The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.
. Plasma levels of soluble CD14 independently predict mortality in HIV infection.
Open accessAbstract
BACKGROUND: Chronic human immunodeficiency virus (HIV) infection is associated with intestinal permeability and microbial translocation that contributes to systemic immune activation, which is an independent predictor of HIV disease progression. The association of microbial translocation with clinical outcome remains unknown. METHODS: This nested case-control study included 74 subjects who died, 120 of whom developed cardiovascular disease and 81 of whom developed AIDS during the Strategies for Management of Anti-Retroviral Therapy (SMART) study with matched control subjects. Intestinal fatty acid binding protein (I-FABP), lipopolysaccharide (LPS), soluble CD14 (sCD14), endotoxin core antibody (EndoCAb), and 16S ribosomal DNA (rDNA) were measured in baseline plasma samples. RESULTS: Subjects with the highest quartile of sCD14 levels had a 6-fold higher risk of death than did those in the lowest quartile (95% confidence interval, 2.2-16.1; P<.001), with minimal change after adjustment for inflammatory markers, CD4(+) T cell count, and HIV RNA level. No other marker was significantly associated with clinical outcomes. I-FABP, LPS, and sCD14 were increased and EndoCAb was decreased in study subjects, compared with healthy volunteers. sCD14 level correlated with levels of IL-6, C-reactive protein, serum amyloid A and D-dimer. CONCLUSIONS: sCD14, a marker of monocyte response to LPS, is an independent predictor of mortality in HIV infection. Therapeutic attenuation of innate immune activation may improve survival in patients with HIV infection.
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“However, as among those without HIV infection, a likely driving force behind this vulnerability to injury is chronic inflammation (67–69).”
From HIV and Aging: State of Knowledge and Areas of Critical Need for Research. A Report to the NIH Office of AIDS Research by the HIV and Aging Working Group (2012) · cites this paper as [69]
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Microbial translocation is a cause of systemic immune activation in chronic HIV infection
Brenchley, J. M., Price, D. A., Schacker, T. W., Asher, T. E., Silvestri, G., Rao, S., Kazzaz, Z., Bornstein, E., Lambotte, O., Altmann, D., et al. (2006) · Nature Medicine · doi:10.1038/nm1511 · Cited by 3,559
Self-citationCD4+ Count–Guided Interruption of Antiretroviral Treatment
The Strategies for Management of Antiretroviral Therapy (SMART) Study Group (2006) · New England Journal of Medicine · doi:10.1056/nejmoa062360 · Cited by 2,250
Brenchley, J. M., Schacker, T. W., Ruff, L. E., Price, D. A., Taylor, J. H., Beilman, G. J., Nguyen, P. L., Khoruts, A., Larson, M. C., Haase, A. T., et al. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20040874 · Cited by 1,836
Self-citation. Inflammatory and coagulation biomarkers and mortality in patients with HIV infection.
Kuller, L. H., Tracy, R., Belloso, W., Wit, S. D., Drummond, F., Lane, H. C., Ledergerber, B., Lundgren, J., Neuhaus, J., Nixon, D., et al. (2008) · PLoS Medicine · doi:10.1371/journal.pmed.0050203 · Cited by 1,617
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LPS, TLR4 and infectious disease diversity
Miller, S., Ernst, R. K., & Bader, M. W. (2005) · Nature Reviews Microbiology · doi:10.1038/nrmicro1068 · Cited by 1,059
Giorgi, J. V., Hultin, L. E., McKeating, J. A., Johnson, T. D., Owens, B. M., Jacobson, L. P., Shih, R., Lewis, J., Wiley, D. J., Phair, J. P., et al. (1999) · The Journal of Infectious Diseases · doi:10.1086/314660 · Cited by 1,032
Hunt, P. W., Martin, J. N., Sinclair, E., Bredt, B. M., Hagos, E., Lampiris, H. W., & Deeks, S. G. (2003) · The Journal of Infectious Diseases · doi:10.1086/374786 · Cited by 852
Self-citationDeeks, S. G., Ramirez, C. M., Liu, L., Guo, H., Gascon, R., Narváez, A. B., Hunt, P. W., Martin, J. N., Kahn, J. S., Levy, J. A., et al. (2004) · Blood · doi:10.1182/blood-2003-09-3333 · Cited by 803
Self-citationJiang, W., Lederman, M. M., Hunt, P. W., Sieg, S. F., Haley, K. P., Rodriguez, B. A., LANDAY, A. L., Martin, J. N., Sinclair, E., Asher, A. I., et al. (2009) · The Journal of Infectious Diseases · doi:10.1086/597476 · Cited by 598
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Systemic Effects of Inflammation on Health during Chronic HIV Infection
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Metadata
- Authors
- Sandler, N. G., Wand, H., Roque, A., Law, M., Nason, M. C., Nixon, D. E., Pedersen, C., Ruxrungtham, K., Lewin, S. R., Emery, S., Neaton, J. D., Brenchley, J. M., Deeks, S. G., Sereti, I., & Douek, D. C.
- Affiliations
- UNSW Sydney (AU)
- National Institutes of Health (US)
- Virginia Commonwealth University (US)
- University of Southern Denmark (DK)
- Chulalongkorn University (TH)
- Burnet Institute (AU)
- University of Minnesota (US)
- San Francisco General Hospital (US)
- ORCID
- Venue
- The Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2011-03-15
- Volume
- 203
- Issue
- 6
- Pages
- 780-790
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- PMC
- PMC3071127
- OpenAlex
- W2098152094
- Cited by
- 1,106
- References
- 50
- Citations by year
- 2026: 32 · 2025: 31 · 2024: 59 · 2023: 48 · 2022: 67 · 2021: 70 · 2020: 76 · 2019: 70 · 2018: 69 · 2017: 83 · 2016: 107 · 2015: 97 · 2014: 111 · 2013: 93 · 2012: 65
- FWCI
- 37.22
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Infectious Diseases (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- University of Southern Denmark Research Portal (University of Southern Denmark) (submittedVersion)
- Funders
- National Center for Genetic Engineering and Biotechnology
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases (AI 76174, P01AI076174)
- Topics
- Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
- Health Sciences › Medicine › Infectious Diseases › HIV-related health complications and treatments
- Health Sciences › Medicine › Infectious Diseases › HIV/AIDS Research and Interventions
- Keywords
- soluble CD14, HIV infection, mortality prediction, microbial translocation, intestinal permeability, lipopolysaccharide, endotoxin core antibody, intestinal fatty acid binding protein, cardiovascular disease, AIDS, innate immune activation, SMART trial, prognostic factors
- MeSH terms
- Adult, Cause of Death, Humans, Lipopolysaccharides, Male, Middle Aged, RNA, Viral, Biomarkers, CD4-Positive T-Lymphocytes, HIV Infections, Logistic Models, Case-Control Studies, Lipopolysaccharide Receptors, Fatty Acid-Binding Proteins, Young Adult
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