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Protective Effects of Towne Cytomegalovirus Vaccine Against Low-Passage Cytomegalovirus Administered as a Challenge
Abstract
To test the protective effect of Towne live attenuated human cytomegalovirus (HCMV) vaccine in normal individuals, we developed a parenteral challenge consisting of a low-passage isolate (Toledo stain) inoculated subcutaneously in graded doses. This challenge virus caused a mild mononucleosis syndrome in seronegative individuals at doses of 10 or 100 pfu. The illness was accompanied by atypical lymphocytosis, raised hepatic enzymes, excretion of HCMV and HCMV-specific immune responses. Naturally seropositive volunteers also developed clinical and laboratory evidence of infection after challenge with 1,000 pfu of Toledo but resisted 10 or 100 pfu. Volunteers who had been vaccinated 1 y earlier also were resistant to disease caused by 10 or 100 pfu of Toledo, although some were asymptomatically infected by the 100 pfu dose. Vaccine-induced immunity to HCMV was as complete as naturally induced immunity when the challenge dose of Toledo was 10 pfu.
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Citations
Cited by
Correlates of protection induced by vaccination
Plotkin, S. A. (2010) · Clinical and Vaccine Immunology · doi:10.1128/cvi.00131-10 · Cited by 1,745
Self-citationVaccines: Correlates of Vaccine‐Induced Immunity
Plotkin, S. A. (2008) · Clinical Infectious Diseases · doi:10.1086/589862 · Cited by 829
Self-citationThe pathogenesis of human cytomegalovirus
Griffiths, P., Baraniak, I., & Reeves, M. (2015) · The Journal of Pathology · doi:10.1002/path.4437 · Cited by 592
Landolfo, S., Gariglio, M., Gribaudo, G., & Lembo, D. (2003) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(03)00034-2 · Cited by 358
Human cytomegalovirus latent infection of granulocyte-macrophage progenitors.
Kondo, K., Kaneshima, H., & Mocarski, E. S. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.25.11879 · Cited by 356
Metadata
- Authors
- Plotkin, S. A., Starr, S. E., Friedman, H. M., Gonczol, E., & Weibel, R. E.
- Venue
- Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 1989-05-01
- Volume
- 159
- Issue
- 5
- Pages
- 860-865
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2066964567
- Cited by
- 166
- References
- 0
- FWCI
- 4.12
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Protective Effects of Towne Cytomegalovirus Vaccine Against Low-Passage Cytomegalovirus Administered as a Challenge. https://app.cochat.ai/papers/10.1093/infdis/159.5.860
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- Plotkin, S. A., Starr, S. E., Friedman, H. M., Gonczol, E., & Weibel, R. E. (1989). Protective Effects of Towne Cytomegalovirus Vaccine Against Low-Passage Cytomegalovirus Administered as a Challenge. Journal of Infectious Diseases. https://doi.org/10.1093/infdis/159.5.860
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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