Cited by 150Pancreatic function and diabetesDiabetes and associated disordersDiabetes Treatment and Management

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Islet Amyloid Polypeptide (IAPP) Transgenic Rodents as Models for Type 2 Diabetes

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Matveyenko, A. V., Butler, P. C.·2006·ILAR Journal

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Abstract

Blood glucose concentrations are maintained by insulin secreted from beta-cells located in the islets of Langerhans. There are approximately 2000 beta-cells per islet, and approximately one million islets of Langerhans scattered throughout the pancreas. The islet in type 2 diabetes mellitus (T2D) has deficient beta-cell mass due to increased beta-cell apoptosis and islet amyloid derived from islet amyloid polypeptide (IAPP). Accumulating evidence implicates toxic IAPP oligomers in the mediation of beta-cell apoptosis in T2D. Humans, monkeys, and cats express an amyloidogenic toxic form of IAPP and spontaneously develop diabetes characterized by islet amyloid deposits. However, longitudinal studies of islet pathology in humans are impossible, and studies in nonhuman primates and cats are costly and impractical. Rodent IAPP is not amyloidogenic, thus commonly used rodent models of diabetes do not recapitulate islet pathology in humans. To investigate the diabetogenic role of human IAPP (h-IAPP), several mouse models and, more recently, a rat model transgenic for h-IAPP have been developed. Studies in these models have revealed that the toxic effect of h-IAPP on beta-cell apoptosis demonstrates a threshold-dependent effect. Specifically, increasing h-IAPP transgene expression by breeding or induction of insulin resistance leads to increased beta-cell apoptosis and diabetes. These transgenic rodent models for h-IAPP provide an opportunity to elucidate the mechanisms responsible for h-IAPP-induced beta-cell apoptosis further and to test novel approaches to the prevention and treatment of T2D.

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Authors: Matveyenko, A. V., & Butler, P. C.
Affiliations: University of California, Los Angeles (US)
ORCID: Matveyenko, A. V.
Butler, P. C.
Venue: ILAR Journal
Publisher: Oxford University Press (OUP)
Published: 2006-01-01
Volume: 47
Issue: 3
Pages: 225-233
ISSN: 1084-2020 (ISSN-L)
DOI: 10.1093/ilar.47.3.225
OpenAlex: W2139785451
Cited by: 150
References: 68
Citations by year: 2026: 4 · 2025: 6 · 2024: 5 · 2023: 8 · 2022: 5 · 2021: 12 · 2020: 7 · 2019: 6 · 2018: 13 · 2017: 9 · 2016: 8 · 2015: 8 · 2014: 7 · 2013: 5 · 2012: 9
FWCI: 1.57
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: ILAR Journal (publishedVersion)
PubMed (publishedVersion)
Funders: Larry L. Hillblom Foundation
Pfizer
National Institutes of Health
University of California, Los Angeles
U.S. Public Health Service
National Institute of Diabetes and Digestive and Kidney Diseases (DK59579, R01DK059579)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Keywords: amylin, type 2 diabetes, transgenic rodent models, beta-cell apoptosis, beta-cell mass, insulin resistance
MeSH terms: Amyloid, Animals, Diabetes Mellitus, Type 2, Disease Models, Animal, Humans, Mice, Transgenic, Insulin-Secreting Cells, Mice, Rats, Islet Amyloid Polypeptide

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Islet Amyloid Polypeptide (IAPP) Transgenic Rodents as Models for Type 2 Diabetes

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