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Monoclonal Versus Polyclonal Antibodies: Distinguishing Characteristics, Applications, and Information Resources
Open accessAbstract
Antibodies are host proteins that comprise one of the principal effectors of the adaptive immune system. Their utility has been harnessed as they have been and continue to be used extensively as a diagnostic and research reagent. They are also becoming an important therapeutic tool in the clinician's armamentarium to treat disease. Antibodies are utilized for analysis, purification, and enrichment, and to mediate or modulate physiological responses. This overview of the structure and function of polyclonal and monoclonal antibodies describes features that distinguish one from the other. A limited review of their use as specific research, diagnostic, and therapeutic reagents and a list of printed and electronic resources that can be utilized to garner additional information on these topics are also included.
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Cites
Inhibitory Fc receptors modulate in vivo cytoxicity against tumor targets
Clynes, R. A., Towers, T. L., Presta, L. G., & Ravetch, J. V. (2000) · Nature Medicine · doi:10.1038/74704 · Cited by 2,768 · cited 1×
“…(trastuzumab) [anti-HER2/neu] has been shown in xenografted mice to be one of the mechanisms by which they may mediate their antitumor effects on non-Hodgkin’s lymphoma and breast cancer, respectively (Baselga and Albanell 2001; Cartron et al. 2004; Clynes et al. 1998, 2000; Waldmann 2003).”
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Cited by
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Metadata
- Authors
- Lipman, N. S., Jackson, L. R., Trudel, L. J., & Weis-Garcia, F.
- Venue
- ILAR Journal
- Publisher
- Oxford University Press (OUP)
- Published
- 2005-01-01
- Volume
- 46
- Issue
- 3
- Pages
- 258-268
- ISSN
- 1084-2020 (ISSN-L)
- OpenAlex
- W2001927093
- Cited by
- 644
- References
- 1
- FWCI
- 4.29
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Lipman, N. S., Jackson, L. R., Trudel, L. J., & Weis-Garcia, F. (2005). Monoclonal Versus Polyclonal Antibodies: Distinguishing Characteristics, Applications, and Information Resources. ILAR Journal. https://doi.org/10.1093/ilar.46.3.258
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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