol acetate (MAM) rat model of PV-IN loss in the ventral hippocampus [17].”
From Parvalbumin interneuron vulnerability and brain disorders (2021) · cites this paper as [17]
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Cites
LeDoux, J. E. (2000) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.23.1.155 · Cited by 8,444 · see citing works
Koob, G. F., & Volkow, N. D. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.110 · Cited by 5,340 · see citing works
Contributions of the Amygdala to Emotion Processing: From Animal Models to Human Behavior
Phelps, E. A., & LeDoux, J. E. (2005) · Neuron · doi:10.1016/j.neuron.2005.09.025 · Cited by 3,203 · cited 1× · see citing works
“, 2012), and may represent a common anatomical substrate to produce the negative emotional states that promote negative reinforcement mechanisms associated with the development of addiction (Weiskrantz, 1956; LeDoux, 2000; Phelps and LeDoux, 2005).”
BackgroundNEURAL MECHANISMS OF ADDICTION: The Role of Reward-Related Learning and Memory
Hyman, S. E., Malenka, R. C., & Nestler, E. J. (2006) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.29.051605.113009 · Cited by 2,647 · see citing works
An opponent-process theory of motivation. I. Temporal dynamics of affect
Solomon, R. L., & Corbit, J. D. (1974) · Psychological Review · doi:10.1037/h0036128 · Cited by 1,704 · see citing works
Phasic vs Sustained Fear in Rats and Humans: Role of the Extended Amygdala in Fear vs Anxiety
Davis, M., Walker, D. L., Miles, L., & Grillon, C. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.109 · Cited by 1,488 · cited 1× · see citing works
“The complex interconnectivity of CeA, which plays prominent roles in fear and anxiety (Rodrigues et al., 2004; Ciocchi et al., 2010; Davis et al., 2010; Haubensak et al., 2010; Tye et al., 2011), has been discovered recently by the emerging optogenetic technique.”
Amygdala circuitry mediating reversible and bidirectional control of anxiety
Tye, K. M., Prakash, R., Kim, S.-Y., Fenno, L. E., Grosenick, L., Zarabi, H., Thompson, K. R., Gradinaru, V., Ramakrishnan, C., & Deisseroth, K. (2011) · Nature · doi:10.1038/nature09820 · Cited by 1,289 · see citing works
Hu, H., Gan, J., & Jonas, P. (2014) · Science · doi:10.1126/science.1255263 · Cited by 1,197 · see citing works
Plasticity of reward neurocircuitry and the ‘dark side’ of drug addiction
Koob, G. F., & Le Moal, M. (2005) · Nature Neuroscience · doi:10.1038/nn1105-1442 · Cited by 963 · see citing works
Encoding of conditioned fear in central amygdala inhibitory circuits
Ciocchi, S., Herry, C., Grenier, F., Wolff, S. B. E., Letzkus, J. J., Vlachos, I., Ehrlich, I., Sprengel, R., Deisseroth, K., Stadler, M. B., et al. (2010) · Nature · doi:10.1038/nature09559 · Cited by 924 · see citing works
Inhibitory control of neostriatal projection neurons by GABAergic interneurons
Koós, T. Z., & Tepper, J. M. (1999) · Nature Neuroscience · doi:10.1038/8138 · Cited by 851 · see citing works
Genetic dissection of an amygdala microcircuit that gates conditioned fear
Haubensak, W., Kunwar, P. S., Cai, H., Ciocchi, S., Wall, N. R., Ponnusamy, R., Biag, J., Dong, H.-W., Deisseroth, K., Callaway, E. M., et al. (2010) · Nature · doi:10.1038/nature09553 · Cited by 840 · cited 2× · see citing works
“The complex interconnectivity of CeA, which plays prominent roles in fear and anxiety (Rodrigues et al., 2004; Ciocchi et al., 2010; Davis et al., 2010; Haubensak et al., 2010; Tye et al., 2011), has been discovered recently by the emerging optogenetic technique.”
BackgroundBehavioral changes associated with ablation of the amygdaloid complex in monkeys.
Weiskrantz, L. (1956) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0088009 · Cited by 837 · see citing works
Kawaguchi, Y. (1993) · Journal of Neuroscience · doi:10.1523/jneurosci.13-11-04908.1993 · Cited by 814 · see citing works
CRH Engagement of the Locus Coeruleus Noradrenergic System Mediates Stress-Induced Anxiety
McCall, J. G., Al-Hasani, R., Siuda, E. R., Hong, D. Y., Norris, A. J., Ford, C. P., & Bruchas, M. R. (2015) · Neuron · doi:10.1016/j.neuron.2015.07.002 · Cited by 666 · see citing works
Zhao, S., Ting, J. T., Atallah, H. E., Qiu, L., Tan, J., Gloss, B., Augustine, G. J., Deisseroth, K., Luo, M., Graybiel, A. M., et al. (2011) · Nature Methods · doi:10.1038/nmeth.1668 · Cited by 653 · see citing works
Corticotropin-releasing factor, norepinephrine, and stress
Koob, G. F. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00164-x · Cited by 629 · see citing works
RIVIER, C. L., Brownstein, M. J., Spiess, J., Rivier, J., & Vale, W. (1982) · Endocrinology · doi:10.1210/endo-110-1-272 · Cited by 555 · see citing works
Experience-dependent modification of a central amygdala fear circuit
Li, H., Penzo, M. A., Taniguchi, H., Kopec, C. D., Huang, Z. J., & Li, B. (2013) · Nature Neuroscience · doi:10.1038/nn.3322 · Cited by 497 · cited 1× · see citing works
“Besides the PV+ and CRH+ neurons in the CeA, there are also a large amount of somatostatin-positive interneurons (Li et al., 2013), PKC-δ+ neurons (Haubensak et al.”
BackgroundMolecular mechanisms underlying emotional learning and memory in the lateral amygdala
Rodrigues, S. M., Schafe, G. E., & LeDoux, J. E. (2004) · Neuron · doi:10.1016/j.neuron.2004.09.014 · Cited by 491 · see citing works
Role of Corticotropin-Releasing Factor in Drug Addiction
Logrip, M. L., Koob, G. F., & Zorrilla, E. P. (2011) · CNS Drugs · doi:10.2165/11587790-000000000-00000 · Cited by 476 · see citing works
Parvalbumin-immunoreactive neurons in the rat neostriatum: a light and electron microscopic study
Kita, H., Kosaka, T., & Heizmann, C. W. (1990) · Brain Research · doi:10.1016/0006-8993(90)90002-s · Cited by 431 · see citing works
Valdez, G. R., Roberts, A. J., Chan, K., Davis, H., Brennan, M., Zorrilla, E. P., & Koob, G. F. (2002) · Alcoholism: Clinical and Experimental Research · doi:10.1111/j.1530-0277.2002.tb02448.x · Cited by 387 · see citing works
A Range of Research-Based Pharmacotherapies for Addiction
O’Brien, C. P. (1997) · Science · doi:10.1126/science.278.5335.66 · Cited by 385 · see citing works
The Role of Corticotropin-Releasing Factor in Drug Addiction
Sarnyai, Z., Shaham, Y., & Heinrichs, S. C. (2001) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01492-3 · Cited by 381 · see citing works
Cytoarchitecture of the central amygdaloid nucleus of the rat
McDonald, A. J. (1982) · Journal of Comparative Neurology · doi:10.1002/cne.902080409 · Cited by 338 · see citing works
Wilson, F. A. W., ÓScalaidhe, S. P., & Goldman‐Rakic, P. S. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.9.4009 · Cited by 303 · see citing works
The role of CRF and CRF-related peptides in the dark side of addiction
Koob, G. F. (2009) · Brain Research · doi:10.1016/j.brainres.2009.11.008 · Cited by 290 · see citing works
Parvalbumin‐containing gabaergic interneurons in the rat neostriatum
Cowan, R. L., Wilson, C. J., Emson, P. C., & Heizmann, C. W. (1990) · The Journal of Comparative Neurology · doi:10.1002/cne.903020202 · Cited by 290 · see citing works
Opponent process theory of motivation: Neurobiological evidence from studies of opiate dependence
Koob, G. F., Stinus, L., Moal, M. L., & Bloom, F. E. (1989) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(89)80022-3 · Cited by 268 · see citing works
Conditioned Withdrawal Drives Heroin Consumption and Decreases Reward Sensitivity
Kenny, P. J., Chen, S. A., Kitamura, O., Markou, A., & Koob, G. F. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.0740-06.2006 · Cited by 268 · see citing works
Sarnyai, Z., Bíró, É., Gardi, J., Vecsernyés, M., Julesz, J., & Telegdy, G. (1995) · Brain Research · doi:10.1016/0006-8993(95)00043-p · Cited by 255 · see citing works
George, O., Ghozland, S., Azar, M. R., Cottone, P., Zorrilla, E. P., Parsons, L. H., O'Dell, L. E., Richardson, H. N., & Koob, G. F. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0707585104 · Cited by 245 · see citing works
Colocalization of calcium-binding proteins and GABA in neurons of the rat basolateral amygdala
McDonald, A. J., & Mascagni, F. (2001) · Neuroscience · doi:10.1016/s0306-4522(01)00214-7 · Cited by 221 · see citing works
The role of withdrawal in heroin addiction: enhances reward or promotes avoidance?
Hutcheson, D. M., Everitt, B. J., Robbins, T. W., & Dickinson, A. (2001) · Nature Neuroscience · doi:10.1038/nn0901-943 · Cited by 205 · see citing works
Valdez, G. R., Roberts, A., Chan, K., Davis, H., Brennan, M., Zorrilla, E. P., & Koob, G. F. (2002) · PubMed · doi:10.1097/01.alc.0000033120.51856.f0 · Cited by 187 · see citing works
Bienvenu, T., Busti, D., Magill, P. J., Ferraguti, F., & Capogna, M. (2012) · Neuron · doi:10.1016/j.neuron.2012.04.022 · Cited by 168 · see citing works
Povysheva, N. V., González‐Burgos, G., Zaitsev, A. V., Kröner, S., Barrionuevo, G., Lewis, D. A., & Krimer, L. S. (2005) · Cerebral Cortex · doi:10.1093/cercor/bhj002 · Cited by 145 · see citing works
Stinus, L., Cador, M., Zorrilla, E. P., & Koob, G. F. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300487 · Cited by 139 · see citing works
Zanos, P., Georgiou, P., Wright, S. R., Hourani, S. M., Kitchen, I., Winsky-Sommerer, R., & Bailey, A. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2013.285 · Cited by 133 · see citing works
Bruijnzeel, A. W., Prado, M., & Isaac, S. K. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.01.010 · Cited by 132 · see citing works
Contarino, A., & Papaleo, F. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506999102 · Cited by 107 · see citing works
Huff, M. L., Miller, R. L., Deisseroth, K., Moorman, D. E., & LaLumiere, R. T. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1219593110 · Cited by 104 · see citing works
Casarotto, P. C., & Andreatini, R. (2007) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2007.03.001 · Cited by 86 · see citing works
Cohen, A., Treweek, J. B., Edwards, S., Leão, R. M., Schulteis, G., Koob, G. F., & George, O. (2013) · Addiction Biology · doi:10.1111/adb.12077 · Cited by 73 · see citing works
Alcohol-induced plasticity in the dynorphin/kappa-opioid receptor system
SIROHI, S. K., Bakalkin, G. Y., & Walker, B. M. (2012) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2012.00095 · Cited by 64 · see citing works
Disruption of the CRF/CRF1 Receptor Stress System Exacerbates the Somatic Signs of Opiate Withdrawal
Papaleo, F., Kitchener, P., & Contarino, A. (2007) · Neuron · doi:10.1016/j.neuron.2007.01.022 · Cited by 63 · see citing works
Pisu, M. G., Dore, R., Mostallino, M. C., Loi, M., Pibiri, F., Mameli, R., Cadeddu, R., Secci, P. P., & Serra, M. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.03.021 · Cited by 60 · see citing works
Bruijnzeel, A. W., Ford, J. L., Rogers, J. A., Scheick, S., Ji, Y. R., Bishnoi, M., & Alexander, J. C. (2011) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2011.12.001 · Cited by 59 · see citing works
Bocchio, M., Fucsina, G., Oikonomidis, L., McHugh, S. B., Bannerman, D. M., Sharp, T., & Capogna, M. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.157 · Cited by 54 · see citing works
Disruption of the CRF2 Receptor Pathway Decreases the Somatic Expression of Opiate Withdrawal
Papaleo, F., Ghozland, S. G., Ingallinesi, M., Roberts, A. J., Koob, G. F., & Contarino, A. (2008) · Neuropsychopharmacology · doi:10.1038/npp.2008.8 · Cited by 46 · see citing works
Ravenelle, R., Neugebauer, N. M., Niedzielak, T. R., & Donaldson, S. T. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.04.048 · Cited by 40 · see citing works
Zahm, D. S., Grosu, S., Irving, J. C., & Williams, E. A. (2003) · Brain Research · doi:10.1016/s0006-8993(03)02801-4 · Cited by 38 · see citing works
CRF2 receptor-deficiency eliminates opiate withdrawal distress without impairing stress coping
Ingallinesi, M., Rouibi, K., Moine, C. L., Papaleo, F., & Contarino, A. (2011) · Molecular Psychiatry · doi:10.1038/mp.2011.119 · Cited by 38 · see citing works
Popescu, A. T., & Paré, D. (2010) · Journal of Neurophysiology · doi:10.1152/jn.00732.2010 · Cited by 35 · see citing works
Fadaei, A., Miladi‐Gorji, H., & Hosseini, S. M. (2014) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2014.11.042 · Cited by 27 · see citing works
Qi, X., Shan, Z. J., Ji, Y., Guerra, V., Alexander, J. C., Ormerod, B. K., & Bruijnzeel, A. W. (2014) · Translational Psychiatry · doi:10.1038/tp.2014.25 · Cited by 24 · see citing works
The corticotropin-releasing factor receptor-2 mediates the motivational effect of opiate withdrawal
Rouibi, K., & Contarino, A. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.05.011 · Cited by 14 · see citing works
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- Authors
- Wang, L., Shen, M., Jiang, C., Ma, L., & Wang, F.
- Affiliations
- Shanghai Medical College of Fudan University (CN)
- Corresponding author
- Wang, Li
- Shen, Minjie
- Jiang, Changyou
- Ma, Lan
- Wang, Feifei
- Venue
- International Journal of Neuropsychopharmacology
- Publisher
- Oxford University Press (OUP)
- Published
- 2016-07-06
- Volume
- 19
- Issue
- 11
- Pages
- pyw060
- ISSN
- 1461-1457 (ISSN-L)
- 1469-5111
- PMC
- PMC5137277
- OpenAlex
- W2468781160
- Cited by
- 29
- References
- 58
- Citations by year
- 2026: 5 · 2025: 1 · 2024: 1 · 2023: 7 · 2022: 5 · 2021: 5 · 2020: 1 · 2019: 2 · 2018: 2
- FWCI
- 0.75
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- The International Journal of Neuropsychopharmacology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Funders
- Natural Science Foundation of China (31430033, 91232307, 31421091)
- Ministry of Science and Technology (2015CB553500-2015CB553501)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- parvalbumin interneurons, central amygdala, morphine withdrawal, negative emotions, corticotropin-releasing factor, conditioned place aversion, anxiety, anhedonia, optogenetic manipulation, neuronal excitability, opioid use disorder, aversive emotions
- MeSH terms
- Affect, Animals, Anxiety, Behavior, Animal, Corticotropin-Releasing Hormone, Disease Models, Animal, Feeding Behavior, Genotype, Interneurons, Mice, Inbred C57BL, Mice, Transgenic, Morphine, Parvalbumins, Phenotype, RNA, Messenger, Saccharin, Substance Withdrawal Syndrome, Signal Transduction, Up-Regulation, Maze Learning, Excitatory Postsynaptic Potentials, Miniature Postsynaptic Potentials, Optogenetics, Central Amygdaloid Nucleus
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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