Facilitated expansion of pneumococcal colonization from the nose to the lower respiratory tract in mice preinfected with influenza virus
Open accessAbstract
A strain of Streptococcus pneumoniae, when inoculated intranasally in 2 microl of suspension into BALB/c mice preinfected with influenza virus, colonized first in the nose, and several days thereafter also colonized significantly in the trachea and lungs with purulent inflammation. Pneumoccocal colonization was also observed in the noses of normal mice after the same bacterial inoculation, but not apparently in the lower respiratory tract. These results suggest that pneumococcal infection may develop from the upper to the lower respiratory tract as a possible sequence preferentially in influenza virus-infected subjects.
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Animal models have confirmed that viral infection, particularly influenza, increases bacterial colonization rates in the URT, enhancing the risk of secondary bacterial infections.
“Animal models have similarly confirmed that viral infection, particularly influenza, increases bacterial colonization rates in the URT, enhancing the risk of secondary bacterial infections”
From Respiratory viral infection-induced microbiome alterations and secondary bacterial pneumonia. (2018) · cites this paper as [97]
Pneumococcal infection may sequentially develop from the URT to the LRT in influenza virus-infected subjects.
“This suggests that pneumococcal infection may sequentially develop from the URT to the LRT in influenza virus-infected subjects (97).”
From Respiratory viral infection-induced microbiome alterations and secondary bacterial pneumonia. (2018) · cites this paper as [97]
S. pneumoniae intranasally inoculated into mice pre-infected with influenza virus first colonized the nose, followed by the trachea and lungs several days later with purulent inflammation.
“S. pneumoniae intranasally inoculated into mice pre-infected with influenza virus first colonized the nose, followed by the trachea and lungs several days later with purulent inflammation.”
From Respiratory viral infection-induced microbiome alterations and secondary bacterial pneumonia. (2018) · cites this paper as [97]
This effect was not observed in uninfected animals.
“However, this effect was not observed in uninfected animals.”
From Respiratory viral infection-induced microbiome alterations and secondary bacterial pneumonia. (2018) · cites this paper as [97]
Co-infection may assist in the spreading of S. pneumoniae infection to the lower respiratory tract.
“These findings are reflected in several other studies, with some even showing that co-infection may assist in the spreading of S. pneumoniae infection to the lower respiratory tract (Takase et al., 1999; Seki et al., 2004).”
From Secondary bacterial infections associated with influenza pandemics (2017) · cites this paper as Takase et al., 1999
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Secondary bacterial infections associated with influenza pandemics
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- Authors
- Takase, H., Nitanai, H., Yamamura, E., & Otani, T.
- Affiliations
- New Product Research Laboratories I Daiichi Pharmaceutical Co. Ltd. Edogawa‐ku Tokyo 134‐8630 Japan
- Corresponding author
- Takase, Hiroyuki
- Venue
- Microbiology and Immunology
- Publisher
- Wiley
- Published
- 1999-09
- Volume
- 43
- Issue
- 9
- Pages
- 905-907
- ISSN
- 0385-5600 (ISSN-L)
- 1348-0421
- OpenAlex
- W2088798774
- Cited by
- 18
- References
- 16
- Citations by year
- 2022: 1 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 1 · 2017: 1 · 2015: 1 · 2014: 2 · 2012: 1
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Microbiology and Immunology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Pneumonia and Respiratory Infections
- Life Sciences › Immunology and Microbiology › Microbiology › Microbial infections and disease research
- Health Sciences › Medicine › Epidemiology › Influenza Virus Research Studies
- Keywords
- Streptococcus pneumoniae, pneumococcal carriage, influenza virus, co-infection, tracheal colonization, lung colonization, purulent inflammation, intranasal inoculation, BALB/c mice
- MeSH terms
- Animals, Humans, Influenza, Human, Lung, Mice, Inbred BALB C, Nose, Influenza A virus, Pneumococcal Infections, Streptococcus pneumoniae, Trachea, Superinfection, Mice
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